Review
Medicine, Research & Experimental
Kwang Ho Yoo, Nikita Thapa, Yong Joon Chwae, Seung Hyun Yoon, Beom Joon Kim, Jung Ok Lee, You Na Jang, Jaeyoung Kim
Summary: Osteoarthritis (OA) still lacks an effective and safe treatment. Targeting transforming growth factor (TGF)-beta and using stem cell-derived exosomes have emerged as potential therapeutic approaches for OA.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hwi Gon Kim, Ye Seon Lim, Seonyeong Hwang, Hye-Yoon Kim, Yuseok Moon, Yong Jung Song, Yong-Jin Na, Sik Yoon
Summary: DEHP, a commonly used plasticizer, may be linked to the development of endometriosis by inducing cell proliferation, migration, inflammation, and stemness through the TGF-β/Smad signaling pathway, providing novel insights into the pathogenesis of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Jitang Chen, Ze-yang Ding, Si Li, Sha Liu, Chen Xiao, Zifu Li, Bi-xiang Zhang, Xiao-ping Chen, Xiangliang Yang
Summary: Targeting TGF beta signaling for cancer therapy presents challenges and opportunities, as inhibitors can enhance chemotherapy efficacy but must also consider the dual role of TGF beta in normal tissues and tumors to avoid unwanted side effects.
Article
Chemistry, Analytical
Anthony T. Giduthuri, Sophia K. Theodossiou, Nathan R. Schiele, Soumya K. Srivastava
Summary: This study explores a method for identifying and separating tenogenically differentiated stem cells. Experimental results show that changes in dielectric properties potentially indicative of early tenogenesis can be detected as early as three days into differentiation. This method has the potential to address challenges in stem cell therapy for tendon injuries.
Article
Chemistry, Multidisciplinary
Dohyun Kim, Youngdae Lee, Kwangsook Park, Danbi Park, Won Jai Lee, Tai Suk Roh, Hyungju Cho, Wooyeol Baek
Summary: This study utilized human tonsil-derived mesenchymal stem cells to produce functional biomimetic nanovesicles with anti-senescence properties, demonstrating enhanced cell proliferation, reduced senescence activity, and impacts on the expression of extracellular matrix and antioxidant genes. These findings suggest that TMSC-NVs can be beneficial for skin rejuvenation applications.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Hyun-Joo Lee, Harry Jung, Dong-Kyu Kim
Summary: Activated T-MSCs expressing IDO and CD40 have the capacity to inhibit immune cell proliferation and cytokine production, thereby modulating immune responses through Th1 and Th2 pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Changshui Wang, Cuilian Sun, Yueshu Zhao, Huimin Song, Zhengyou Li, Feng Jin, Changmeng Cui
Summary: Moyamoya disease (MMD) is a chronic cerebrovascular occlusion disease with poorly understood etiology. RNF213 gene is associated with MMD onset by affecting angiogenesis and pro-inflammatory factors. Knockdown of RNF213 may lead to aberrant TGF-β1 expression through an unidentified pathway, suggesting its important role in MMD pathogenesis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell & Tissue Engineering
Yan Zhang, Yingjin Pan, Yanhong Liu, Xiheng Li, Liang Tang, Mengna Duan, Jiang Li, Guokun Zhang
Summary: Both UCB-MSCs and UCB-MSC-exo can accelerate wound healing, reduce scar formation, and improve the regeneration of skin appendages, nerves, and vessels, as well as regulate the natural distribution of collagen fibers in wound healing. UCB-MSC-exo also suppress excessive formation of myofibroblasts and collagen I.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Gi Cheol Park, Ji Min Kim, Sung-Chan Shin, Yong-il Cheon, Eui-Suk Sung, Minhyung Lee, Jin-Choon Lee, Byung-Joo Lee
Summary: Human tonsil-derived mesenchymal stem cells (TMSCs) have a higher proliferation rate and differentiation potential compared to adipose-tissue-derived MSCs (AMSCs) or bone-marrow-derived MSCs (BMSCs). TMSCs exhibit a significantly higher expression of the tensin3 gene (TNS3) than AMSCs or BMSCs. TNS3 plays a vital role in regulating cell migration, gene and protein expression, and integrin activity in TMSCs.
