Article
Immunology
Jingjing Zhang, Xingli Xu, Suqin Duan, Yang Gao, Danjing Ma, Rong Yue, Fengyuan Zeng, Xueqi Li, Ziyan Meng, Xinghang Li, Zhenye Niu, Guorun Jiang, Li Yu, Yun Liao, Dandan Li, Lichun Wang, Heng Zhao, Ying Zhang, Qihan Li
Summary: This study revealed the strategy of how HSV-1 infection of dendritic cells interferes with the immune system, by investigating the impact of virus infection on both innate and adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Mizuki Watanabe, Jun Arii, Kosuke Takeshima, Ayano Fukui, Masayuki Shimojima, Hiroko Kozuka-Hata, Masaaki Oyama, Takeharu Minamitani, Teruhito Yasui, Yuji Kubota, Mutsuhiro Takekawa, Isao Kosugi, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasuko Mori, Yasushi Kawaguchi
Summary: The host cell protein prohibitin-1 contributes to HSV-1 cell-to-cell spread via the MAPK/ERK pathway, a mechanism that is conserved in representative members of every herpesvirus subfamily.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Article
Immunology
Tianhao Shan, Yanling Huang, Zibo Zhao, Feng Li, Yifei Wang, Cuifang Ye, Kai Zheng, Zhe Ren
Summary: This study shows that a ketogenic diet (KD), a low-carbohydrate high-fat diet, can restrict the neurotropic infection of HSV-1 and the progression of herpes simplex encephalitis (HSE) in mice. Depletion of gut microbes by antibiotics attenuated the protective function of KD on HSV-1-related neuroinflammation and HSE development.
MICROBES AND INFECTION
(2023)
Article
Neurosciences
Francisca Acuna-Hinrichsen, Adriana Covarrubias-Pinto, Yuta Ishizuka, Maria Francisca Stolzenbach, Carolina Martin, Paula Salazar, Maite A. Castro, Clive R. Bramham, Carola Otth
Summary: HSV-1 infection may induce structural disassembly and functional deregulation in early stages, leading to altered glutamate response, increased accumulation of Arc protein within somata, and decreased expression of dendritic spine scaffolding proteins.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Gabrielle Pageau, Marianne Levasseur, Teresa Paniconi, Eric Jubinville, Valerie Goulet-Beaulieu, Guy Boivin, Julie Jean
Summary: This study investigated the persistence of HSV-1 on surfaces and in food, suggesting that sharing food with infected carriers may pose certain risks.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Immunology
Mette Ratzer Freytag, Sofie Eg Jorgensen, Michelle Molgaard Thomsen, Ali Al-Mousawi, Alon Schneider Hait, David Olagnier, Jakob T. Bay, Marie Helleberg, Trine H. Mogensen
Summary: This study describes a 19-year-old woman with systemic HSV-1 infection and HLH, as well as a fatal course of neonatal herpesvirus infection postpartum. Investigation showed impaired antiviral responses in the mother's cells, potentially caused by variants in CASP8 or other noncoding regions of the genome.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Jie Wang, Kun-Te Shang, Qiong-Hong Ma, Zhao-Ying Dong, Yi-Hong Chen, Yu-Feng Yao
Summary: This study aimed to determine whether HSV-1 can be transmitted through TNTs and to investigate the effect of inhibiting the Arp2/3 complex on the intercellular transmission of HSV-1. The results showed that HSV-1 can be transmitted through TNTs and that inhibiting the Arp2/3 complex reduces the number of TNTs and the spread of HSV-1. This finding provides new insights into the transmission mode of HSV-1 and suggests a potential new antiviral target.
Article
Microbiology
Max E. Mertens, David M. Knipe
Summary: Cells activate DNA damage response when infected by DNA viruses such as herpes simplex virus 1, with different DDR kinase pathways in infected and uninfected cells. Key host gene products and DDR components have opposite effects on the replication of herpes simplex virus 1, suggesting the virus manipulates the host cell DDR to facilitate its replication while deactivating antiviral aspects.
