Article
Cell Biology
Yehoshua Willinger, Gadi Turgeman
Summary: Post-traumatic stress disorder (PTSD) is associated with impaired hippocampal neurogenesis and deficits in cognitive and social skills. Lowering the levels of interleukin-17A (IL-17A) may increase neurogenesis and alleviate symptoms in a murine model of PTSD. However, neutralizing IL-17A with an antibody resulted in increased serum levels of IL-17A and impaired neurogenesis. Conversely, targeting interleukin-23 (IL-23) increased neurogenesis.
Article
Biochemistry & Molecular Biology
Amra Jujic, Joao P. P. Vieira, Hana Matuskova, Peter M. Nilsson, Ulf Lindblad, Michael H. Olsen, Joao M. N. Duarte, Anja Meissner, Martin Magnusson
Summary: Epidemiological studies have found associations between plasma galectin-4 (Gal-4) levels and diabetes as well as coronary artery disease. However, there is a lack of data on the association between plasma Gal-4 and stroke. This study investigated the association between plasma Gal-4 and prevalent stroke in a population-based cohort, as well as the response of plasma Gal-4 to ischemic stroke in mice fed a high-fat diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Vera Kim, Kyungwoo Lee, Hong Tian, Su Hwa Jang, Betty Diamond, Sun Jung Kim
Summary: This study found that there is an increase in the number of follicular helper T cells (Tfh cells) in lupus-prone mice, and these cells play a role in promoting the differentiation of antibody-secreting cells (ASCs). The increased ASC differentiation is mainly due to the elevated expression of molecules in the IL-23/IL-17 pathway in Tfh cells. IL-17A and IL-21 are the key cytokines secreted by Tfh cells, and neutralizing them can reduce ASC differentiation. Additionally, the lack of BLIMP-1 expression in dendritic cells (DCs) leads to an increased number of Tfh cells and functionally distinct Tfh cells, contributing to the increased ASC differentiation.
Article
Gastroenterology & Hepatology
Dingwu Li, Jianing Chen, Bingru Lin, Yanjun Guo, Jiaqi Pan, Chaohui Yu, Xingyong Wan
Summary: This study aimed to investigate the protective effect of celastrol on liver injury induced by ConA and its potential mechanisms. The results showed that pretreatment with celastrol significantly ameliorated liver injury and inhibited IL-17 signaling, suggesting the potential of celastrol in treating immune-mediated liver diseases.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Immunology
Yutaka Matsumura, Rei Watanabe, Manabu Fujimoto
Summary: B cells, including regulatory B cells (Bregs), regulate inflammation through an inhibitory mechanism mediated by interleukin 10 (IL-10). Bregs have been reported in various disease models and play a role in autoimmune diseases, infectious diseases, cancer, and organ-transplant rejection. In addition to IL-10, other cytokines and membrane-binding molecules are also involved in the suppressive functions of Bregs. The identification and classification of Breg fractions remains challenging due to the variations in their activity and differentiation stages in different disease models.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Ana Rodriguez Sanchez-Archidona, Celine Cruciani-Guglielmacci, Clara Roujeau, Leonore Wigger, Justine Lallement, Jessica Denom, Marko Barovic, Nadim Kassis, Florence Mehl, Jurgen Weitz, Marius Distler, Christian Klose, Kai Simons, Mark Ibberson, Michele Solimena, Christophe Magnan, Bernard Thorens
Summary: Plasma triacylglycerols (TAGs) showed strong correlations with key regulators of glucose-and lipid-regulated insulin secretion and the insulin signaling pathway in both mice and humans. The identification of PITPNC1 as a candidate regulator of glucose-stimulated insulin secretion was a significant finding from the cross-species comparative analysis.
