Article
Chemistry, Analytical
Celia Lhoste, Margherita Bazzoni, Justine Bonnet, Aurelie Bernard, Francois-Xavier Felpin, Patrick Giraudeau, Jean-Nicolas Dumez
Summary: In this study, ultrafast 2D NMR schemes were developed to acquire full spectral width 2D NMR spectra from continuously flowing samples in a short time. By using an interleaved acquisition strategy and an optimized solvent suppression strategy, it was possible to monitor chemical reactions online at high time resolution.
Article
Chemistry, Analytical
Celia Lhoste, Margherita Bazzoni, Justine Bonnet, Aurelie Bernard, Francois-Xavier Felpin, Patrick Giraudeau, Jean-Nicolas Dumez
Summary: This article presents a method for rapid acquisition of broadband homonuclear 2D NMR spectra from continuously flowing samples. The use of interleaved acquisition and optimized solvent suppression allows for obtaining full spectra width in a short period of time. This development is important for online monitoring with high time resolution using flow 2D NMR.
Article
Chemistry, Multidisciplinary
Anna J. Parker, Arnab Dey, Mohammad Usman Qureshi, Jakob M. Steiner, John W. Blanchard, Jochen Scheuer, Nikolas Tomek, Stephan Knecht, Felix Josten, Christoph Mueller, Patrick Hautle, Ilai Schwartz, Patrick Giraudeau, Tim R. Eichhorn, Jean-Nicolas Dumez
Summary: The HYPNOESYS method, relying on the dissolution of optically polarized crystals, enhances the sensitivity of NMR spectroscopy in the solution state. This study demonstrates the acquisition of 2D NMR spectra from HYPNOESYS-polarized samples using single-scan methods, paving the way for a sensitive, information-rich, and affordable analytical technique.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Hui Zhou, Zixuan Chen, Evgenia Kountoupi, Athanasia Tsoukalou, Paula M. Abdala, Pierre Florian, Alexey Fedorov, Christoph R. Mueller
Summary: Early transitional metal carbides, such as 2D-Mo2C, show promising catalytic activity for CO2 hydrogenation through surface group manipulation, resulting in tunable selectivity and activity for the reaction. This study highlights the importance of surface termination groups in controlling the performance of carbide catalysts for CO2 conversion to value-added chemicals.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Martin Bornemann-Pfeiffer, Jakob Wolf, Klas Meyer, Simon Kern, Davide Angelone, Artem Leonov, Leroy Cronin, Franziska Emmerling
Summary: The lack of standardization in chemistry literature leads to reproducibility difficulties and dependence on tacit knowledge; online NMR integration with automated chemical synthesis machine enables real-time analysis and adjustment of reactions; validation experiments demonstrate the potential of Chemputer in dynamically controlling synthesis processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Alexandar L. Hansen, Erriks Kupce, Da-Wei Li, Lei Bruschweiler-Li, Cheng Wang, Rafael Brueschweiler
Summary: This study presents sensitivity-improved versions of two-dimensional NMR experiments optimized for small biological molecules encountered in metabolomics, allowing for rapid acquisition techniques and incorporation into supersequences for compact acquisition of multiple 2D NMR data sets. These new pulse sequences offer an attractive approach for efficient measurement of multiple 2D NMR spectra in a single experiment, enhancing identification and quantitation of metabolites in metabolomics samples. The advantages of 2D NMR have been extended to metabolomics studies with larger sample cohorts.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Sergio Alejandro Ortiz Restrepo, Alina Adams
Summary: Glycols are important chemicals with various applications, but the presence of water can affect their properties. This study introduces a novel method using low-field Nuclear Magnetic Resonance (NMR) spectroscopy to accurately determine water content in glycols. The method is fast, cost-effective, and does not require reagents or calibration data. Results show that the NMR-based approach can accurately quantify water concentration in ethylene glycol (EG) and triethylene glycol (TEG) mixtures, with high agreement with Karl-Fischer titration results.
Article
Chemistry, Analytical
Borja Caja-Munoz, Kevin Chighine, Jean-Pierre Dognon, Lionel Dubois, Patrick Berthault
Summary: A mini organic redox-flow battery, built by 3D printing on the basis of a high-resolution nuclear magnetic resonance probehead, enables modern spectroscopy and imaging experiments. The device was tested for real-time monitoring of 9,10-anthraquinone-2,7-disulfonic acid disodium salt (2,7-AQDS) redox cycling in acidic conditions, revealing the significant role of dimerization in the oxidation and reduction processes. Quantum chemical and multilevel modeling workflows confirmed hypotheses about molecular processes during charge and discharge.