Article
Biochemistry & Molecular Biology
Bishajit Sarkar, Md. Asad Ullah, Yusha Araf, Sowmen Das, Md. Hasanur Rahman, Abu Tayab Moin
Summary: HSV is a highly infectious virus with two types, HSV-1 and HSV-2, infecting millions worldwide. This study designed three polyvalent subunit vaccines targeting multiple strains of HSV, which showed stability and potential effectiveness through molecular docking and simulation studies. Validation of these vaccines in wet lab-based studies is still needed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Eduardo I. Tognarelli, Luisa F. Duarte, Monica A. Farias, Felipe A. Cancino, Nicolas Corrales, Francisco J. Ibanez, Claudia A. Riedel, Susan M. Bueno, Alexis M. Kalergis, Pablo A. Gonzalez
Summary: Stimulating HO-1 expression in HSV-infected dendritic cells can promote cell viability and inhibit viral egress. It also promotes the expression of anti-inflammatory molecules and activation of virus-specific CD4(+) T cells. Transferring HSV-infected dendritic cells with induced HO-1 expression can enhance virus-specific T cell activation and improve the outcome of HSV-1 skin infection.
Article
Microbiology
Ye Liu, Qiao You, Fang Zhang, Deyan Chen, Zhenping Huang, Zhiwei Wu
Summary: Harringtonine (HT) significantly inhibited HSV-1 infection and two ACV-resistant strains by mainly targeting HVEM and reducing the early stage of HSV-1 infection. The study demonstrated that HT could be a promising therapeutic candidate for mitigating HSV-1-induced pathogenesis.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Oncology
Hayle Scanlan, Zachary Coffman, Jeffrey Bettencourt, Timothy Shipley, Debra E. Bramblett
Summary: This review provides an overview of HSV-1 as an oncolytic virus candidate and the genomic organization of T-VEC. The advantages and limitations of T-VEC compared to other HSV-1 oncolytic virus variants currently in clinical trials are discussed. Additionally, future directions for the use of HSV-1 oncolytic viruses as cancer therapy are explored.
FRONTIERS IN ONCOLOGY
(2022)
Article
Microbiology
Yao Liu, Li Chen, Wenjun Liu, Dan Li, Jiuseng Zeng, Qiong Tang, Yuexin Zhang, Fei Luan, Nan Zeng
Summary: CEP can significantly inhibit HSV-1 replication and viral protein expression by indirectly inhibiting the phosphorylation of targets in the PI3K/Akt and p38 MAPK signaling pathways. Additionally, CEP induces apoptosis in infected cells, arrests the cell cycle at the G(2)/M phase, and reduces HSV-1 infection and reproduction.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Pu Huang, Xu Wang, Mengyue Lei, Ying Ma, Hongli Chen, Jing Sun, Yunzhang Hu, Jiandong Shi
Summary: This study investigates the metabolic interaction between host cells and HSV-1. By analyzing the metabolic profiles in HSV-1-infected lung fibroblasts, the researchers found that HSV-1 induces metabolic reprogramming in host cells to promote or resist viral replication. They confirmed that the addition of the tryptophan metabolite kynurenine promotes viral replication, while the addition of 25-Hydroxycholesterol inhibits replication. Additionally, HSV-1 replication was enhanced in choline metabolic rate-limiting enzyme-deficient mouse macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xiaole Li, Shichao Duan, Yingjuan Zheng, Yongqiang Yang, Lei Wang, Xinqiang Li, Qing Zhang, Rick F. Thorne, Wencai Li, Daoke Yang
Summary: The study found that hyperthermia can rapidly destabilize c-Myc levels in NPC cells, inhibiting tumor growth and proposing new strategies for targeting c-Myc-driven cancers using hyperthermia.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Physics, Particles & Fields
Feng-Zhi Chen, Xin-Qiang Li, Shi-Can Peng, Ya-Dong Yang, Hong-Hao Zhang
Summary: This study investigated CP asymmetries in tau decays within an effective field theory framework, revealing the potential impact of non-standard interactions. Numerical results were obtained based on experimental data, updating standard model predictions and imposing constraints on non-standard scalar and tensor interactions.
