Article
Allergy
Martina Turrin, Michele Rizzo, Matteo Bonato, Erica Bazzan, Manuel G. Cosio, Umberto Semenzato, Marina Saetta, Simonetta Baraldo
Summary: This study evaluated the symptom control and comorbidities in early-onset and late-onset asthma patients. Early-onset persistent asthma and late-onset asthma are distinct phenotypes with different underlying inflammatory patterns and different comorbidities affecting symptom control.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Clinical Neurology
Murali Palathinkara, Abrahim N. Razzak, Obada E. Ababneh, Delaney Cairns, Ahmed Z. Obeidat
Summary: This study revealed novel clinical and imaging characteristic differences between VLOMS and LOMS. The current classification of LOMS may benefit from revision to better align with chronological age classification for old age >60 instead of the current standard in the literature of >50 years.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Medicine, General & Internal
Bing-Chen Wu, Chiung-Hsin Chang, Yun-Chen Tsai, Tin-Yu Lin, Po-Jui Chang, Chun-Yu Lo, Shu-Min Lin
Summary: Late-onset asthma differs from early-onset asthma in terms of prognosis and treatment response. This study found that patients with early-onset asthma experienced greater declines in lung function and higher exacerbation rates compared to patients with late-onset asthma, especially those without atopy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Meiling Liu, Ben Chen, Xiaomei Zhong, Min Zhang, Qiang Wang, Huarong Zhou, Zhangying Wu, Le Hou, Qi Peng, Si Zhang, Minfeng Yang, Gaohong Lin, Yuping Ning
Summary: There is a difference in odor identification (OI) dysfunction between patients with late onset depression (LOD) and early onset depression (EOD), with LOD patients exhibiting worse OI. Additionally, OI dysfunction is not significantly correlated with cognitive function in LOD patients.
Article
Allergy
Pinja Ilmarinen, Anna Julkunen-Iivari, Lic Odont, Marie Lundberg, Annika Luukkainen, Mikko Nuutinen, Jussi Karjalainen, Heini Huhtala, Juha Pekkanen, Hannu Kankaanranta, Sanna Toppila-Salmi
Summary: This study conducted a phenotypic clustering analysis of adult-onset asthma in Finland, identifying two clusters with early and late onset, and found partial overlap with clusters identified in clinical settings. These results are important for a better understanding of adult-onset asthma phenotypes and support personalized management.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Critical Care Medicine
Nipasiri Voraphani, Debra A. Stern, Julie G. Ledford, Amber L. Spangenberg, Jing Zhai, Anne L. Wright, Wayne J. Morgan, Monica Kraft, Duane L. Sherrill, John A. Curtin, Clare S. Murray, Adnan Custovic, Inger Kull, Jenny Hallberg, Anna Bergstrom, Esther Herrera-Luis, Marilyn Halonen, Fernando D. Martinez, Angela Simpson, Erik Melen, Stefano Guerra
Summary: The study found that circulating CC16 deficits are associated with asthma with frequent symptoms from childhood through midadult life and predict the persistence of asthma symptoms into adulthood. These findings suggest a possible protective role of CC16 in asthma.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Hirotaka Yamagata, Hiroyuki Ogihara, Koji Matsuo, Shusaku Uchida, Ayumi Kobayashi, Tomoe Seki, Masaaki Kobayashi, Kenichiro Harada, Chong Chen, Shigeo Miyata, Masato Fukuda, Masahiko Mikuni, Yoshihiko Hamamoto, Yoshifumi Watanabe, Shin Nakagawa
Summary: The study identified DNA methylation markers more suitable for adult-onset depression (AOD) patients than for late-onset depression (LOD) patients. The methylation profile of AOD group was distinct and more homogeneous compared to the LOD group. Six identified methylation CpG sites were validated as potential markers for AOD, and a combination of three specific methylation markers achieved the highest accuracy.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Kathryn Nicholson, Lauren E. Griffith, Nazmul Sohel, Parminder Raina
Summary: This study examined the characteristics and health outcomes of multimorbidity in older adults in Canada, distinguishing between early and late onset. The majority of participants with multimorbidity were categorized with late onset, and both early and late onset were associated with increased risk of physical disability, social limitation, increased frailty, and negative perceived health status. Clinical and public health interventions targeting onset age are important in preventing and managing multimorbidity.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Clinical Neurology
