Article
Biochemistry & Molecular Biology
Nataliya Yaglova, Dibakhan A. Tsomartova, Sergey S. Obernikhin, Valentin V. Yaglov, Svetlana Nazimova, Elina S. Tsomartova, Elizaveta Chereshneva, Marina Y. Ivanova, Tatiana A. Lomanovskaya
Summary: DDT exposure during prenatal and postnatal development results in lower testosterone production and increased estradiol levels in male rats after maturation, while postnatal exposure leads to accelerated growth of gonads and higher testosterone production during puberty. Both types of exposure affect sex steroid hormone production in an age-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Baek Kiook, Park Jong-Tae, Kwak Kyeongmin
Summary: The study found that urinary bisphenol S (BPS) played an important role in the diagnosis of asthma in Korean adolescent females. Compared to patients diagnosed with asthma after 60 months, high urinary BPS significantly increased the odds of lifetime asthma prevalence.
Article
Environmental Sciences
Niedson Correia de Lima Junior, Juliana Franco Camilo, Pamella Rodrigues do Carmo, Marcelle Novaes de Andrade, Bernardo Ferreira Braz, Ricardo Erthal Santelli, Lycia de Brito Gitirana, Andrea Claudia Freitas Ferreira, Denise Pires de Carvalho, Leandro Miranda-Alves, Glaecir Roseni Mundstock Dias
Summary: Subacute exposure to lead acetate disrupts thyroid gland function in both sexes, leading to changes in learning and memory abilities.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Raquel Chamorro-Garcia, Nathalie Poupin, Marie Tremblay-Franco, Cecile Canlet, Riann Egusquiza, Roselyne Gautier, Isabelle Jouanin, Bassem M. Shoucri, Bruce Blumberg, Daniel Zalko
Summary: Metabolomics confirmed transgenerational obesogenic effects of environmentally relevant doses of TBT in male mice, while also showing impaired liver biotransformation capacity in females. This study demonstrates the transgenerational effects of EDC exposure and highlights the potential use of metabolomic fingerprints in identifying individuals susceptible to adverse health effects from ancestral exposure to obesogens.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Toxicology
Anne Milcamps, Roman Liska, Ingrid Langezaal, Warren Casey, Matthew Dent, Jenny Odum
Summary: The AR-CALUX (R) in vitro method is an effective way to detect endocrine active chemicals with androgenic or anti-androgenic potential. An international ring trial confirmed its high reproducibility and low variability within and between laboratories, leading to almost 100% concordance of classifications. The method has been approved for inclusion in the updated OECD test guideline TG458, along with two other mechanistically similar methods.
TOXICOLOGICAL SCIENCES
(2021)
Review
Environmental Sciences
Miaoliang Wu, Fuhui Yan, Qian Liu, Ganzhong Liao, Yilin Shen, Zhi Bai, Xiaoshan Liu
Summary: Preeclampsia (PE) is a disease that occurs after 20 weeks of pregnancy and is characterized by new onset hypertension and albuminuria or other end-organ damage. It is a major complication of pregnancy that can increase morbidity and mortality in pregnant women and fetuses, causing significant social burden. Recent research suggests that exposure to environmental xenobiotic compounds, particularly endocrine disruptors, may contribute to the development of PE. However, the specific mechanisms underlying this relationship remain unclear. This paper reviews the role and potential mechanism of PE induced by exogenous chemicals and provides an outlook on the environmental etiology of PE.
