Article
Hematology
Steve Raoul Noumegni, Thomas Grangereau, Arzu Demir, Luc Bressollette, Francis Couturaud, Clement Hoffmann
Summary: Cardiovascular diseases occur more frequently in patients with VTE compared to the general population, particularly cardiovascular deaths. The proportion of cardiovascular deaths among all causes of deaths in patients with VTE is significant.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Hematology
Steve Raoul Noumegni, Vincent Mansourati, Cecile Tromeur, Raphael Le Mao, Clement Hoffmann, Emmanuelle Le Moigne, Bahaa Nasr, Jean-Christophe Gentric, Marie Guegan, Elise Poulhazan, Luc Bressollette, Karine Lacut, Francis Couturaud, Romain Didier
Summary: This study found that risk factors for CVDT after VTE in patients include some traditional cardiovascular risk factors as well as other risk factors related to characteristics of VTE and patients' comorbidities. Specific factors such as age, cancer-associated VTE, unprovoked VTE, tobacco use history, hypertension, chronic heart failure, etc., were associated with the risk of CVDT.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Environmental Sciences
Jonas Tagt, Emilie Helte, Carolina Donat-Vargas, Susanna C. Larsson, Karl Michaelsson, Alicja Wolk, Marie Vahter, Maria Kippler, Agneta Akesson
Summary: This study assessed the association of urinary cadmium (U-Cd) with fractures, myocardial infarction, heart failure, ischemic stroke, and mortality in postmenopausal women. The results indicated that long-term cadmium exposure might be associated with increased risk of fractures and all-cause mortality at lower levels than previously suggested.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Dong D. Wang, Yanping Li, Shilpa N. Bhupathiraju, Bernard A. Rosner, Qi Sun, Edward L. Giovannucci, Eric B. Rimm, JoAnn E. Manson, Walter C. Willett, Meir J. Stampfer, Frank B. Hu
Summary: The study found that consuming approximately 5 servings of fruits and vegetables per day was associated with lower total mortality and mortality from cancer, cardiovascular disease, and respiratory disease. Higher intake beyond this level did not provide additional risk reduction.
Article
Cardiac & Cardiovascular Systems
Bin Zhang, Zhi-Fei Li, Zhuo-Yu An, Li Zhang, Jing-Yi Wang, Meng-Di Hao, Yi-Jing Jin, Dong Li, An-Jian Song, Qiang Ren, Wen-Biao Chen
Summary: The study found that asthma patients have an increased risk of cardiovascular disease morbidity and mortality, as well as all-cause mortality. Female asthma patients have a higher risk of cardiovascular disease morbidity and all-cause mortality, and late-onset asthma patients have a higher risk of cardiovascular disease morbidity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Nutrition & Dietetics
Raul Sanchez-Gimenez, Wahiba Ahmed-Khodja, Yesica Molina, Oscar M. Peiro, Gil Bonet, Anna Carrasquer, George A. Fragkiadakis, Monica Bullo, Alfredo Bardaji, Christopher Papandreou
Summary: Gut microbiota-derived metabolites, including trimethylamine N-oxide, bile acids, and branched-chain amino acids, are associated with adverse cardiovascular events and cardiovascular disease.
Article
Medicine, General & Internal
Nzechukwu M. Isiozor, Jari A. Laukkanen, Ari Voutilainen, Isabela M. Bensenor, Setor K. Kunutsor
Summary: This study aimed to examine the prospective association between LE8 score and the risks of ASCVD and VTE. The results showed that a high LE8 score was significantly associated with a lower risk of ASCVD, but not with VTE risk.
