Article
Hematology
Nnaemeka Ibeh, Ian Baine, Louella Fuentes Rudon, Christine Lomas-Francis, Jeffrey S. Jhang, Patricia Galdon, Connie M. Westhoff, Randall W. Velliquette, Suzanne A. Arinsburg
Summary: A trypsin-based method was demonstrated to effectively remove DARA interference in antibody testing, with successful identification of known alloantibodies and no false-negative results. This method provides a safe and cost-effective option for pretransfusion testing in patients receiving DARA.
Article
Medical Laboratory Technology
Chiu-Che Feng, Ci-Wen Chang, Zhi-Yi Lien, Jinun-An Lin, Tzu-Ting Chen, Su-Peng Yeh
Summary: The Polybrene method is a cost-effective alternative to the DTT-IAT in overcoming anti-CD38 interference, especially for populations with a high prevalence of anti-M and anti-Mi(a) antibodies. However, both methods have a low detection sensitivity for anti-K.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Hematology
Ye Zhou, Leiyu Chen, Tianshu Jiang, Liangfeng Fan, Hang Lei, Yuqing Wang, Hasiyati Heililahong, Jianqing Mi, Danxin Du, Tianhong Miao, Rong Xia, Xuefeng Wang, Dong Xiang, Xiaohong Cai, Xiaofeng Tang
Summary: The study found that treating RBCs with 2-ME or using the Polybrene method can eliminate DARA interference with antibody screening or cross-matching, although the K antigen is denatured during treatment. This suggests that 2-ME-based IATs or the Polybrene method could be viable alternatives to DTT-based IATs for mitigating DARA interference.
Article
Hematology
Fleur Aung, Jeff Spencer, David Potter, Thuy-Dung Pham, Naheed Farooqui, Kathryn R. Platt, Raja Zayat, Melanie Oliveira, Robin Smeland-Wagman, Eric Petersen, Richard M. Kaufman
Summary: The study evaluated a new anti-idiotype antibody's ability to neutralize DARA in vitro and eliminate anti-CD38 interference. Results showed that a 1:1 ratio of anti-DARA to DARA successfully eliminated interference in IATs and allowed detection of other alloantibodies. This new approach provides a promising solution for blood compatibility testing in patients receiving anti-CD38 therapy.
Article
Computer Science, Information Systems
Hamidreza Karami, Mohammad Azadifar, Zhaoyang Wang, Marcos Rubinstein, Farhad Rachidi
Summary: This paper introduces a novel localization technique based on the time-reversal cavity (TRC) concept for electromagnetic interference (EMI) sources, validates its effectiveness through experimentation, and verifies the time-reversal process through numerical simulations. The experimental setup involves a partially open cavity and two monopole antennas, achieving a small three-dimensional location error in the experimental validation.
Article
Psychology, Experimental
Francois Maquestiaux, Eric Ruthruff
Summary: The study found that as individuals age, they tend to rely more on central attention to carry out tasks, even when those tasks do not require it. Older adults showed larger age differences in dual-task performance in IM tasks compared to younger adults.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
(2021)
Article
Hematology
Yuyuan Li, Chengyao Li, Ling Zhang, Jiao Li, Qixin Li, Haining Ouyang, Jiaona Luo, Linrui Zhu, Kui Cai
Summary: The objective of this study was to establish a storage protocol for reagent red blood cells treated with 0.01 mol/L DTT and evaluate its utility in pre-transfusion examinations of patients treated with daratumumab. The optimal incubation time for DTT-treated RBCs was determined to be 40-50 min. RBCs could be stored for 18 days after adding ID-CellStab, and the protocol did not significantly affect the antigens of most blood group systems. The storage protocol allows for quick pre-transfusion examinations in patients treated with daratumumab, addressing the limitations of currently available reagent RBCs.
Article
Hematology
Craig Tauscher, Sheila Moldenhauer, Sandra Bryant, Margaret DiGuardo, Eapen K. Jacob
Summary: The study aimed to evaluate RBC utilization and alloimmunization in patients receiving Dara, showing that these patients did not have a higher incidence of alloantibody formation following RBC transfusion compared to similar patient populations.
