Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Taavy A. Miller, James H. Campbell, Nick Bloom, Shane R. Wurdeman
Summary: This study examined the timing variations of lower-limb amputation (LLA) among diabetic foot ulcer (DFU) patients by race/ethnicity and sex, finding that Black/African Americans were more likely to have earlier LLA after DFU compared to non-Hispanic/Whites, and more men received earlier LLA than women.
Article
Endocrinology & Metabolism
Hongping Gong, Yan Ren, Zhenyi Li, Panpan Zha, Raju Bista, Yan Li, Dawei Chen, Yun Gao, Lihong Chen, Xingwu Ran, Chun Wang
Summary: This study analyzed the clinical characteristics of diabetic inpatients with foot ulcers and explored the risk factors for lower extremity amputation. The study found that diabetic patients with amputation were older, had longer duration of diabetes, poor glycemic control, malnutrition, peripheral arterial disease, and severe foot ulcers with infection. A history of prior amputation, foot gangrene, and low ankle brachial index were independent predictors of lower extremity amputation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Mayland Chang, Trung T. Nguyen
Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Katherine McDermott, Michael Fang, Andrew J. M. Boulton, Elizabeth Selvin, Caitlin W. Hicks
Summary: Diabetic foot ulcers are a preventable cause of morbidity in adults with diabetes, leading to functional decline, infection, hospitalization, amputation, and death. The lifetime risk of foot ulcer is increasing and recurrent ulcers are common. Amputation and mortality rates are high and linked to poor diabetes management. Prevention and early detection through multidisciplinary care are crucial to reduce morbidity and disparities associated with diabetic foot ulcers.
Article
Endocrinology & Metabolism
Qingwei Lu, Jun Wang, Xiaolu Wei, Gang Wang, Yang Xu
Summary: Through logistic regression analysis, independent factors associated with major amputation included previous amputation history, smoking, coronary artery disease, ankle brachial index <0.4, Wagner 5, activated partial thromboplastin time, glycosylated hemoglobin A1c, hemoglobin, plasma albumin, and white blood cell count.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Medicine, Research & Experimental
Denisa Tanasescu, Dan Sabau, Andrei Moisin, Claudia Gherman, Radu Fleaca, Ciprian Bacila, Calin Mohor, Ciprian Tanasescu
Summary: The prevalence of diabetes has increased dramatically in the past decade, particularly in developing countries. This study developed a risk score system for diabetic foot ulcer patients based on clinical and statistical data to assess the risk of amputation. Factors such as smoking, obesity, dyslipidemia, unbalanced diabetes, long duration of diabetes, hepatic steatosis, and co-existing heart diseases were found to aggravate diabetic foot injuries.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Dermatology
Ka-Huen Yip, Yuk-Chiu Yip, Wai-King Tsui
Summary: This study explored the thoughts and experiences of patients with diabetic foot ulcers in Hong Kong regarding lower-limb amputation. It found that lower-limb amputation is considered a forbidden topic, making it culturally difficult for Chinese patients to discuss the matter with healthcare authorities and family members. Healthcare workers should be aware of how they communicate regarding lower-limb amputation.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Dong-Il Chun, Jahyung Kim, Eun Myeong Kang, Chi Young An, Tae-Hong Min, Sangyoung Kim, Jaeho Cho, Young Yi, Sung Hun Won
Summary: This study aimed to investigate the relationship between diabetic foot ulcer and depression based on treatment methods. The results showed that female sex, severity of comorbidities, and the use of limb-saving treatment methods were significant risk factors.
APPLIED SCIENCES-BASEL
(2022)
Article
Dermatology
Mohamed S. Imam, Ahmed Khalid Almutairi, Abdullah Mutrik Alhajri, Mishary Mosleh Alharby, Mohammed H. Alanazi, Ahmad G. Alotaibi, Mohamed E. A. Abdelrahim
Summary: This meta-analysis aimed to assess the effect of hyperbaric oxygen treatment on diabetic foot ulcers. The results showed that hyperbaric oxygen treatment had significantly higher rates of healed ulcers, adverse events, and ulcer area reduction, as well as lower mortality, compared to standard treatment. However, there was no significant difference in amputation and healing time between the two treatments. It is important to note that the selected studies had small sample sizes and limited comparisons.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Rebecca A. Burmeister, Christine Jarocki, Crystal M. Holmes, Gary M. Rothenberg, Michael E. Munson, Brian M. Schmidt
Summary: The study found that patients discharged to skilled nursing facilities after diabetes-related limb salvage surgery had longer healing time, increased risk of rehospitalization and subsequent major lower-extremity amputation on the same side, as well as a higher mortality rate compared to patients discharged home.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Immunology
Ofer Perzon, Avivit Cahn, Yechiel N. Gellman, Michal Leibovitch, Shahar Peled, Ofer Elishoov, Amir Haze, Karen Olshtain-Pops, Hila Elinav
Summary: Diabetic foot infections are often caused by multiple pathogens, and the relevance of each isolated pathogen is unclear. This study found that enterococcal infections have a high prevalence and pathogenicity in diabetic foot infections, but the impact of targeted treatment is still unknown.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Editorial Material
Surgery
Babak Hajhosseini, Grace J. Chiou, Sarah S. Virk, Venita Chandra, Shawn Moshrefi, Shannon Meyer, Kathryn J. Kamperman, Geoffrey C. Gurtner
Summary: The study demonstrates the effects of hyperbaric oxygen therapy on perfusion in chronic wounds and proposes the use of indocyanine green angiography as a potential biomarker for predicting healing. Results show that improved perfusion after hyperbaric oxygen therapy sessions is associated with better wound healing outcomes, indicating the benefits of this therapy in improving angiogenesis and ameliorating hypoxia in chronic wounds.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Immunology
Shiwei Zhou, Brian M. Schmidt, Oryan Henig, Keith S. Kaye
Summary: Patients with diabetic foot osteomyelitis who deferred amputation and opted for medical therapy had a higher risk of mortality during the follow-up period compared to those who underwent amputation.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Michal Leibovitch, Avivit Cahn, Yechiel N. Gellman, Amir Haze, Shahar Peled, Sharon Amit, Ofer Elishoov, Karen Olshtain-Pops
Summary: This study found that ESBL-producing bacteria are common in patients with acute DFI, particularly in older patients with PVD, advanced ulcers, and recent hospitalization. Patients infected with ESBL-producing bacteria are more likely to undergo major amputations.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)