Article
Reproductive Biology
Carolina Marques Bedolo, Thalles Fernando Rocha Ruiz, Gustavo Matheus Amaro, Patricia Simone Leite Vilamaior, Ellen Cristina Rivas Leonel, Sebastiao Roberto Taboga, Silvana Gisele Pegorin de Campos
Summary: This study aimed to describe the histopathological alterations in the prostate of adult female gerbils caused by perinatal exposure to BPA (50 μg/kg) and E2 (35 μg/kg). The results showed that both BPA and E2 induced proliferative lesions in the female prostate by modulating steroid receptors in the epithelium. BPA was also found to be a pro-inflammatory and pro-angiogenic agent, with more pronounced impacts in the prostatic stroma.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anna Tabecka-Lonczynska, Bartosz Skora, Edyta Kaleniuk, Konrad A. A. Szychowski
Summary: Tris(2,3-dibromopropyl) isocyanurate (TBC), a novel brominated flame retardant, has been widely used in industry and found in the environment and living organisms. TBC acts as an endocrine disruptor through estrogen receptors, affecting male reproductive processes. This study evaluated the effect of TBC on mouse spermatogenic cells in vitro and observed cytotoxic and apoptotic effects. The dysregulation of the steroid-based pathway may be the cause of male infertility, but further research is needed to fully understand the mechanism of TBC involvement.
Article
Engineering, Environmental
Phum Tachachartvanich, Ettayapuram Ramaprasad Azhagiya Singam, Kathleen A. Durkin, J. David Furlow, Martyn T. Smith, Michele A. La Merrill
Summary: Research findings indicate that emerging per- and poly-fluoroalkyl substances (PFASs) may have adverse effects on the human endocrine system and exhibit competitive antiandrogenic effects.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Filiz Boran, Abbas Gungordu
Summary: The effects of drugs containing synthetic thyroid hormone and an anti-thyroid drug on different early developmental stages of Xenopus laevis vary, with more effective growth retardation in embryos than tadpoles. Inhibition of biomarker enzymes was significant in tadpoles, showing differences in sensitivity and responses to drugs at different stages.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Review
Environmental Sciences
Juan P. Munoz, Tammy C. Bleak, Gloria M. Calaf
Summary: Glyphosate, a broad-spectrum herbicide introduced in 1974, has had a significant impact on the crop industry and is considered one of the most successful herbicides in history. However, recent studies have raised concerns about its safety, with conflicting opinions from international agencies regarding its effects on human health, particularly as an endocrine-disrupting chemical and carcinogen.
Editorial Material
Biochemistry & Molecular Biology
Borja Quiroga
Summary: BPA, a common component of plastics worldwide, has been shown to act as an endocrine disruptor with some hormonal functions. High levels of BPA are related to cardiovascular events and carcinogenesis pathways, and CKD patients have higher serum concentrations of BPA due to impaired renal function. Efforts to reduce BPA levels in these patients include developing BPA-free dialysis filters and other techniques.
Article
Environmental Sciences
David A. Geier, Mark R. Geier
Summary: A study using NHANES data found that 82% of the tested individuals in the United States had detectable concentrations of glyphosate in their urine. There was a significant inverse correlation between glyphosate concentrations and total testosterone and total estradiol concentrations, but no correlation with sex hormone binding globulin concentrations.
Article
Food Science & Technology
Camila Helena Facina, Silvana Gisele Pegorin Campos, Thalles Fernando Rocha Ruiz, Rejane Maira Goes, Patricia Simone Leite Vilamaior, Sebastiao Roberto Taboga
Summary: Curcumin and piperine can mitigate the detrimental effects of BPA on the prostate gland, reducing nuclear atypia and maintaining the homeostasis of prostate epithelial cells. The protective action of these phytotherapeutic agents is associated with weight loss, anti-inflammatory potential, and control of prostate epithelial cell homeostasis.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Danielle Regina Gomes Ribeiro-Brasil, Italo Braga Castro, Marcelo Petracco, Rodrigo Moco Batista, Leandro Schlemmer Brasil, Johnata Azevedo Ferreira, Thais Angelica da Costa Borba, Marcelo Rollnic, Gilberto Fillmann, Lilian Lund Amado
Summary: In this study, the spatial distribution of Butyltins (BTs) in surface sediments and gastropod tissues in the Eastern Amazon estuarine system was quantified. The results indicate that BTs concentrations are associated with area use and local hydrodynamics in the region.