Lingxiao Cao, Hailong Li, Xinyu Hu, Jing Liu, Yingxue Gao, Kaili Liang, Lianqing Zhang, Xinyue Hu, Xuan Bu, Lu Lu, Yanlin Wang, Shi Tang, Qiyong Gong, Xiaoqi Huang
Summary: This study aimed to identify pathophysiological specifics in OCD with different onset times by assessing amygdala subregional functional connectivity alterations. The findings emphasized different patterns of amygdala subregional connectivity alterations associated with EO-OCD and LO-OCD patients, providing unique insights into constructing distinct OCD subtypes based on brain intrinsic connectivity. Specific management for EO-OCD and LO-OCD patients may be needed based on these results.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Lubna Hamdan, Simon Vandekar, Andrew J. Spieker, Herdi Rahman, Danielle Ndi, Emily S. Shekarabi, Jyotsna Thota, Danielle A. Rankin, Zaid Haddadin, Tiffanie Markus, David M. Aronoff, William Schaffner, Jennifer A. Gaddy, Natasha B. Halasa
Summary: The study found racial disparities in rates of early-onset and late-onset GBS disease among infants, with black infants showing significant decreasing temporal trends in both EOGBS and LOGBS over the past decade in Tennessee. In contrast, there were no changes noted among white infants. Additional studies are needed to further characterize these disparities and identify factors influencing them.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Jessica L. Petrick, Lauren E. Barber, Shaneda Warren Andersen, Andrea A. Florio, Julie R. Palmer, Lynn Rosenberg
Summary: Colorectal cancer incidence rates have increased in American Indians/Alaskan Natives, Hispanics, and Whites, while rates of colorectal neuroendocrine tumors are increasing in all racial/ethnic groups. The disparity in early-onset CRC rates between Blacks and Whites has narrowed, with rates stabilizing in Blacks, but neuroendocrine tumor rates are rising. Blacks and American Indians/Alaskan Natives have the highest rates of both early- and late-onset CRC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Critical Care Medicine
Nipasiri Voraphani, Debra A. Stern, Jing Zhai, Anne L. Wright, Marilyn Halonen, Duane L. Sherrill, Jenny Hallberg, Inger Kull, Anna Bergstrom, Clare S. Murray, Lesley Lowe, Adnan Custovic, Wayne J. Morgan, Fernando D. Martinez, Erik Melen, Angela Simpson, Stefano Guerra
Summary: This study reveals that nutritional problems during pregnancy, being born small for gestational age, and underweight during childhood are early-life risk factors for spirometric restriction in adulthood. Improving prenatal and childhood growth trajectories may help prevent spirometric restriction and its associated morbidity and mortality.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Medicine, General & Internal
Min Wang, Changlian Tan, Qin Shen, Sainan Cai, Qinru Liu, Haiyan Liao
Summary: This study used a surface-based method to investigate brain functional alteration patterns in early-onset Parkinson's disease (EOPD) and late-onset Parkinson's disease (LOPD). The findings provide more reliable imaging indicators for the assessment of the two subtypes. The research discovered regional brain functional changes in both subtypes, which may contribute to a better understanding of the mechanisms underlying Parkinson's disease and its divergent clinical presentations.
Article
Medicine, Research & Experimental
Zhonglu Ren, Yunfei Gao, Yue Gao, Guanmei Liang, Qian Chen, Sijia Jiang, Xiaoxue Yang, Cuixia Fan, Haizhen Wang, Jing Wang, Yi-Wu Shi, Chaoqun Xiao, Mei Zhong, Xinping Yang
Summary: The study found that early-onset severe preeclampsia and late-onset severe preeclampsia have different molecular mechanisms, with the former associated with metabolism-related pathways and the latter with immune-related pathways. Some key transcription factors may be driving the widespread gene dysregulation in both early-onset and late-onset patients.
Article
Cardiac & Cardiovascular Systems
Parisa Torabi, Giulia Rivasi, Viktor Hamrefors, Andrea Ungar, Richard Sutton, Michele Brignole, Artur Fedorowski
Summary: The age at first syncope impacts the final diagnosis, with a bimodal distribution of first-ever syncope incidence. Older patients are more likely to present recent syncope with orthostatic hypotension and carotid sinus syndrome being more common. In patients with early-onset syncope, vasovagal and complex syncope are more common.
