Article
Rheumatology
Yi-Lin Dan, Chan-Na Zhao, Yan-Mei Mao, Qian Wu, Yi-Sheng He, Yu-Qian Hu, Kun Xiang, Xiao-Ke Yang, Napoleon Bellua Sam, Guo-Cui Wu, Hai-Feng Pan
Summary: This study found that the single nucleotide polymorphisms (SNPs) of the Period 2 (PER2) gene are associated with the genetic susceptibility and clinical manifestations of systemic lupus erythematosus (SLE).
Article
Rheumatology
Yan-Mei Mao, Yi-Sheng He, Guo-Cui Wu, Yu-Qian Hu, Kun Xiang, Tao Liao, Yu-Lu Yan, Xiao-Ke Yang, Zong-Wen Shuai, Gui-Hong Wang, Hai-Feng Pan, Dong-Qing Ye
Summary: The study revealed an association between the MALAT-1 gene rs4102217 locus and susceptibility to SLE, with the GG+CG genotype potentially decreasing the risk of developing SLE.
Article
Medicine, General & Internal
Ilce Valeria Roman-Fernandez, Jesus Rene Machado-Contreras, Jose Francisco Munoz-Valle, Alvaro Cruz, Diana Celeste Salazar-Camarena, Claudia Azucena Palafox-Sanchez
Summary: This study investigated the association between PTPN22, IL10, OAS2, CD70 mRNA expression and clinical characteristics, as well as serum levels of IL-10, IFN-gamma, and IL-17 in SLE patients. The results showed that PTPN22 and IL10 gene expression were negatively correlated with Mex-SLEDAI score and were downregulated in SLE patients with lupus nephritis. These findings suggest that assessing IL10 and PTPN22 mRNA may be useful for monitoring disease activity in SLE patients with renal involvement.
Article
Immunology
Ding-Ping Chen, Wei-Tzu Lin, Kuang-Hui Yu
Summary: This study investigated the correlation between SLE and the genetic polymorphisms of co-stimulatory/co-inhibitory molecules, and found nine SNPs associated with SLE. These SNPs play an important role in immune regulation and pathogenic mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Weijie Wang, Xinchang Wang, Kepeng Yang, Yongsheng Fan
Summary: This study showed that the polymorphisms of BCL2 and the IL19 SNP rs2243188 are closely related to the pathogenesis of SLE. Carrying specific genotypes of these genes may increase the risk of developing SLE.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Rheumatology
Jianzhao Zhai, Ping Zhang, Naidan Zhang, Yubin Luo, Yongkang Wu
Summary: The study revealed that the PHLDB1 rs7389T/G and WDFY4 rs7097397G/A polymorphisms were associated with SLE susceptibility in western China. The rs7389T/G variant was linked to increased TNF-alpha levels, while the rs7097397G/A variant was correlated with decreased IL-1 beta and IL-6 levels as well as an elevated positive rate of antinuclear antibodies.
CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Riham Eid, Ayman Hammad, Maha Abdelsalam, Aya Ahmed Fathy, Dena M. Abd-El Ghafaar, Eman B. Elmarghany, Aya A. El-Hanafy, Nora Mostafa, Nermeen A. Niazey, Mai S. Korkor, Nashwa Hamdy
Summary: The study suggests that the G allele and GG genotype of TNFR II rs1061622 and the T allele and TT genotype of PTPN22 rs2476601 may be risk factors for the development of SLE. Moreover, the presence of the T allele of PTPN22 rs2476601 could potentially increase the risk of concomitant thyroiditis in Egyptian children with SLE.
Article
Biotechnology & Applied Microbiology
Yun Yu, Liang Liu, Long-Long Hu, Ling-Ling Yu, Jun-Pei Li, Jing-an Rao, Ling-Juan Zhu, Qian Liang, Rong-Wei Zhang, Hui-Hui Bao, Xiao-Shu Cheng
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. This study used bioinformatics methods to identify potential therapeutic targets for SLE, revealing tissue-specific expression differences in hematological markers and increased expression of CCL2, MMP9, and RSAD2 in SLE samples. These key genes could serve as potential therapeutic targets for treating SLE.
Article
Cell Biology
Concetta Scimone, Luigi Donato, Simona Alibrandi, Concetta Alafaci, Angela D'Ascola, Sergio Vinci, Rosalia D'Angelo, Antonina Sidoti
Summary: This study reveals the importance of epitranscriptomic modifications in gene expression regulation and suggests the involvement of altered epitranscriptome profile in the development of CCM. These findings provide new insights for further investigation into the pathogenesis of CCM.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Rheumatology
Yasser B. M. Ali, Basima A. El-Akhras, R. El-Shazly, Iman H. Bassyouni
Summary: Cytokine polymorphisms are associated with SLE pathogenicity, including the important cytokine IL-27. A study on Egyptian population showed that the TG genotype and G allele of the IL-27p28 gene may be risk factors for SLE susceptibility.
CLINICAL RHEUMATOLOGY
(2021)
Article
Immunology
Melissa Northcott, Linden J. Gearing, Julie Bonin, Rachel Koelmeyer, Alberta Hoi, Paul J. Hertzog, Eric F. Morand
Summary: The effects of medication on gene module expression in SLE patients are significant, emphasizing the need to control for medication exposure in studies of gene expression in SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ivan Sammir Aranda-Uribe, Juan Carlos Lopez-Vazquez, Rosa Elda Barbosa-Cobos, Julian Ramirez-Bello
Summary: The study investigated the association between TLR4 and TLR9 gene polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Mexican patients, and found that these variants are not risk factors for RA or SLE in this population.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Rheumatology
Zahra Bagheri-Hosseinabadi, Mohammad Reza Mirzaei, Mina Aliakbari, Mitra Abbasifard
Summary: This study found an association between IL33 gene rs1929992 and rs7044343 single nucleotide polymorphisms (SNPs) and the risk of SLE, as well as the relationship between these SNPs and inflammatory cytokines.
