Article
Medicine, General & Internal
Stefano Mastrobuoni, Manuel Johanns, Martial Vergauwen, Gwen Beaurin, Mark Rider, Pierre Gianello, Alain Poncelet, Olivier Van Caenegem
Summary: Transplantation of heart following donation after circulatory death (DCD) has been introduced into clinical practice. In a porcine model of DCD heart, we tested the effect of different temperatures on cardiac metabolism during ex vivo reperfusion. We observed a steep fall in ATP concentrations at the end of warm ischemic time, limited regeneration during reperfusion, and an increase in lactate concentration. However, the temperature did not have an effect on ATP or lactate concentration. Additionally, all cardiac allografts experienced significant weight increase due to cardiac edema, regardless of the temperature.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Wei Kelly Wu, Rei Ukita, Yatrik J. Patel, Michael Cortelli, Vincent Q. Trinh, Ioannis A. Ziogas, Sean A. Francois, Meredith Mentz, Nancy L. Cardwell, Jennifer R. Talackine, William M. Grogan, John W. Stokes, Youngmin A. A. Lee, Jinho Kim, Sophoclis P. Alexopoulos, Matthew Bacchetta
Summary: Xenogeneic cross-circulation technique has been successfully used to support and rehabilitate declined donor livers, resulting in preservation of organ structure and function, improved viability markers, and potential for further research in organ recovery and rehabilitation.
Article
Surgery
Stine Lohmann, Merel B. F. Pool, Kaithlyn M. Rozenberg, Anna K. Keller, Cyril Moers, Ulla Moldrup, Bjarne K. Moller, Stina J. M. Lignell, Soren Krag, Jesus M. Sierra-Parraga, Maria L. Lo Faro, James Hunter, Martin J. Hoogduijn, Carla C. Baan, Henri G. D. Leuvenink, Rutger J. Ploeg, Marco Eijken, Bente Jespersen
Summary: This study aimed to evaluate the safety and feasibility of using MSC treatment during NMP in a porcine autotransplantation model, and found that infusing MSCs during ex vivo NMP of porcine kidneys was safe and feasible. However, no beneficial effects of ex vivo MSC therapy could be demonstrated during the short posttransplant follow-up period of 14 days.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Michael Olausson, Deepti Antony, Galina Travnikova, Martin Johansson, Nikhil B. Nayakawde, Debashish Banerjee, John Mackay Softeland, Goditha U. Premaratne
Summary: This study demonstrates that kidneys from extended uDCD, without aCPR/EC, can be salvaged using thrombolytic treatment to remove fibrin thrombi while preserving histology. These kidneys can then be transplanted with clinically acceptable early function.
Review
Respiratory System
Tiago N. Machuca, Marcelo Cypel, Shaf Keshavjee
Summary: Ex vivo lung perfusion has emerged as a safe method for preserving and reassessing marginal lung grafts, expanding the donor pool and increasing global lung transplant activity. Additionally, it serves as a platform for advanced diagnostics, enabling specific targeted or personalized treatments.
JOURNAL OF THORACIC DISEASE
(2021)
Review
Biotechnology & Applied Microbiology
Chuanyan Shen, Hongwei Cheng, Tingting Zong, Hongli Zhu
Summary: The gap between the number of liver transplant patients and available donors is a significant issue in the field of transplantation. Limited access to liver transplantation has led to the use of extended criteria donors to address the growing demand. Preservation before transplantation plays a crucial role in determining patient outcomes, and the use of normothermic machine perfusion shows promise in improving graft viability and assessing viability before transplantation. This review provides an overview of normothermic machine perfusion and its application in liver preservation and pre-transplantation, as well as data from current clinical trials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Immunology
Christopher J. E. Watson, Stephen MacDonald, Christopher Bridgeman, Rebecca Brais, Sara S. Upponi, Theodora Foukaneli, Lisa Swift, Corrina Fear, Linda Selves, Vasilis Kosmoliaptsis, Michael Allison, Rachel Hogg, Kourosh Saeb Parsy, Will Thomas, Rohit Gaurav, Andrew J. Butler
Summary: This study aimed to determine the underlying cause of biliary complications leading to liver retransplantation and evaluate the role of fibrinolysis. The results showed the presence of fibrin during cold storage and its association with poor posttransplant outcomes. Fibrinolytic therapy may be a promising intervention.
