Review
Critical Care Medicine
Guang Fu, Meihong Deng, Matthew D. Neal, Timothy R. Billiar, Melanie J. Scott
Summary: Platelet-monocyte aggregates may be an important prognostic indicator in sepsis, but the mechanisms and effects are still unclear. Despite the unique functions of platelets and monocytes in inflammation and immune responses during sepsis, there is limited research on their combined functions.
Article
Cell Biology
Silvia Oggero, Monica de Gaetano, Simone Marcone, Stephen Fitzsimons, Andreia L. Pinto, Dinara Ikramova, Mary Barry, David Burke, Trinidad Montero-Melendez, Dianne Cooper, Thomas Burgoyne, Orina Belton, Lucy V. Norling, Eoin P. Brennan, Catherine Godson, Mauro Perretti
Summary: Extracellular vesicles released by mixed aggregates of monocytes and platelets have pro-inflammatory effects on endothelial cells and atherosclerotic plaques, and modulating platelet activation can alter the composition and actions of these vesicles, potentially providing therapeutic avenues for atherosclerosis treatment. Patients with coronary artery disease requiring intervention show elevated levels of specific EV subsets in plasma.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Biochemistry & Molecular Biology
Anais Mariscal, Carlos Zamora, Cesar Diaz-Torne, Ma Angels Ortiz, Juan Jose de Agustin, Delia Reina, Paula Estrada, Patricia Moya, Hector Corominas, Silvia Vidal
Summary: The binding of platelets to monocytes is increased in rheumatoid arthritis, and this interaction is modulated by IL-6 blockage. After treatment, the percentage of CD14+PLT+ increases in patients who achieve remission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Adele Ruder, Suzan M. W. Wetzels, Lieve Temmerman, Erik A. L. Biessen, Pieter Goossens
Summary: Monocytes differentiate into macrophages at sites of inflammation and contribute to the development of cardiovascular disease. Different subtypes of monocytes, characterized by the expression of CD14 and CD16, have been identified. The middle subtype has been found to be associated with atherosclerosis, myocardial infarction, and heart failure. However, more research is needed to understand their exact role and predictive value in cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2023)
Article
Sport Sciences
Shu-Chun Huang, Chih-Chin Hsu, Tieh-Cheng Fu, Carl P. C. Chen, Ming-Feng Liao, Chien-Ya Hsu, Jong-Shyan Wang
Summary: The study found that stepper-based exercise training can improve cardiopulmonary fitness in nonambulatory hemiplegic patients with ischemic stroke and reduce heteroaggregation of monocytes with platelets. This research provides new possibilities for the rehabilitation of nonambulatory hemiplegic patients.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Cardiac & Cardiovascular Systems
Christina C. Rolling, Tessa J. Barrett, Jeffrey S. Berger
Summary: Platelets, as vital components in primary hemostasis and thrombosis, have been recognized as important cellular mediators in innate immunity and inflammation. Through forming monocyte-platelet aggregates (MPA) with circulating monocytes, activated platelets have the ability to modulate the phenotype and function of monocytes. The platelet-monocyte axis serves as a crucial link between thrombosis and inflammation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Hematology
Christina C. Rolling, Marcin A. Sowa, Tricia T. T. Wang, MacIntosh Cornwell, Khrystyna Myndzar, Tamar Schwartz, Hanane El Bannoudi, Jill Buyon, Tessa J. Barrett, Jeffrey S. Berger
Summary: Monocyte-platelet aggregates (MPAs) play a role in the intersection of thrombosis and inflammation, and targeting this axis could suppress thromboinflammation. The effect of platelets on monocyte activation and the impact of antiplatelet therapy (APT) on MPA and platelet-induced monocyte activation were analyzed.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, Research & Experimental
P. Vishnyakova, A. Poltavets, E. Karpulevich, A. Maznina, V. Vtorushina, L. Mikhaleva, E. Kananykhina, A. Lokhonina, S. Kovalchuk, A. Makarov, A. Elchaninov, G. Sukhikh, T. Fatkhudinov
Summary: Macrophages play a crucial role in innate immunity and are activated by various factors. This study found that macrophages derived from CD14+ monocytes exhibit higher sensitivity to pro-inflammatory induction, showing increased levels of pro-inflammatory and anti-inflammatory cytokines compared to CD16+-derived macrophages. This data may be valuable for macrophage-based cell therapy applications, providing insights for manipulating donor monocytes for transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Marta Brambilla, Maria Talmon, Paola Canzano, Luigia G. Fresu, Sandra Brunelleschi, Elena Tremoli, Marina Camera
Summary: This study evaluated the effects of microvesicles derived from platelets and monocytes on endothelial function, and found that platelet-derived microvesicles can impair endothelial function in the acute phase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Gregory E. Miller, Edith Chen, Eric Finegood, Daichi Shimbo, Steve W. Cole
Summary: Children exposed to neighborhood violence show higher systemic inflammatory activity and specific transcriptional profiles indicative of increased pro-inflammatory effector functions, potentially linking threatening experiences with health risks.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Medicine, General & Internal
Andrew S. Tseng, Marlene Girardo, Christine Firth, Shubhang Bhatt, David Liedl, Paul Wennberg, Win-Kuang Shen, Leslie T. Cooper, Fadi E. Shamoun
Summary: The study examines the relationship between peripheral arterial disease (PAD) and incident atrial fibrillation (AF), finding that PAD patients are at increased risk for developing AF, ischemic stroke, and all-cause mortality. Patients with abnormal ankle-brachial index (ABI), especially those with severe PAD and cardiac structural abnormalities, may benefit from routine monitoring for AF and management of cardiovascular risk factors.
