Article
Multidisciplinary Sciences
Joseph Han, Aneesh Agarwal, Jade N. Young, Shayan Owji, Yen Luu, Dina Poplausky, Daniel Yassky, Yeriel Estrada, Jonathan Ungar, James G. Krueger, Nicholas Gulati
Summary: Immune checkpoint inhibitors (ICIs), such as pembrolizumab, have revolutionized the treatment of advanced melanoma. However, many patients do not respond to ICIs alone, creating a need for additional treatment options. Diphencyprone (DPCP), a topical immunomodulator, has shown clinical use in the treatment of advanced melanoma, particularly in cutaneous metastases. In this study, the authors analyzed proteomic data from a patient treated with pembrolizumab and DPCP, and observed upregulation of checkpoint inhibitor proteins during DPCP monotherapy, downregulation during pembrolizumab monotherapy, and robust upregulation during dual therapy. This suggests potential synergy between DPCP and ICIs in the treatment of cutaneous melanoma metastases.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Agneta Zickert, Klas Lannfelt, Jan Schmidt Mende, Birgitta Sundelin, Iva Gunnarsson
Summary: In patients with MLN, repeat renal biopsies showed increased resorption of immune complexes after RTX treatment, which was associated with clinical response. This phenomenon was not observed in patients treated with conventional therapies, suggesting that evaluation using electron microscopy findings may be useful for assessing treatment response in MLN.
Article
Multidisciplinary Sciences
Jonathan D. Herman, Chuangqi Wang, Carolin Loos, Hyunah Yoon, Johanna Rivera, M. Eugenia Dieterle, Denise Haslwanter, Rohit K. Jangra, Robert H. Bortz, Katharine J. Bar, Boris Julg, Kartik Chandran, Douglas Lauffenburger, Liise-Anne Pirofski, Galit Alter
Summary: The study provides insights into the significant impact of convalescent plasma on modulating humoral responses by focusing on spike/nucleocapsid in recipients.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Marije S. Koks, Gurbey Ocak, Britt B. M. Suelmann, Cornelia A. R. Hulsbergen-Veelken, Saskia Haitjema, Marieke E. Vianen, Marianne C. Verhaar, Karin A. H. Kaasjager, Meriem Khairoun
Summary: This study aimed to investigate the incidence, risk factors, renal outcomes, and mortality of AKI in patients receiving checkpoint inhibitors for cancer treatment. The study found that one third of AKI cases were associated with checkpoint inhibitors, with an overall incidence of 14.2%. Checkpoint inhibitor-associated AKI was mostly low-grade and resulted in persistent renal dysfunction in approximately 40% of patients. Patients with all-cause AKI had a twofold increased mortality risk, but checkpoint inhibitor-associated AKI did not increase mortality.
Article
Emergency Medicine
Kah-Meng Chong, Ching-Yao Yang, Chien-Chin Lin, Wan-Ching Lien
Summary: We report a rare case of severe immune thrombocytopenia in an Asian woman following the administration of the Moderna COVID-19 vaccine. This highlights a potential adverse effect of mRNA-based vaccines in cancer patients receiving immune checkpoint inhibitors.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Cell Biology
Solange Moll, Andrea Angeletti, Leonardo Scapozza, Andrea Cavalli, Gian Marco Ghiggeri, Marco Prunotto
Summary: Macrophages play a crucial role in maintaining tissue homeostasis, inflammation, and tissue repair, particularly within the kidney. Limited research is available on the role of macrophages in human glomerulonephritis, highlighting the need for further study to define their specific role accurately.
Article
Medicine, General & Internal
Yuya Hirasawa, Kiyoshi Yoshimura, Hiroto Matsui, Yutaro Kubota, Hiroo Ishida, Jun Arai, Masashi Sakaki, Nao Oguro, Midori Shida, Makoto Taniguchi, Kazuyuki Hamada, Hirotsugu Ariizumi, Tomoyuki Ishiguro, Ryotaro Ohkuma, Takehiko Sambe, Atsushi Horiike, Chiyo K. Imamura, Eisuke Shiozawa, Satoshi Wada, Junji Tsurutani, Sanju Iwamoto, Naoki Uchida, Yuji Kiuchi, Genshu Tate, Shinichi Kobayashi, Takuya Tsunoda
Summary: This case report describes a severe case of sclerosing cholangitis-like irAE in a patient with Stage IV squamous cell lung carcinoma, who ultimately died from liver failure despite treatment with three immunosuppressive agents. The ineffectiveness of triple immunosuppressant combination therapy highlights the need for more appropriate treatment strategies for severe cases of sclerosing cholangitis-like irAEs based on robust evidence.