Review
Immunology
Sanne J. J. Langmuur, Jorik H. Amesz, Kevin M. Veen, Ad J. J. C. Bogers, Olivier C. Manintveld, Yannick J. H. J. Taverne
Summary: This article presents a meta-analysis on the use of the Organ Care System (OCS) for heart transplantation. The analysis found that using OCS for heart perfusion showed similar outcomes to static cold storage in terms of survival and secondary outcomes.
Review
Surgery
Belle Liew, David Nasralla, Satheesh Iype, Joerg-Matthias Pollok, Brian Davidson, Dimitri A. Raptis
Summary: Machine perfusion, especially hypothermic machine perfusion, showed advantages in reducing early allograft dysfunction and improving recipient outcomes in liver transplant surgeries. Normothermic machine perfusion was associated with reduced graft injury and major complication risks. Both techniques have the potential to lead to cost savings.
BRITISH JOURNAL OF SURGERY
(2021)
Review
Immunology
Nikhil K. Prasad, Chetan Pasrija, Tara Talaie, Alexander S. Krupnick, Yunge Zhao, Christine L. Lau
Summary: There is a significant shortage of donor organs for lung transplantation, and new strategies are needed to meet the growing global demand. Ex vivo lung perfusion has emerged as a powerful tool for evaluating and optimizing donor lungs before transplantation, providing exciting future opportunities for lung transplantation.
Article
Surgery
Lin Zhu, Arshna Qureshi, Mohamed Awad, Alfred Hausladen, Silvia Perez-Protto, Samir Q. Latifi, Daniel J. Lebovitz, Kenneth Chavin, Jonathan S. Stamler, James D. Reynolds
Summary: The study demonstrated that adding ethyl nitrite to the preservation solution can significantly improve perfusion parameters in pumped human kidneys, increasing flow rate and decreasing resistance. This improvement may be explained by elevated levels of cyclic guanosine monophosphate and increased levels of interleukin-10.
Article
Cardiac & Cardiovascular Systems
Robert Qaqish, Yui Watanabe, Konrad Hoetzenecker, Jon Yeung, Manyin Chen, Andrew Pierre, Kazuhiro Yasufuku, Laura Donahoe, Marc de Perrot, Tom Waddell, Shaf Keshavjee, Marcelo Cypel
Summary: Short- and long-term outcomes are similar between recipients of lungs from donation after neurologic determination of death and donation after circulatory determination of death. Different intervals between withdrawal of life-sustaining therapies and cardiac arrest did not impact recipient outcomes, and the maximum acceptable duration of this interval remains to be established.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Surgery
Nikolas H. Zaphiros, Jing Nie, Michael W. Alchaer, Liise K. Kayler
Summary: Donation after circulatory death (DCD) kidneys, exposed to warm ischemia and cold ischemia time, have increased risk of delayed graft function (DGF) and worse graft survival. This study evaluated the impact of cold ischemia time on DCD kidney outcomes. The results showed that prolonged cold ischemia time had a dose-dependent effect on graft survival, with longer time intervals associated with higher risks of graft failure. These findings highlight the importance of minimizing cold ischemia time in DCD kidney transplantation to improve long-term outcomes.
CLINICAL TRANSPLANTATION
(2023)
Article
Engineering, Biomedical
Bassam Shukrallah, Asvin M. Ganapathi, Bryan A. Whitson
Summary: The creation of a new pulmonary artery conduit using the donor aorta can alleviate the issue of inadequate pulmonary artery for ex vivo lung perfusion. This technique will become increasingly important as donation after circulatory death donor (DCD) heart procurements become more common. Time constraints associated with DCD recovery approach may lead to the necessity of this new pulmonary artery conduit.