EUROPEAN HEART JOURNAL
(2022)
Article
Rehabilitation
Benjamin J. Tarrant, Elizabeth Quinn, Rebecca Robinson, Megan Poulsen, Louise Fuller, Greg Snell, Bruce R. Thompson, Brenda M. Button, Anne E. Holland
Summary: This study aimed to establish the feasibility and safety of intensive acute physiotherapy post-lung transplantation. The results showed that acute, intensive physiotherapy was feasible and safe, with no intervention-related adverse events observed.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Article
Allergy
Daniel J. Tan, Caroline J. Lodge, Eugene Haydn Walters, Adrian J. Lowe, Dinh S. Bui, Gayan Bowatte, Rangi Kandane-Rathnayake, Fahad M. Aldakheel, Bircan Erbas, Garun S. Hamilton, Paul S. Thomas, Mark Hew, Mimi L. K. Tang, Michael J. Abramson, Jennifer L. Perret, Shyamali C. Dharmage
Summary: This study found that subclinical inflammation exists in adults with spontaneous asthma remission, and these inflammatory biomarkers are associated with future asthma relapse and lung function decline. Bronchial hyperresponsiveness (BHR) and serum inflammatory cytokines have prognostic value in predicting outcomes in adults with spontaneous asthma remission, suggesting the need for closer monitoring and follow-up in high-risk individuals.
Article
Respiratory System
Melvin Tandra, E. Haydn Walters, Jennifer Perret, Adrian J. Lowe, Caroline J. Lodge, David P. Johns, Paul S. Thomas, Gayan Bowatte, Peter G. Davis, Michael J. Abramson, Shyamali C. Dharmage, Dinh S. Bui
Summary: The association between birth weight relative to gestational age and adult lung function was investigated in this study. It was found that infants born small for gestational age had reduced lung function in middle age, while higher birth weight was associated with better lung function. Adult height played a significant mediating role in these associations.
Article
Critical Care Medicine
Shyamali C. Dharmage, Dinh S. Bui, Eugene H. Walters, Adrian J. Lowe, Bruce Thompson, Gayan Bowatte, Paul Thomas, Judith Garcia-Aymerich, Debbie Jarvis, Garun S. Hamilton, David P. Johns, Peter Frith, Chamara Senaratna, Nur S. Idrose, Richard R. Wood -Baker, John Hopper, Lyle Gurrin, Bircan Erbas, George R. Washko, Rosa Faner, Alvar Agusti, Michael J. Abramson, Caroline J. Lodge, Jennifer L. Perret
Summary: This study is the first to characterize lifetime phenotypes of obstruction and restriction simultaneously using objective data-driven techniques. Early interventions might be beneficial for individuals with mixed and obstructive-only patterns, while those with restrictive-only pattern are at increased risk of true lung restriction and multiple morbidities in middle age.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Environmental Sciences
Yao Wu, Rongbin Xu, Shanshan Li, Ee Ming Wong, Melissa C. Southey, John L. Hopper, Michael J. Abramson, Shuai Li, Yuming Guo
Summary: A study found that short-term temperature fluctuations can affect DNA methylation levels and are associated with various diseases such as cancer and mental disorders, providing evidence for exploring the biological mechanisms underlying the health impact of temperature fluctuations.