MAYO CLINIC PROCEEDINGS
(2021)
Review
Immunology
Julie Sellau, Tobias Puengel, Stefan Hoenow, Marie Groneberg, Frank Tacke, Hannelore Lotter
Summary: Monocytes play a pivotal role in infectious liver diseases by maintaining inflammation and supporting resolution of inflammation. Tight regulation of monocyte recruitment and termination of monocyte-driven immune responses is prerequisite to appropriate healing of organ damage.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Hematology
Fatemeh Shahneh, Hans Christian Probst, Sabine C. Wiesmann, Noelia A-Gonzalez, Wolfram Ruf, Kerstin Steinbrink, Verena K. Raker, Christian Becker
Summary: This study investigated the role of inflammatory Ly6C(hi) monocytes in deep vein thrombosis, and found that thrombus formation, growth, and resolution can be therapeutically manipulated with a NR4A1 agonist.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mathilde Mura, Michele Weiss-Gayet, Nellie Della-Schiava, Erica Chirico, Patrick Lermusiaux, Marie Chambion-Diaz, Camille Faes, Anaelle Boreau, Benedicte Chazaud, Antoine Millon, Vincent Pialoux
Summary: Atherosclerosis is associated with chronic inflammation involving circulating monocytes. Physical activity has been shown to decrease inflammation and the risk of stroke. This study found that moderately active patients had a lower percentage of classical and intermediate monocytes compared to non-active and highly active patients. In contrast, the percentage of non-classical monocytes increased in moderately active patients. These findings suggest that physical activity can be beneficial for patients by reducing the risk of ischemic stroke and promoting lesion healing.
Article
Immunology
Parveen Kumar, Mikita Patel, Robert A. Oster, Vidhush Yarlagadda, Adam Ambrosetti, Dean G. Assimos, Tanecia Mitchell
Summary: This study found that dietary oxalate loading may impact monocyte metabolism and immune response in healthy adults, but the responses are variable. Further research is needed to understand oxalate-mediated mechanisms on circulating monocytes and how this potentially influences CaOx kidney stone formation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Silvio Quick, Ulrike Reuner, Marie Weidauer, Charlotte Hempel, Felix Martin Heidrich, Christoph Mues, Krunoslav Michael Sveric, Karim Ibrahim, Heinz Reichmann, Axel Linke, Uwe Speiser
ORPHANET JOURNAL OF RARE DISEASES
(2019)
Letter
Genetics & Heredity
Kun Zhang, Ulrike Reuner, Marie Weidauer, Uwe Speiser, Karim Ibrahim, Marian Christoph, Frank R. Heinzel, Burkert Pieske, Felix M. Heidrich, Silvio Quick
ORPHANET JOURNAL OF RARE DISEASES
(2019)
Article
Cardiac & Cardiovascular Systems
Kun Zhang, Stephan Wiedemann, Martin Dschietzig, Melissa M. Cremers, Antje Augstein, David M. Poitz, Silvio Quick, Christian Pfluecke, Frank R. Heinzel, Burkert Pieske, Volker Adams, Axel Linke, Ruth H. Strasser, Felix M. Heidrich
CARDIOVASCULAR PATHOLOGY
(2020)
Article
Medicine, General & Internal
Mandy Flechsig, Tobias F. Ruf, Willi Troeger, Stephan Wiedemann, Silvio Quick, Karim Ibrahim, Christian Pfluecke, Akram Youssef, Krunoslav M. Sveric, Robert Winzer, Frank R. Heinzel, Axel Linke, Ruth H. Strasser, Kun Zhang, Felix M. Heidrich
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
C. Pfluecke, S. Wydra, K. Berndt, D. Tarnowski, M. Cybularz, S. Jellinghaus, J. Mierke, G. Ende, D. M. Poitz, P. Barthel, F. M. Heidrich, S. Quick, K. M. Sveric, U. Speiser, A. Linke, K. Ibrahim
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Johannes Mierke, Tobias Loehn, Georg Ende, Sabrina Jahn, Silvio Quick, Uwe Speiser, Stefanie Jellinghaus, Christian Pfluecke, Axel Linke, Karim Ibrahim
Summary: The study investigated the effects of LV unloading on SHRD in patients with refractory CS. Results showed that 19 patients with SHRD immediately transitioned to a stable heart rhythm after insertion of a micro-axial heart pump, with some not requiring additional defibrillation. Patients with HRS required more frequent and longer resuscitation compared to those without HRS.