MARINE POLLUTION BULLETIN
(2021)
Article
Chemistry, Multidisciplinary
Opeoluwa Ogunsuyi, Olusegun Ogunsuyi, Olubukola Akanni, Okunola Alabi, Chibuisi Alimba, Oluwatosin Adaramoye, Sebastien Cambier, Santhana Eswara, Arno C. Gutleb, Adekunle Bakare
Summary: The study investigated the in vivo toxic effect of a mixture of TiO(2)NPs and ZnO NPs, revealing that the mixture induced a higher systemic toxicity than when TiO(2)NPs or ZnO NPs were used individually. Comprehensive risk assessments should be carried out on NP mixtures before their utilization in consumer products.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anca Pop, Catalina Bogdan, Ionel Fizesan, Sonia Iurian, Rahela Carpa, Cecilia Bacali, Laurian Vlase, Daniela Benedec, Mirela L. Moldovan
Summary: This study evaluated the biological activities of four extracts from Vitis vinifera by-products, revealing their antioxidant, anti-inflammatory, and antimicrobial properties. The freeze-drying mouthwash formulation containing poloxamer-407, xylitol, and mannitol exhibited desirable mechanical properties and reconstitution time.
Article
Biochemistry & Molecular Biology
Denisa-Madalina Zalar, Cristina Pop, Elena Buzdugan, Bela Kiss, Maria-Georgia Stefan, Steliana Ghibu, Doinita Crisan, Alexandra Buruiana-Simic, Adriana Grozav, Ileana Monica Borda, Cristina Ionela Mogosan
Summary: The study evaluated the effect of colchicine in an animal model of hyperlipidemia. The results showed that colchicine reduced lipid levels, oxidative stress, and inflammation markers, and improved endothelial dysfunction. However, the use of colchicine may have adverse effects.
Article
Biochemistry & Molecular Biology
Roxana Banc, Daniela-Saveta Popa, Anamaria Cozma-Petrut, Lorena Filip, Bela Kiss, Anca Farcas, Andras Nagy, Doina Miere, Felicia Loghin
Summary: The study found that moderate consumption of red wine can significantly protect rats from acrylamide-induced liver injury and oxidative stress, with better protective effects compared to white wine.
Article
Biochemistry & Molecular Biology
Stefan Nitica, Ionel Fizesan, Roxana Dudric, Lucian Barbu-Tudoran, Anca Pop, Felicia Loghin, Nicoleta Vedeanu, Constantin Mihai Lucaciu, Cristian Iacovita
Summary: Coating ferrimagnetic nanoparticles with a silica layer using an oil-in-water microemulsion-based method significantly enhances their heating ability. The silica-coated clusters have a high hydrodynamic diameter, biocompatibility, increased cellular uptake, and improved intracellular heating performance.
Article
Chemistry, Medicinal
Cristina-Ioana Barbalata, Alina Silvia Porfire, Tibor Casian, Dana Muntean, Iulia Rus, Mihaela Tertis, Cecilia Cristea, Anca Pop, Julien Cherfan, Felicia Loghin, Ioan Tomuta
Summary: This study optimized a liposomal formulation co-encapsulating simvastatin and doxorubicin for potential use in anticancer therapy. Quality by Design concept was implemented and critical factors such as phospholipid, simvastatin, and doxorubicin concentration were identified. The optimal formulation met quality requirements and showed concentration-dependent antiproliferative effects.