MOLECULAR METABOLISM
(2021)
Article
Pathology
Ullas Batra, Shrinidhi Nathany, Mansi Sharma, Sunil Pasricha, Abhishek Bansal, Parveen Jain, Anurag Mehta
Summary: This study aimed to determine the concordance between immunohistochemistry (IHC), fluorescence in situ hybridisation (FISH), and next-generation sequencing (NGS) for ALK biomarker detection in non-small cell lung carcinoma (NSCLC). The results showed a concordance of 75.9% between IHC and FISH, and 84.5% between IHC and NGS. NGS demonstrated higher sensitivity (87.5%) compared to FISH (75.6%), with differences in progression-free survival observed between different biomarker detection methods.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Immunology
Ying Li, Tao Ding, Jing Chen, Jinjun Ji, Weijie Wang, Bin Ding, Weihong Ge, Yongsheng Fan, Li Xu
Summary: Lupus nephritis, the most severe manifestation of systemic lupus erythematosus, is commonly treated with glucocorticoids. However, this treatment can lead to drug resistance and adverse effects in the long term. Combining glucocorticoids with traditional Chinese medical prescriptions, such as Hedyotis diffusa Willd, can attenuate the adverse effects and improve therapeutic efficiency. The study identified the chemical compounds in Hedyotis diffusa Willd extract, and found that the IL-17 signaling pathway was highly enriched. The combination treatment with Hedyotis diffusa Willd improved the blood parameters and reduced kidney inflammation in a mouse model of lupus nephritis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Xianzhang Zeng, Jun Li, Weiran Shan, Zhongmeng Lai, Zhiyi Zuo
Summary: This study suggests that aging contributes to worsened outcome and increased inflammation after ischemic stroke, and the gut microbiota-valeric acid-interleukin-17 pathway may be involved in these aging-related changes. Valeric acid, activated by free fatty acid receptor 2, may increase interleukin-17 levels and worsen stroke outcome. Transplantation of feces from young mice may improve stroke outcome in old mice.
Article
Microbiology
Jordi Mayneris-Perxachs, Anna Castells-Nobau, Maria Arnoriaga-Rodriguez, Josep Garre-Olmo, Josep Puig, Rafael Ramos, Francisco Martinez-Hernandez, Aurelijus Burokas, Claudia Coll, Jose Maria Moreno-Navarrete, Cristina Zapata-Tona, Salvador Pedraza, Vicente Perez-Brocal, Lluis Ramio-Torrenta, Wifredo Ricart, Andres Moya, Manuel Martinez-Garcia, Rafael Maldonado, Jose-Manuel Fernandez-Real
Summary: Growing evidence suggests a connection between the gut microbiome and cognition, with viruses as a commonly overlooked component of the gut virome. This study found that higher levels of Caudovirales and Siphoviridae in the gut microbiome were associated with better executive processes and verbal memory, while increased Microviridae levels were linked to greater impairment in executive abilities. Transplanting microbiota with specific high levels of Caudovirales resulted in improved memory performance in mice and up-regulated memory-promoting genes in the prefrontal cortex. Adding lactococcal Siphoviridae phages to the diet of fruit flies also enhanced memory scores and upregulated memory-related brain genes. These findings suggest that bacteriophages play a role in the microbiome-brain axis.
CELL HOST & MICROBE
(2022)
Review
Immunology
Yun Chen, Marco Colonna
Summary: Alzheimer's disease is characterized by the activation of microglia in response to amyloid beta peptides and tau aggregates, leading to the conversion of homeostatic microglia into disease-associated microglia. Different populations of reactive microglia have been identified, suggesting that microglia play a critical role in disease progression. Further research into the impact of microglia in AD pathogenesis is needed to better understand the parallels and discrepancies between human and mouse models.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sara D. Coelho, Carolina Levis, Fabricio B. Baccaro, Fernando O. G. Figueiredo, Andre Pinassi Antunes, Hans Ter Steege, Marielos Pena-Claros, Charles R. Clement, Juliana Schietti
Summary: Plants in the Amazon rainforest have been used by local people for thousands of years, with useful species having larger populations compared to non-useful ones, suggesting a correlation between abundance and usefulness. The study also found that incipiently domesticated species are the most abundant, highlighting the importance of long-term management by indigenous peoples and local communities in shaping plant abundance.
Article
Multidisciplinary Sciences
Sara D. Coelho, Carolina Levis, Fabricio B. Baccaro, Fernando O. G. Figueiredo, Andre Pinassi Antunes, Hans ter Steege, Marielos Pena-Claros, Charles R. Clement, Juliana Schietti
Summary: The study reveals the significant usefulness of arboreal species in the Amazonian forests to local peoples, with useful species having population sizes six times larger than non-useful species. Incipiently domesticated species are the most abundant.