Article
Surgery
Pedro Ventura-Aguiar, Joana Ferrer, David Paredes, Camino Rodriguez-Villar, Angel Ruiz, Josep Fuster, Constantino Fondevila, Juan Carlos Garcia-Valdecasas, Enric Esmatjes, Ramon Adalia, Federico Oppenheimer, Josep M. Campistol, Fritz Diekmann, Maria J. Ricart
Summary: The study found that the cardiac arrest time in donors after brain death does not have a significant impact on pancreas transplant outcomes, but patients with longer CAT may need to postpone donation for a more comprehensive evaluation.
Article
Transplantation
Walid Al-Qerem, Noel Carter, Jonathan Ling
Summary: This study adapted an existing questionnaire into Arabic to understand the lower organ donation rates in the Arabic-speaking world. The findings showed that among Jordanian adults, there was a good understanding of organ donation and positive attitudes towards it, with concerns focused more on distrust of health services.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Walid Al-Qerem, Anan Jarab, Alaa Hammad, Alaa Hussein Alsajri, Shadan Waleed Al-Hishma, Jonathan Ling, Asal Saad Alabdullah, Ali Salama, Rami Mosleh
Summary: There is hesitancy among Iraqi adults towards accepting COVID-19 booster doses, with reasons including perceived lack of necessity and conspiracy beliefs. Low socioeconomic status and limited knowledge about COVID-19 and its vaccines are associated with vaccine hesitancy.
PATIENT PREFERENCE AND ADHERENCE
(2022)
Article
Environmental Sciences
Alaa M. Hammad, Walid Al-Qerem, Fawaz Alasmari, Jonathan Ling, Raghda Qarqaz, Hakam Alaqabani
Summary: This study found that Syrian refugees in the Zaatari refugee camp have multiple drug therapy problems (DTPs) among their medications. Greater focus should be placed on their medical care, in order to prevent any future complications due to DTPs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Judith Eberhardt, Jonathan Ling, Louis Horsley, Jessie Cunnett, Ella Fryer-Smith, Jacob Lant, Sue Edwards, Euan Ross
Summary: This qualitative study aimed to understand the factors affecting COVID-19 vaccine hesitancy in Black and Asian individuals in England. The findings suggest that respecting individuals' agency, transparency of information, and independence of the bodies providing information are important. Local networks should be used instead of targeted messaging to increase vaccine uptake among Black and Asian individuals.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2023)
Article
Psychology, Clinical
Judith Eberhardt, Jonathan Ling
Summary: The present study examines the association between COVID-19 vaccination intention in younger adults and Protection Motivation Theory (PMT), including coronavirus conspiracy beliefs. The findings suggest that severity, self-efficacy, maladaptive response reward, and coronavirus conspiracy beliefs are associated with the intention to get vaccinated. The study highlights the need to address perceived severity and perceived ability to get vaccinated while reducing the perceived reward of not getting vaccinated, as well as addressing coronavirus conspiracy beliefs in vaccine-hesitant individuals.
Article
Allergy
Walid Al-Qerem, Anan Jarab, Shrouq R. Abu Heshmeh, Jonathan Ling
Summary: The majority of asthmatic patients had insufficiently managed disease. The main factors that contributed to poor asthma control were respiratory infection history, increased exposure to asthma symptoms triggers, and nonuse of inhaled corticosteroids.
Article
Health Policy & Services
Parisa Diba, Jonathan Bowden, Andrew Divers, Beth Taylor, Dorothy Newbury-Birch, Jonathan Ling
Summary: This study explores the development of integrated well-being services in two local authorities in North-East England. The research utilized a mixed-methods approach and identified the benefits and challenges of an integrated service model. The findings indicate that the integrated service model has promising potential for local authorities.
JOURNAL OF INTEGRATED CARE
(2023)
Article
Health Care Sciences & Services
Jonathan Ling, Karen McCabe, Ann Crosland, Laura Kane, Judith Eberhardt
Summary: This study examined the impact of tailored multicomponent interventions on the lives of people recently diagnosed with dementia and their carers. The findings indicate that providing ongoing support can greatly reduce carer burden and enhance emotional wellbeing.
