Article
Geriatrics & Gerontology
Qu Yi, Yu-Peng Chen, Jiang-Ting Li, Jing-Yi Li, Qi-Xiong Qin, Dan-Lei Wang, Jing-Wei Zhao, Zhi-Juan Mao, Yong-Jie Xiong, Min Zhe, Xue Zheng
Summary: Poor sleep is associated with more severe symptoms in Parkinson's disease (PD), and both insufficient and excessive time spent in bed and nocturnal sleep duration are correlated with higher non-motor symptom burdens. Non-motor symptoms play a mediating role in sleep quality, quality of life, PD severity, and motor symptoms.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Elisa Montanaro, Alberto Romagnolo, Margherita Fabbri, Carlo Alberto Artusi, Gabriele Imbalzano, Mario Giorgio Rizzone, Leonardo Lopiano, Maurizio Zibetti
Summary: In advanced PD patients, sleep disturbances selectively correlate with specific neuropsychological functions and not with short-term memory and consolidation. It is suggested to consider treatment of sleep disturbances to minimize their potential impact on cognition.
JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Jiangnan Ma, Kaixin Dou, Ruize Liu, Yajin Liao, Zengqiang Yuan, Anmu Xie
Summary: Sleep disorders, including pRBD and daytime sleepiness, are associated with depression in early and prodromal PD patients, partially mediated by autonomic dysfunction.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Food Science & Technology
Steven D. Mitchell, Christos Sidiropoulos
Summary: Parkinson's disease presents not only with motor symptoms but also with various autonomic dysfunctions. Botulinum neurotoxin has shown potential in improving these autonomic symptoms, along with additional indications such as pain management in Parkinson's disease.
Review
Neurosciences
Daniel J. van Wamelen, Katarina Rukavina, Aleksandra M. Podlewska, K. Ray Chaudhuri
Summary: This study aimed to provide an updated review on advances in pharmacological, non-pharmacological, and exercise-based interventions for non-motor symptoms (NMS) in Parkinson's disease (PD). The study found that since 2017, new strategies for managing NMS have emerged, such as the use of droxidopa for orthostatic hypotension, various dopaminergic treatment options for insomnia, and a range of non-pharmacological and exercise-based interventions for cognitive and neuropsychiatric symptoms, pain, and insomnia and excessive sleepiness. The conclusion is that targeted non-pharmacological treatments and other NMS management options may have a significant beneficial effect on the quality of life and should be considered in the treatment pathways of PD.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Si-Chun Gu, Qing Ye, Chang-De Wang, Shao-Rong Zhao, Jie Zhou, Chen Gao, Yu Zhang, Zhen-Guo Liu, Can-Xing Yuan
Summary: Pingchan granule (PCG) has a long-lasting and extensive symptomatic efficacy for both motor and non-motor symptoms of Parkinson's disease (PD) with good tolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Katarina Rukavina, Lucia Batzu, Valentina Leta, K. Ray Chaudhuri
Summary: Non-motor symptoms (NMSs) in Parkinson's disease have a negative impact on the quality of life, but clinical trials mainly focus on motor symptoms. Therefore, there is a need for more industry and researcher awareness to conduct high-quality, large-scale clinical trials targeting pain, autonomic dysfunction, and sleep disturbances in Parkinson's disease patients.
Article
Neurosciences
Miriam Sklerov, Nina Browner, Eran Dayan, David Rubinow, Flavio Frohlich
Summary: This study investigated the association between autonomic and depression symptoms in early Parkinson's disease (PD), and their evolution over time. The results showed that depression predicted autonomic symptoms in all groups, with a stronger influence in the PD groups compared to controls, and strongest in PD at visit 12. Depression also predicted the presence of orthostatic hypotension only in the PD group at visit 12.
JOURNAL OF PARKINSONS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Frank C. Church
Summary: Parkinson's disease is a progressive neurodegenerative disorder that mainly affects older adults. Treatment options include rehabilitation, therapy, restorative programs, maintenance with complementary and alternative medicine, and surgery as a last resort. Currently, there is no cure for PD and the focus is on slowing disease progression and improving quality of life for patients.
