Article
Chemistry, Organic
Logan Mikesell, Dhananjani N. A. M. Eriyagama, Yipeng Yin, Bao-Yuan Lu, Shiyue Fang
Summary: The traditional synthesis of monodisperse polyethylene glycols (PEGs) involves the use of an acid-labile protecting group and multiple steps in two pots, while the new synthesis method utilizes a base-labile protecting group and reactions in only one pot, simplifying the process significantly and lowering synthesis costs.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Davide Ceradini, Kirill Shubin
Summary: For the first time, yttrium triflate was utilized as a green catalyst in the synthesis of alpha-aminophosphonates through a one-pot three-component Birum-Oleksyszyn reaction, enhancing the yield and reaction chemoselectivity by achieving a proper balance in the complex network of reactions.
Article
Chemistry, Organic
Rezvan Kardooni, Ali Reza Kiasat
Summary: This method involves a catalyst-free, cost-effective and environmentally friendly protocol for the synthesis of 3-substituted indoles through a multicomponent condensation reaction in polyethylene glycol 400 (PEG-400) as a reaction medium and promoter, with a key feature being the selectivity in forming heterodimer products over homodimer adducts.
POLYCYCLIC AROMATIC COMPOUNDS
(2021)
Article
Chemistry, Multidisciplinary
Seiji Ogo, Takeshi Yatabe, Tamon Tome, Riko Takenaka, Yoshihito Shiota, Kenji Kato
Summary: This paper reports a method for the synthesis of H2O2 using a homogeneous catalyst in water, using only H2 and O2 without flammable mixtures or cocatalysts. The catalyst can remove electrons from H2, store them for the reduction of O2, and allow the protonation of the reduced oxygen to form H2O2. The turnover number (TON) is 910 under an H2/O2 (95/5) atmosphere (1.9 MPa) for 12 hours at 23 degrees C, which is the highest among any homogeneous catalysts. Furthermore, a reaction mechanism based on two crystal structures is proposed.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Seiji Ogo, Takeshi Yatabe, Tamon Tome, Riko Takenaka, Yoshihito Shiota, Kenji Kato
Summary: In this study, a homogeneous catalyst is used to synthesize hydrogen peroxide using H2 and O2 in water, eliminating the need for flammable H2/O2 mixtures and cocatalysts. The catalyst is capable of extracting electrons from H2, storing them for the reduction of O2, and then converting the reduced oxygen to H2O2. The catalyst exhibits the highest turnover number (TON) among all homogeneous catalysts.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Balasingh Thangadurai Jebaslinhepzybai, Thamodaran Partheeban, Deepak S. Gavali, Ranjit Thapa, Manickam Sasidharan
Summary: A facile one-pot ethyleneglycol-mediated solvothermal synthesis of orthorhombic Co2P with particle size around 20-30 nm was reported as an efficient catalyst for both HER and OER. Co2P showed low overpotentials and long-term stability in acidic and alkaline medium for HER, as well as an overpotential of 364 mV at 10 mA cm(-2) current density for OER. XPS analysis confirmed the formation of amorphous cobalt oxyhydroxide (CoOOH) as an intermediate during the OER process.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Pharmacology & Pharmacy
Akos Kuki, Mahir Hashimov, Tibor Nagy, Csaba Toth, Miklos Zsuga, Sandor Keki
Summary: A novel methodology using MALDI-MS was developed to quantitate PEG 400 excretion in human urine. The method was successfully applied to a large-scale study involving nearly two hundred volunteers, revealing a difference in intestinal permeability between men and women.
Article
Chemistry, Multidisciplinary
Isobel M. Wilson, Sandeep K. Padamati, Antonia D. Bobitan, Michael J. Porter, Katherine B. Holt
Summary: Carbon surfaces (glassy carbon, graphite, and boron-doped diamond) were functionalized with layers composed of linked pyridinium and pyridine moieties using simple electrochemical reduction of trifluoroacetylpyridinium. The functionalization process allows for rapid screening of surface properties and presents a means to test the specific catalytic performance of pyridinic groups toward key processes such as oxygen and CO2 reduction.
Article
Polymer Science
Shang-Lin Yeh, Piyush Deval, Wei-Bor Tsai
Summary: In this study, a simple and universal technique using pyrogallol-assisted immobilization of poly(ethylene glycol) (PEG) was introduced to deposit a thin antifouling layer on biomaterials. By controlling the amounts of PG and PEG and the coating time, the PG/PEG coating was able to reduce more than 99% of cell adhesion and protein adsorption, while providing a transparent and robust coating that can survive sterilization conditions. This technique has great potential for applications in transparent antifouling coatings for biomedical devices.
Article
Chemistry, Organic
Lucas Wolf, Joao C. P. Mayer, Natalia Quoos, Andre C. Sauer, Ricardo S. Schwab, Oscar E. D. Rodrigues, Luciano Dornelles
Summary: A series of sulfur- and selenium-bearing, amino acid-derived 1,2,4-oxadiazoles were successfully synthesized by a simple method. The results demonstrated that this approach is fast, easy to perform, and effective in obtaining the desired compounds with good functional group tolerance, potentially enabling future applications in organic synthesis.
