Interspecies chimeric complementation for the generation of functional human tissues and organs in large animal hosts

Regenerative medicine: targeted genome editing in vivo

(2015) Lixia Wang et al.   CELL RESEARCH

Dynamic Pluripotent Stem Cell States and Their Applications

(2015) Jun Wu et al.   Cell Stem Cell

Generation of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem Cells

(2015) Yongchang Chen et al.   Cell Stem Cell

Stem Cell Therapies in Clinical Trials: Progress and Challenges

(2015) Alan Trounson et al.   Cell Stem Cell

Interspecific in vitro assay for the chimera-forming ability of human pluripotent stem cells

(2015) H. Masaki et al.   DEVELOPMENT

An alternative pluripotent state confers interspecies chimaeric competency

(2015) Jun Wu et al.   NATURE

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

Metabolic exit from naive pluripotency

(2015) Jun Wu et al.   NATURE CELL BIOLOGY

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

(2015) Henrik Sperber et al.   NATURE CELL BIOLOGY

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice

(2015) Tomomi Aida et al.   GENOME BIOLOGY

Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection

(2015) Daniel Oliver et al.   PLoS One

The Nature of Embryonic Stem Cells

(2014) Graziano Martello et al.   Annual Review of Cell and Developmental Biology

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

(2014) Yuyu Niu et al.   CELL

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

(2014) Tang Hai et al.   CELL RESEARCH

TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys

(2014) Hailiang Liu et al.   Cell Stem Cell

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

(2014) Thorold W. Theunissen et al.   Cell Stem Cell

Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes

(2014) Shuo-Ting Yen et al.   DEVELOPMENTAL BIOLOGY

Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

(2014) Jichang Wang et al.   NATURE

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

(2014) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

(2014) John P Guilinger et al.   NATURE BIOTECHNOLOGY

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects

(2014) Bin Shen et al.   NATURE METHODS

Derivation of naive human embryonic stem cells

(2014) C. B. Ware et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiated human stem cells resemble fetal, not adult, β cells

(2014) Sinisa Hrvatin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

Generating rats with conditional alleles using CRISPR/Cas9

(2013) Yuanwu Ma et al.   CELL RESEARCH

Induction of a Human Pluripotent State with Distinct Regulatory Circuitry that Resembles Preimplantation Epiblast

(2013) Yun-Shen Chan et al.   Cell Stem Cell

The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak

(2013) Yoji Kojima et al.   Cell Stem Cell

Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases

(2013) Y. H. Sung et al.   GENOME RESEARCH

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

(2013) Prashant Mali et al.   NATURE BIOTECHNOLOGY

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Knockout mice created by TALEN-mediated gene targeting

(2013) Young Hoon Sung et al.   NATURE BIOTECHNOLOGY

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

(2013) Vikram Pattanayak et al.   NATURE BIOTECHNOLOGY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Generation of Kidney from Pluripotent Stem Cells via Blastocyst Complementation

(2012) Jo-ichi Usui et al.   AMERICAN JOURNAL OF PATHOLOGY

Generation of Chimeric Rhesus Monkeys

(2012) Masahito Tachibana et al.   CELL

RETRACTED: Engineered whole organs and complex tissues

(2012) Stephen F Badylak et al.   LANCET

Efficient derivation of bovine embryonic stem cells needs more than active core pluripotency factors

(2012) Julien Maruotti et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

In Vivo Differentiation Potential of Epiblast Stem Cells Revealed by Chimeric Embryo Formation

(2012) Yali Huang et al.   Cell Reports

Isolation of Epiblast Stem Cells from Preimplantation Mouse Embryos

(2011) Fadi J. Najm et al.   Cell Stem Cell

Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras

(2011) Ayako Isotani et al.   GENES TO CELLS

Harnessing the potential of induced pluripotent stem cells for regenerative medicine

(2011) Sean M. Wu et al.   NATURE CELL BIOLOGY

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

(2011) J. Hauschild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells

(2010) Toshihiro Kobayashi et al.   CELL

Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix

(2010) Basak E Uygun et al.   NATURE MEDICINE

Human hepatocyte transplantation: current experience and future challenges

(2010) Anil Dhawan et al.   Nature Reviews Gastroenterology & Hepatology

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

(2010) J. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-Engineered Lungs for in Vivo Implantation

(2010) T. H. Petersen et al.   SCIENCE

No shortcuts to pig embryonic stem cells

(2010) T.A.L. Brevini et al.   THERIOGENOLOGY

Naive and Primed Pluripotent States

(2009) Jennifer Nichols et al.   Cell Stem Cell

Basic FGF and Activin/Nodal but not LIF signaling sustain undifferentiated status of rabbit embryonic stem cells☆

(2009) Arata Honda et al.   EXPERIMENTAL CELL RESEARCH

Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

(2009) Aron M. Geurts et al.   SCIENCE

Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts

(2008) Ping Li et al.   CELL

Capture of Authentic Embryonic Stem Cells from Rat Blastocysts

(2008) Mia Buehr et al.   CELL

Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts

(2008) Haisong Liu et al.   Cell Stem Cell

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

(2008) Trond Aasen et al.   NATURE BIOTECHNOLOGY

Marked differences in differentiation propensity among human embryonic stem cell lines

(2008) Kenji Osafune et al.   NATURE BIOTECHNOLOGY

Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart

(2008) Harald C Ott et al.   NATURE MEDICINE

Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation

(2008) Guerard W. Byrne et al.   XENOTRANSPLANTATION