Article
Cardiac & Cardiovascular Systems
Minna Koivunen, Juho Tynkkynen, Niku Oksala, Markku Eskola, Jussi Hernesniemi
Summary: This study aimed to provide comprehensive information on the epidemiology of sudden cardiac arrests (SCA) and sudden cardiac deaths (SCD) after acute coronary syndrome. Through a retrospective study of 10,316 patients with acute coronary syndrome, it was found that the incidence of SCA and SCD was relatively high, accounting for nearly one-third of deaths due to cardiovascular causes. Patients with ST-elevation myocardial infarction and non-ST-elevation myocardial infarction had a higher incidence of SCA.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Samuel J. Tu, Celine Gallagher, Adrian D. Elliott, Dominik Linz, Bradley M. Pitman, Jeroen M. L. Hendriks, Dennis H. Lau, Prashanthan Sanders, Christopher X. Wong
Summary: This study used data from the UK Biobank to investigate the associations of alcohol consumption with incident ventricular arrhythmias (VAs) and sudden cardiac death (SCD). The results showed no clear association between total alcohol consumption and incident VA, but a U-shaped association with SCD. Different types of beverages were associated with different risks of VAs and SCD.
Article
Multidisciplinary Sciences
Andrew E. Radbill, Lucy Y. Lei, Sachin Y. Paranjape, Daniel J. Blackwell, Robert L. Abraham, Derek S. Chew, Satish R. Raj, Bjorn C. Knollmann
Summary: This study aimed to assess rate-dependence of clinical surrogates of contractility and repolarization in humans with hypertrophic cardiomyopathy. Findings show that rapid pacing trains triggered ventricular ectopy in hypertrophic cardiomyopathy patients, but not controls. However, there were no significant differences observed in surrogate measures for cardiac contractility, suggesting that altered length-dependent myofilament activation may not have significant clinical implications in these patients.
Article
Cardiac & Cardiovascular Systems
James P. Curtain, Carly Adamson, Toru Kondo, Jawad Butt, Akshay S. Desai, Faiez Zannad, Jean L. Rouleau, Luis E. Rohde, Lars Kober, Inder S. Anand, Dirk J. van Veldhuisen, Michael R. Zile, Martin P. Lefkowitz, Scott D. Solomon, Milton Packer, Mark C. Petrie, Pardeep S. Jhund, John J. McMurray
Summary: This study examined the incidence of ventricular tachycardia (VT) and ventricular fibrillation (VF) in patients with heart failure and their relationship with mortality. The results showed that VT/VF events were uncommon but strongly associated with mortality in heart failure patients. These events seem to be markers of disease severity rather than risk of sudden death.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Sumeet S. Chugh, Kyndaron Reinier, Audrey Uy-Evanado, Harpriya S. Chugh, David Elashoff, Christopher Young, Angelo Salvucci, Jonathan Jui
Summary: This study successfully developed a novel algorithm for predicting sudden cardiac arrest with ventricular fibrillation/ventricular tachycardia, with good discrimination in training and validation datasets, potentially enhancing primary prevention efforts.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Matthijs J. M. Cluitmans, Jason Bayer, Laura R. Bear, Rachel M. A. ter Bekke, Jordi Heijman, Ruben Coronel, Paul G. A. Volders
Summary: Sudden cardiac death is often caused by ventricular arrhythmias driven by reentry. This study provides a comprehensive characterization of trigger-substrate interaction leading to reentry and proposes a new mechanistic framework called the Circle of Reentry. The findings highlight the importance of local dispersion of excitability, critical relative size of excitable and inexcitable regions, and appropriate timing and origin of triggers in reentry initiation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Ameenathul M. M. Fawzy, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Gregory Y. H. Lip, Laurent Fauchier
Summary: This study investigated the association between atrial fibrillation (AF) and ventricular arrhythmias (VAs) and sudden death in hospitalized patients in France. The results showed that AF patients had significantly higher incidence and risk of VAs and cardiac arrest compared to non-AF patients. This association remained significant after adjusting for confounders, indicating a clear association between AF and VAs and sudden death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Brian Martin, Rebecca R. Vanderpool, Brian L. Henry, Joshua B. Palma, Beth Gabris, Yen-Chun Lai, Jian Hu, Stevan P. Tofovic, Rajiv P. Reddy, Ana L. Mora, Mark T. Gladwin, Guillermo Romero, Guy Salama
Summary: The study found that treatment with Relaxin in a PAH animal model can prevent cardiac dysfunctions and arrhythmias, suggesting a potential protective role against these conditions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
David M. Raffel, Thomas C. Crawford, Yong-Woon Jung, Robert A. Koeppe, Guie Gu, Jill Rothley, Kirk A. Frey