ANNALS OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Anne Gulbech Ording, Peter Bronnum Nielsen, Flemming Skjoth, Thure Filskov Overvad, Simon Noble, Timothy L. Lash, Samuel Zachery Goldhaber, Thomas Decker Christensen, Torben Bjerregaard Larsen, Mette Sogaard
Summary: This study describes the risk of recurrent venous thromboembolism in patients with active cancer and highlights the variations in recurrence risks based on cancer type and patient characteristics.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Hematology
Shuai Yuan, Maria Bruzelius, Niclas Hakansson, Agneta Akesson, Susanna C. Larsson
Summary: This study suggests that being physically active and adhering to a healthy diet may lower the risk of VTE in women and men. Cigarette smoking was positively associated with VTE in women.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Kasper Bonnesen, Morten Schmidt, Erzsebet Horvath-Puho, Henrik T. Sorensen
Summary: The study found a biological interaction between comorbidity and VTE, which explained a significant proportion of VTE mortality. The interaction effect increased with comorbidity burden, especially within the first 30 days.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Shuai Yuan, Maria Bruzelius, Scott M. Damrauer, Niclas Hakansson, Alicja Wolk, Agneta Akesson, Susanna C. Larsson
Summary: The study suggests that consuming foods with high anti-inflammatory potential may play a role in preventing VTE in smokers, but not in never smokers. French fries were found to be associated with VTE risk while other foods in the anti-inflammatory diet index were not.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Gastroenterology & Hepatology
Katsuyoshi Ando, Mikihiro Fujiya, Kenji Watanabe, Sakiko Hiraoka, Hisashi Shiga, Shinji Tanaka, Hideki Iijima, Tsunekazu Mizushima, Taku Kobayashi, Masakazu Nagahori, Hiroki Ikeuchi, Shingo Kato, Takehiro Torisu, Kiyonori Kobayashi, Masaaki Higashiyama, Toshiro Fukui, Takashi Kagaya, Motohiro Esaki, Shunichi Yanai, Daiki Abukawa, Makoto Naganuma, Satoshi Motoya, Masayuki Saruta, Shigeki Bamba, Makoto Sasaki, Kazuhiko Uchiyama, Katsuyuki Fukuda, Hideo Suzuki, Hiroshi Nakase, Toshiaki Shimizu, Masahiro Iizuka, Mamoru Watanabe, Yasuo Suzuki, Tadakazu Hisamatsu
Summary: The study investigated the mortality and risk factors of TE in IBD patients in Japan. The incidence of TE among 31,940 IBD patients was 1.89%, with 10.7% developing severe TE and 1.0% TE-associated mortality. Ischemic heart disease was the only risk factor for severe ATE and ATE-associated death, while age, VTE location, and disease severity were independent risk factors for severe VTE and VTE-associated death.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Geriatrics & Gerontology
Sultana Monira Hussain, Andrew M. Tonkin, Gerald F. Watts, Paul Lacaze, Chenglong Yu, Lawrence J. Beilin, Zhen Zhou, Anne B. Newman, Johannes T. Neumann, Cammie Tran, John J. Mcneil
Summary: This study found that higher HDL-C levels are associated with increased risk of cancer and non-cancer non-CVD mortality in healthy older men, but not with CVD mortality. No significant association was found between HDL-C levels and mortality in women.
Review
Food Science & Technology
Sina Naghshi, Mohammad Naemi, Omid Sadeghi, Manije Darooghegi Mofrad, Mehrasa Moezrad, Leila Azadbakht
Summary: This study aimed to investigate the association between calcium intake and mortality risk. The findings suggested that moderate intake of total and dietary calcium were inversely associated with mortality risk, while supplemental calcium intake showed no significant association. Nonlinear relationships were observed between calcium intake and all-cause, CVD, and cancer mortality risk.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Pharmacology & Pharmacy
M-L Hua, L. Li, L. L. Diao
Summary: Asthma is significantly associated with an increased risk of cardiovascular disease (CVD). Patients with asthma have higher risks of cardiovascular heart disease (CHD), cardiovascular mortality (CVM), heart failure (HF), and myocardial infraction (MI). Active asthmatic patients have a higher risk of atrial fibrillation (AF). Females with asthma have a higher risk of CHD, while active asthmatic patients have a higher risk of CVM.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Hematology
Reiner K. Mailer, Mikel Allende, Marco Heestermans, Michaela Schweizer, Carsten Deppermann, Maike Frye, Giordano Pula, Jacob Odeberg, Mathias Gelderblom, Stefan Rose-John, Albert Sickmann, Stefan Blankenberg, Tobias B. Huber, Christian Kubisch, Coen Maas, Stepan Gambaryan, Dmitri Firsov, Evi X. Stavrou, Lynn M. Butler, Thomas Renne
Summary: Polyphosphate, an inorganic polymer of linear-linked orthophosphate residues, plays a critical role in blood coagulation, with platelet XPR1 identified as a major regulator of polyphosphate metabolism. Pharmacological interference with XPR1 activity led to enhanced platelet-driven coagulation and thrombus formation via the polyphosphate/factor XII pathway. Deletion of Xpr1 in platelets resulted in polyphosphate accumulation, accelerated arterial thrombosis, and increased activated platelet-driven pulmonary embolism in mice. These findings highlight the importance of phosphate homeostasis in thrombosis.