Article
Electrochemistry
Meshal H. Almabadi, Florina Maria Truta, Gyako Adamu, Todd Cowen, Mihaela Tertis, Kaseb D. M. Alanazi, Maria-Georgia Stefan, Elena Piletska, Bela Kiss, Cecilia Cristea, Karolien De Wael, Sergey A. Piletsky, Alvaro Garcia Cruz
Summary: A graphene-assisted molecularly imprinted polymer nanoparticle-based sensor was developed for the detection of amphetamine. The sensor used electroactive nanoparticles as specific actuators and embedded a ferrocene redox probe for the detection of non-electroactive amphetamine. The 3D printed nanoMIPs/graphene sensors displayed the highest selectivity and sensitivity, allowing for quantitative determination of amphetamine and easy manufacturing.
ELECTROCHIMICA ACTA
(2023)
Article
Medicine, General & Internal
Valentina Sas, Paraschiva Chereches-Panta, Diana Borcau, Cristina-Nicoleta Schnell, Edita-Gabriela Ichim, Daniela Iacob, Alina-Petronela Coblisan, Tudor Drugan, Sorin-Claudiu Man
Summary: Electronic nose (e-nose) is a new technology used to identify volatile organic compounds (VOC) in breath air. It can adequately identify airway inflammation in asthma patients. In this study, the e-nose was able to discriminate pediatric patients with asthma from controls, but the accuracy was lower in the external validation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Lidia Neamti, Tudor Drugan, Cristina Drugan, Ciprian Silaghi, Lidia Ciobanu, Alexandra Craciun
Summary: This study aimed to analyze the most commonly used biomarkers for patient monitoring and follow-up, both independently and as a group, in order to propose an improved activity score that accurately reflects the changes at the intestinal level, to reduce the number of colonoscopic interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Larisa Cujba, Cristina Stan, Ovidiu Samoila, Tudor Drugan, Ancuta Benedec (Cutas), Cristina Nicula
Summary: Multiple sclerosis (MS) is a neurological disease that affects the optic nerve and can be diagnosed and monitored using optical coherence tomography (OCT). In a clinical study, patients with MS were compared to healthy controls, and significant thinning of the retinal nerve fiber layer (pRNFL) was observed in MS patients, especially those with optic neuritis. The study also found that retinal changes in MS start from the fovea and spread to the posterior pole.
Article
Medicine, General & Internal
Ioana-Andreea Gheban-Rosca, Bogdan-Alexandru Gheban, Bogdan Pop, Daniela-Cristina Mironescu, Vasile Costel Siserman, Elena Mihaela Jianu, Tudor Drugan, Sorana D. Bolboaca
Summary: This study aimed to evaluate the macro- and microscopic biomarkers of lung damage in patients with fatal COVID-19. The researchers retrospectively analyzed lung tissue samples from autopsies in Romania. The study found that age and infection with the beta variant of the virus were significant factors associated with diffuse alveolar damage.
Article
Environmental Sciences
Nina Vogel, Rosa Lange, Phillipp Schmidt, Laura Rodriguez Martin, Sylvie Remy., Andrea Springer, Vladimira Puklova, Milena Cerna, Peter Rudnai, Szilvia Kozepesy, Beata Janasik, Danuta Ligocka, Lucia Fabelova, Branislav Kolena, Ida Petrovicova, Michal Jajcaj, Milada Estokova, Marta Esteban-Lopez, Argelia Castano, Janja Snoj Tratnik, Anja Stajnko, Lisbeth E. Knudsen, Jorma Toppari, Katharina M. Main, Anders Juul, Anna-Maria Andersson, Niels Jorgensen, Hanne Frederiksen, Cathrine Thomsen, Amrit Kaur Sakhi, Agneta Akesson, Christina Hartmann, Marie Christine Dewolf, Gudrun Koppen, Pierre Biot, Elly Den Hond, Stefan Voorspoels, Liese Gilles, Eva Govarts, Aline Murawski, Antje Gerofke, Till Weber, Maria Ruether, Arno C. Gutleb, Cedric Guignard, Tamar Berman, Holger M. Koch, Marike Kolossa-Gehring
Summary: Phthalates are widely used as plasticizers and can have negative impacts on reproductive functions. However, existing human biomonitoring studies on internal exposure to phthalates in Europe differ in many aspects, making comparability challenging. The HBM4EU initiative gathered data from 29 studies across Europe to describe the general population's exposure to phthalates from 2005 to 2019. This study is an important step towards making internal exposures to phthalates comparable across countries and provides suggestions for improved harmonization in future studies.