Summary: The study evaluated the performance of F-18-4F-MHPG and F-18-3F-PHPG in cardiomyopathy patients, demonstrating their robustness in quantifying regional cardiac sympathetic nerve density. Both tracers provided comparable metrics of nerve density and left ventricular denervation, with F-18-4F-MHPG showing advantages of faster liver clearance and more consistent plasma metabolism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Cicely Anne Dye, Erica Engelstein, Sean Swearingen, Jeanine Murphy, Timothy Larsen, Annabelle Santos Volgman
Summary: Arrhythmias and sudden cardiac death with sexual activity are rare, but recent studies suggest that these events are occurring in younger individuals, with a higher proportion of female decedents than previously described. Open dialogue between the cardiovascular team and the cardiac patient is necessary to provide education and reassurance for safe sexual activity participation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jean-Philippe Empana, Ivan Lerner, Eugenie Valentin, Fredrik Folke, Bernd Boettiger, Gunnar Gislason, Martin Jonsson, Mattias Ringh, Frankie Beganton, Wulfran Bougouin, Eloi Marijon, Marieke Blom, Hanno Tan, Xavier Jouven
Summary: This study aimed to determine the incidence of sudden cardiac death and out-of-hospital cardiac arrest in the European Union by utilizing data from four large population-based registries with at least 5 years of data collection.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Teddy Tai Loy Lee, Jeremy Man Ho Hui, Yan Hiu Athena Lee, Danish Iltaf Satti, Yuki Ka Ling Shum, Pias Tang Hoi Kiu, Abraham Ka Chung Wai, Tong Liu, Wing Tak Wong, Jeffrey Shi Kai Chan, Bernard Man Yung Cheung, Ian Chi Kei Wong, Shuk Han Cheng, Gary Tse
Summary: This study compared the risk of ventricular arrhythmia or sudden cardiac death between metformin and sulfonylurea users in patients with type 2 diabetes. The study found that sulfonylurea use is associated with a higher risk of ventricular arrhythmia or sudden cardiac death than metformin in patients with type 2 diabetes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Medicine, General & Internal
G. Riva, J. Hollenberg
Summary: Out-of-hospital cardiac arrest is a major cause of death in the Western world. Initiating CPR is key to improving survival rates, with early CPR and prompt defibrillation being important factors that influence survival rates.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Cell Biology
Christine Mages, Heike Gampp, Pascal Syren, Ann-Kathrin Rahm, Florian Andre, Norbert Frey, Patrick Lugenbiel, Dierk Thomas
Summary: This review highlights the pathomechanisms underlying arrhythmogenicity in patients with heart failure, such as myocardial fibrosis and ion channel remodeling. It emphasizes the association of dysregulated ion channel expression with cardiomyopathy and arrhythmia development, and discusses potential therapeutic options.
Review
Medicine, General & Internal
Natallia Laptseva, Valentina A. Rossi, Isabella Sudano, Rahel Schwotzer, Frank Ruschitzka, Andreas J. Flammer, Firat Duru
Summary: Amyloidosis is a systemic disease characterized by extracellular deposits of insoluble amyloid in various tissues and organs. Cardiac amyloidosis is a frequent feature of the disease, causing a progressive, restrictive type of cardiomyopathy, and is associated with adverse clinical outcomes and increased mortality. This review aims to provide insights into the arrhythmic features of cardiac amyloidosis by discussing the pathogenesis, challenges in risk stratification, and management strategies for these arrhythmias.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Maxim Grymonprez, Tine L. De Backer, Andreas Capiau, Delphine Vauterin, Els Mehuys, Koen Boussery, Stephane Steurbaut, Lies Lahousse
Summary: This study investigated the use of oral anticoagulants in Belgian atrial fibrillation patients and found a continuous increase in the use of non-vitamin K antagonist oral anticoagulants (NOACs) since 2013, while vitamin K antagonists (VKAs) were less commonly used. Female patients showed a potential underuse of oral anticoagulants.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Sara R. A. Wijnant, Elizabeth Benz, Annemarie Luik, Fernando Rivadeneira, Trudy Voortman, Guy G. Brusselle, Lies Lahousse
Summary: Frailty transitions are more common in participants with PRISm or COPD, and physical frailty assessment improves risk stratification for predicting increased life years in patients with impaired spirometry.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Dagje Boeykens, Lara Decoster, Dorine Lenoir, An De Sutter, Reini Haverals, Lies Lahousse, Peter Pype, Dominique Van de Velde, Pauline Boeckxstaens, Patricia De Vriendt
Summary: To understand the concept of goal-oriented care (GOC), interviews were conducted with 50 people living with chronic conditions. The deductive approach focused on attributes generated in a concept analysis on GOC, while the inductive approach used descriptive phenomenology. Goal-elicitation was recognized, but goal-setting and goal-evaluation were experienced to a lesser extent.