HEALTH EXPECTATIONS
(2023)
Article
Immunology
Walid Al-Qerem, Anan Jarab, Alaa Hammad, Fawaz Alasmari, Jonathan Ling, Enas Al-Zayadneh, Montaha Al-Iede, Badi'ah Alazab, Leen Hajeer
Summary: This study investigated the knowledge, attitudes, and practices of parents of asthmatic children towards influenza vaccination. The results showed that 60.4% of asthmatic children had never received a flu vaccine, with reasons including perceived lack of necessity and forgetfulness. The study emphasized the importance of raising awareness among parents of asthmatic children about the importance of vaccination.
Article
Allergy
Walid Al-Qerem, Anan Jarab, Yazun Jarrar, Enas Al-Zayadneh, Montaha Al-Iede, Jonathan Ling, Khawla Abu Hammour, Sally S. Alabdullah, Asal Saad Alabdullah, Yamam Al Refaie, Dina Lubbad, Ameen Alassi, Sarah Ibrahim, Mahmood Al-Ibadah, Abdel Qader Al Bawab
Summary: This study aimed to assess factors related to asthma management, especially atopy level and the impact of genetic variants of the vitamin D receptor (VDR) gene. The results indicated that many asthma patients had poorly controlled asthma, and factors associated with poor asthma control included poor inhaler technique.
Article
Immunology
Walid Al-Qerem, Anan Jarab, Yara Shawabkeh, Jonathan Ling, Alaa Hammad, Badi'ah Alazab, Fawaz Alasmari
Summary: This study examines the intention of pregnant and lactating women towards receiving a booster dose of the COVID-19 vaccine and its associated factors. The findings suggest that factors such as older age, chronic disease, high education, high income, and high perceived risk of COVID-19 are associated with higher knowledge about COVID-19. Moreover, participants who anticipated contracting COVID-19, had high perceived risk, high knowledge, received the COVID-19 vaccine based on conviction, and were smokers expressed a higher intention to receive a booster dose of the vaccine.
Article
Medicine, General & Internal
Isabella G. Ighaede-Edwards, Xiaoqun Liu, David B. Olawade, Jonathan Ling, Aderonke Odetayo, Aanuoluwapo C. David-Olawade
Summary: This study aimed to determine the prevalence and predictors of bullying in secondary schools in Edo State, Nigeria. The study found that approximately half of the respondents (51.9%) had experienced at least one type of bullying, while 173 (27.9%) reported themselves as bullies. The study also found that junior students were more likely to be bullied than senior students, and students living in rural areas were more likely to be bullied than those in urban areas.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Judith Eberhardt, John Kabuye, Jonathan Ling
Summary: The uptake of COVID-19 booster vaccines among minority ethnic individuals in the UK is lower compared to the general population. This study explored the attitudes and perceptions of ethnic minority individuals in North East England towards the COVID-19 booster vaccination. Results showed that perceived susceptibility to COVID-19, time constraints, lack of practical support, lack of confidence in the vaccine, and medical mistrust were factors contributing to vaccine hesitancy. The involvement of community leaders in addressing concerns and improving confidence in COVID-19 vaccination was suggested.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
Article
Social Sciences, Interdisciplinary
Marie Kotzur, Rana Amiri, Lauren Gatting, Kathryn A. Robb, Jonathan Ling, John D. Mooney, Floor Christie-de Jong
Summary: Early diagnosis of cancer through screening can reduce deaths and treatment burden. However, ethnic minority groups face inequalities in screening participation. This article describes a successful online participatory research that used faith-based messages to reduce cancer screening barriers, specifically targeting Muslim women. The findings highlight the importance of interactive discussion and low participant burden in online co-design.
INTERNATIONAL JOURNAL OF QUALITATIVE METHODS
(2023)
Review
Urology & Nephrology
Ozkan Gungor, Mustafa Sevinc, Sena Ulu, Ismail Kocyigit
Summary: Cardiovascular disease is common in patients with chronic kidney disease and is the leading cause of mortality. Advanced age, hypertension, uremic toxins, and other factors contribute to increased cardiovascular disease risk. Sarcopenia, a decrease in muscle strength, is prevalent in chronic kidney disease patients and is associated with lower quality of life and increased mortality risk.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