Article
Pediatrics
Michael L. Moritz, Juan C. Ayus, Joel B. Nelson
Summary: This study evaluated the occurrence of local infusion reactions associated with 3% NaCl over a 10-year period in a large healthcare system and found no reported cases. This suggests that 3% NaCl can be safely administered through a peripheral IV or central venous catheter.
Article
Biology
Thao Phuong Ho-Le, Thach S. Tran, Dana Bliuc, Hanh M. Pham, Steven A. Frost, Jacqueline R. Center, John A. Eisman, Tuan Nguyen
Summary: This study found that women were more likely to experience refractures, but men had a higher risk of mortality. Post-fracture mortality risk was mainly influenced by gender, age, and bone density. These findings can help facilitate discussions between doctors and patients regarding fracture vulnerability and treatment decisions.
Review
Medicine, General & Internal
Elia Segui, Carles Zamora-Martinez, Tanny Daniela Barreto, Joan Padrosa, Margarita Viladot, Javier Marco-Hernandez
Summary: Immune checkpoint inhibitors have revolutionized cancer treatment but can also lead to immune-related adverse events. It is important for clinicians to learn how to identify and manage these adverse events properly.
Article
Endocrinology & Metabolism
F-P Chen, T-S Fu, Y-C Lin, Y-J Lin
Summary: The study showed that dexamethasone plus acetaminophen was effective in significantly reducing the incidence and severity of acute phase response (APR) following initial zoledronic acid infusion, especially in reducing myalgia, as well as increasing patient adherence for redosing zoledronic acid.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Oncology
Michael Li, Danny Wong, Jordan S. Sack, Alexander S. Vogel, F. Stephen Hodi, Lawrence Fong, Jennifer C. Lai, Shilpa Grover, Stephen D. Zucker
Summary: This study evaluated the impact of gastroenterology/hepatology consultation on the management of severe immune checkpoint inhibitor-induced hepatitis. The findings suggested that early consultation could result in faster resolution of biochemical abnormalities in steroid-refractory hepatitis. This beneficial effect was primarily attributed to earlier initiation of additional immunosuppressive therapy.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Neurosciences
Robert S. Eisinger, Zachary A. Sorrentino, Brandon Lucke-Wold, Sonya Zhou, Brooke Barlow, Brian Hoh, Carolina B. Maciel, Katharina M. Busl
Summary: This retrospective study aimed to investigate the trajectory of post-aSAH headaches and their associations with clinical features. Two distinct headache pain trajectory cohorts were identified, with the moderate-severe pain group being younger, receiving more opioid analgesia, and having lower serum sodium concentrations compared to the mild-moderate pain group.
Article
Oncology
Sunho Park, John D. Karalis, Changjin Hong, Jean R. Clemenceau, Matthew R. Porembka, In -Ho Kim, Sung Hak Lee, Sam C. Wang, Jae-Ho Cheong, Tae Hyun Hwang
Summary: In this study, the association between tumor ACTA2 expression and overall survival (OS) as well as response to immune checkpoint inhibitors (ICI) in gastric cancer patients was investigated. It was found that high ACTA2 expression was associated with worse OS and poorer response to ICI treatment. Additionally, ACTA2 expression in cancer-associated fibroblasts (CAF) was found to be specifically related to ICI response.
CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, General & Internal
Zhaohui Bai, Wentao Xu, Lu Chai, Xiaojie Zheng, Nahum Mendez-Sanchez, Cyriac Abby Philips, Gang Cheng, Xingshun Qi
Summary: Retrospective study suggests that human albumin (HA) infusion can effectively prevent and improve hyponatremia in cirrhotic patients, which may have significant implications for patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
