Article
Immunology
Allison J. Kwong, W. Ray Kim, John Lake, Peter G. Stock, Connie J. Wang, James B. Wetmore, Marc L. Melcher, Andrew Wey, Nicholas Salkowski, Jon J. Snyder, Ajay K. Israni
Summary: A study found that livers with macrovesicular steatosis are less likely to be transplanted due to their higher risk of graft failure. To facilitate the use of these higher-risk organs, the SRTR now includes the variable of macrovesicular steatosis in their risk-adjustment models.
Article
Surgery
Raphael Pascal Henri Meier, Yvonne Kelly, Hillary Braun, Daniel Maluf, Chris Freise, Nancy Ascher, John Roberts, Garrett Roll
Summary: This study compares graft survival and biliary complications in liver transplantation using donation-after-circulatory-death, donation-after-brain-death, and living-donation methods. The results show that despite higher rates of biliary complications, donation-after-circulatory-death and living-donation have excellent graft survival.
TRANSPLANT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Robert Qaqish, Yui Watanabe, Konrad Hoetzenecker, Jon Yeung, Manyin Chen, Andrew Pierre, Kazuhiro Yasufuku, Laura Donahoe, Marc de Perrot, Tom Waddell, Shaf Keshavjee, Marcelo Cypel
Summary: Short- and long-term outcomes are similar between recipients of lungs from donation after neurologic determination of death and donation after circulatory determination of death. Different intervals between withdrawal of life-sustaining therapies and cardiac arrest did not impact recipient outcomes, and the maximum acceptable duration of this interval remains to be established.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Health Care Sciences & Services
Amedeo Bianchini, Cristiana Laici, Noemi Miglionico, Maria Giacinta Bianchi, Elena Tarozzi, Enrico Bernardi, Jessica Toni, Erika Cordella, Giovanni Vitale, Antonio Siniscalchi
Summary: An essential method for collecting more abdominal donor organs is controlled donation after circulatory death (cDCD). This study presents a case where transesophageal echocardiography (TEE) was used to effectively procure viable abdominal organs from a cDCD donor in the shortest time frame. TEE use leads to a more efficient and effective abdominal normothermic regional perfusion (A-NRP) procedure with limited complications, allowing observation of circulation in both thoracic and abdominal organs with one fast exam. Although prospective studies are needed, TEE could potentially become a standard practice for all DCD organ retrieval procedures.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Kristopher P. Croome, Amit K. Mathur, Bashar Aqel, Liu Yang, Timucin Taner, Julie K. Heimbach, Charles B. Rosen, Ricardo Paz-Fumagalli, C. Burcin Taner
Summary: This study provides a detailed analysis of the natural history and clinical course of IC, showing that IC can be classified into 4 distinct patterns with different clinical courses.
Editorial Material
Cardiac & Cardiovascular Systems
Ismail Vokshi, Stephen Large, Marius Berman, Steven Tsui
Summary: This article reports a successful heart transplantation from a high-risk DCD donor, in which the donor heart was reconditioned using thoraco-abdominal normothermic regional perfusion. The recipient required brief mechanical circulatory support post-transplant but eventually made a good recovery.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Ethics
Emil J. Nielsen Busch, Marius T. Mjaaland
Summary: The vital status of patients involved in cDCD is a controversial topic in bioethical literature. This article argues that both opponents and proponents of cDCD protocols often misunderstand the moral implications of the dead donor rule. The authors contend that the rule does not require an assessment of a donor's vital status, but rather whether the procurement of organs in cDCD causes the donor's death. They further argue that commonly practiced cDCD protocols do not violate the dead donor rule as the donation process does not cause the donor's death.
