Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 85, Issue -, Pages 36-60Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2016.04.004
Keywords
Analytical performance; Biosensor; Clinical analysis; Figure of merit; Sensor
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Funding
- Portuguese Science Foundation (FCT) under POCH funds [SFRH/BPD/95961/2013]
- European Social Fund
- Portuguese National Funds from MEC
- national funds via FCT/MEC (PIDDAC) [IF/00407/2013/CP1162/CT0023]
- CESAM [UID/AMB/50017]
- FCT/MEC
- FEDER
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Sensors and biosensors have been increasingly used for clinical analysis due to their miniaturization and portability, allowing the construction of diagnostic devices for point-of-care testing. This paper presents an up-to-date overview and comparison of the analytical performance of sensors and biosensors recently used in clinical analysis. This includes cancer and cardiac biomarkers, hormones, biomolecules, neurotransmitters, bacteria, virus and cancer cells, along with related significant advances since 2011. Some methods of enhancing the analytical performance of sensors and biosensors through their figures of merit are also discussed. (C) 2016 Elsevier B.V. All rights reserved.
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