Article
Engineering, Environmental
Ting Liu, Xi Zhang, Lizhen He, Zehang Zhang, Yuhan Sun, Junmei Feng, Zhiming Lin, Tianfeng Chen
Summary: This study developed a selenium nanosystem with surface decoration of calf thymus DNA to specifically recognize and remove anti-dsDNA autoantibodies in SLE patients. The nanotherapeutics showed excellent biocompatibility and safety, and had higher clearance ratio compared to other clinical products. Furthermore, the nanotherapeutics could visualize the distribution of anti-dsDNA antibodies in kidney lesions and semi-quantify the antibody deposition.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Fariza Cheldieva, Maria Cherkasova, Alexander Lila, Evgeny Nasonov
Summary: This study investigates the role of IgA antibodies to cardiolipin (aCL) and IgA antibodies to beta-2 glycoprotein 1 (anti-beta(2)-GP1) in the development of vascular complications in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). The results show that the levels of IgA aCL and IgA anti-beta(2)-GP1 are significantly higher in APS patients compared to SLE patients and the control group. These antibodies are closely associated with thrombosis in APS, demonstrating high specificity but low sensitivity for the diagnosis of APS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Maurizio Bruschi, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Francesco Locatelli, Giulia Pazzola, Giampaola Pesce, Marcello Bagnasco, Angelo Manfredi, Giuseppe A. Ramirez, Pasquale Esposito, Giuseppe Murdaca, Simone Negrini, Leda Cipriani, Barbara Trezzi, Giacomo Emmi, Ilaria Cavazzana, Valentina Binda, Matteo d'Alessandro, Paride Fenaroli, Isabella Pisani, Giacomo Garibotto, Carlomaurizio Montecucco, Domenico Santoro, Francesco Scolari, Stefano Volpi, Marta Mosca, Angela Tincani, Giovanni Candiano, Marco Prunotto, Enrico Verrina, Andrea Angeletti, Angelo Ravelli, Gian Marco Ghiggeri
Summary: The circulating anti-ENO1, anti-H2A, and anti-ANXA1 antibodies were associated with high proteinuria in lupus nephritis patients, with the anti-ENO1 antibody showing the maximum reduction within 12 months paralleling the decrease in proteinuria. Anti-dsDNA antibodies were not linked to renal outcome parameters. New IgG2 antibody signatures have the potential to be used as markers for personalized therapies in lupus nephritis.
Article
Medicine, Research & Experimental
Jinyan Guo, Guangying Cui, Wei Huang, Zhaohui Zheng, Tianfang Li, Guanmin Gao, Zhen Huang, Yuwei Zhan, Suying Ding, Shengyun Liu, Zujiang Yu, Zhigang Ren
Summary: This study compared the characteristics of the oral microbiome between patients with systemic lupus erythematosus (SLE) and healthy controls, and developed an SLE classifier based on the oral microbiota. The results showed that SLE patients had increased oral microbial diversity and a different microbial community compared to healthy controls. Specific microbial changes were identified and used to construct a classifier for diagnosing SLE.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Aleida Susana Castellanos Gutierrez, Francesc Figueras, Diana M. Morales-Prieto, Ekkehard Schleussner, Gerard Espinosa, Nuria Banos
Summary: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that mainly affects women of childbearing age. During pregnancy, SLE is associated with a higher risk of perinatal morbidity and mortality. Several studies have suggested that placental dysfunction may play a crucial role in this association.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Robin Arcani, Daniel Bertin, Nathalie Bardin, Karin Mazodier, Rodolphe Jean, Pierre Suchon, Geoffroy Venton, Aurelie Daumas, Estelle Jean, Patrick Villani, Gilles Kaplanski, Pierre-Andre Jarrot
Summary: The study shows that anti-NuMA antibodies are mainly associated with pSS and SLE, and patients with these antibodies have less severe clinical profiles and require less treatment. Anti-NuMA antibodies may be a useful diagnostic marker when other auto-antibodies are negative and could indicate a good prognosis in autoimmune diseases.
Article
Pharmacology & Pharmacy
Haruka Takata, Taro Shimizu, Yoshino Kawaguchi, Hiro Ueda, Nehal E. Elsadek, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
Summary: Research shows that nucleic acids associated with PEGylated cationic liposomes induce anti-DNA or anti-RNA antibodies in healthy mice, but do not cause SLE-like symptoms. However, in mice with SLE, nucleic acids associated with PCL exacerbate lupus nephritis symptoms.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Rheumatology
Jiawei Zhao, Xin You, Xiaofeng Zeng
Summary: This article reviews the prevalence and pathogenesis of BKV infection in SLE patients. The results show higher rates of BKV infection and reactivation in SLE patients, and some immunosuppressive drugs may have a protective effect. BKV infection plays a role in the occurrence and development of SLE.
