Journal
SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY
Volume 46, Issue 10, Pages 1532-1540Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15533174.2015.1137012
Keywords
chitosan/alginate; nanoparticles; cisplatin; drug delivery system
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The major aim of this study was to design chitosan/alginate nanoparticles as swelling controlled drug release system for anticancer drugs. The prepared nanoparticles were characterized by FTIR and transmission electron microscopy analysis and their biocompatibility and in vitro cytotoxicity were evaluated. The nanoparticles were loaded with widely used anticancer drug, cisplatin, and controlled release of drug was investigated to observe the effects of various parameters such as percent loading of the drug, pH, temperature, and nature of release media on the release profiles. The release of cisplatin was also studied in various simulated biological fluids.
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