JOURNAL OF HIGH ENERGY PHYSICS
(2022)
Article
Physics, Nuclear
Shao-Ping Li, Xin-Qiang Li, Xin-Shuai Yan, Ya-Dong Yang
Summary: The Dirac neutrino masses are generated by a neutrinophilic scalar doublet with a vacuum scale of O(keV), which is distinct from the electroweak vacuum. While the keV-scale vacuum scenario is inert in low-energy flavor physics, it can explain the baryon asymmetry of the Universe through baryogenesis realized via the lightest Dirac neutrino. Additionally, the Dirac neutrinos with a keV-vacuum scalar can produce a shift in the effective neutrino number, which can be probed by future Simons Observatory experiments.
Article
Engineering, Electrical & Electronic
Mengqi Xu, Ke Ma, Yuhao Qi, Xu Cai, Xinqiang Li, Aiguo Wang, Luhai Zheng
Summary: The high-power density design of the insulated gate bipolar transistor power module may lead to complicated thermal behaviors, and the thermal-coupling effect among multiple chips is a major focus in the field of thermal modeling and characterization. The existing modeling methods simply describe the thermal coupling effect as a superposition of temperatures caused by lateral thermal diffusion, while this article proposes a novel thermal model considering the heat flow coupling by conducting frequency domain analysis and utilizing finite-element methods simulations. The proposed method simplifies the thermal modeling of the heat coupling effect and has been verified by both simulation and experiment.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2023)
Article
Optics
Xinqiang Li, Jin Shen, Mengjie Wang, Tongtong Mu, Wei Liu, Yajing Wang, Talha Younas, Mingliang Gao, Qin Wang
Summary: In this study, a method has been proposed to obtain the velocity and particle size distribution of flowing aerosols through the analysis of light intensity autocorrelation function (ACF) and the application of regularization method. The results from simulations and experiments demonstrate that the proposed method can accurately measure the velocity and particle size distribution of flowing aerosols under different noise levels.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Nutrition & Dietetics
Zifei Qin, Shuyi Duan, Yuan Li, Xinqiang Li, Han Xing, Zhihong Yao, Xiaojian Zhang, Xinsheng Yao, Jing Yang
Summary: This study analyzed the holistic chemical profiles and anti-atherosclerosis effects of volatile oils derived from Allium macrostemon Bge. (AMB) and Allium chinense G. Don (ACGD). The results showed that both AMB and ACGD volatile oils have lipid-lowering and cardiovascular protective effects. Sulfur compounds were found to be closely associated with the garlic flavor and efficacy.
FRONTIERS IN NUTRITION
(2023)
Article
Astronomy & Astrophysics
Xin-Qiang Li, Ze-Jun Xie, Ya-Dong Yang, Xing -Bo Yuan
Summary: The recently updated measurement of the W-boson mass by the CDF collaboration deviates 7 sigma from the SM expectation, indicating the presence of new physics beyond the SM. The observed discrepancy could be explained by the influence of new fermions on the vacuum polarization of gauge bosons. These new fermions, having the same quantum numbers as SM quarks, can mix with them and modify the penguin diagrams governing b -> st+t- transitions. The study proposes a model with a vector-like top partner gauged under a new U(1)(gamma) symmetry to investigate the relation between the W-boson mass shift and b -> st+t- anomalies.
Article
Chemistry, Multidisciplinary
Songyang Li, Pei Lin, Han Xing, Xinqiang Li, Zhihong Yao, Xiaojian Zhang, Xinsheng Yao, Jing Yang, Zifei Qin
Summary: AMB and ACGD are medicinal herbs used for the treatment of coronary heart disease. They have similar lipid-lowering and anti-atherosclerosis effects. There are 365 differential compounds between AMB and ACGD, involving in various metabolic pathways. The spatial metabolome analysis also reveals differences in the chemical distribution of these herbs.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Physics, Particles & Fields
Xin-Qiang Li, Xin Xu, Ya-Dong Yang, Dong-Hui Zheng
Summary: The semitauonic B-c -> J/psi tau decay is a clean mode to investigate new physics effects in b -> c(tau)-(nu) over bar (tau) transitions. The spin density matrix method is used to study the underlying physics of the B-c- J/psi tau decay, considering both polarized tau lepton and J/psi meson. The energy and angular distributions of the charged final-state particles are extracted by studying the subsequent decays of J/psi -> mu+mu- and tau- -> pi- nu(tau), tau- -> rho- tau, and tau- -> l-(nu) over bar (l) nu(tau).