AMERICAN JOURNAL OF BIOETHICS
(2023)
Article
Medicine, General & Internal
J. N. Schroder, C. B. Patel, A. D. DeVore, B. S. Bryner, S. Casalinova, A. Shah, J. W. Smith, A. G. Fiedler, M. Daneshmand, S. Silvestry, A. Geirsson, V. Pretorius, D. L. Joyce, J. Y. Um, F. Esmailian, K. Takeda, K. Mudy, Y. Shudo, C. T. Salerno, S. M. Pham, D. J. Goldstein, J. Philpott, J. Dunning, L. Lozonschi, G. S. Couper, H. R. Mallidi, M. M. Givertz, D. T. Pham, A. W. Shaffer, M. Kai, M. A. Quader, T. Absi, T. S. Attia, B. Shukrallah, B. C. Sun, M. Farr, M. R. Mehra, J. C. Madsen, C. A. Milano, D. A. D'Alessandro
Summary: This study compares the efficacy and safety of heart transplantation using hearts donated after circulatory death with those donated after brain death. The results demonstrate that the 6-month survival rate after transplantation with reanimated hearts from circulatory death is not inferior to that with cold-stored hearts from brain death, and there were no significant differences in serious adverse events between the two groups at 30 days post-transplantation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Sarah E. Scheuer, Paul C. Jansz, Peter S. Macdonald
Summary: Heart transplantation from DCD donors is a rapidly expanding practice with excellent outcomes, and is expected to become a major source of heart donation worldwide. Current protocols and methods have contributed to comparable outcomes to DBD heart transplants.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Arnold, Adrian Segiser, Selianne Graf, Natalia Mendez-Carmona, Maria N. Sanz, Rahel K. Wyss, Nina Kalbermatter, Nino Keller, Thierry Carrel, Sarah Longnus
Summary: DCD-related pre-ischemic lactate levels negatively impact post-ischemic functional and mitochondrial recovery in hearts, while inhibition of mitochondrial calcium uptake during reperfusion could improve recovery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Katrien Vandendriessche, Vincent Tchana-Sato, Didier Ledoux, Karlien Degezelle, Steffen Rex, Arne Neyrinck, Ina Jochmans, Diethard Monbaliu, Christophe Vandenbriele, Johan Van Cleemput, Bart Meyns, Filip Rega
Summary: This study investigates the safety and feasibility of heart transplantation after circulatory death using thoraco-abdominal normothermic regional perfusion and subsequent cold storage. The results show a 100% survival rate and good cardiac function in four procedures.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Surgery
Elsaline Rijkse, Sebastiaan Ceuppens, Hongchao Qi, Jan N. M. IJzermans, Dennis A. Hesselink, Robert C. Minnee
Summary: Despite a higher risk of graft loss in the first year after transplantation, long-term outcomes of DCD kidney transplants are similar to DBD, encouraging the implementation of DCD programs.
INTERNATIONAL JOURNAL OF SURGERY
(2021)
Article
Surgery
James A. Richards, Rohit Gaurav, Sara S. Upponi, Lisa Swift, Corrina Fear, Gwilym J. Webb, Michael E. D. Allison, Christopher J. E. Watson, Andrew J. Butler
Summary: The liver is crucial for life, and without a transplant from a donor, patients with liver failure will die. Unfortunately, limited availability of liver organs results in some patients dying while waiting. This article presents a novel technique that enables resuscitation and testing of potential donor livers, increasing the chances for safe transplantation.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Shin Tanaka, Jose Luis Campo-Canaveral de la Cruz, Silvana Crowley Carrasco, Alejandra Romero Roman, Lucas Hoyos Mejia, Jose Manuel NaranjoGomez, Mar Cordoba Pelaez, Alvaro Sanchez Calle, Mariana Gil Barturen, Marina Perez Redondo, Christian Garcia Fadul, Andres Varela de Ugarte, David Gomez-de-Antonio
Summary: This study compared lung transplantation outcomes using lungs procured from cDCD donors using the A-NRP and abdominal RR techniques, and found no significant differences in terms of primary graft dysfunction, hospital mortality, and 1-year survival rate between the two groups.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Review
Cardiac & Cardiovascular Systems
Lauren K. Truby, Sarah Casalinova, Chetan B. Patel, Richa Agarwal, Christopher L. Holley, Robert J. Mentz, Carmelo Milano, Benjamin Bryner, Jacob N. Schroder, Adam D. DeVore
Summary: Heart transplantation is the preferred treatment for end-stage heart failure, but the supply of donor hearts falls short of demand. Donation after circulatory death (DCD) has gained interest and development in recent years as a potential solution. This article reviews the history of DCD heart transplantation, describes current procurement protocols, and discusses clinical challenges and outcomes.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Surgery
Tommy Ivanics, Rodrigo Vianna, Chandrashekhar A. Kubal, Kishore R. Iyer, George Mazariegos, Cal S. Matsumoto, Richard Mangus, Thiago Beduschi, Marwan Abouljoud, Jonathan A. Fridell, Shunji Nagai
Summary: The update in liver allocation from DSA to AC had varying impacts on waitlist mortality and transplant probability for patients listed for combined liver-intestine transplantation, with lower transplant probability observed in adults but similar outcomes in pediatric patients. Additionally, there was a decrease in the proportion of patients who underwent transplant with exception points post-AC. Efforts should be made to ensure equitable organ allocation in this vulnerable patient population.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Marwan Ghabril, Jiayi Ma, Kavish R. Patidar, Lauren Nephew, Archita P. Desai, Eric S. Orman, Raj Vuppalanchi, Shekhar Kubal, Naga Chalasani
Summary: Over the past quarter century, there have been significant changes in the trends of drug-induced acute liver failure (DIALF) in the United States, including shifts in patient demographics, changes in implicated agents, and notably improved post-liver transplantation survival rates for patients with DIALF.
LIVER TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Kawthar A. Mohamed, Marwan Ghabril, Archita Desai, Eric Orman, Kavish R. Patidar, John Holden, Susan Rawl, Naga Chalasani, Chandra Shekhar Kubal, Lauren D. Nephew
Summary: This study aimed to investigate the impact of race, gender, rural versus urban residence, and neighborhood socioeconomic indicators on liver transplantation waitlisting and death during the evaluation period. The results showed an association between neighborhood poverty and waitlisting as well as death during LT evaluation.