Article
Obstetrics & Gynecology
Carolyn E. Cesta, Silvia Segovia Chacon, Anders Engeland, Anne Broe, Per Damkier, Kari Furu, Helle Kieler, Par Karlsson
Summary: In the Scandinavian countries over the last decades, few pregnant women used PDE5 inhibitors, with only a small proportion having a diagnosis of pulmonary arterial hypertension, suggesting off-label use in most cases. The majority of users were mothers over the age of 35. The safety of fetal exposure to sildenafil and other PDE5 inhibitors during pregnancy has not been established and further evaluation is needed as maternal age increases and additional uses are explored.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Multidisciplinary Sciences
Misbah Razzaq, Maria Jesus Iglesias, Manal Ibrahim-Kosta, Louisa Goumidi, Omar Soukarieh, Carole Proust, Maguelonne Roux, Pierre Suchon, Anne Boland, Delphine Daiain, Robert Olaso, Sebastian Havervall, Charlotte Thalin, Lynn Butler, Jean-Francois Deleuze, Jacob Odeberg, Pierre-Emmanuel Morange, David-Alexandre Tregouet
Summary: The study identified the new susceptibility gene PLXNA4 for PE through artificial neural networks and genome-wide association study, which was associated with worsened respiratory function in COVID-19 patients. The research effectively distinguished high-risk PE patients, providing new insights for the prevention and treatment of PE.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Max Karlsson, Cheng Zhang, Loren Mear, Wen Zhong, Andreas Digre, Borbala Katona, Evelina Sjoestedt, Lynn Butler, Jacob Odeberg, Philip Dusart, Fredrik Edfors, Per Oksvold, Kalle von Feilitzen, Martin Zwahlen, Muhammad Arif, Ozlem Altay, Xiangyu Li, Mehmet Ozcan, Adil Mardonoglu, Linn Fagerberg, Jan Mulder, Yonglun Luo, Fredrik Ponten, Mathias Uhlen, Cecilia Lindskog
Summary: Advances in molecular profiling have enabled the creation of high-resolution single-cell type maps of human tissues, combining single-cell transcriptomics analysis with spatial antibody-based protein profiling. This technology allows researchers to explore the expression of human protein-coding genes and determine the number of elevated genes in different cell types, facilitating comparisons with bulk transcriptomics data. The analysis reveals distinct expression clusters corresponding to cell types with similar functions within and between organs.
Article
Hematology
Maria J. Iglesias, Larissa D. Kruse, Laura Sanchez-Rivera, Linnea Enge, Philip Dusart, Mun-Gwan Hong, Mathias Uhlen, Thomas Renne, Jochen M. Schwenk, Goran Bergstrom, Jacob Odeberg, Lynn M. Butler
Summary: This study identified 216 proteins associated with cardiovascular disease risk factor exposure, and showed a relationship between individual cardiovascular disease risk and corresponding biomarker profiles. The findings indicate that EC proteins in plasma could reflect vascular health status.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Philip Smith, Axel Rosell, Maria Farm, Maria Bruzelius, Katherina Aguilera Gatica, Nigel Mackman, Jacob Odeberg, Charlotte Thalin
Summary: This study found the presence of neutrophil activation and NET formation in VTE patients using specific markers. However, adding NE or H3Cit-DNA to D-dimer did not improve the diagnostic accuracy compared to D-dimer alone. This study provides information on the feasibility of using markers of NETs as diagnostic tools in acute VTE, but suggests that their potential is limited in this setting.
Article
Cell Biology
Marthe Norreen-Thorsen, Eike Christopher Struck, Sofia Oling, Martin Zwahlen, Kalle Von Feilitzen, Jacob Odeberg, Cecilia Lindskog, Fredrik Ponten, Mathias Uhlen, Philip James Dusart, Lynn Marie Butler
Summary: This study profiles cell-type-enriched transcriptomes in human adipose tissue using bulk RNA-seq data, identifying over 2,300 cell-type-enriched transcripts and uncovering male-specific enriched genes. Additionally, the primary driver of variation between subcutaneous and visceral adipose tissue is found to be mesothelial cells.
Article
Genetics & Heredity
Ozvan Bocher, Thomas E. Ludwig, Marie-Sophie Oglobinsky, Gaeelle Marenne, Jean-Francois Deleuze, Suryakant Suryakant, Jacob Odeberg, Pierre-Emmanuel Morange, David-Alexandre Tregoueet, Herve Perdry, Emmanuelle Genin
Summary: This study proposes a new strategy, RAVA-FIRST, for performing RVAT on WGS data. It consists of three steps and has been found to outperform other WGS-based RVAT methods. RAVA-FIRST enables investigations of rare non-coding variants in complex diseases and has been implemented in the R package Ravages.