Article
Chemistry, Analytical
Florina Truta, Alvaro Garcia Cruz, Mihaela Tertis, Christopher Zaleski, Gyako Adamu, Natalie S. Allcock, Maria Suciu, Maria-Georgia Stefan, Bela Kiss, Elena Piletska, Karolien De Wael, Sergey A. Piletsky, Cecilia Cristea
Summary: A highly sensitive and portable electrochemical sensor based on molecularly imprinted nanoparticles (nanoMIPs) was developed for the selective determination of amphetamine in street samples. The sensor employed nanoMIPs designed to specifically recognize amphetamine, which were then synthesized using solid phase synthesis. The nanoMIPs were immobilized onto screen-printed carbon electrodes using a composite film containing chitosan, nanoMIPs, and graphene oxide. Incorporation of ferrocenylmethyl methacrylate in nanoMIPs enabled electrochemical detection, with the signal dependent on the interaction between amphetamine and nanoMIPs. The sensor exhibited high sensitivity and satisfactory recoveries when tested with street samples, and the results were validated using UPL-MS/MS.
MICROCHEMICAL JOURNAL
(2023)
Article
Environmental Sciences
Laura Rodriguez Martin, Liese Gilles, Emilie Helte, Agneta Akesson, Jonas Tagt, Adrian Covaci, Amrit K. Sakhi, An Van Nieuwenhuyse, Andromachi Katsonouri, Anna-Maria Andersson, Arno C. Gutleb, Beata Janasik, Brice Appenzeller, Catherine Gabriel, Cathrine Thomsen, Darja Mazej, Denis Sarigiannis, Elena Anastasi, Fabio Barbone, Hanna Tolonen, Hanne Frederiksen, Jana Klanova, Jani Koponen, Janja Snoj Tratnik, Kim Pack, Koppen Gudrun, Kristin Olafsdottir, Lisbeth E. Knudsen, Loic Rambaud, Loreta Strumylaite, Lubica Palkovicova Murinova, Lucia Fabelova, Margaux Riou, Marika Berglund, Mate Szabados, Medea Imboden, Michelle Laeremans, Milada Estokova, Natasa Janev Holcer, Nicole Probst-Hensch, Nicole Vodrazkova, Nina Vogel, Pavel Piler, Phillipp Schmidt, Rosa Lange, Sonia Namorado, Szilvia Kozepesy, Tamas Szigeti, Thorhallur I. Halldorsson, Till Weber, Tina Kold Jensen, Valentina Rosolen, Vladimira Puklova, Wojciech Wasowicz, Ovnair Sepai, Lorraine Stewart, Marike Kolossa-Gehring, Marta Esteban-Lopez, Argelia Castano, Jos Bessems, Greet Schoeters, Eva Govarts
Summary: This study evaluated the exposure levels of children and women in Europe over time. The results showed that exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. These findings are important for policy efficacy monitoring and highlight the role of HBM in supporting policies.
Article
Biochemistry & Molecular Biology
Dana Hales, Dana-Maria Muntean, Maria Adriana Neag, Bela Kiss, Maria-Georgia Stefan, Lucia Ruxandra Tefas, Ioan Tomuta, Alina Sesarman, Ioana-Adela Ratiu, Alina Porfire
Summary: This study investigates the effects of a curcumin-loaded oral-drug-delivery system in an experimental model of ulcerative colitis (UC). The results show that the system has a significant preventive effect in reducing oxidative stress caused by acetic acid. Histopathological assessment also confirms the anti-inflammatory and antioxidant effects of this system.
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)
