Journal
SYNLETT
Volume 27, Issue 7, Pages 1027-1040Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0035-1561954
Keywords
phosphoric acids; non-covalent catalysis; heterodimeric self-assembly; carboxylic acids; enol catalysis; branched ketones
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Funding
- Max-Planck-Society
- European Research Council
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Chiral phosphoric acid diesters arguably constitute the most exploited class of catalysts in asymmetric BrOnsted acid catalysis. Despite being highly investigated for their acidic properties, these compounds display an amphoteric nature, which has instead been considerably overlooked. The potential of this dichotomous polarity has recently been disclosed and applied to the development of novel reaction modes in organocatalysis. In this account, we present our recent advances in this area, focusing on the establishment of heterodimeric interactions toward the nucleophilic activation of carboxylic acids, thiocarboxylic acids and ketones (via their enols) in asymmetric transformations. 1Introduction 2Discovery of Heterodimeric Self-Assemblies 3Activation of Carboxylic Acids 3.1The Enantioselective Carboxylysis of Aziridines 3.2An Asymmetric Hydrolysis of Epoxides 4Activation of Thiocarboxylic Acids 5Enol Catalysis 5.1Asymmetric Michael Addition 5.2Asymmetric -Amination 5.3Asymmetric -Allylation 6Concluding Remarks
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