Article
Biotechnology & Applied Microbiology
Mantas Malinauskas, Lina Jankauskaite, Lauryna Aukstikalne, Lauryna Dabasinskaite, Augustinas Rimkunas, Tomas Mickevicius, Alius Pockevicius, Edvinas Krugly, Dainius Martuzevicius, Darius Ciuzas, Odeta Baniukaitiene, Arvydas Usas
Summary: Polycaprolactone (PCL) is a suitable material for cartilage tissue engineering due to its mechanical strength, low immunogenicity, elasticity, and biodegradability. Enhancing the hydrophilicity of PCL scaffolds is necessary, and in this study, ozone treatment and TGF beta 3 loading were used to improve the properties of electrospun bilayer PCL scaffolds. In vitro and in vivo evaluations showed that the ozone-treated scaffold loaded with TGF beta 3 and rMDSCs demonstrated better chondrogenic potential and cartilage regeneration outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell & Tissue Engineering
Ji-Hye Song, Se-Young Oh, Sangmee Ahn Jo
Summary: This study identified the optimal conditions for the neuronal differentiation of TMSCs and demonstrated the characteristics of the differentiated cells. The differentiated TMSCs showed potential for use as a therapeutic tool in treating neurological disorders.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Cell Biology
Ji Min Kim, Jeong Hun Kim, Keunyoung Kim, Sung-Chan Shin, Yong-Il Cheon, Hyung Sik Kim, Jin-Choon Lee, Eui-Suk Sung, Minhyung Lee, Gi-Cheol Park, Byung-Joo Lee
Summary: The study found that extracellular vesicles derived from T-MSCs are effective in treating salivary gland dysfunction occurring after menopause, reducing inflammatory cytokine expression and levels of collagen and TGF beta I.
Article
Cell & Tissue Engineering
Beilei Ma, Tengkai Wang, Juan Li, Qian Wang
Summary: This study found that ECM derived from Wharton's Jelly-derived mesenchymal stem cells could improve the angiogenesis ability of HUVECs in vitro in a time-dependent manner. Mechanically, WJ-MSCs ECM activated the FAK/P38 signaling pathway via integrin alpha V beta 3 to promote c-Myc expression, subsequently increasing VEGF expression through P300-mediated histone acetylation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Mengxuan Liu, Megumi Honjo, Reiko Yamagishi, Nozomi Igarashi, Natsuko Nakamura, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Makoto Aihara
Summary: This study investigated the potential role of TGF-beta 3 in the fibrotic response of human trabecular meshwork cells and examined its relationship and interaction with ATX. The findings suggest that TGF-beta 3 can regulate the expression and signaling of ATX, leading to the upregulation of fibrogenic proteins. The study highlights the importance of trans-signaling between TGF-beta 3 and ATX in the development of trabecular meshwork fibrosis.