Article
Medicine, General & Internal
Diego Santos-Garcia, Ariadna Laguna, Jorge Hernandez-Vara, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Maria Cristina Iniguez-Alvarado, Iago Garcia Diaz, Silvia Jesus, Maria Teresa Boungiorno, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso G. Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Menendez Gonzalez, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. Lopez M. Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: This study analyzed sex difference manifestations in Spanish patients with Parkinson's disease (PD) and found important differences. Symptoms such as depression, fatigue, and pain were more frequent and/or severe in females, while symptoms such as hypomimia, speech problems, rigidity, and hypersexuality were more noted in males. Women received a lower levodopa equivalent daily dose and had worse perception of quality of life. After two years of follow-up, the NMS burden increased more significantly in males, while the functional capacity was more impaired in females.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Behavioral Sciences
Keisuke Suzuki, Hiroaki Fujita, Takeo Matsubara, Yasuo Haruyama, Taro Kadowaki, Kei Funakoshi, Yuji Watanabe, Koichi Hirata
Summary: This study demonstrated the beneficial effects of Zonisamide on motor symptoms and sleep problems in levodopa-treated PD patients with motor fluctuation. ZNS may be more effective for several nonmotor symptoms in PD patients with tremor compared with those without tremor.
BRAIN AND BEHAVIOR
(2021)
Review
Biochemistry & Molecular Biology
Bonn Lee, Charlotte Edling, Shiraz Ahmad, Fiona E. N. Lebeau, Gary Tse, Kamalan Jeevaratnam
Summary: This study reviewed clinical and non-clinical literature on cardiovascular disease risks, electrocardiograms, neurocardiac lesions in Parkinson's disease, and fundamental electrophysiological studies. Pathological evidence suggests that the hearts of Parkinson's disease patients may undergo alpha-synucleinopathy. Future research is needed to integrate cardiac electrophysiology and pathological alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Maithrayie Kumaresan, Safeera Khan
Summary: Parkinson's disease is primarily a movement disorder but also encompasses a range of non-motor symptoms such as sleep disorders, gastrointestinal dysfunction, anxiety, and depressive episodes. These non-motor symptoms can appear years before motor symptoms and can significantly impact the quality of life for patients. Early detection and management of non-motor symptoms can lead to better outcomes for Parkinson's patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Health Care Sciences & Services
Wei-Ti Hsu, Chieh-Min Hsu, Shao-Chi Hung, Shih-Ya Hung
Summary: This study systematically evaluated the efficacy of acupuncture in treating non-motor symptoms (sleep disorders, depression, anxiety, and fatigue) in Parkinson's disease patients. The meta-analysis of clinical trials showed that acupuncture improved sleep disorders and depression in PD patients but had no effect on anxiety and fatigue. Acupuncture can be used as a complementary treatment for sleep disturbances and depression in PD patients and may have a dual therapeutic effect on motor and non-motor symptoms.
Review
Neurosciences
Xiao-Zhong Jing, Xiang-Zhen Yuan, Xingguang Luo, Shu-Yun Zhang, Xiao-Ping Wang
Summary: Nondopaminergic neurotransmitters play a role in Parkinson's disease (PD) and their receptors are potential targets for developing new treatments. This review summarizes the recent findings on nondopaminergic treatments for PD, including drugs to reduce motor complications and improve non-motor symptoms. Several drugs have been approved for managing motor fluctuations and levodopa-induced dyskinesia, while ongoing research is focused on serotonergic and glutamatergic agents. Nondopaminergic drugs also show promise in treating non-motor symptoms such as hallucinations and delusions, daytime sleepiness, depression, and urinary tract symptoms.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Clinical Neurology
Monica Gagliardi, Radha Procopio, Giuseppe Nicoletti, Maurizio Morelli, Marco D'Amelio, Aldo Quattrone, Grazia Annesi
Summary: The study aimed to evaluate LRP10 gene mutations in PD and DLB patients from Southern Italy, finding only 2 missense and 3 synonymous variants in patients and control subjects, and a rare variant p.L622F in a PD case. These results indicate that LRP10 mutations are not a common cause of PD and DLB in Southern Italy.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Valentina Arnao, Giuseppe Salemi, Salvatore Scondotto, Nicola Casuccio, Marianna Riolo, Marco D'Amelio, Paolo Ragonese, Paolo Aridon
Summary: The study found that the incidence and case fatality rates of stroke in the elderly population investigated were lower compared to Italian and most European populations, and these rates increased linearly with age and were higher in males, consistent with previous studies.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Cesare Gagliardo, Paolo Ragonese, Gerardo Domenico Iacopino, Giuseppe Salemi, Massimo Midiri, Marco D'Amelio
Summary: Transcranial magnetic resonance-guided focused ultrasound is a non-invasive treatment option for controlling tremors, with potential effectiveness for essential tremor in patients with multiple sclerosis. In two reported cases of patients with multiple sclerosis, this technique showed promise in controlling tremors without evidence of disease progression.
