Journal
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Volume 42, Issue 6, Pages 617-621Publisher
WILEY-BLACKWELL
DOI: 10.1111/1440-1681.12393
Keywords
ageing; lithium; sex difference
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Funding
- National Basic Research Program of China [2013CB530800]
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Two studies have concluded that lithium exposure extends the lifespan of Caenorhabditis elegans. However, the effect of lithium on another widely used model organism, Drosophila melanogaster, remains unclear. Here, we demonstrate that chronic treatment with a low to moderate dose of lithium chloride does not extend lifespan in D.melanogaster and that the drug abolishes the female lifespan advantage in flies.
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