ENVIRONMENT INTERNATIONAL
(2023)
Editorial Material
Respiratory System
Michael J. Abramson, Deborah C. Glass
Article
Critical Care Medicine
Daniel J. Tan, Caroline J. Lodge, E. Haydn Walters, Adrian J. Lowe, Dinh S. Bui, Gayan Bowatte, Jonathan Pham, Bircan Erbas, Jennie Hui, Garun S. Hamilton, Paul S. Thomas, Mark Hew, George Washko, Richard Wood-Baker, Michael J. Abramson, Jennifer L. Perret, Shyamali C. Dharmage
Summary: This study aimed to characterize the longitudinal phenotypes of asthma and identified five distinct longitudinal asthma phenotypes. The results showed differential effects of these phenotypes on the risk of chronic obstructive pulmonary disease and nonrespiratory comorbidities at age 53 years.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Respiratory System
Sanja Stanojevic, David A. Kaminsky, Martin Miller, Bruce Thompson
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Respiratory System
Jennifer Perret, Sui Wah Sean Yip, Nur Sabrina Idrose, Kerry Hancock, Michael J. Abramson, Shyamali C. Dharmage, E. Haydn Walters, Nilakshi Waidyatillake
Summary: Despite being a major global cause of mortality and hospitalization, chronic obstructive pulmonary disease (COPD) is often undiagnosed or inaccurately diagnosed in clinical settings. This systematic review synthesized all peer-reviewed papers from primary healthcare settings that reported data on undiagnosed COPD and overdiagnosed COPD, in order to provide a comprehensive understanding of the prevalence and accuracy of COPD diagnosis in primary healthcare settings.
BMJ OPEN RESPIRATORY RESEARCH
(2023)
Letter
Critical Care Medicine
David J. Martino, Dinh S. Bui, Shuai Li, Sabrina Idrose, Jennifer Perret, Adrian J. Lowe, Caroline J. Lodge, Gayan Bowatte, Yuben Moodley, Paul S. Thomas, Graeme Zosky, Philip M. Hansbro, John W. Holloway, Cecilie Svanes, Rosa Faner, Eugene H. Walters, Shaymali C. Dharmage
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Allergy
Chia-Lun Chang, Gulshan Bano Ali, Jonathan Pham, Shyamali C. C. Dharmage, Caroline J. J. Lodge, Mimi L. K. Tang, Adrian J. J. Lowe
Summary: This study systematically synthesized the association between BMI trajectories in childhood and allergic diseases. The findings suggest that a persistently high BMI between 6 and 10 years of age may be associated with an increased risk of asthma at 18 years, and a rapid increase in BMI in the first 2 years of life may be associated with subsequent asthma. Maintaining a normal BMI trajectory during childhood may reduce the risk of asthma.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Review
Pharmacology & Pharmacy
Faith A. A. Kwa, Bang V. Bui, Bruce R. Thompson, Lauren N. Ayton
Summary: Vision loss has a significant impact on individuals and communities, both financially and emotionally. Age-related macular degeneration, diabetic retinopathy, glaucoma, and retinitis pigmentosa are common causes of vision loss. As the global population grows and ages, it is crucial to develop therapies that can prevent early pathological events. This review outlines the preclinical research on sulforaphane, a compound derived from broccoli, in ocular diseases and discusses its potential for future clinical testing.
DRUG DISCOVERY TODAY
(2023)
Article
Respiratory System
Chamara V. Senaratna, Adrian Lowe, E. Haydn Walters, Michael J. Abramson, Dinh Bui, Caroline Lodge, Bircan Erbas, John Burgess, Jennifer L. Perret, Garun S. Hamilton, Shyamali C. Dharmage
Summary: This study provides the first known evidence for individual and profiled early-life and childhood risk factors for OSA in adults.
Article
Respiratory System
Nawar Alotaibi, Brigitte M. Borg, Michael J. Abramson, Eldho Paul, Nicholas Zwar, Grant Russell, Sally Wilson, Anne E. Holland, Billie Bonevski, Ajay Mahal, Johnson George
Summary: Case finding using validated questionnaires and handheld devices can improve the diagnosis of COPD in primary care. Handheld spirometry devices can facilitate case finding of COPD in smokers and ex-smokers attending general practice.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Pediatrics
Rachel L. Peters, Victoria Xsoriano, Kate Lycett, Catherine Flynn, Nur Sabrina Idrose, Mimi L. K. Tang, Rushani Wijesuriya, Katrina J. Allen, Sarath Ranganathan, Adrian J. Lowe, Kirsten P. Perrett, Caroline J. Lodge, Jennifer J. Koplin, Shyamali C. Dharmage
Summary: This study aimed to investigate the relationship between infant food allergy phenotypes and lung function deficits and asthma in childhood. The findings suggest that food allergy in infancy is associated with reduced lung function and an increased risk of asthma at age 6 years. Additionally, food-sensitised tolerance and food allergy at age 1 year were both associated with an increased risk of asthma at age 6 years.
LANCET CHILD & ADOLESCENT HEALTH
(2023)