Journal
TETRAHEDRON LETTERS
Volume 57, Issue 50, Pages 5649-5652Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.11.006
Keywords
Organocatalysis; o-Quinone methide; Dihydrocoumarin
Categories
Funding
- Thousand Plan Youth Program
- Fundamental Research Funds for the Central Universities
- East China University of Science Technology
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A [4+2] annulation of aldehydes and o-quinone methides catalyzed by a secondary amine is developed. This process leads to biologically important dihydrocoumarins in moderate to good yields after oxidation. In addition, the employment of a chiral secondary amine catalyst allows access to optically active dihydrocoumarins with up to 64% ee. (C) 2016 Elsevier Ltd. All rights reserved.
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