ANALYTICAL CHEMISTRY
(2023)
Review
Agronomy
Andres Perez-San Martin, Frutos C. Marhuenda-Egea, Maria Angeles Bustamante, Gustavo Curaqueo
Summary: This review critically analyzes and updates the chemical spectroscopy methods for evaluating the transformation of organic matter in composting, and discusses their potential applications in optimizing compost quality for agricultural use.
Article
Environmental Sciences
Uttam Singh, Pramod Kumar Sharma
Summary: The combination of ERT and surface NMR methods was used to study the seasonal changes in subsurface aquifer properties, and compared with the QTI scheme. The results showed small-scale variability in ERT and surface inversions, but this can be neglected at the field scale. Surface NMR measurements revealed significant increase in water content during the post-monsoon and monsoon seasons. The QTI model was considered accurate for this study. Therefore, the combination of ERT and surface NMR is a powerful tool for subsurface characterization assessment.
ENVIRONMENTAL EARTH SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Achille Marchand, Rituraj Mishra, Aurelie Bernard, Jean-Nicolas Dumez
Summary: Online monitoring by flow NMR spectroscopy is a powerful tool for studying chemical reactions and processes, providing mechanistic understanding and driving optimizations. However, some useful methods for mixture analysis and reaction monitoring are not directly applicable in flow conditions. In this study, a fast and flow-compatible diffusion NMR experiment is described, allowing accurate diffusion data to be collected for samples flowing at up to 3 mL/min. This one-shot flow-compatible diffusion NMR opens up new possibilities for reaction monitoring applications.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Polymer Science
Xu Chen, Changzhu Lv, Yahui Li, Zishuo Wu, Renkuan Cao, Weihang Fei, Jin Lv, Wei Chen
Summary: The complicated chemical structure and acetalization mechanism of poly(vinyl butyral) (PVB) were revealed using multidimensional NMR with 13C labeling. Isotope enrichment helped determine the sequence distribution of vinyl butyral (VB) and vinyl alcohol (VA) monomers in the PVB backbone, while NMR experiments identified primary, secondary, and tertiary carbons. Various 2D-NMR experiments established coupling through chemical bond or space correlation. The resolved information from 1H and 13C NMR spectra provided insights into the acetalization reaction mechanism.
Article
Multidisciplinary Sciences
Michael J. Jaroszewicz, Mengxiao Liu, Jihyun Kim, Guannan Zhang, Yaewon Kim, Christian Hilty, Lucio Frydman
Summary: Nuclear magnetic resonance (NMR) spectroscopy provides detailed information about dynamic processes through line-shape changes under equilibrium conditions. However, studying chemical reactions under off-equilibrium conditions and monitoring the reactants and products in real time can provide additional valuable information. In this study, the authors propose and demonstrate a time-resolved kinetic NMR experiment that combines rapid mixing techniques, continuous flow, and single-scan spectroscopic imaging methods, leading to a 2D spectrotemporal NMR correlation that provides high-quality kinetic information of off-equilibrium chemical reactions.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Miranda D. Louwerse, David A. Sivak
Summary: By using minimum-work protocols in multidimensional control-parameter space, we can efficiently manipulate the configurational state of a system and reduce resistance and work.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Margherita Bazzoni, Celia Lhoste, Justine Bonnet, Kouakou Eric Konan, Aurelie Bernard, Patrick Giraudeau, Francois-Xavier Felpin, Jean-Nicolas Dumez
Summary: This work demonstrates the online monitoring of a flow photochemical reaction using advanced NMR methods. By analyzing the reaction mixture directly, both 1D and ultrafast 2D experiments provide valuable information, especially for complex molecules. The study highlights the efficiency of ultrafast 2D COSY experiments for real-time monitoring and quantitative analysis, enabling effective screening of reaction conditions.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Alexander C. Forse, Kristen A. Colwell, Miguel Gonzalez, Stefan Benders, Rodolfo M. Torres-Gavosto, Bernhard Blumich, Jeffrey A. Reimer, Jeffrey R. Long
