Article
Chemistry, Applied
Shaofang Ma, Zihan Zhu, Jianfei Xu, Jing Wang, Xinjing Tang, Wei Bian
Summary: Novel green-emitting fluorescent carbon dots (CDs) were successfully designed and synthesized through cross amide formation of two precursors under hydrothermal treatment. The obtained CDs exhibited good photoluminescent properties with a high quantum yield. They also demonstrated good fluorescence sensitivity and selectivity for Hg2+, making them applicable for Hg2+ detection in real water samples and intracellular Hg2+ fluorescence detection.
Article
Chemistry, Analytical
Hao Guo, Xiaoqiong Wang, Ning Wu, Mengni Xu, Mingyue Wang, Longwen Zhang, Wu Yang
Summary: A novel dual-emission ratiometric fluorescent sensor (CDs@Eu-MOFs) was successfully synthesized for the detection of Hg2+ in environmental water samples, with wide linear range and low detection limit. The sensor showed excellent luminescence performance and good stability in aqueous solution.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Farid Ahmed, Shahzad Iqbal, Long Zhao, Hai Xiong
Summary: The study developed a fluorescence sensor based on N,S-CDs for selective detection of mercury ions and guanine, which can be successfully applied for the detection of mercury ions in water samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Spectroscopy
Dan Chang, Zhonghua Zhao, Wenjing Niu, Lihong Shi, Yongxing Yang
Summary: This study introduces an eco-friendly synthesis method for carbon dots and a label-free sensing platform for ultrasensitive Fe3+ recognition. The CDs prepared through hydrothermal strategy exhibit exceptional stability and biocompatibility, making them suitable for multicolour imaging applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Bin Wang, Xiao-Qin Zhou, Jun-Ming Lin, Shu-Yu Liu, Cong-Hua Lu, Li-Juan Liu, Yu Chen, Li-Ping Yu
Summary: The study synthesized HPEI-CDs with concentration-modulated dual-excitation fluorescence property and successfully detected Fe3+ using them as a ratiometric sensor, demonstrating a wide linear response concentration range and low detection limit. The sensor showed good selectivity and anti-interference capacity due to the high concentration of HPEI-CDs.
MICROCHEMICAL JOURNAL
(2021)
Article
Spectroscopy
Linlin Wang, Jayasmita Jana, Jin Suk Chung, Won Mook Choi, Seung Hyun Hur
Summary: Low-cost nitrogen and boron-doped carbon nanodots (CPAP-CDs) with high quantum yield were synthesized through a facile hydrothermal treatment. These CPAP-CDs showed wide absorption, strong fluorescence, and pH-dependent behavior, making them suitable for detecting nitrite ions. The method had a low detection limit, wide linear detection range, and was successfully applied to different water samples testing.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Biochemistry & Molecular Biology
Saman Sargazi, Iqra Fatima, Maria Hassan Kiani, Vahideh Mohammadzadeh, Rabia Arshad, Muhammad Bilal, Abbas Rahdar, Ana M. Diez-Pascual, Razieh Behzadmehr
Summary: Fluorescent-based bioprobes have unique attributes that make them suitable for creating highly sensitive nano-biosensors for detecting various biological and chemical agents. These sensors are superior to other analytical instrumentation techniques in terms of being biodegradable, eco-friendly, and more economical and cost-effective. This paper provides a comprehensive overview of the electrochemical sensors that use nanomaterials to detect biological macromolecules based on fluorescent emission spectra.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemical Research Methods
Maolin Wu, Nan Wang, Zihan Lin, Xingguang Su
Summary: A simple and rapid ratiometric fluorescent sensing system for determining D-penicillamine has been developed using yellow carbon dots and thiochrome combination. The system showed a good linear response and acceptable results in real sample testing.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Qingxiang Zhou, Yongli Liu, Yalin Wu, Zhi Li, Yanhui Li, Menghua Liu, Tongxu Qu, Chunmao Chen
Summary: This study developed a fluorescent chemoprobe using carbon dots and silver nanoparticles to monitor mercury ions, showing high sensitivity and good recoveries. The data indicated that the fluorescent chemoprobe was sensitive, selective, stable, and reliable, providing a new tool for mercury detection in aqueous samples.
Article
Chemistry, Applied
Ruyan Xie, Yaoyao Qu, Mingyu Tang, Jingqiang Zhao, Sophie Chua, Tingting Li, Fang Zhang, Andrew E. H. Wheatley, Fang Chai
Summary: A unique fluorescent carbon dot-magnetic nanocomposite (Fe3O4/CDs) was prepared for sensitive detection of Hg2+, showing higher selectivity and sensitivity with a detectable limit of 0.3 nM. The emission quenched by Hg2+ could be restored in the presence of saturated EDTA solution. The Fe3O4/CDs also demonstrated effective removal of Hg2+ from samples, making it a promising probe in environmental monitoring.
Article
Spectroscopy
Guiqiao Wang, Shurong Zhang, Jinzhi Cui, Wensu Gao, Xing Rong, Yaxin Lu, Canzhu Gao
Summary: A fluorescent signal-closing probe based on nitrogen-doped carbon quantum dots (NCQDs) was developed for quantitative detection of mercury ions (Hg2+). The NCQDs showed high selectivity and excellent anti-interference ability, and the detection system had a linear relationship between fluorescence quenching efficiency and Hg2+ concentration. The detection limit was 0.9 μM.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Qiren Tan, Xiaoying Li, Lumei Wang, Jie Zhao, Qinyan Yang, Peng Sun, Yun Deng, Guoqing Shen
Summary: A rapid, simple, and sensitive parallel detection method for Cd2+ and Hg2+ using carbon dots as fluorescent sensors was developed in this study. The method showed good selectivity and detection limits for Cd2+ and Hg2+, and has been successfully applied in fruits and vegetables.
FRONTIERS IN CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Changfang Lu, Hao Ding, Yutong Wang, Chaoying Xiong, Xianxiang Wang
Summary: A colorimetric and turn-on fluorometric assay with high sensitivity and selectivity for detecting mercury (II) ions was developed. The method involves the use of carbon dots with -SH and gold nanoparticles, and was successfully applied for determination of Hg2+ in real water samples.
Article
Chemistry, Analytical
Yi Cai, Jing Zhang, Min Zhang, Minghao Wang, Yong Zhao
Summary: Carbon quantum dots (CQDs) have great potential as fluorescent probes for metal ions sensing. A sensing platform based on CQDs and optical fiber has been developed for online detection in narrow spaces. The platform can be assembled quickly by in-situ polymerization, without the need for any mold. It has a small size and light weight, making it suitable for field applications. The platform has been successfully tested for the detection of ferric ions, with quantitative analysis capabilities and a quick response time.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Environmental
Dan Wang, Li-Jie Zhang, Ming-Hui Liu, Fang-Fang Du, Ze-Ya Shen, Longwei He, Li-Li Wang
Summary: A rhodamine-functionalized carbon dots (o -CDs-Rho) was synthesized and used for sensing UO22+ through an aggregation-enhanced FRET strategy. The weak FRET efficiency (16.2%) of o-CDs-Rho in dispersed solution is significantly enhanced (>77.2%) after UO22+ triggered aggregation. This is the first ratiometric fluorescence sensor with an inverse change of fluorescence intensity at dual emission wavelengths under single-wavelength excitation for UO22+.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).