Article
Biochemistry & Molecular Biology
Aroa Duro-Castano, Laura Rodriguez-Arco, Lorena Ruiz-Perez, Cesare De Pace, Gabriele Marchello, Carlos Noble-Jesus, Giuseppe Battaglia
Summary: This study presents a one-pot synthesis method for oxidation-sensitive supramolecular micelles and vesicles, utilizing polymerization-induced self-assembly to form various nanoscale structures under specific conditions. The obtained vesicles and wormlike micelles demonstrated degradation under controlled oxidant conditions, expanding their potential applications in drug release and cellular scaffolding in tissue engineering.
Article
Chemistry, Applied
Akshay R. Mankar, Arindam Modak, K. K. Pant
Summary: The catalytic valorization of biomass, particularly cellulose, has attracted significant attention globally. By using heteropolyacid/zirconia and Ru/C catalyst, a one-pot conversion of cellulose was achieved with high selectivity towards hexitols and ethylene glycol. Pre-treatment of cellulose with ball-milling showed improved catalytic performance, leading to almost complete conversion of cellulose and high yields of hexitols and ethylene glycol.
FUEL PROCESSING TECHNOLOGY
(2021)
Article
Chemistry, Applied
Bahareh Abtahi, Hossein Tavakol
Summary: An environmentally friendly method using CuI catalyst was developed for the synthesis of various benzofuran derivatives, with a one-pot, 3-component reaction in a specific deep eutectic solvent. The method showed easy workup and high yields, preparing 12 different derivatives in 7 hours at 80 degrees C.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Vishal Suresh Kudale, Mohana Reddy Mutra, Ching-Piao Chu, Jeh-Jeng Wang
Summary: The study outlines a process in which PEG-400 is converted into acetyl radicals through aerobic oxidative tandem conversion, followed by silver-catalyzed addition to the C-3 position of quinoxalin-2(1H)-one. This environmentally-friendly protocol utilizes PEG-400 as the acetyl source and solvent, allowing for a broad range of electron-deficient quinoxalin-2(1H)-one compounds to be coupled with in situ generated acetyl radicals in a menisci-type reaction.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Physical
Bin Zou, Fei Gao, Huaming You, Zhuolin Li, Yangping Zhang, Zhengying Wu, Tongxin Song, Yukou Du
Summary: The recent focus has been on the excellent electrocatalytic performance of two-dimensional metal nanosheets in direct alcohol fuel cells. PdRu nanosheets were successfully synthesized using a one-pot method, exhibiting superior electrocatalytic activity. PdRu NSs showed significantly higher mass activity in ethylene glycol and glycerol oxidation reactions compared to other catalysts.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Medicinal
Chandrakant D. Pawar, Aniket P. Sarkate, Kshipra S. Karnik, Sushilkumar S. Bahekar, Dattatraya N. Pansare, Rohini N. Shelke, Chetan S. Jawale, Devanand B. Shinde
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2016)
Article
Chemistry, Multidisciplinary
Vidya S. Dofe, Aniket P. Sarkate, Deepak K. Lokwani, Santosh H. Kathwate, Charansingh H. Gill
RESEARCH ON CHEMICAL INTERMEDIATES
(2017)
Article
Chemistry, Organic
William Doherty, Nikoletta Adler, Andrew Knox, Derek Nolan, Joanna McGouran, Anna Pratima Nikalje, Deepak Lokwani, Aniket Sarkate, Paul Evans
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Chemistry, Organic
Vidya S. Dofe, Aniket P. Sarkate, Zarina M. Shaikh, Charansingh H. Gill
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Shailee V. Tiwari, Sumaiya Siddiqui, Julio A. Seijas, M. Pilar Vazquez-Tato, Aniket P. Sarkate, Deepak K. Lokwani, Anna Pratima G. Nikalje
Article
Chemistry, Multidisciplinary
Santosh A. Jadhav, Aniket P. Sarkate, Anil V. Raut, D. B. Shinde
RESEARCH ON CHEMICAL INTERMEDIATES
(2017)
Article
Chemistry, Multidisciplinary
Vidya S. Dofe, Aniket P. Sarkate, Rajaram Azad, Charansingh H. Gill
RESEARCH ON CHEMICAL INTERMEDIATES
(2017)
Article
Chemistry, Organic
Santosh A. Jadhav, Aniket P. Sarkate, Mahesh G. Shioorkar, Devanand B. Shinde
SYNTHETIC COMMUNICATIONS
(2017)
Article
Chemistry, Organic
Sanjeev R. Patil, Aniket P. Sarkate, Kshipra S. Karnik, Ashish Arsondkar, Vrushali Patil, Jaiprakash N. Sangshetti, Anil S. Bobade, Devanand B. Shinde
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Rohini N. Shelke, Dattatraya N. Pansare, Aniket P. Sarkate, Kshipra S. Karnik, Ajinkya P. Sarkate, Devanand B. Shinde, Shankar R. Thopate
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
(2019)
Article
Chemistry, Medicinal
Vaibhav V. V. Raut, Shashikant V. V. Bhandari, Shital M. M. Patil, Aniket P. P. Sarkate
Summary: Novel oxadiazole-isatin pharmacophore-containing molecules were designed and their structural requirements related to anticancer activity were explored using molecular modeling studies. Docking studies revealed promising results, showing that Compound 5 had the best fit to the active site pocket of the enzyme. The newly designed compounds showed drug-like pharmacokinetic properties.