CHEMISTRY OF MATERIALS
(2020)
Article
Chemistry, Physical
Soren Lehmkuhl, Martin Suefke, Arne Kentner, Yi-Fen Yen, Bernhard Bluemich, Matthew S. Rosen, Stephan Appelt, Thomas Theis
JOURNAL OF CHEMICAL PHYSICS
(2020)
Article
Biochemical Research Methods
Till Ueberrueck, Michael Adams, Josef Granwehr, Bernhard Bluemich
JOURNAL OF MAGNETIC RESONANCE
(2020)
Article
Chemistry, Multidisciplinary
Franziska Busse, Christian Rehorn, Markus Kueppers, Naira Ruiz, Heike Stege, Bernhard Bluemich
MAGNETIC RESONANCE IN CHEMISTRY
(2020)
Article
Biochemical Research Methods
Alexander Goerges, Stefan Benders, Marcus Greferath, Markus Kueppers, Michael Adams, Bernhard Bluemich
JOURNAL OF MAGNETIC RESONANCE
(2020)
Article
Biochemical Research Methods
Yang Gao, Bernhard Bluemich
JOURNAL OF MAGNETIC RESONANCE
(2020)
Article
Chemistry, Analytical
Claudia Invernizzi, Giacomo Fiocco, Magdalena Iwanicka, Magdalena Kowalska, Piotr Targowski, Bernhard Blumich, Christian Rehorn, Valeria Gabrielli, Danilo Bersani, Maurizio Licchelli, Marco Malagodi
MICROCHEMICAL JOURNAL
(2020)
Article
Biochemical Research Methods
Anton Duchowny, Pablo Matias Dupuy, Hege Christin Wideroe, Ole Johan Berg, Audun Faanes, Anfinn Paulsen, Holger Thern, Oliver Mohnke, Markus Kuppers, Bernhard Blumich, Alina Adams
Summary: The setup presented provides a simple yet highly versatile solution for benchtop NMR analysis of gases at high-pressure. It allows for independent adjustment of pressures up to 200 bar and the production of gas mixtures in situ, demonstrating long-term stability and repeatability in measurements. The versatility of the setup is showcased through various applications, including analyzing hydrocarbon gases, improving resolution of NMR spectra from solid polymers, and visualizing the ingress of gases into liquids.
JOURNAL OF MAGNETIC RESONANCE
(2021)
Article
Biochemistry & Molecular Biology
Sabina Haber-Pohlmeier, David Caterina, Bernhard Bluemich, Andreas Pohlmeier
Summary: Magnetic resonance imaging is sensitive to water and can be used for 3D mapping of soil water processes. Ultrafast detection pulse sequences allow for detection of rapidly relaxing fractions of water in natural porous media. ZTE and UTE sequences have the potential to detect all water fractions with sufficiently broad bandwidths.
Article
Engineering, Biomedical
Brian J. Archer, Julia J. Mack, Sara Acosta, Russell Nakasone, Fadi Dahoud, Khalid Youssef, Abraham Goldstein, Amichai Goldsman, Mathias C. Held, Martin Wiese, Bernhard Blumich, Matthias Wessling, Meike Emondts, Jurgen Klankermayer, M. Luisa Iruela-Arispe, Louis-S. Bouchard
Summary: The study introduces a new approach for independently quantifying cell viability and density, allowing mapping of cell number and health within optically opaque bioreactors. This noninvasive method provides valuable feedback for monitoring and controlling cell populations in biomanufacturing.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Energy & Fuels
Anton Duchowny, Oliver Mohnke, Holger Thern, Pablo Matias Dupuy, Hege Christin Wideroe, Audun Faanes, Anfinn Paulsen, Markus Kueppers, Bernhard Bluemich, Alina Adams
Summary: This study demonstrates that benchtop NMR combined with chemometrics can reliably and quickly quantify complex hydrocarbon-gas mixtures.
Article
Biochemical Research Methods
Dennis Woertge, Matthew Parziale, Jan Claussen, Behzad Mohebbi, Siegfried Stapf, Bernhard Bluemich, Matthew Augustine
Summary: The matrix pencil method (MPM) is tested for quantitatively processing multiexponential low-field nuclear magnetic resonance T1 relaxometry data. The data is obtained from T1 saturation recovery curves measured in a highly inhomogeneous magnetic field. Different concentrations of a Gd3+ contrast agent doped in 0.9% brine solutions are used as test liquids. MPM shows superior performance in separating and quantifying relaxation components, as well as exploring the sensitivity to relative contribution of each component and resolving systems with multiple components.
