Article
Surgery
Kazuto Harada, Hyunsoo Hwang, Xuemei Wang, Ahmed Abdelhakeem, Masaaki Iwatsuki, Mariela A. Blum Murphy, Dipen M. Maru, Brian Weston, Jeffrey H. Lee, Jane E. Rogers, Irene Thomas, Namita Shanbhag, Meina Zhao, Manoop S. Bhutani, Quynh-Nhu Nguyen, Stephen G. Swisher, Naruhiko Ikoma, Brian D. Badgwell, Wayne L. Hofstetter, Jaffer A. Ajani
Summary: The study evaluated the frequency of paratracheal lymph node metastases and their prognostic impact on resectable esophageal or gastroesophageal junction adenocarcinoma patients. Results indicated that paratracheal LN metastases were associated with a shorter survival, suggesting the need for alternate approaches to prolong survival in this patient group.
Article
Surgery
Vignesh Raman, Oliver K. Jawitz, Norma E. Farrow, Soraya L. Voigt, Kristen E. Rhodin, Chi-Fu J. Yang, Megan C. Turner, Thomas A. D'Amico, David H. Harpole, Betty C. Tong
Summary: In this study of patients with upfront, complete resection of node-positive esophageal adenocarcinoma, adjuvant chemotherapy was associated with improved survival for LNR >=12%. LNR may be used as an adjunct in decision-making about adjuvant therapies in this patient population.
Article
Gastroenterology & Hepatology
Annieke W. Gotink, Steffi E. M. van de Ven, Fiebo J. C. ten Kate, Daan Nieboer, Lucia Suzuki, Bas L. A. M. Weusten, Lodewijk A. A. Brosens, Richard van Hillegersberg, Lorenza Alvarez Herrero, Cees A. Seldenrijk, Alaa Alkhalaf, Freek C. P. Moll, Erik J. Schoon, Ineke van Lijnschoten, Thjon J. Tang, Hans van Der Valk, Wouter B. Nagengast, Gursah Kats-Ugurlu, John T. M. Plukker, Martin H. M. G. Houben, Jaap S. van Der Laan, Roos E. Pouw, Jacques J. G. H. M. Bergman, Sybren L. Meijer, Mark I. van Berge Henegouwen, Bas P. L. Wijnhoven, Pieter Jan F. de Jonge, Michael Doukas, Marco J. Bruno, Katharina Biermann, Arjun D. Koch
Summary: This study focused on predicting the risk of lymph node metastasis in patients with pT1b EAC after endoscopic resection or surgery. Factors like submucosal invasion depth, tumor size, and lymphovascular invasion were found to be associated with an increased risk of metastases. The developed prediction model demonstrated good discriminative ability in estimating the probability of post-resection metastases.
Article
Cardiac & Cardiovascular Systems
Lieven Depypere, Gert De Hertogh, Johnny Moons, An-Lies Provoost, Toni Lerut, Xavier Sagaert, Willy Coosemans, Hans Van Veer, Philippe Nafteux
Summary: In cN+ esophageal adenocarcinoma patients treated with nCRT, those with ypN0 and no signs of lymph node response (LNR) have a tripled median overall survival compared to those with LNR, and their survival is comparable to cN+/pN0 upfront esophagectomy patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Kieran Foley, David Shorthouse, Eric Rahrmann, Lizhe Zhuang, Ginny Devonshire, Rebecca C. OCCAMS Consortium, Rebecca C. Fitzgerald, Benjamin A. Hall
Summary: Metastasis in oesophageal adenocarcinoma (OAC) is a crucial factor affecting survival. Radiological staging is commonly used to assess metastases, but its accuracy is limited. This study analyzed lymph node metastases and identified new roles of genes SMAD4 and KCNQ3 in metastasis. The findings suggest that both genes could serve as novel biomarkers for metastatic risk and offer potential new targets for drug treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Gastroenterology & Hepatology
Nicolas Benech, Marc O'Brien, Maximilien Barret, Jeremie Jacques, Gabriel Rahmi, Guillaume Perrod, Valerie Hervieu, Alexandre Jaouen, Aurelie Charissoux, Olivier Guillaud, Romain Legros, Thomas Walter, Jean-Christophe Saurin, Jerome Rivory, Frederic Prat, Vincent Lepilliez, Thierry Ponchon, Mathieu Pioche
Summary: This study found that for superficial oesophageal adenocarcinomas, there were no lymph node metastases even with high-risk histological features after endoscopic resection; only submucosal tumours with lymphovascular invasion or poorly differentiated cancer or with a depth of invasion >1000 μm were associated with lymph node metastasis.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Steffi E. M. van de Ven, Lucia Suzuki, Annieke W. Gotink, Fiebo J. C. ten Kate, Daan Nieboer, Bas L. A. M. Weusten, Lodewijk A. A. Brosens, Richard van Hillegersberg, Lorenza Alvarez Herrero, Cees A. Seldenrijk, Alaa Alkhalaf, Freek C. P. Moll, Wouter Curvers, Ineke G. van Lijnschoten, Thjon J. Tang, Hans van der Valk, Wouter B. Nagengast, Gursah Kats-Ugurlu, John T. M. Plukker, Martin H. M. G. Houben, Jaap S. van der Laan, Roos E. Pouw, Jacques J. G. H. M. Bergman, Sybren L. Meijer, Mark I. van Berge Henegouwen, Bas P. L. Wijnhoven, Pieter J. F. de Jonge, Michael Doukas, Marco J. Bruno, Katharina Biermann, Arjun D. Koch