Review
Immunology
Marten Trendelenburg
Summary: This review discusses the mechanisms and importance of anti-C1q in the development of SLE, highlighting the potential role of C1q in the inflammatory process and exploring its clinical application as a biomarker.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Haofang Zhu, Bin Kong, Min Nie, Cheng Zhao, Rui Liu, Ying Xie, Yuanjin Zhao, Lingyun Sun
Summary: In this study, a peptide dendrimer-based microgel encapsulated with MSCs was developed using a microfluidic approach for the treatment of SLE. The microgels had tunable diameters, porous microstructures, mechanical stiffness, and immune-isolation potential. The results showed that the MSCs encapsulated microgels enhanced cellular bioactivity, immunomodulatory function, and alleviated disease symptoms.
Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Kamila Nurbaeva, Ivan Ptashnik, Anna Kudriaeva, Alexey Belogurov Jr, Aleksandr Lila, Evgeny Nasonov
Summary: This study aimed to assess the role of neutrophil extracellular traps (NETs) markers, MPO-DNA complex and nucleosomes, in the diagnosis of systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). The study found that levels of MPO-DNA complex were higher in SLE patients and associated with SLE activity and lupus glomerulonephritis. Lower levels of nucleosomes were observed in SLE patients and associated with SLE activity and arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Benoit Brilland, Maxime Bach-Bunner, Christopher Nunes Gomes, Vincent Larochette, Etienne Foucher, Marc Plaisance, Patrick Saulnier, Nathalie Costedoat-Chalumeau, Pascale Ghillani, Cristina Belizna, Yves Delneste, Jean-Francois Augusto, Pascale Jeannin
Summary: The study found that IL-26 levels were significantly higher in SLE patients compared to controls, and were also significantly higher in patients with active disease compared to those with inactive disease. IL-26 levels correlated positively with SLEDAI score and uPCR. Patients with high IL-26 levels showed higher disease activity markers and complement consumption, indicating IL-26 may be a useful biomarker for active disease identification in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Tetsuo Kubota
Summary: Anti-DNA antibodies play an important role in SLE by entering cells and affecting the pathophysiology. Activated circulating neutrophils in SLE release immunogenic NETs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
George C. Drosos, Daisy Vedder, Eline Houben, Laura Boekel, Fabiola Atzeni, Sara Badreh, Dimitrios T. Boumpas, Nina Brodin, Ian N. Bruce, Miguel Angel Gonzalez-Gay, Soren Jacobsen, Gyorgy Kerekes, Francesca Marchiori, Chetan Mukhtyar, Manuel Ramos-Casals, Naveed Sattar, Karen Schreiber, Savino Sciascia, Elisabet Svenungsson, Zoltan Szekanecz, Anne-Kathrin Tausche, Alan Tyndall, Vokko van Halm, Alexandre Voskuyl, Gary J. Macfarlane, Michael M. Ward, Michael T. Nurmohamed, Maria G. Tektonidou
Summary: This study developed recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, emphasizing the importance of regular screening and management of modifiable CVR factors as well as patient education. The recommendations covered CVR prediction tools, interventions on traditional CVR factors, and interventions on disease-related CVR factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Elisabet Svenungsson, Jonas Spaak, Karin Strandberg, Hakan N. Wallen, Stefan Agewall, Elin B. Brolin, Olov Collste, Maria Daniel, Christina Ekenback, Mats Frick, Loghman Henareh, Karin Malmqvist, Kerstin Elvin, Peder Sorensson, Shams Y-Hassan, Claes Hofman-Bang, Per Tornvall
Summary: Recent studies have shown an overrepresentation of prothrombotic antiphospholipid antibodies in patients with myocardial infarction due to coronary artery disease, but their association with MI with nonobstructive coronary arteries remains unclear. This study confirmed the higher levels of aPL IgG in patients with MI due to coronary artery disease, indicating a potential link with hypercoagulability.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Rheumatology
Sofie A. M. Gernaat, Julia F. Simard, Anna-Karin Wikstrom, Elisabet Svenungsson, Elizabeth V. Arkema