CLINICAL RHEUMATOLOGY
(2023)
Article
Cell Biology
Chun-Hong Liu, Yu-Lan Lu, Hua-Tuo Huang, Chun-Fang Wang, Hong-Cheng Luo, Gui-Jiang Wei, Ming Lei, Tan Tan, Yan Wang, Yan-Yun Huang, Ye-Sheng Wei, Yan Lan
Summary: This study focused on the association of LncRNA-GAS5 polymorphism with SLE risk and explored its involvement in the disease's occurrence. The rs145204276 ID/DD genotypes were found to be associated with a decreased risk of SLE and a reduced incidence of renal disorders. Additionally, the LncRNA-GAS5/miR-21/PTEN signaling pathway was identified to play a role in SLE development, where LncRNA-GAS5 acted as an miR-21 target regulating PTEN expression.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Genetics & Heredity
Haihong Zhang, Yanli Wang, Jinghui Feng, Shuya Wang, Yan Wang, Weisi Kong, Zhiyi Zhang
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with high morbidity and mortality rates due to challenges in diagnosis. An integrated analysis of two RNA-seq datasets identified 790 common differentially expressed genes (DEGs) that are significantly enriched in immune-related processes and pathways. This analysis provides new insights into the pathogenic mechanisms and potential biomarkers for SLE.
FRONTIERS IN GENETICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Alvaro Cruz, Luis Gerardo Gascon, Claudia Azucena Palafox-Sanchez, Christian Flores-Garcia, Noemi Espinoza-Garcia, Nefertari Sagrero-Fabela, Luciano Tavares Angelo Cintra, Rocio Mejia-Flores, Diana Celeste Salazar-Camarena
Summary: This case-control study aimed to evaluate the association between the TNFSF13B rs9514828 polymorphism and soluble BAFF in apical periodontitis patients. The results showed that the rs9514828 mutation was associated with increased susceptibility to primary AP and decreased risk of secondary AP. It suggests that the TNFSF13B rs9514828 polymorphism may play a role in primary AP susceptibility and that BAFF may be involved in acute and chronic AP.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Medicine, General & Internal
Miguel Marin-Rosales, Claudia Azucena Palafox-Sanchez, Ramon Antonio Franco-Topete, Francisco Josue Carrillo-Ballesteros, Alvaro Cruz, Diana Celeste Salazar-Camarena, Jose Francisco Munoz-Valle, Francisco Ramos-Solano
Summary: This study aimed to evaluate the tissular expression of BAFF in lupus nephritis (LN) and found that BAFF and its receptors are mainly associated with LN class IV, highlighting the role of these receptors as essential pathogenic factors in kidney involvement in SLE patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Paula Annahi Menchaca-Tapia, Miguel Marin-Rosales, Diana Celeste Salazar-Camarena, Alvaro Cruz, Edith Oregon-Romero, Raziel Tapia-Llanos, Jose Francisco Munoz-Valle, Claudia Azucena Palafox-Sanchez
Summary: A study on Mexican mestizo subjects found that multiple single-nucleotide polymorphisms (SNPs) in the PTPN22 gene were not associated with susceptibility to primary Sjogren's syndrome (pSS). However, PTPN22 expression may serve as a useful diagnostic biomarker for pSS.
Article
Dentistry, Oral Surgery & Medicine
Claudia Azucena Palafox- Sanchez, Alvaro Cruz, Diana Celeste Salazar-Camarena, Luis Gerardo Gascon, Luciano Tavares Angelo Cintra, Jose Francisco Munoz-Vale, Samuel Garcia-Arelano, Carlos Estrela, Paula Annahi Menchaca-Tapia
Summary: This study investigated the changes in systemic cytokine levels in patients with acute apical abscesses (AAA), and found that patients with AAA had increased serum levels of TNF-a, IL-6, and IL-10. Antibiotic treatment was associated with a decrease in IL-6 and IL-10 levels, while TNF-a levels decreased after antibiotic and endodontic treatment.
JOURNAL OF ENDODONTICS
(2023)
Article
Rheumatology
Nefertari Sagrero-Fabela, Pablo C. Ortiz-Lazareno, Diana C. Salazar-Camarena, Alvaro Cruz, Sergio Cerpa-Cruz, Jose F. Munoz-Valle, Miguel Marin-Rosales, Jhonatan A. Alvarez-Gomez, Claudia A. Palafox-Sanchez
Summary: This study aimed to evaluate the association of cTfh and Tph subpopulations with the BAFF system expression and clinical activity in SLE patients. The results showed that SLE patients had higher percentages of cTfh and Tph cells, which were positively correlated with disease activity. These findings highlight the importance of cTfh and Tph cells in the pathogenesis of SLE.
Article
Immunology
Jhonatan Antonio alvarez Gomez, Diana Celeste Salazar-Camarena, Ilce Valeria Roman-Fernandez, Pablo Cesar Ortiz-Lazareno, Alvaro Cruz, Jose Francisco Munoz-Valle, Miguel Marin-Rosales, Noemi Espinoza-Garcia, Nefertari Sagrero-Fabela, Claudia Azucena Palafox-Sanchez
Summary: This study aims to analyze the expression of the BAFF system in CXCR5- CD11c+ atypical B cell subsets in SLE patients and found increased expression in these subsets. Additionally, decreased TACI expression on atypical B cells DN2 was associated with higher disease activity.
FRONTIERS IN IMMUNOLOGY
(2023)