Editorial Material
Urology & Nephrology
Jaquelyne T. Hughes
Summary: Strengthening genuine and committed partnerships between the Australian government, health-care providers and Aboriginal and Torres Strait Islander peoples is crucial for achieving the goal of reducing the inequitable burden of kidney disease.
NATURE REVIEWS NEPHROLOGY
(2021)
Article
Multidisciplinary Sciences
Regan Seipp, Nan Zhang, Sumi Sukumaran Nair, Hasan Khamash, Amit Sharma, Scott Leischow, Raymond Heilman, Mira T. Keddis
Summary: Compared to Whites, Indigenous patients have more baseline risk factors and differences in certain indicators after kidney transplant, but there is generally no significant difference in cardiovascular events, graft outcomes, and infectious complications.
Article
Biochemistry & Molecular Biology
Nadja Sparding, Federica Genovese, Daniel Guldager Kring Rasmussen, Morten A. Karsdal, Nicoline V. Krogstrup, Marie Bodilsen Nielsen, Mads Hornum, Subagini Nagarajah, Henrik Birn, Bente Jespersen, Martin Tepel, Rikke Norregaard
Summary: This study evaluated endotrophin (ETP) as a prognostic marker in kidney transplant recipients. It found that ETP levels in the blood on the first day after transplantation were strongly associated with delayed graft function, while ETP levels in the urine at the third month after transplantation were significantly correlated with kidney graft function at twelve months. The measurement of collagen type VI formation could aid in predicting graft function in kidney transplant recipients.
Article
Immunology
Helle Kiellberg Larsen, Susanne K. Kjaer, Merete Haedersdal, Alexander K. Kjaer, Jesper Hansen Bonde, Soren Schwartz Sorensen, Louise T. Thomsen
Summary: Female kidney transplant recipients (KTRs) had a high prevalence of anal high-risk (hr) human papillomavirus (HPV) (46%) and almost 3-fold higher odds of anal hrHPV than immunocompetent controls. More than 50% of anal hrHPV-positive KTRs were infected with HPV types covered by the nonavalent HPV vaccine.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Neurosciences
Michael Waller, Rachel F. Buckley, Colin L. Masters, Francis R. Nona, Sandra J. Eades, Annette J. Dobson
Summary: This study compared dementia mortality rates between Indigenous and non-Indigenous Australians using data from 2006 to 2014. It found that Indigenous Australians had a 57% higher rate of death with dementia, especially at younger ages, and were more likely to have their dementia coded as 'unspecified' on their death certificate.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Urology & Nephrology
Cihan Heybeli, Andrew J. Bentall, Mariam Priya Alexander, Hatem Amer, Francis K. Buadi, Angela Dispenzieri, David Dingli, Morie A. Gertz, Naim Issa, Prashant Kapoor, Aleksandra Kukla, Shaji Kumar, Elizabeth C. Lorenz, S. Vincent Rajkumar, Carrie A. Schinstock, Nelson Leung
Summary: Data on kidney transplantation outcomes for patients with multiple myeloma are limited. This study investigated the outcomes of kidney transplantation in multiple myeloma patients between 1994 and 2019. The results showed that patients who received bortezomib treatment had better outcomes, but there was still a risk of relapse. Further research is needed to determine which patients benefit from kidney transplantation.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Erin Bolen, Karen Stern, Mitchell Humphreys, Alexandra Brady, Todd Leavitt, Nan Zhang, Mira Keddis
Summary: This study is the largest investigation on transplant nephrolithiasis, confirming that hypocitraturia and hyperoxaluria are the most significant urine metabolic risk factors associated with allograft nephrolithiasis, and hyperoxaluria is the predominant driver for calcium oxalate stone composition.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Medicine, General & Internal
Natsuki Eguchi, Ekamol Tantisattamo, Dean Chung, Uttam G. Reddy, Antoney Ferrey, Donald Dafoe, Hirohito Ichii
Summary: This study aims to investigate the kidney transplant outcomes of undocumented immigrants at an academic medical center in California. The retrospective cohort study found that the kidney transplant outcomes of undocumented immigrants were not inferior to those of US residents.
Article
Medicine, General & Internal
Su-Hsin Chang, Massini Merzkani, Haris Murad, Mei Wang, Benjamin Bowe, Krista L. Lentine, Ziyad Al-Aly, Tarek Alhamad
Summary: This cohort study found that exposure to increased levels of ambient fine particulate matter (PM2.5) air pollution is associated with increased risks of adverse posttransplant outcomes among patients with kidney transplants, including acute rejection, graft failure, and death. These findings suggest that efforts to reduce PM2.5 levels may lead to improved outcomes after kidney transplants.