Article
Medical Laboratory Technology
Anna Feldman, Adrian M. Duek, Mathilda Mandel-Benado, Liz A. Cohen, Daniel R. Feldman, Merav Leiba
Summary: This study aimed to provide a DARAEx((R)) protocol for application with the Grifols platform in patients treated with daratumumab. By introducing a modified protocol (AssutaBB protocol), the study successfully provided antibody screen results for all samples, offering a wider choice for detection under daratumumab treatment.
CLINICAL LABORATORY
(2022)
Article
Medical Laboratory Technology
Anna Feldman, Adrian M. Duek, Mathilda Mandel-Benado, Liz A. Cohen, Daniel R. Feldman, Merav Leiba
Summary: This study provides a DARAEx (R) protocol for application with the Grifols platform, allowing the use of a more widespread platform in daratumumab-treated patients.
CLINICAL LABORATORY
(2022)
Article
Engineering, Chemical
M. V. A. Raju Bahubalendruni, Bhavasagar Putta
Summary: The recent advances in Industry 4.0 have led to the adoption of augmented reality (AR), virtual reality (VR), and mixed reality (MR) in manufacturing industries for visualization and training purposes. This research presents a novel method for automated assembly task simulation that improves geometric feasibility testing. The proposed framework uses textual instructions to generate a virtual assembly task plan and ensures collision-free operations. The framework is implemented and validated for various products to ensure its correctness and completeness.
Review
Hematology
Marilyn T. Nedumcheril, Robert A. DeSimone, Sabrina E. Racine-Brzostek, Ok Kyong Chaekal, Ljiljana V. Vasovic
Summary: Daratumumab, a monoclonal antibody therapeutic, is highly effective in treating multiple myeloma and amyloidosis, but can interfere with pre-transfusion testing. Various methods have been developed to address this interference, requiring coordination between blood bank and clinical teams for implementation. Efforts to improve daratumumab safety in blood transfusions include timely involvement of transfusion services and educational efforts by both blood banks and clinical providers.
JOURNAL OF BLOOD MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Clemence M. Canivet, Ming-Hua Zheng, Sami Qadri, Luisa Vonghia, Kee-Huat Chuah, Charlotte Costentin, Jacob George, Angelo Armandi, Leon A. Adams, Naomi F. Lange, Odile Blanchet, Valerie Moal, Ramy Younes, Marine Roux, Wah-Kheong Chan, Nathalie Sturm, Mohammed Eslam, Elisabetta Bugianesi, Zhengyi Wang, Jean-Francois Dufour, Sven Francque, Hannele Yki-Jaervinen, Kenneth I. Zheng, Jerome Boursier
Summary: The blood test MACK-3 is an accurate tool to improve patient selection in NASH therapeutic trials.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Hamza Abu Owida, Jamal Al-Nabulsi, Jumana Ma'touq, Bassam Al-Naami, Feras Alnaimat
Summary: This study validates the earlobe as an alternate test site for blood glucose testing and compares it with the standard reference sites of fingertip and forearm. The results indicate no significant difference between the three testing methods.
TECHNOLOGY AND HEALTH CARE
(2022)
Article
Psychiatry
Anthony J. Rothschild, Sagar Parikh, Daniel Hain, Rebecca Law, Michael E. Thase, Boadie W. Dunlop, Charles DeBattista, Charles R. Conway, Brent P. Forester, Richard C. Shelton, Matthew Macaluso, Krystal Brown, David Lewis, Alexander Gutin, Michael R. Jablonski, John F. Greden
Summary: In patients with major depressive disorder, a combinatorial pharmacogenomic test was a better predictor of patient outcomes and medication blood levels compared to guidelines based on individual genes.
