Journal
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Volume 181, Issue 1, Pages 110-117Publisher
WILEY-BLACKWELL
DOI: 10.1111/cei.12618
Keywords
B cell; follicular T helper; HIV; memory; paediatric
Categories
Funding
- Imperial College Academic Health Science Centre
- Medicines for Children Research Network
- North West London Comprehensive Local Research Network
- National Institute of Health Research (NIHR) [RTF/08/01/009]
- European Society for Pediatric Infectious Diseases (ESPID)
- NIHR [NIHR/SRF-2009-02-07]
- Medical Research Council/DFID [MR/K007602/1]
- Engineering and Physical Sciences Research Council
- Westminster Medical Research Trust
- St Stephen's AIDS Trust
- MRC [MC_EX_MR/K011944/1, MC_UP_A900_1122] Funding Source: UKRI
- Medical Research Council [MC_EX_MR/K011944/1, MC_UP_A900_1122] Funding Source: researchfish
- National Institute for Health Research [SRF-2009-02-07, NF-SI-0611-10066, RTF/01/009] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [RTF/01/009] Funding Source: National Institutes of Health Research (NIHR)
Ask authors/readers for more resources
Antiretroviral therapy (ART) only partially restores HIV-induced alterations in lymphocyte populations. We assessed B and T cell phenotypes in a cohort of children from a single centre in the United Kingdom with perinatally acquired HIV compared to healthy controls. The majority of HIV infected children (44 of 56) were on fully suppressive combination ART. Children with perinatally acquired HIV had significantly lower memory B and CD4(+)CD45RO(+)CXCR5(+) [follicular T helper cell (Tfh)-like] T cell percentages. Detectable viraemia was associated with higher CD21(-) (activated and exhausted/tissue-like memory) B cells. A greater proportion of life spent on suppressive ART was associated with higher memory B cell percentages. These results suggest that early and sustained suppressive ART may preserve B and T cell phenotypes in perinatally acquired HIV and limit deficits in humoral immunity. A lower proportion of circulating Tfh-like cells in HIV infected children appears to be independent of HIV treatment history and ongoing HIV viraemia and warrants further investigation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available