Article
Urology & Nephrology
Maroun Chedid, Hasan-Daniel Kaidbay, Stijn Wigerinck, Yaman Mkhaimer, Byron Smith, Dalia Zubidat, Imranjot Sekhon, Reddy Prajwal, Parikshit Duriseti, Naim Issa, Ziad M. Zoghby, Christian Hanna, Sarah R. Senum, Peter C. Harris, LaTonya J. Hickson, Vicente E. Torres, Vuyisile T. Nkomo, Fouad T. Chebib
Summary: ADPKD transplant recipients have a favorable cardiac profile pretransplantation, with better patient survival and MACE-free survival rates. However, they experience worsening valvular function and an increase in the sinus of Valsalva diameter post-transplantation.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Multidisciplinary Sciences
Hyo Jeong Kim, Ro Han, Kyung Pyo Kang, Jung-Hwa Ryu, Myung-Gyu Kim, Kyu Ha Huh, Jae Berm Park, Chan-Duck Kim, Seungyeup Han, Hyung Woo Kim, Beom Seok Kim, Jaeseok Yang
Summary: After kidney transplantation, dynamic changes occur in iron storage. The study found that high iron status, indicated by high TSAT levels, increases the risk of graft failure or kidney functional deterioration in kidney transplant patients.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Scott D. Landes, Margaret A. Turk, Marco R. Damiani, Philip Proctor, Sarah Baier
Summary: This study identified the risk factors for COVID-19 diagnosis and mortality among people with intellectual and developmental disabilities receiving residential support services in New York City. Factors such as age, preexisting health conditions, and number of residents were associated with COVID-19 outcomes. Individuals with Down syndrome had an increased risk of COVID-19 diagnosis.
Article
Medicine, General & Internal
Cullan Donnelly, Maria Keller, Liise Kayler
Summary: The study found that prolonged DGF lasting over 20 days indicates a significantly higher risk for reduced eGFR at 1 year compared to lesser degrees of DGF, thus serving as a threshold indicator of increased risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Lee-Moay Lim, Jer-Ming Chang, Hung-Tien Kuo
Summary: Kidney transplant recipients have unique characteristics due to their single functioning kidney, immunosuppressive agent usage, and long-term complications related to transplantation. Post-transplant diabetes mellitus (PTDM) has a significant impact on renal outcomes. PTDM is a key risk factor for cardiovascular morbidity and mortality in transplant recipients, and its pathophysiology and clinical features differ from type 2 diabetes. Transplantation itself, with chronic exposure to immunosuppressive agents, is a risk factor for PTDM. This article discusses the risk factors, pathogenesis, diagnostic criteria, prevention strategies, and management of PTDM, as well as the safety and potential drug-drug interactions of therapeutic options with immunosuppressive agents.
Article
Criminology & Penology
Robin Fitzgerald, Heather Douglas, Lachlan Heybroek
Summary: Research indicates disparities in sentencing for Indigenous and non-Indigenous populations in relation to domestic violence cases in Australia, with harsher penalties more frequently used for Indigenous defendants. While ensuring the safety of Indigenous women is crucial, supporting a harsher sentencing regime for DVO breaches is deemed ineffective, emphasizing the need for flexible strategies within and for Indigenous communities in Australia.
JOURNAL OF INTERPERSONAL VIOLENCE
(2021)
Article
Medicine, General & Internal
Namrata Khanal, Paul D. Lawton, Alan Cass, Stephen P. McDonald
INTERNAL MEDICINE JOURNAL
(2023)
Article
Health Care Sciences & Services
Gillian Gorham, Kirsten Howard, Joan Cunningham, Paul Damian Lawton, A. M. Shamsir Ahmed, Federica Barzi, Alan Cass
Summary: Aboriginal people in the Northern Territory of Australia, especially those living in remote areas, face a heavy burden of kidney failure. Due to a lack of dialysis services in these remote areas, many Aboriginal people are required to relocate to access treatment. This study explores the relationship between the location of dialysis services, dialysis attendance patterns, and health service utilization among Aboriginal patients in the Northern Territory. The findings suggest that missing dialysis treatments is more common among Aboriginal people attending urban services, resulting in higher rates of hospital admissions and emergency department presentations. On the other hand, those receiving care in rural and remote settings have higher dialysis attendance and lower health service utilization. The study concludes that access to rural and remote models of care can potentially improve dialysis attendance and reduce the need for hospitalization among Aboriginal patients.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Transplantation
Sradha Kotwal, Sanjeeva Herath, Jonathan Erlich, Sally Boardman, Jennifer Qian, Paul Lawton, Craig Campbell, Andrew Whatnall, Su Teo, A. Rita Horvath, Zoltan H. Endre
Summary: This study demonstrates the potential benefits of early recognition of hospital-acquired acute kidney injury (AKI) in improving patient management and outcomes. Implementation of an intervention bundle may reduce length of stay and improve documentation of AKI and other management measures.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Public, Environmental & Occupational Health
Janet Kelly, Tahlee Stevenson, Melissa Arnold-Chamney, Samantha Bateman, Shilpanjali Jesudason, Stephen McDonald, Kim O'Donnell, Odette Pearson, Nari Sinclair, Inawinytji Williamson
Summary: This study describes the experiences, perceptions, and suggested improvements in healthcare identified by Aboriginal patients, families, and community members living with kidney disease in South Australia. The results highlight the importance of family and community, prevention and early detection, better access to quality care, and the need for more Aboriginal health professionals and peer navigators in improving healthcare outcomes for Aboriginal people.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Samantha Bateman, Melissa Arnold-Chamney, Shilpanjali Jesudason, Rhanee Lester, Stephen McDonald, Kim O'Donnell, Kelli Owen, Odette Pearson, Nari Sinclair, Tahlee Stevenson, Inawinytji Williamson, Janet Kelly
Summary: This study describes the process of repositioning and valuing the knowledge and lived experiences of Aboriginal community members, with the aim of strengthening relationships, research processes, and outcomes. Through co-creation and community-based participatory action research (cb-PAR), deeply respectful community engagement was possible. This approach resulted in multiple positive impacts and beneficial relationships between community members, clinicians, and academics. Meaningful consultation with Aboriginal communities guides culturally safe research processes, health policy, and service delivery.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH
(2022)
Article
Health Policy & Services
Dharmenaan Palamuthusingam, Elaine M. Pascoe, Carmel M. Hawley, David W. Johnson, Gishan Ratnayake, Stephen McDonald, Neil Boudville, Matthew Jose, Magid Fahim
Summary: This study assessed the concordance between comorbidities recorded in the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry and those in state-based hospital admission datasets. The results showed that the accuracy of diabetes mellitus recording was the highest, while the accuracy of cerebrovascular disease recording was the lowest.