PSYCHIATRY RESEARCH
(2021)
Article
Oncology
Alba Matas-Cespedes, Anna Vidal-Crespo, Vanina Rodriguez, Neus Villamor, Julio Delgado, Eva Gine, Heleia Roca-Ho, Pablo Menendez, Elias Campo, Armando Lopez-Guillermo, Dolors Colomer, Gael Roue, Adrian Wiestner, Paul W. H. I. Parren, Parul Doshi, Jeroen Lammerts van Bueren, Patricia Perez-Galan
CLINICAL CANCER RESEARCH
(2017)
Letter
Hematology
Sanne J. de Haart, Lisa Holthof, Willy A. Noort, Monique C. Minnema, Maarten E. Emmelot, Tineke Aarts-Riemens, Parul Doshi, Kate Sasser, Huipin Yuan, Joost de Bruijn, Anton C. M. Martens, Niels W. C. J. van de Donk, Henk M. Lokhorst, Richard W. J. Groen, Tuna Mutis
Review
Hematology
Alyssa Ziman, Claudia Cohn, Patricia M. Carey, Nancy M. Dunbar, Mark K. Fung, Andreas Greinacher, Simon Stanworth, Nancy M. Heddle, Meghan Delaney
Letter
Hematology
Sanne J. de Haart, Lisa Holthof, Willy A. Noort, Monique C. Minnema, Maarten E. Emmelot, Tineke Aarts-Riemens, Parul Doshi, Kate Sasser, Huipin Yuan, Joost de Bruijn, Anton C. M. Martens, Niels W. C. J. van de Donk, Henk M. Lokhorst, Richard W. J. Groen, Tuna Mutis
Article
Management
Kartikeya Puranam, David C. Novak, Marilyn T. Lucas, Mark Fung
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2017)
Article
Hematology
Amy Yu, Erin Morris, Richard Adams, Mark K. Fung
Letter
Hematology
James P. AuBuchon, Mark K. Fung, Gabriela Perez, Barbee Whitaker
Article
Hematology
Meghan Delaney, Agneta Wikman, Leo van de Watering, Henk Schonewille, Jennie P. Verdoes, Stephen P. Emery, Michael F. Murphy, Julie Staves, Susanne Flach, Donald M. Arnold, Richard M. Kaufman, Alyssa Ziman, Sarah K. Harm, Mark Fung, Catherine S. Eppes, Nancy M. Dunbar, Andreas Buser, Erin Meyer, Helen Savoia, Padmakumari Abeysinghe, Nancy Heddle, Alan Tinmouth, Aicha N. Traore, Mark H. Yazer
Article
Hematology
Mark H. Yazer, Miguel Lozano, Mark Fung, Jose Kutner, Michael F. Murphy, Torunn Oveland Apelseth, Ryszard Poglod, Kathleen Selleng, Alan Tinmouth, Silvano Wendel, Vered Yahalom
Article
Oncology
Kelly Kersten, Seth B. Coffelt, Marlous Hoogstraat, Niels J. M. Verstegen, Kim Vrijland, Metamia Ciampricotti, Chris W. Doornebal, Cheei-Sing Hau, Max D. Wellenstein, Camilla Salvagno, Parul Doshi, Esther H. Lips, Lodewyk F. A. Wessels, Karin E. de Visser
Article
Oncology
Ajai Chari, Suzanne Arinsburg, Sundar Jagannath, Toshihisa Satta, Ivey Treadwell, Donna Catamero, Gillian Morgan, Huaibao Feng, Clarissa Uhlar, Imran Khan, Parul Doshi, Saad Usmani
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2018)
Article
Hematology
Anna Vidal-Crespo, Alba Matas-Cespedes, Vanina Rodriguez, Cedric Rossi, Juan G. Valero, Neus Serrat, Alejandra Sanjuan-Pla, Pablo Menendez, Gael Roue, Armando Lopez-Guillermo, Eva Gine, Elias Campo, Dolors Colomer, Christine Bezombes, Jeroen Lammerts van Bueren, Christopher Chiu, Parul Doshi, Patricia Perez-Galan
Article
Oncology
Xun Ma, Sandy W. Wong, Ping Zhou, Chakra P. Chaulagain, Parul Doshi, Andreas K. Klein, Kellie Sprague, Adin Kugelmass, Denis Toskic, Melissa Warner, Kenneth B. Miller, Lisa Lee, Cindy Varga, Raymond L. Comenzo
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2018)
Article
Oncology
Simon Papillon-Cavanagh, Parul Doshi, Radu Dobrin, Joseph Szustakowski, Alice M. Walsh