Article
Cell & Tissue Engineering
Minjoo Yoo, Sungkuk Cho, Sunhye Shin, Jung-Mi Kim, Hyeon-Gyeong Park, Sungyoo Cho, Yu Kyeong Hwang, Dae Hwi Park
Summary: The study found that IL1 beta priming TMSCs displayed beneficial effects on bone density both in vitro and in vivo, indicating a potential new direction for treating osteoporosis.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Orthopedics
Ki Hyuk Sung, Soon-Sun Kwon, Moon Seok Park, Kyoung Min Lee, Jonghyun Ahn, Seung Yeol Lee
FOOT AND ANKLE SURGERY
(2019)
Article
Medicine, General & Internal
Jun-Beom Lee, Ho Geol Woo, Yoonkyung Chang, Yoon Mi Jin, Inho Jo, Jinkwon Kim, Tae-Jin Song
ANNALS OF MEDICINE
(2019)
Article
Cell & Tissue Engineering
Se-Young Oh, Da Hyeon Choi, Yoon Mi Jin, Yeonsil Yu, Ha Yeong Kim, Gyungah Kim, Yoon Shin Park, Inho Jo
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Jung-Hyun Park, Du-Hyong Cho, Yun-Jin Hwang, Jee Young Lee, Hyeon-Ju Lee, Inho Jo
BIOMOLECULES & THERAPEUTICS
(2020)
Editorial Material
Cell & Tissue Engineering
Inho Jo
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Orthopedics
Soon-Sun Kwon, Hyang Kim, Sang-Jin Shin, Seung Yeol Lee
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2020)
Article
Food Science & Technology
Hyeon-Ju Lee, Jung-Hyun Park, Se-Young Oh, Du-Hyong Cho, Suji Kim, Inho Jo
Article
Cell & Tissue Engineering
Da Hyeon Choi, Se-Young Oh, Ju Kwang Choi, Kyeong Eun Lee, Ju Yeon Lee, Yoon Jeong Park, Inho Jo, Yoon Shin Park
STEM CELL RESEARCH & THERAPY
(2020)
Article
Food Science & Technology
Hyeon-Ju Lee, Se-Young Oh, Inho Jo
Summary: This study found that Zearalenone induces endothelial cell apoptosis through activation of an ERK1/2/p53/caspase 3 signaling pathway via release of Ca2+ from the endoplasmic reticulum, independent of reactive oxygen species production and estrogen receptor activation.
Article
Biochemistry & Molecular Biology
Ji Yeon Kim, Saeyoung Park, Se-Young Oh, Yu Hwa Nam, Young Min Choi, Yeonzi Choi, Ha Yeong Kim, Soo Yeon Jung, Han Su Kim, Inho Jo, Sung-Chul Jung
Summary: In this study, the authors standardized the differentiation rate of Tonsil-derived MSCs (T-MSCs) into parathyroid-hormone (PTH)-releasing cells (T-MSC-PTHCs) to overcome donor-dependent variation and provide a potential solution for treating hypoparathyroidism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yeonsil Yu, Se-Young Oh, Ha Yeong Kim, Ji-Young Choi, Sangmee Ahn Jo, Inho Jo
Summary: Our study found that the level of CCN1 increases as osteogenic differentiation progresses in tonsil-derived mesenchymal stem cells (TMSCs). We investigated how CCN1 is regulated through HDAC inhibition in TMSCs and their relationship with osteogenesis. Valproic acid (VPA), a well-known HDAC inhibitor, was found to inhibit TMSC proliferation and increase osteogenic differentiation, while decreasing adipogenesis and chondrogenesis. The effects of VPA on CCN1 were mediated through the stability of the CCN1 protein instead of gene expression. These findings demonstrate the potential of VPA as an inhibitor of HDAC1 to promote osteogenic differentiation in TMSCs.
Article
Biochemistry & Molecular Biology
Ha Yeong Kim, Ji Min Seok, Soo Yeon Jung, Min Ji Lee, An Nguyen-Thuy Tran, Seon Ju Yeo, Su A. Park, Han Su Kim
Summary: This study investigated the feasibility of using three-dimensional structural microbeads fabricated with tonsil-derived mesenchymal stem cells (TMSCs) and alginate to treat hypoparathyroidism. The results showed that differentiated alginate microbeads with TMSCs had significantly higher protein expression of parathyroid hormone (PTH). In vivo experiments on rats with hypoparathyroidism showed that the group with implanted differentiated alginate microbeads had the highest survival rate and weight change, as well as an increase in serum intact PTH levels. Immunofluorescence analysis also confirmed higher expression of PTH in the retrieved tissues.
Article
Geriatrics & Gerontology
Yi-Jun Kim, Yongho Jee, Sholhui Park, Eun-Hee Ha, Inho Jo, Hyang Woon Lee, Myung Seon Song
Summary: The study showed that COVID-19 patients with dementia have a significantly higher risk of early death within 14 days compared to non-dementia patients, even after propensity score matching.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2022)
Review
Cell & Tissue Engineering
Se-Young Oh, Young Min Choi, Ha Yeong Kim, Yoon Shin Park, Sung-Chul Jung, Joo-Won Park, So-Youn Woo, Kyung-Ha Ryu, Han Su Kim, Inho Jo