Prorenin stimulates a pro-angiogenic and pro-inflammatory response in retinal endothelial cells and an M1 phenotype in retinal microglia

NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy

(2013) Jennifer L. Wilkinson-Berka et al.   ANTIOXIDANTS & REDOX SIGNALING

Brain and retinal microglia in health and disease: An unrecognized target of the renin-angiotensin system

(2013) Claudia A McCarthy et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Nucleus of the Solitary Tract (Pro)Renin Receptor-Mediated Antihypertensive Effect Involves Nuclear Factor-κB-Cytokine Signaling in the Spontaneously Hypertensive Rat

(2013) Jasenka Zubcevic et al.   HYPERTENSION

The (pro)renin receptor blocker handle region peptide upregulates endothelium-derived contractile factors in aliskiren-treated diabetic transgenic (mREN2)27 rats

(2013) Wendy W. Batenburg et al.   JOURNAL OF HYPERTENSION

Angiopoietins in angiogenesis

(2012) Ernesta Fagiani et al.   CANCER LETTERS

(Pro)renin receptor is associated with angiogenic activity in proliferative diabetic retinopathy

(2012) A. Kanda et al.   DIABETOLOGIA

Neovascularization Is Attenuated With Aldosterone Synthase Inhibition in Rats With Retinopathy

(2012) Devy Deliyanti et al.   HYPERTENSION

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

The retinal renin–angiotensin system: Roles of angiotensin II and aldosterone

(2012) Jennifer L. Wilkinson-Berka et al.   PEPTIDES

Activation of retinal microglia rather than microglial cell density correlates with retinal neovascularization in the mouse model of oxygen-induced retinopathy

(2011) Franziska Fischer et al.   Journal of Neuroinflammation

Aliskiren reduces prorenin receptor expression and activity in cultured human aortic smooth muscle cells

(2011) Nicola Ferri et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Differential Macrophage Polarization Promotes Tissue Remodeling and Repair in a Model of Ischemic Retinopathy

(2011) Valentina Marchetti et al.   Scientific Reports

RILLKKMPSV Influences the Vasculature, Neurons and Glia, and (Pro)Renin Receptor Expression in the Retina

(2010) Jennifer L. Wilkinson-Berka et al.   HYPERTENSION

The renin–angiotensin system in retinal health and disease: Its influence on neurons, glia and the vasculature

(2010) Erica L. Fletcher et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Prorenin induces ERK activation in endothelial cells to enhance neovascularization independently of the renin–angiotensin system

(2009) Maki Uraoka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement

(2009) D. J. Campbell et al.   CLINICAL CHEMISTRY

Proliferative retinopathies: Angiogenesis that blinds

(2009) Przemyslaw Sapieha et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

(Pro)renin Receptor Promotes Choroidal Neovascularization by Activating Its Signal Transduction and Tissue Renin-Angiotensin System

(2008) Shingo Satofuka et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of a Retinal Aldosterone System and the Protective Effects of Mineralocorticoid Receptor Antagonism on Retinal Vascular Pathology

(2008) Jennifer L. Wilkinson-Berka et al.   CIRCULATION RESEARCH

Angiotensin II Type 1 Receptor Signaling Contributes to Synaptophysin Degradation and Neuronal Dysfunction in the Diabetic Retina

(2008) T. Kurihara et al.   DIABETES

(Pro)Renin Receptor Peptide Inhibitor “Handle-Region” Peptide Does Not Affect Hypertensive Nephrosclerosis in Goldblatt Rats

(2008) Dominik N. Muller et al.   HYPERTENSION

Critical Review of Prorenin and (Pro)renin Receptor Research

(2008) Duncan J. Campbell   HYPERTENSION

The Putative (Pro)renin Receptor Blocker HRP Fails to Prevent (Pro)renin Signaling

(2008) S. Feldt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials

(2008) Nish Chaturvedi et al.   LANCET

Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial

(2008) Anne Katrin Sjølie et al.   LANCET