JOURNAL OF HIGH ENERGY PHYSICS
(2023)
Article
Medicine, General & Internal
Yuehui Su, Yiming Zhang, Mengjiao Zhou, Ruijin Zhang, Siang Chen, Lili Zhang, Hao Wang, Dongdong Zhang, Ting Zhang, Xinqiang Li, Chunyan Zhang, Bingjie Wang, Shuyu Yuan, Mengzhuo Zhang, Yingying Zhou, Lili Cao, Mengzhen Zhang, Jianjun Luo
Summary: Clear cell adenocarcinoma of the cervix (CCAC) is a rare type of cervical cancer that is not related to HPV. It is difficult to diagnose early and has a poor prognosis. This study analyzed the genetic alterations in patients with CCAC and identified CMTM5 as a shared mutated gene. The study also found that certain genes related to reproductive cancers had higher mutation rates in patients with CCAC. Pathway analysis showed that non-HPV cervical cancer has a weaker immune response compared to HPV-infected cervical cancer.
FRONTIERS IN MEDICINE
(2023)
Article
Optics
Han Jinzhuang, Li Xinqiang, Shen Jin, Wang Baojun, Liu Wei, Wang Yajing
Summary: Dynamic Light Scattering (DLS) is a technique used for measuring submicron and nano Particles Size Distribution (PSD) and widely applied in science and engineering. DLS measurements for non-flowing particles in suspension may be different from flowing particles as the translational motion of flowing particles leads to extra fluctuations of scattered light.
ACTA PHOTONICA SINICA
(2022)
Article
Physics, Particles & Fields
Shao-Ping Li, Xin-Qiang Li, Xin-Shuai Yan, Ya-Dong Yang
Summary: If leptoquarks proposed for explaining the anomalies observed in semileptonic B-meson decays and the anomalous magnetic moment of the muon can be embedded into the scotogenic Dirac neutrino mass models, it could provide a unified explanation for all these flavor anomalies, as well as the origin of neutrino masses and the nature of dark matter.
EUROPEAN PHYSICAL JOURNAL C
(2022)
Article
Physics, Particles & Fields
Fang-Min Cai, Shuichiro Funatsu, Xin-Qiang Li, Ya-Dong Yang
Summary: We update the predictions for the branching ratios of rare top-quark decays and find that the aligned two-Higgs-doublet model (A2HDM) can reach higher rates compared to the standard model. However, no significant enhancements are observed in the four conventional two-Higgs-doublet models (2HDMs) with Z(2) symmetries. These results have important implications for the expected sensitivities of future high-energy colliders.
EUROPEAN PHYSICAL JOURNAL C
(2022)
Article
Immunology
Nazanin Kiapour, Bing Wu, Yan Wang, Maryamsadat Seyedsadr, Sahil Kapoor, Xin Zhang, Manal Elzoheiry, Ezgi Kasimoglu, Yisong Wan, Silva Markovic-Plese
Summary: The objective of this study is to determine the mechanism of action of anti-CD52 mAb treatment in patients with RRMS. The study using EAE animal models showed that the therapeutic effect of anti-CD52 mAb is dependent on the presence of Tregs. In vitro studies on human PBMCs demonstrated that IL-7 induced expansion of CD4(+) CD25(+) CD127(-) Tregs and increased their suppressive phenotype.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Astronomy & Astrophysics
Li-Fen Lai, Xin-Qiang Li, Xin-Shuai Yan, Ya-Dong Yang
Summary: In this study, we investigate the potential for searching and identifying leptoquark effects in the charm sector through low-energy polarized scattering processes. We find that different leptoquark models can be distinguished by measuring four spin asymmetries constructed in terms of the polarized cross sections. Additionally, investing in transversely polarized processes in future experiments can directly probe into the imaginary part of the Wilson coefficients in the low-energy effective Lagrangian.