HEALTH INFORMATION MANAGEMENT JOURNAL
(2023)
Article
Surgery
Dharmenaan Palamuthusingam, Carmel M. Hawley, Elaine M. Pascoe, David W. Johnson, Palvannan Sivalingam, Stephen McDonald, Neil Boudville, Matthew D. Jose, Girish Talaulikar, Magid Fahim
Summary: This study found that patients receiving chronic kidney replacement therapy have high rates of surgery and morbidity, with older age, diabetes, dialysis modality, and time all influencing these rates.
Article
Endocrinology & Metabolism
Matthew J. L. Hare, Louise J. Maple-Brown, Jonathan E. Shaw, Jacqueline A. Boyle, Paul D. Lawton, Elizabeth L. M. Barr, Steven Guthridge, Vanya Webster, Denella Hampton, Gurmeet Singh, Roland F. Dyck, Federica Barzi
Summary: This study aimed to investigate the risk of developing chronic kidney disease (CKD) or end-stage kidney disease (ESKD) following a pregnancy complicated by gestational diabetes mellitus (GDM) or pre-existing diabetes among Aboriginal women in the Northern Territory (NT), Australia. The findings showed that Aboriginal women with GDM or pre-existing diabetes during pregnancy are at high risk of developing CKD and ESKD.
Article
Orthopedics
Ian A. Harris, Michelle F. Lorimer, Christopher E. Davies, Dominic Keuskamp, Kathryn B. Dansie, Peter L. Lewis, Stephen E. Graves, Stephen P. McDonald
Summary: This study compared the rate of revision surgery and mortality following THA between patients who have kidney failure receiving long term dialysis or who had a kidney transplant and those who did not have kidney failure. The results showed that patients on dialysis had a higher risk of mortality after THA compared to those with a functioning kidney transplant or no kidney failure, but there was no early excess mortality due to the surgery.
JOURNAL OF ARTHROPLASTY
(2023)
Editorial Material
Urology & Nephrology
Stephen P. Mcdonald, Katie Cundale, Kelli J. Owen, Matilda D'Antoine, Jaquelyne T. Hughes
Summary: Indigenous people in Australia are disadvantaged in accessing kidney transplantation. The National Indigenous Kidney Transplant Taskforce was established to address this issue by providing support to clinicians, implementing and evaluating innovative practices, and developing strategies to overcome barriers in the care system.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Biology
Ken-Soon Tan, Stephen McDonald, Wendy Hoy
Summary: This study compared the performance of a clinical diagnosis to biopsy-proven diagnosis of diabetic kidney disease (DKD) and found that a clinical diagnosis has high sensitivity but low specificity, indicating the possibility of overdiagnosis.
Letter
Urology & Nephrology
Richard Le Leu, Paul N. Bennett, Kathryn Dansie, Lisa Shanahan, Anna Chur-Hansen, Kathryn L. Collins, Anne L. J. Burke, Fiona Donnelly, Emily Duncanson, Anthony Meade, Stephen McDonald, Shilpanjali Jesudason
JOURNAL OF NEPHROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Nishanta Tangirala, Erandi Hewawasam, Amanda Poprzeczny, Christopher Davies, Zhouyang Li, Elizabeth Sullivan, Stephen Mcdonald, Shilpa Jesudason
Meeting Abstract
Urology & Nephrology
Samantha Bateman, Michael Riceman, Kelli Owen, Rhanee Lester, Nari Sinclair, Odette Pearson, Stephen Mcdonald, Martin Howell, David Tunnicliffe, Shilpanjali Jesudason
Meeting Abstract
Urology & Nephrology
Jayson Catiwa, Sarah Coggan, Alan Cass, Nicholas Gray, Stephen Jan, Stephen Mcdonald, Kevan Polkinghorne, Girish Talaulikar, Martin Gallagher, Sradha Kotwal