Summary: The study found a risk association between systemic lupus erythematosus (SLE) and gestational diabetes mellitus (GDM), with women with SLE being more likely to develop GDM during pregnancy compared to general population controls.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Sindhu R. Johnson, Dafna D. Gladman, Hermine Brunner, David Isenberg, Ann E. Clarke, Megan R. W. Barber, Laurent Arnaud, Paul R. Fortin, Marta Mosca, Alexandre E. Voskuyl, Susan Manzi, Cynthia Aranow, Anca Askanase, Graciela S. Alarcon, Sang-Cheol Bae, Nathalie Costedoat-Chalumeau, Jessica A. English, Guillermo J. Pons-Estel, Bernardo A. Pons-Estel, Rebecca Gilman, Ellen M. Ginzler, John G. Hanly, Soren Jacobsen, Kenneth Kalunian, Diane L. Kamen, Chynace Lambalgen, Alexandra Legge, S. Sam Lim, Anselm Mak, Eric F. Morand, Christine A. Peschken, Michelle Petri, Anisur Rahman, Rosalind Ramsey-Goldman, John A. Reynolds, Juanita Romero-Diaz, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Elisabet Svenungsson, Zahi Touma, Murray Urowitz, Evelyne Vinet, Ronald F. van Vollenhoven, Heather Waldhauser, Daniel J. Wallace, Asad Zoma, Ian N. Bruce
Summary: The SLICC, ACR, and Lupus Foundation of America are developing a revised SLE damage index (SDI) due to shifts in the concept of damage in SLE. A qualitative study was conducted to evaluate contemporary constructs in SLE damage and develop a conceptual framework for the revised SDI.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Medicine, General & Internal
Charlotte de Vries, Guillermo Ruacho, Elin Kindstedt, Barbara Aleksandra Potempa, Jan Potempa, Bjorn Klinge, Pernilla Lundberg, Elisabet Svenungsson, Karin Lundberg
Summary: There is accumulating evidence suggesting that periodontitis is associated with an increased risk of systemic and autoimmune diseases. A recent study investigated the potential of antibodies to the Porphyromonas gingivalis virulence factor arginine gingipain as a biomarker for periodontitis patients at risk of autoimmunity and systemic disease. The study found that anti-Rgp IgG levels were elevated in severe periodontitis, individuals positive for certain autoantibodies, and myocardial infarction patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Sahwa Elbagir, Lina-Marcela Diaz-Gallo, Giorgia Grosso, Agneta Zickert, Iva Gunnarsson, Michael Mahler, Elisabet Svenungsson, Johan Ronnelid
Summary: HLA-DRB1 alleles are associated with thrombosis and production of aPL in SLE patients. HLA-DRB1*13 increases the risk of aPS-PT production and thrombosis, while HLA-DRB1*03 is associated with reduced thrombotic events and favorable lipid levels in aPL-positive SLE patients.
Article
Rheumatology
Christian Lundtoft, Pascal Pucholt, Myriam Martin, Matteo Bianchi, Emeli Lundstrom, Maija-Leena Eloranta, Johanna K. Sandling, Christopher Sjowall, Andreas Jonsen, Iva Gunnarsson, Solbritt Rantapaa-Dahlqvist, Anders A. Bengtsson, Dag Leonard, Eva Baecklund, Roland Jonsson, Daniel Hammenfors, Helena Forsblad-d'Elia, Per Eriksson, Thomas Mandl, Sara Magnusson Bucher, Katrine B. Norheim, Svein Joar Auglaend Johnsen, Roald Omdal, Marika Kvarnstrom, Marie Wahren-Herlenius, Antonella Notarnicola, Helena Andersson, Oyvind Molberg, Louise Pyndt Diederichsen, Jonas Almlof, Ann-Christine Syvanen, Sergey Kozyrev, Kerstin Lindblad-Toh, Bo Nilsson, Anna M. Blom, Ingrid E. Lundberg, Gunnel Nordmark, Lina Marcela Diaz-Gallo, Elisabet Svenungsson, Lars Ronnblom
Summary: Copy number variation of C4A is associated with the autoimmune repertoire in systemic autoimmune diseases, with a low C4A copy number strongly linked to the presence of autoantibodies. These findings have implications for understanding the mechanisms of autoimmune diseases and patient stratification based on genetic profiles.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Guillermo Ruacho, Ronaldo Lira-Junior, Iva Gunnarsson, Elisabet Svenungsson, Elisabeth A. Bostrom
Summary: This study found that saliva could be a novel alternative body fluid for monitoring general disease activity (DA) in patients with SLE, while urine is more informative for SLE patients with predominantly renal DA.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Rheumatology
Oscar Plunde, Elisabet Svenungsson, Giulia Ferrannini, Anders Franco-Cereceda, Magnus Back
Summary: The study revealed that antiphospholipid antibodies (aPL) are more common in calcific aortic valve stenosis (CAVS) patients in the general population. The positivity of aPL was associated with altered aortic valve transcriptomics related to interferon pathways. Further research is needed to establish aPL as a possible risk marker and/or causal factor for CAVS and to explore new precision therapeutic targets.