HEART LUNG AND CIRCULATION
(2021)
Article
Medicine, General & Internal
Kun Zhang, Ulrike Reuner, Charlotte Hempel, Uwe Speiser, Karim Ibrahim, Frank R. Heinzel, Burkert Pieske, Marian Christoph, Felix M. Heidrich, Silvio Quick
Summary: Cardiac magnetic resonance-based strain analysis was conducted on 61 WD patients and 61 age and sex-matched controls, revealing reduced left ventricular global longitudinal strain and right ventricular global longitudinal strain in the WD patients, suggesting potential early signs of cardiac manifestation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Genetics & Heredity
Silvio Quick, Max Winkler, Uwe Speiser, Karim Ibrahim, Jochen Schafer, Axel Linke, Kun Zhang, Marian Christoph, Felix M. Heidrich
Summary: Cardiac magnetic resonance-based strain analysis in LGMD2A patients did not show evidence of significant cardiac dysfunction, with normal global longitudinal, circumferential, and radial strains in both ventricles. No malignant ventricular arrhythmias were detected, suggesting less frequent cardiac follow-up may be acceptable in these patients with non-pathological initial exams, unless symptoms warrant further investigation.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Marian Christoph, David Poitz, Christian Pfluecke, Mathias Forkmann, Yan Huo, Thomas Gaspar, Steffen Schoen, Karim Ibrahim, Silvio Quick, Carsten Wunderlich
Summary: The study found that during atrial fibrillation ablation using irrigated, point-by-point RF ablation, a large number of microembolic signals were detected in transcranial ultrasound, especially during RF current application. The number of MES depends on the total procedure time and the reached ACT during ablation. The use of contact force monitoring may reduce MES during RF ablation.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Silvio Quick, Felix Matthias Heidrich, Max-Valentin Winkler, Anna Helene Winkler, Karim Ibrahim, Axel Linke, Uwe Speiser, Ulrich Grabmaier, Carsten Buhmann, Franz Marxreiter, Carsten Saft, Adrian Danek, Andreas Hermann, Kevin Peikert
Summary: The study revealed differences in cardiac manifestations between ChAc and MLS patients, with ChAc patients generally having lower cardiac involvement and MLS patients more prone to left ventricle dilatation and ventricular tachycardia.
PARKINSONISM & RELATED DISORDERS
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Quick, U. Reuner, M. Weidauer, F. M. Heidrich, C. Mues, C. Hempel, K. Sveric, K. Ibrahim, A. Linke, U. Speiser
EUROPEAN HEART JOURNAL
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Mierke, T. Loehn, G. Ende, Y. Akram, S. Jahn, T. Schweigler, S. Quick, C. Pfluecke, S. Jellinghaus, A. Linke, K. Ibrahim
EUROPEAN HEART JOURNAL
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
S. Q. Quick, U. Reuner, C. H. Hempe, M. C. Weidauer, F. M. Heidrich, K. Ibrahim, K. M. Sveric, A. Linke, U. Speiser
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2019)
Letter
Medicine, General & Internal
Karim Ibrahim, Marian Christoph, Silvio Quick
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Oncology
Joerg Herold, Felix M. Heidrich, Silvio Quick, Tobias Loehn, Karim Ibrahim, Adrian Mahlmann, Akram Youssef
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)