PATIENT EDUCATION AND COUNSELING
(2023)
Letter
Respiratory System
Johnmary T. Arinze, Tjeerd van der Veer, Daniel Bos, Bruno Stricker, Katia M. C. Verhamme, Guy Brusselle
Letter
Respiratory System
Dave Singh, Alberto Papi, Guy Brusselle, J. Christian Virchow, Giorgio Walter Canonica, Eva Topole, Andrea Vele, George Georges
Article
Cardiac & Cardiovascular Systems
Maxim Grymonprez, Andreas Capiau, Stephane Steurbaut, Koen Boussery, Els Mehuys, Annemie Somers, Mirko Petrovic, Tine L. De Backer, Lies Lahousse
Summary: Concomitant use of pharmacodynamic interacting drugs is associated with higher bleeding risks in NOAC-treated atrial fibrillation patients, particularly with P2Y12 inhibitors and corticosteroids.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Maxim Grymonprez, Stephane Steurbaut, Andreas Capiau, Delphine Vauterin, Frauke Van Vaerenbergh, Els Mehuys, Koen Boussery, Tine L. De Backer, Lies Lahousse
Summary: Poor adherence to NOACs is associated with increased risks of thromboembolism and all-cause mortality. The minimal adherence threshold should be ≥ 90%, preferably even ≥ 95%.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Environmental Sciences
Arce Domingo-Relloso, Roby Joehanes, Zulema Rodriguez-Hernandez, Lies Lahousse, Karin Haack, M. Daniele Fallin, Miguel Herreros-Martinez, Jason G. Umans, Lyle G. Best, Tianxiao Huan, Chunyu Liu, Jiantao Ma, Chen Yao, Allan Jerolon, Jose D. Bermudez, Shelley A. Cole, Dorothy A. Rhoades, Daniel Levy, Ana Navas-Acien, Maria Tellez-Plaza
Summary: This study investigated the role of DNA methylation in mediating the association between smoking and lung cancer. Differential methylation sites related to smoking and lung cancer were identified through blood DNA methylation analysis. The findings were validated in another study and showed downregulated gene expression related to cancer. Therefore, the association between smoking and lung cancer can be partly explained by differences in baseline blood DNA methylation.
ENVIRONMENTAL POLLUTION
(2023)
Article
Respiratory System
Christian R. Osadnik, Lisa J. Brighton, Chris Burtin, Matteo Cesari, Lies Lahousse, Will D. C. Man, Alessandra Marengoni, Andreja Sajnic, Jonathan P. Singer, Lies ter Beek, Ioanna Tsiligianni, Janos T. Varga, Stefano Pavanello, Matthew Maddocks
Summary: Frailty is a complex syndrome characterized by a loss of physiological reserves, making individuals more susceptible to adverse health outcomes. While most of our knowledge about frailty comes from geriatric medicine, its importance as a treatable trait in chronic respiratory diseases is becoming more recognized. Understanding frailty and its impact in chronic respiratory diseases is crucial for optimizing clinical management in the future.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Maxim Grymonprez, Laura Carnoy, Andreas Capiau, Koen Boussery, Els Mehuys, Tine L. De Backer, Stephane Steurbaut, Lies Lahousse
Summary: This study investigated the impact of P-glycoprotein (P-gp) and CYP3A4 inhibitors and inducers on clinical outcomes in patients with atrial fibrillation (AF) treated with non-vitamin K antagonist oral anticoagulants (NOACs). The results showed that concomitant use of P-gp/CYP3A4 inhibitors was associated with higher risks of major bleeding and all-cause mortality, while concomitant use of P-gp/CYP3A4 inducers was associated with a higher risk of stroke.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Review
Respiratory System
Delphine Vauterin, Frauke Van Vaerenbergh, Anna Vanoverschelde, Jennifer K. Quint, Katia Verhamme, Lies Lahousse
Summary: This article systematically reviews the existing methods for assessing adherence to COPD medication in healthcare databases and evaluates the reporting of influencing variables. The study finds significant variations in adherence assessment methods and recommends attention to transparency and reporting of variables.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Respiratory System
Elizabeth Benz, Lies Lahousse, Johnmary T. Arinze, Sara Wijnant, Maria de Ridder, Fernando Rivadeneira, Guy Brusselle, Bruno H. Stricker
Summary: This study aimed to investigate the association between the use of OCS and muscle strength and mass in older people, as well as its interaction with chronic airway diseases. The results showed that OCS use was associated with a decline in handgrip strength in people with COPD, and this association was dependent on the frequency and duration of OCS use.
Article
Respiratory System
Christian Domingo, Klaus F. Rabe, David Price, Guy Brusselle, Michael E. Wechsler, Changming Xia, Nami Pandit-Abid, Rebecca Gall, Paul J. Rowe, Yamo Deniz, Juby A. Jacob-Nara, Amr Radwan
Summary: This post hoc analysis evaluates the long-term effects of dupilumab on severe OCS-dependent asthma, and finds that it improves clinical outcomes and reduces OCS dose irrespective of baseline disease severity.
Article
Respiratory System
Antoine Froidure, Benjamin Bondue, Caroline Dahlqvist, Julien Guiot, Natacha Gusbin, Gil Wirtz, Guy Brusselle, Danielle Strens, Hans Slabbynck, Wim A. Wuyts
Summary: This study compares the characteristics and clinical course of patients with suspected familial pulmonary fibrosis (FPF) and sporadic IPF. The results show that patients with FPF, despite being younger and exposed to less tobacco, have an equally aggressive progression as observed in sporadic IPF patients.