Article
Pharmacology & Pharmacy
Bianca E. Suur, Melody Chemaly, Moritz Lindquist Liljeqvist, Djordje Djordjevic, Markus Stenemo, Otto Bergman, Eva Karlof, Mariette Lengquist, Jacob Odeberg, Eva Hurt-Camejo, Per Eriksson, Daniel F. J. Ketelhuth, Joy Roy, Ulf Hedin, Michael Nyberg, Ljubica Matic
Summary: This study investigated the expression landscape and potential therapeutic targets of the PCSK family in cardiovascular disease. The results showed that PCSK6, PCSK5, PCSK7, and FURIN are potential therapeutic targets with differential expression patterns in plaques and aneurysms. The study provides insights into the role of PCSKs in cardiovascular diseases and potential new treatment options.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Elena Dudukina, Szimonetta Komjathine Szepligeti, Par Karlsson, Kofi Asomaning, Anne Kjersti Daltveit, Katja Hakkarainen, Fabian Hoti, Helle Kieler, Astrid Lunde, Ingvild Odsbu, Matti Rantanen, Johan Reutfors, Laura Saarelainen, Vera Ehrenstein, Gunnar Toft
Summary: This study investigated the association between prenatal exposure to pregabalin and the risks of adverse birth and postnatal neurodevelopmental outcomes. The findings suggest a possible link between prenatal pregabalin exposure and increased risk of stillbirth and major congenital malformations.
Article
Multidisciplinary Sciences
Maria Jesus Iglesias, Laura Sanchez-Rivera, Manal Ibrahim-Kosta, Clement Naudin, Gaelle Munsch, Louisa Goumidi, Maria Farm, Philip M. Smith, Florian Thibord, Julia Barbara Kral-Pointner, Mun-Gwan Hong, Pierre Suchon, Marine Germain, Waltraud Schrottmaier, Philip Dusart, Anne Boland, David Kotol, Fredrik Edfors, Mine Koprulu, Maik Pietzner, Claudia Langenberg, Scott M. Damrauer, Andrew D. Johnson, Derek M. Klarin, Nicholas L. Smith, David M. Smadja, Margareta Holmstrom, Maria Magnusson, Angela Silveira, Mathias Uhlen, Thomas Renne, Angel Martinez-Perez, Joseph Emmerich, Jean-Francois Deleuze, Jovan Antovic, Jose Manuel Soria Fernandez, Alice Assinger, Jochen M. Schwenk, Joan Carles Souto Andres, Pierre-Emmanuel Morange, Lynn Marie Butler, David-Alexandre Tregouet, Jacob Odeberg
Summary: This study uses proteomics profiling to screen plasma from patients with suspected acute VTE and multiple case-control studies to identify CFHR5 as a plasma biomarker associated with VTE. Higher levels of CFHR5 in plasma are associated with increased thrombin generation potential and platelet activation. GWAS analysis identifies six loci associated with CFHR5 plasma levels, but Mendelian randomization experiments do not establish causality between CFHR5 and VTE.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Hanna Englert, Josephine Goebel, Danika Khong, Maryam Omidi, Nina Wolska, Sandra Konrath, Maike Frye, Reiner K. Mailer, Manu Beerens, Julian C. Gerwers, Roger J. S. Preston, Jacob Odeberg, Lynn M. Butler, Coen Maas, Evi X. Stavrou, Tobias A. Fuchs, Thomas Renne
Summary: In this study, a dual-active DNase with DNase1 and DNase1L3 activities was engineered and its potential for degrading NETs was characterized in vitro. By transferring specific regions of DNase1L3 to DNase1, a dual-active DNase1 mutant with chromatin degrading activity was generated, which outperformed DNase1 and DNase1L3 in degrading dsDNA and chromatin, respectively. Transgenic mouse experiments confirmed the stability of the dual-active DNase1 mutant in circulation and its elimination via bile, suggesting its potential therapeutic application for thromboinflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Melody Chemaly, David Marlevi, Maria-Jesus Iglesias, Mariette Lengquist, Malin Kronqvist, Daniel Bos, Dianne H. K. van Dam-Nolen, Anja van der Kolk, Jeroen Hendrikse, Mohamed Kassem, Ljubica Matic, Jacob Odeberg, Margreet R. de Vries, M. Eline Kooi, Ulf Hedin
Summary: This study explored the biomarker potential of plasma BLVRB, finding that it is associated with intraplaque hemorrhage (IPH) in carotid plaques and the risk of recurrent ischemic stroke. Additionally, the study demonstrated that plasma BLVRB levels can be used to monitor the efficacy of pharmacotherapy targeting IPH. These findings suggest that plasma BLVRB may serve as a biomarker for atherosclerotic plaque instability.
Meeting Abstract
Hematology
Bianca E. Suur, Melody Chemaly, Moritz Lindquist Liljeqvist, Djordje Djordjevic, Markus Stenemo, Otto Bergman, Eva Karlof, Mariette Lengquist, Jacob Odeberg
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Hematology
Fredrik Edfors, Maria Jesus Iglesias, Lynn M. Butler, Jacob Odeberg
Summary: This article explores the application of plasma proteomics in the research of venous thromboembolism. It discusses the potential for improving diagnostic and risk prediction tools through the identification of plasma proteins. The use of affinity and mass spectrometry-based methods allows for broad screening and identification of novel plasma biomarkers, and the article provides future perspectives on discovery strategies and emerging technologies.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)