LIVER TRANSPLANTATION
(2022)
Letter
Immunology
Burcin Ekser, Wenjun Zhang, Ping Li, Heather Francis, Gianfranco Alpini
Article
Immunology
Plamen Mihaylov, Burcin Ekser, Jonathan Fridell, Shekhar Kubal
Summary: This study investigates the release of proinflammatory cytokines and chemokines after liver transplantation and their relationship with ischemic reperfusion injury and acute kidney injury. The study finds that there is a certain pattern of expression for various cytokines and chemokines in all patients with ischemic reperfusion injury. Cold ischemia, macrosteatosis, postreperfusion syndrome, and the use of multiple vasoactive agents are identified as independent risk factors for ischemic reperfusion injury. The findings suggest that these immune cytokine signatures can be used for therapeutic interventions to improve post-transplant graft outcomes.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Oncology
Ludovica Ceci, Tianhao Zhou, Ilaria Lenci, Vik Meadows, Lindsey Kennedy, Ping Li, Burcin Ekser, Martina Milana, Wenjun Zhang, Chaodong Wu, Keisaku Sato, Sanjukta Chakraborty, Shannon S. Glaser, Heather Francis, Gianfranco Alpini, Leonardo Baiocchi
Summary: This review provides an overview of the research progress on the risk factors and mechanisms of cholangiocarcinoma. These studies contribute to understanding the etiology and treatment options for cholangiocarcinoma.
Article
Gastroenterology & Hepatology
Vik Meadows, Corinn Marakovits, Burcin Ekser, Debjyoti Kundu, Tianhao Zhou, Konstantina Kyritsi, Linh Pham, Lixian Chen, Lindsey Kennedy, Ludovica Ceci, Nan Wu, Guido Carpino, Wenjun Zhang, Abdulkadir Isidan, Alison Meyer, Travis Owen, Eugenio Gaudio, Paolo Onori, Gianfranco Alpini, Heather Francis
Summary: Primary sclerosing cholangitis (PSC) is characterized by increased ductular reaction, liver fibrosis, hepatic total bile acid levels, and mast cell infiltration. Inhibition of apical sodium bile acid transporter (ASBT) reduces PSC phenotypes. This study evaluates the role of ASBT in PSC and has clinical significance.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Pathology
Wenjun Zhang, Konstantina Kyritsi, Abdulkadir Isidan, Yujin Park, Ping Li, Arthur A. Cross-Naja, Kevin Lopez, Lindsey Kennedy, Keisaku Sato, Shannon Glaser, Heather Francis, Gianfranco Alpini, Burcin Ekser
Summary: Researchers have developed a scaffold-free multicellular three-dimensional cholangiocyte organoid model to study the pathophysiology of primary sclerosing cholangitis (PSC). This model effectively mimics the phenotypic features of PSC patients and can be used for related research.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Review
Surgery
Serkan Sucu, Kerem E. Basarir, Plamen Mihaylov, Emre Balik, Jason T. C. Lee, Jonathan A. Fridell, Juliet A. Emamaullee, Burcin Ekser
Summary: The gut microbiota is closely related to liver transplantation, and dysbiosis, antibiotic use, surgical stress, and immunosuppressive drugs can all affect the success of liver transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Letter
Gastroenterology & Hepatology
Burcin Ekser, Serkan Sucu, Plamen Mihaylov, Juliet A. Emamaullee
Letter
Gastroenterology & Hepatology
Burcin Ekser
Letter
Gastroenterology & Hepatology
Zachary P. Rokop, Joseph Zenisek, Kyle Frick, Richard S. Mangus, Lava Timsina, Elizabeth Kroepfl, Chandrashekhar Kubal
LIVER TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Menghao Huang, Yang Zhang, Jimin Park, Kushan Chowdhury, Jiazhi Xu, Alex Lu, Lu Wang, Wenjun Zhang, Burcin Ekser, Liqing Yu, X. Charlie Dong
Summary: This study reveals that ATG14 is localized to lipid droplets in hepatocytes, and it enhances lipid droplet breakdown through interactions with adipose triglyceride lipase (ATGL) and CGI-58.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Surgery
Jiayi Ma, James E. Slaven, Lauren Nephew, Kavish R. Patidar, Archita P. Desai, Eric Orman, Chandrashekhar Kubal, Naga Chalasani, Marwan Ghabril
Summary: The study found that cumulative organ failure, especially neurologic and respiratory failure, significantly impacts waitlist and post-LT mortality in patients with ALF, which may inform risk-prioritized allocation of organs.
CLINICAL TRANSPLANTATION
(2023)
Article
Cell Biology
Kevin J. Lopez, John Paul Spence, Wei Li, Wenjun Zhang, Barry Wei, Arthur A. Cross-Najafi, James R. Butler, David K. C. Cooper, Burcin Ekser, Ping Li
Summary: This study clarifies the role of pULBP-1 in the interaction between NK cells and pig cells. The results demonstrate that pULBP-1 is not a crucial factor in initiating xenogeneic human NK cell activation.