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Giovanni Abbruzzese, Jaime Kulisevsky, Bruno Bergmans, Juan C. Gomez-Esteban, Georg Kagi, Jason Raw, Alessandro Stefani, Tobias Warnecke, Wolfgang H. Jost
Summary: The study confirms the good safety profile of Safinamide in PD patients, with significant clinical improvements in motor complications and UPDRS scores seen in the long-term.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Neurosciences
Cesare Gagliardo, Roberto Cannella, Costanza D'Angelo, Patrizia Toia, Giuseppe Salvaggio, Paola Feraco, Maurizio Marrale, Domenico Gerardo Iacopino, Marco D'Amelio, Giuseppe La Tona, Ludovico La Grutta, Massimo Midiri
Summary: This study compared intraoperative imaging obtained with a dedicated FUS-Head coil and a standard body radiofrequency coil during tcMRgFUS thalamotomy. The results showed that using the dedicated 2ch-FUS coil significantly improved the signal-to-noise ratio and visualization of lesional zones, enhancing the monitoring of patients undergoing tcMRgFUS with a 1.5-T MR scanner.
Article
Multidisciplinary Sciences
Cesare Gagliardo, Roberto Cannella, Giuseppe Filorizzo, Patrizia Toia, Giuseppe Salvaggio, Giorgio Collura, Antonia Pignolo, Rosario Maugeri, Alessandro Napoli, Marco D'amelio, Tommaso Vincenzo Bartolotta, Maurizio Marrale, Gerardo Domenico Iacopino, Carlo Catalano, Massimo Midiri
Summary: Preoperative neuroradiological findings are common in patients undergoing tcMRgFUS thalamotomy for functional neurological disorders, requiring additional measures to prevent harmful non-targeted heating.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Mayowa O. Owolabi, Amanda G. Thrift, Sheila Martins, Walter Johnson, Jeyaraj Pandian, Foad Abd-Allah, Cherian Varghese, Ajay Mahal, Joseph Yaria, Hoang T. Phan, Gregory Roth, Seana L. Gall, Richard Beare, Thanh G. Phan, Robert Mikulik, Bo Norrving, Valery L. Feigin
Summary: The survey found that low-income countries have fewer surveillance activities and lower overall scores for prevention compared to high-income countries. High-income countries have a higher proportion of stroke units and acute stroke treatments, while low-income countries lag behind. LMICs also provide less rehabilitation services.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Public, Environmental & Occupational Health
Mayowa O. Owolabi, Amanda G. Thrift, Ajay Mahal, Marie Ishida, Sheila Martins, Walter Johnson, Jeyaraj Pandian, Foad Abd-Allah, Joseph Yaria, Hoang T. Phan, Greg Roth, Seana L. Gall, Richard Beare, Thanh G. Phan, Robert Mikulik, Rufus O. Akinyemi, Bo Norrving, Michael Brainin, Valery L. Feigin
Summary: Stroke is a major global threat to life and disability, particularly in low- and middle-income countries that struggle to address its challenges. This article provides an overview of primary stroke prevention, estimating the cost and identifying deficiencies in guidelines and primary prevention approaches. Pragmatic solutions are offered, emphasizing the role of governments and population-wide strategies. Implementation of primary stroke prevention involves various stakeholders across the lifespan.