JOURNAL OF MAGNETIC RESONANCE
(2023)
Article
Engineering, Biomedical
Frederik Dreyer, Qing Yang, Belal Alnajjar, Daniel Kruger, Bernhard Blumich, Jens Anders
Summary: This article presents a portable NMR relaxometry system optimized for the point-of-care analysis of body liquids, demonstrating excellent concentration sensitivity and making it an ideal candidate for future biomarker detection.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2023)
Article
Energy & Fuels
Anton Duchowny, Karin Engelander, Bernhard Bluemich, Alina Adams
Summary: Understanding aging phenomena of alternative fuels is crucial due to the introduction of different aging-related phenomena. A novel test rig was designed to simulate real conditions and achieve knowledge gain for fuel aging and additive technology development. The results showed that pure FAME performed well in the realistic setup due to its high polarity preventing deposit accumulation. Insightful information with minimal effort and sample volume was obtained through benchtop 1H Nuclear Magnetic Resonance (NMR) spectroscopy. Conventional fuel and FAME blends were found to lead to system failures and large quantities of deposits.
JOURNAL OF THE ENERGY INSTITUTE
(2023)
Article
Humanities, Multidisciplinary
Bernhard Blumich, Eleonora Del Federico, Denis Jaschtschuk, Markus Kuppers, Katelin Fallon, Adelaide Steinfeld, Paolo Tomassini
Summary: Roman wall paintings at Ostia Antica were studied in situ for the first time using NMR, XRF, and VIL to explore construction materials and evolution of painting techniques. Analysis revealed a shift from a diverse pigment palette in early paintings to iron-based pigments in later ones, with the presence of Egyptian Blue in early paintings.
Review
Chemistry, Analytical
Claudia Campanale, Silvia Galafassi, Francesca Di Pippo, Iulian Pojar, Carmine Massarelli, Vito Felice Uricchio
Summary: Biodegradable plastic mulches (BDMs) have the potential to be an eco-friendly alternative to conventional plastic mulches in agriculture. However, their long-term impacts on soil ecosystems are still uncertain, and further research is needed. Incorporating BDMs into the soil may stimulate microbial activity, but there is also a risk of incomplete degradation and release of residual microplastics and additives.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Xuechi Yin, Sijie Liu, Deepak Kukkar, Jianlong Wang, Daohong Zhang, Ki-Hyun Kim
Summary: The lateral flow immunoassay strip is a classic and dominant tool in point-of-care detection, known for its portability and simplicity. However, current colored nanomaterials used as signal labels in LFIA have limited sensing potential, leading to the recognition of composite nanoparticles as alternatives to enhance sensitivity, signal readout diversity, anti-matrix interference, and cost-effectiveness.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Yaxin Cao, Longyi Shao, Timothy P. Jones, Wenjing Deng, M. Santosh, Pengju Liu, Cheng-Xue Yang, Yaowei Li, Daizhou Zhang, Kelly Berube
Summary: The toxicity of fibrous particles in ambient air can be higher than other types of particles. Microfibers can be organic or inorganic and their presence in the atmosphere as a result of human activity raises concerns for environmental and public health. Accurate collection, identification, and understanding of the health hazards associated with these fibers are crucial for mitigation strategies and protection of public health.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Chenchen Xie, Chen Meng, Huilin Liu, Baoguo Sun
Summary: The development of food hazard factor (FHF) detection has been moving towards on-site inspection and mobile law enforcement, calling for simple, fast, and affordable analysis technology to ensure food safety and quality. This review comprehensively summarizes the progress in research on smartphone-assisted MIP optosensors, focusing on the key issues of accuracy and sensitivity.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Guillem Peris-Pastor, Cristian Azorin, Jose Grau, Juan L. Benede, Alberto Chisvert
Summary: Green Analytical Chemistry plays an important role in every stage of method development, including sample preparation. Extraction techniques have evolved from conventional ones to a variety of miniaturized techniques in order to enhance analytical performance and ensure safety for operators and the environment. Green metric tools are used to evaluate the impact and sustainability of methods, with AGREEprep selected as the most suitable tool for evaluating published methods in various applications. The miniaturization of sample preparation strategies has led to the use of less and safer solvents, reduced waste generation and energy consumption, and improved portability and throughput.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Helena Hruskova, Roman Reminek, Frantisek Foret
Summary: This review article summarizes the progress and recent studies in offline electromigration preparative techniques between 2018 and 2023. It covers various techniques including electrophoresis, free-flow electrophoresis, isoelectric focusing, and isotachophoresis, providing theoretical aspects, trends, and solutions to existing limitations in each technique.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Mayank Garg, Nicole Pamme