Article
Cell Biology
Silvia Fukuzaki, Renato Fraga Righetti, Tabata Maruyama dos Santos, Leandro do Nascimento Camargo, Luciana R. C. R. B. Aristoteles, Flavia C. R. Souza, Aurelio C. Garrido, Beatriz Mangueira Saraiva-Romanholo, Edna Aparecida Leick, Carla Maximo Prado, Milton de Arruda Martins, Iolanda de Fatima Lopes Calvo Tiberio
Summary: Both treatments with anti-IL-17 contributed to improving inflammation and extracellular matrix remodeling in a model of lung injury, leading to reductions in multiple inflammatory markers and cell counts.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Cell Biology
Sarah E. Gilbertson, Hannah C. Walter, Katherine Gardner, Spencer N. Wren, Golnaz Vahedi, Amy S. Weinmann
Summary: Distinguishing between conserved and divergent regulatory mechanisms is crucial for translating preclinical research from mice to humans. Evolutionary genome rearrangements disrupt TAD boundaries, enabling sequence-conserved enhancer elements from divergent genomic locations between species to create unique regulatory modules.
Article
Immunology
Kevin W. Tosh, Lara Mittereder, Sandra Bonne-Armee, Sara Hieny, Thomas B. Nutman, Steven M. Singer, Alan Sher, Dragana Jankovic
JOURNAL OF IMMUNOLOGY
(2016)
Article
Cell Biology
Shahram Solaymani-Mohammadi, Omar Lakhdari, Ivelina Minev, Steve Shenouda, Blake F. Frey, Rolf Billeskov, Steven M. Singer, Jay A. Berzofsky, Lars Eckmann, Martin F. Kagnoff
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Immunology
Jenny Maloney, Aleksander Keselman, Erqiu Li, Steven M. Singer
MICROBES AND INFECTION
(2015)
Article
Immunology
Aleksander Keselman, Erqiu Li, Jenny Maloney, Steven M. Singer
INFECTION AND IMMUNITY
(2016)
Article
Immunology
Erqiu Li, Ernest A. Tako, Steven M. Singer
INFECTION AND IMMUNITY
(2016)
Article
Immunology
Zahra Babaei, Najmeh Malihi, Naser Zia-Ali, Iraj Sharifi, Mohammad A. Mohammadi, Martin F. Kagnoff, Lars Eckmann, Steven M. Singer, Shahram Solaymani-Mohammadi
MICROBES AND INFECTION
(2016)
Article
Medicine, Research & Experimental
Luther A. Bartelt, James Roche, Glynis Kolling, David Bolick, Francisco Noronha, Caitlin Naylor, Paul Hoffman, Cirle Warren, Steven Singer, Richard Guerrant
JOURNAL OF CLINICAL INVESTIGATION
(2013)
Article
Immunology
S. Solaymani-Mohammadi, S. M. Singer
MUCOSAL IMMUNOLOGY
(2013)
Article
Multidisciplinary Sciences
Camila Henriques Coelho, Adriana Oliveira Costa, Ana Carolina Carvalho Silva, Maira Mazzoni Pucci, Angela Vieira Serufo, Haendel Goncalves Nogueira Oliveira Busatti, Mauricio Durigan, Jonas Perales, Alex Chapeaurouge, Daniel Almeida da Silva e Silva, Maria Aparecida Gomes, Juliano Simoes Toledo, Steven M. Singer, Rosiane A. Silva-Pereira, Ana Paula Fernandes
Article
Microbiology
Ernest A. Tako, Maryam F. Hassimi, Erqiu Li, Steven M. Singer
Article
Biotechnology & Applied Microbiology
Erqiu Li, Mingqiu Liu, Steven M. Singer
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2014)
Editorial Material
Infectious Diseases
Camila H. Coelho, Steven M. Singer
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Microbiology
Tiara Cascais-Figueiredo, Phelipe Austriaco-Teixeira, Maria Fantinatti, Maria Luciana Silva-Freitas, Joanna Reis Santos-Oliveira, Camila H. Coelho, Steven M. Singer, Alda Maria Da-Cruz
Article
Immunology
N. R. Barash, J. G. Maloney, S. M. Singer, S. C. Dawsona
INFECTION AND IMMUNITY
(2017)