LANCET PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Antonia Pignolo, Sergio Mastrilli, Chiara Davi, Valentina Arnao, Paolo Aridon, Felipe Augusto dos Santos Mendes, Cesare Gagliardo, Marco D'Amelio
Summary: Vitamin D plays a crucial role in bone metabolism, calcium and phosphorous homeostasis, as well as brain development and neuroprotection. Patients with Parkinson's disease often have a high frequency of vitamin D deficiency, which may be related to disease severity and progression. However, the evidence regarding the use of vitamin D supplementation to reduce symptoms and disability in patients with Parkinson's disease is limited. Further clinical studies are needed to confirm the potential benefits and risks of vitamin D supplementation in this population.
Article
Environmental Sciences
Alessandra Amato, Sara Baldassano, Sonya Vasto, Giuseppe Schiro, Chiara Davi, Patrik Drid, Felipe Augusto Dos Santos Mendes, Rosalia Caldarella, Marco D'Amelio, Patrizia Proia
Summary: This study found that 11 weeks of resistance training for people with PD can significantly improve manual dexterity, static and dynamic balance, reaction time, cervical range of motion, and reduce bone loss.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Clinical Neurology
Walter A. Rocca, Paolo Ragonese, Marco D'Amelio, Giovanni Savettieri
JOURNAL OF MOVEMENT DISORDERS
(2022)
Article
Geriatrics & Gerontology
Monica Gagliardi, Radha Procopio, Mariagrazia Talarico, Andrea Quattrone, Gennarina Arabia, Maurizio Morelli, Marco D'Amelio, Donatella Malanga, Giuseppe Bonapace, Aldo Quattrone, Grazia Annesi
Summary: Recently, a novel pathogenic variant in Annexin A1 protein has been identified in an Iranian family with autosomal recessive Parkinsonism. This study aimed to identify rare ANXA1 variants in early-onset PD patients from South Italy. However, sequencing analysis revealed only 2 synonymous variants, suggesting that the recently published ANXA1 mutation is not a common cause of EOPD in Southern Italy.
NEUROBIOLOGY OF AGING
(2023)
Review
Clinical Neurology
Salvatore Iacono, Giuseppe Schiro, Chiara Davi, Sergio Mastrilli, Michelle Abbott, Fabrizio Guajana, Valentina Arnao, Paolo Aridon, Paolo Ragonese, Cesare Gagliardo, Claudia Colomba, Nicola Scichilone, Marco D'Amelio
Summary: SARS-CoV-2 infection may be a potential risk factor for the development of Parkinson's disease, and the two diseases may have a complex relationship and share some pathological and clinical features. Large, longitudinal, and population-based studies are needed to better assess the risk of developing PD after COVID-19.
FRONTIERS IN NEUROLOGY
(2023)
Article
Rehabilitation
Poliany Silva Rocha, Bianca Brenda Leite de Sousa, Marco D'Amelio, Jose Eduardo Pompeu, Patricia Azevedo Garcia, Josevan Cerqueira Leal, Felipe Augusto Dos Santos Mendes
Summary: This overview systematically synthesizes and evaluates the available evidence from systematic reviews and meta-analyses on the effects of exergaming therapy on balance, gait, and quality of life. Most reviews demonstrate significant effects of exergaming therapy on balance, but the conclusions regarding quality of life and gait outcomes are inconclusive.
PHYSIOTHERAPY RESEARCH INTERNATIONAL
(2023)
Article
Clinical Neurology
Antonia Pignolo, Maria Aprile, Cesare Gagliardo, Giovanni Maurizio Giammanco, Marco D'Amelio, Paolo Aridon, Giuseppe La Tona, Giuseppe Salemi, Paolo Ragonese
Summary: SARS-CoV-2 infection may trigger the onset or relapse of multiple sclerosis, with serum IgG testing showing antibody seroconversion but not necessarily providing full protection against reinfection. Therefore, the importance of vaccination for individuals with MS is underscored.
NEUROLOGY INTERNATIONAL
(2021)