Summary: This review focuses on the removal strategies of templates from molecularly imprinted polymers (MIPs) used in diagnostic biosensors. Chemical-based and electrochemical-based template extraction approaches are summarized and evaluated, providing guidance for researchers in the fields of analytical chemistry, diagnostics, and materials science for the design of MIP-based sensors.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Ivneet Banga, Anirban Paul, Nathan Kodjo Mintah Churcher, Ruchita Mahesh Kumar, Sriram Muthukumar, Shalini Prasad
Summary: Breathomics is an emerging field that focuses on analyzing exhaled breath to diagnose and monitor respiratory diseases. Electrochemical sensors, with their high sensitivity, selectivity, and low cost, play a significant role in breathomics and can be integrated into portable devices for point-of-care diagnosis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Fabjola Bilo, Paola Cirelli, Laura Borgese
Summary: This review explores the application of X-ray fluorescence (XRF) spectrometry for elemental analysis of particulate matter (PM) in air quality monitoring. It discusses the fundamentals of XRF, experimental configurations, PM sampling devices and substrate, sample preparation strategies, qualitative and quantitative analysis, as well as the challenges faced by XRF in becoming a reliable analytical technique for PM analysis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Hakim Faraji
Summary: The dispersive liquid-liquid microextraction (DLLME) technique is widely popular in analytical chemistry due to its high efficiency, cost-effectiveness, and simplicity. Recent advancements have addressed the limitations of DLLME, incorporating greener solvents, innovative dispersion strategies, and simplified procedures. These changes have made DLLME a more sustainable and efficient technique.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Sherin F. Hammad, Inas A. Abdallah, Alaa Bedair, Reda M. Abdelhameed, Marcello Locatelli, Fotouh R. Mansour
Summary: Carbon nanomaterials (CNMs) have excellent capabilities in terms of adsorption, enhanced oxidation, and photocatalysis, attracting widespread attention in different fields. Metal-organic frameworks (MOFs) have been widely used due to their regular network structure, porous nature, and large specific surface area. However, the instability of MOFs in aqueous solutions limits their applications in chemical sensing. Recent studies have focused on increasing the stability of MOFs in water-based matrices through chemical modifications using CNMs.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Alexandra Pape, Oliver J. Schmitz
Summary: Low temperature plasmas based on dielectric barrier discharges have emerged as a recent development in ion source research. These ion sources are applicable to heat-sensitive analytes and can ionize a wide range of compounds. Despite intensive research on important parameters such as configuration, shape, size, and materials in the past two decades, the actual ionization mechanism for all plasma gases has not been fully elucidated. This review provides an overview of atmospheric pressure ion sources, with a focus on plasma and dielectric barrier discharge based ion sources, summarizing the reactions occurring in the plasma and discussing the applications developed by different research groups.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Hai Xiong, Fengli Li, Linyu Zeng, Qiyu Lei
Summary: This review provides an overview of the emerging trends in the use of functional COF nanomaterials as biosensors for DNA/RNA detection. It summarizes the construction of DNA/RNA hybridized COF nanoprobes and their potential applications in bioanalyte detection, biosensing, biomarker imaging, and clinical biomedicine.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Bing Yan
Summary: This article summarizes the recent progress in logic gate computing and operation based on multiple luminescence response and chemical sensing for lanthanide functionalized MOF hybrid systems. The article first describes multi-color luminescence and the subsequent multiple luminescence response. The basic concept of logic gate operation and the advantages of lanthanide-based hybrid materials are then introduced. Reports on logic gate operation using pure lanthanide MOFs are provided, followed by a detailed summary of logic gate operations using lanthanide functionalized MOF hybrid materials. Additionally, the article discusses the practical luminescent detection of analytes by correlating the luminescence responsive signals and the concentration of different analytes. Finally, the article concludes with a prospect for this topic.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Brij Mohan, Gurjaspreet Singh, Rakesh Kumar Gupta, Pawan Kumar Sharma, Alexander A. Solovev, Armando J. L. Pombeiro, Peng Ren
Summary: Porous materials, particularly hydrogen-bonded organic frameworks (HOFs), have gained significant attention due to their versatile applications and unique properties such as well-defined crystalline structure and easy regeneration processes. This article provides a comprehensive overview of HOFs, including synthesis methods, hydrogen bonding motifs, recent advancements, and potential applications, offering valuable guidance for further exploration in this dynamic field.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