Article
Cardiac & Cardiovascular Systems
Giulia Ferrannini, Mariam Almosawi, Kare Buhlin, Ulf De Faire, Barbro Kjellstrom, Bjorn Klinge, Ake Nygren, Per Nasman, Elisabet Svenungsson, Lars Ryden, Anna Norhammar
Summary: In a long-term follow-up study of patients after their first myocardial infarction (MI) compared with matched controls, it was found that there was a higher risk of cardiovascular events in the MI group, while mortality did not differ significantly. The access to high-quality care and cardiac rehabilitation may contribute to the lower rates of adverse outcomes.
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2022)
Article
Rheumatology
Christian Lundtoft, Christopher Sjowall, Solbritt Rantapaa-Dahlqvist, Anders A. Bengtsson, Andreas Jonsen, Pascal Pucholt, Yee Ling Wu, Emeli Lundstrom, Maija-Leena Eloranta, Iva Gunnarsson, Eva Baecklund, Roland Jonsson, Daniel Hammenfors, Helena Forsblad-d'Elia, Per Eriksson, Thomas Mandl, Sara Bucher, Katrine B. Norheim, Svein Joar Auglaend Johnsen, Roald Omdal, Marika Kvarnstrom, Marie Wahren-Herlenius, Lennart Truedsson, Bo Nilsson, Sergey Kozyrev, Matteo Bianchi, Kerstin Lindblad-Toh, Chack-Yung Yu, Gunnel Nordmark, Johanna K. Sandling, Elisabet Svenungsson, Dag Leonard, Lars Ronnblom
Summary: This study reveals that a genetic pattern involving partial deficiencies of C2 and C4A in the classical complement pathway is a strong risk factor for SLE and primary SS, highlighting the central role of the complement system in the pathogenesis of both diseases.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Aliisa Hayry, Francesca Faustini, Agneta Zickert, Anders Larsson, Timothy B. Niewold, Elisabet Svenungsson, Vilija Oke, Iva Gunnarsson
Summary: This study investigated the potential of interleukin (IL) 16 as a biomarker for lupus nephritis (LN). The results showed that IL-16 levels were elevated in active systemic lupus erythematosus (SLE) patients and could differentiate between different subtypes of LN. The study also found that IL-16 was expressed in kidney infiltrating cells. These findings suggest that IL-16 could be used as a diagnostic and therapeutic target for LN.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Oncology
Megan Mulholland, Eva Kritikou, Pernilla Katra, Jan Nilsson, Harry Bjorkbacka, Andrew H. Lichtman, Annabelle Rodriguez, Daniel Engelbertsen
Summary: Loss of LAG3 function promotes T cell activation and accumulation in plaques while not affecting plaque burden. Combination therapy of anti-PD-1 and anti-LAG3 has an additive effect on T cell activation and cytokine production and promotes plaque infiltration of T cells.
JACC: CARDIOONCOLOGY
(2022)
Article
Rheumatology
Linnea Karlsson, Agneta Zickert, Elisabet Svenungsson, Jan Schmidt-Mende, Francesca Faustini, Iva Gunnarsson
Summary: This study retrospectively analyzed the histopathological findings of first-time kidney biopsies in 139 SLE patients. The results showed that 88.5% of the patients had histopathological findings consistent with lupus nephritis, while 11.5% had other renal diseases. These findings highlight the importance of kidney biopsy in diagnosing and managing inflammatory renal diseases.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Lina-Marcela Diaz-Gallo, Vilija Oke, Emeli Lundstrom, Kerstin Elvin, Yee Ling Wu, Susanna Eketjall, Agneta Zickert, Johanna T. Gustafsson, Andreas Jonsen, Dag Leonard, Daniel J. Birmingham, Gunnel Nordmark, Anders A. Bengtsson, Lars Ronnblom, Iva Gunnarsson, Chack-Yung Yu, Leonid Padyukov, Elisabet Svenungsson
Summary: Our study identified four distinct subgroups among patients with SLE based on autoantibody profiles, which differ in associations with HLA-DRB1 alleles and immunological and clinical features, indicating diverse disease pathways.
ACR OPEN RHEUMATOLOGY
(2022)