LETTERS IN DRUG DESIGN & DISCOVERY
(2023)
Review
Chemistry, Organic
Shashikant Vasantarao Bhandari, Pranali Kuthe, Shital Manoj Patil, Om Nagras, Aniket Pardip Sarkate
Summary: Cancer is a major global cause of death and can be treated with naturally occurring Curcumin nuclei that have anti-inflammatory and anti-cancer properties. However, Curcumin has limitations such as instability at physiological pH and weak pharmacokinetic profile due to the β-diketone moiety present in it. To overcome this, researchers have focused on mono-ketone moieties in curcumin, known as mono-carbonyl curcumin.
CURRENT ORGANIC SYNTHESIS
(2023)
Article
Biochemistry & Molecular Biology
Shashikant V. Bhandari, Pranali V. Kuthe, Shital M. Patil, Om G. Nagras, Aniket P. Sarkate, Somdatta Y. Chaudhari, Sandip V. Surve
Summary: This study aimed to design new mono-carbonyl curcumin derivatives and analyze their drug likeness properties. Through research on three distinct EGFR crystal structures, it was found that NME 1 and NME 2 had better binding affinity to wild-type EGFR, while NME 3 showed comparable binding and more stability against the L858R/T790M/C797S mutated protein structure.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Medicinal
Vidya S. Dofe, Aniket P. Sarkate, Shailee Tiwari, Deepak K. Lokwani, Kshipra S. Karnik, Ishwari A. Kale, Suneel Dodamani, Sunil S. Jalalpure, Prasad V. L. S. Burra
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Organic
Dilek Isik Tasgin, Irem Bayraktar
Summary: We present a synthetic method for pyrrolizine-3-one derivatives and investigate their photophysical properties. These compounds are prepared through a series of reactions involving substituted pyrroles in one-pot, two-step oxidation, and intramolecular cyclization processes. The photophysical properties of the synthesized compounds are studied using UV-Vis and fluorescence spectroscopy in various solvents. The introduction of pyrrolyl substituents has a significant impact on Stokes shifts and quantum yield values.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Satish Kumar Burra, Vaikunta Rao Lakinani, Raghunadh Akula, Chiranjeevi Yankkanti
Summary: A novel and green strategy for the construction of biologically relevant substituted indolyl-4H-chromenes scaffolds is reported, using L-proline as a catalyst and water as a promoter solvent. This catalytic system offers wider applicability, shorter reaction times, and high yields, making it an ideal condition for green chemistry.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif, Hamid Sdassi
Summary: Nitrobenzimidazoles have become increasingly important in the design of new compounds in medicinal, therapeutic and chemical fields. This review provides an overview of the synthesis strategies and biological activities of nitrobenzimidazole derivatives.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Nilesh Raghunath Khedkar, Alex Joseph, Milind Sindkhedkar
Summary: In this study, a new library of 3-(2-(pyrimidin-5-yl)thiazol-4-yl)-1,2,4-oxadiazole compounds was designed and synthesized as potential anticancer agents using in silico fragment-based drug design. The compounds were tested for their anticancer activity in vitro, and one compound exhibited excellent activity against multiple cancer cell lines.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Terungwa H. Iorkula, Bryce A. Tolman, Scott R. Burt, Matt A. Peterson
Summary: A new method for synthesizing C-6 substituted products has been discovered in this study, which utilizes lower doses of fluoride and CsF as a catalyst, with high reaction yields and cost-effectiveness under suitable conditions.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Ranjana Aggarwal, Swati Sharma
Summary: This review article mainly focuses on the synthesis of 3(5)-trifluoromethylpyrazoles via condensation reaction of trifluoromethyl-beta-diketones with hydrazines. It emphasizes the importance of fluorine-containing compounds and pyrazoles in the field of biology. The literature reported condensation reactions of trifluoromethyl-beta-diketones with hydrazines are covered.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
F. M. Alshareef, Sami A. Al-Harbi, Esam S. Allehyani, Omeima Abdullah, Magdy A. Ibrahim
Summary: This study aimed to construct a novel category of linear annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines. The chemical reactivity of the synthesized compounds was investigated, and they showed significant antimicrobial activity against various strains.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Preethi Dhanapal, S. L. Manju
Summary: Thiazole based Schiff base scaffolds have become an integral part of drug development in recent years, playing a versatile role as building blocks for lead drug molecules. This study presents a facile one pot synthetic method for producing novel 4-aryl thiazoles with high yield, shorter reaction time, and milder conditions, without the need for catalysts or purification techniques.
SYNTHETIC COMMUNICATIONS
(2024)
