Journal
TRENDS IN IMMUNOLOGY
Volume 37, Issue 6, Pages 364-374Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2016.03.009
Keywords
-
Categories
Funding
- Else-Kroner-Fresenius-Stiftung (EKFS) [2013_A297]
- DFG [HO4281/2-1, TU 90/8-1, SFB 854 TP 27]
Ask authors/readers for more resources
Phenotype switching contributes to nongenomic heterogeneity in melanoma and other cancers. These dynamic and in part reversible phenotype changes impose diagnostic and therapeutic challenges. Understanding the reciprocal coevolution of melanoma and immune cell phenotypes during disease progression and in response to therapy is a prerequisite to improve current treatment strategies. Here we discuss how proinflammatory signals promote melanoma cell plasticity and govern interactions of melanoma and immune cells in the tumor microenvironment. We examine phenotypic plasticity and heterogeneity in different melanoma mouse models with respect to their utility for translational research and emphasize the interplay between melanoma cells and neutrophils as a critical driver of metastasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available