Journal
TETRAHEDRON LETTERS
Volume 57, Issue 51, Pages 5719-5729Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.10.083
Keywords
Alkynes; [2+2+2] cycloaddition; Cyclotrimerization; Condensation reactions; Transition metal-free reactions; Dehydro-Diels-Alder reactions; Domino reactions
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG)
- Leibniz-Gemeinschaft
- Fonds der Chemischen Industrie (FCI)
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Cyclotrimerization reactions of alkynes and their oligomers with themselves or other heterocumulenes are usually performed by stoichiometric or catalytic mediacy of transition metal complexes. However, a number of transition metal-free variations have appeared, ranging from stepwise cyclizations of alkynes or oligoalkynes under rather drastical reaction conditions to trimeric condensation reactions of ketoalkynes under amine catalysis and finally uncatalyzed cyclizations of oligoalkynes under partially rather mild conditions. Consequentially a range of different reaction conditions and mechanism are involved in these transformations. The presented digest accounts selected examples of such transition metal-free formal [2+2+2] cycloadditions and exemplarily discusses their mechanistic course of action. (C) 2016 Elsevier Ltd. All rights reserved.
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