Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 79, Issue -, Pages 233-238Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2015.10.016
Keywords
Capacitive transduction; Ultra-sensitive; Affinity biosensor; Gold surface; Electropolymerization; MIP; Microcontact imprinting
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Funding
- Swedish Research Council
- Sweden Innovation Agency (Vinnova)
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Capacitive binding assays have long been considered highly sensitive. The underlying method in such assays includes sending short potential pulses and then registering the current. However, with the introduction of current pulses and registration of potential responses, the stability improved significantly, leading to assays of extreme sensitivities. The new assaying technology has been applied in a range of affinity binding assays, from immunoassays via DNA base pairing to the use of molecularly imprinted polymers (MIPs). Overall, very good sensitivities have been recorded, and the MIPs exhibit high stability and reusability. (C) 2015 Elsevier B.V. All rights reserved.
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