Summary: This study aimed to quantify lymphovascular invasion (LVI) in patients with pT1b esophageal adenocarcinoma to assess its prognostic value. The risk of metastases increased with a higher number of LVI foci. A prediction model with good discriminative ability was developed but requires external validation before clinical implementation.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Oncology
Seong Yong Park, Junghee Lee, Yeong Jeong Jeon, Jong Ho Cho, Hong Kwan Kim, Yong Soo Choi, Jae Il Zo, Young Mog Shim
Summary: The presence of supraclavicular lymph node metastasis did not significantly impact the overall survival of esophageal squamous cell carcinoma patients who underwent 3-field lymph node dissection, regardless of clinical suspicion or pathologic confirmation.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
James Wyatt, Simon G. Powell, Salma Ahmed, James Arthur, Kiran Altaf, Shakil Ahmed, Muhammad Ahsan Javed
Summary: Inguinal lymph nodes are a rare but recognized site of metastasis in rectal adenocarcinoma. This review aims to provide a contemporary and comprehensive analysis of the published literature to aid clinical decision-making.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Oncology
Jonathan L. Moore, Michael Green, Aida Santaolalla, Harriet Deere, Richard P. T. Evans, Mona Elshafie, Anita Lavery, Damian T. McManus, Andrew McGuigan, Rosalie Douglas, Joanne Horne, Robert Walker, Hira Mir, Monica Terlizzo, Sivesh K. Kamarajah, Mieke Van Hemelrijck, Nick Maisey, Ailsa Sita-Lumsden, Sarah Ngan, Mark Kelly, Cara R. Baker, Sacheen Kumar, Jesper Lagergren, William H. Allum, James A. Gossage, Ewen A. Griffiths, Heike I. Grabsch, Richard C. Turkington, Tim J. Underwood, Elizabeth C. Smyth, Rebecca C. Fitzgerald, David Cunningham, Andrew R. Davies
Summary: This study aimed to evaluate the influence of lymph node (LN) regression on survival after surgery for esophageal adenocarcinoma. The results showed that patients with complete LN regression, partial LN regression, or negative LNs had a lower mortality rate compared to those with poor/no LN regression.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Iam Palatnik de Sousa, Marley M. B. R. Vellasco, Eduardo Costa da Silva
Summary: This study presents a novel evolutionary approach for Explainable Artificial Intelligence, combining Local Interpretable Model Agnostic Explanations (LIME) with Multi-Objective Genetic Algorithms. The results show that this methodology can find high quality explanations and has the advantage of automated parameter fine tuning.
Article
Gastroenterology & Hepatology
Harunobu Sato, Kotaro Maeda, Yusuke Kinugasa, Hiroyasu Kagawa, Shunsuke Tsukamoto, Keiichi Takahashi, Hiroaki Nozawa, Yasumasa Takii, Tsuyoshi Konishi, Yoshito Akagi, Takeshi Suto, Shigeki Yamaguchi, Heita Ozawa, Koji Komori, Masayuki Ohue, Junichiro Hiro, Seiichi Shinji, Kazuhito Minami, Tomoharu Shimizu, Kazuhiro Sakamoto, Kay Uehara, Hiroshi Takahashi, Kenichi Sugihara
Summary: This study aimed to investigate the surgical treatment and management of inguinal lymph node metastases secondary to rectal and anal canal adenocarcinoma. The results showed that differentiated carcinoma, solitary lymph node metastasis, and lymph node dissection were independent predictive factors associated with a favourable prognosis. There was no significant difference in the frequency of recurrence between patients with synchronous and metachronous lymph node metastases. Aggressive lymph node dissection could improve the prognosis of low rectal and anal canal adenocarcinoma with lymph node metastases.
COLORECTAL DISEASE
(2022)
Article
Surgery
Rosemary Nustas, Ahmed A. Messallam, Theresa Gillespie, Steven Keilin, Saurabh Chawla, Vaishali Patel, Qiang Cai, Field F. Willingham
Summary: In a large national cohort in the US, factors such as lymphovascular invasion, high-grade histology, T stage, and tumor size were independently associated with lymph node metastasis in early gastric adenocarcinoma. Patients with low-grade tumors, smaller than 3 cm, and without lymphovascular invasion had a very low risk of nodal involvement, suggesting they may be considered for endoscopic resection.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Bian, Zhilin Zheng, Xu Fang, Hui Jiang, Mengmeng Zhu, Jieyu Yu, Haiyan Zhao, Ling Zhang, Jiawen Yao, Le Lu, Jianping Lu, Chengwei Shao
Summary: In this study, an automated preoperative artificial intelligence algorithm was developed and validated for the segmentation of tumor and lymph nodes in patients with pancreatic ductal adenocarcinoma (PDAC) using CT imaging. The performance of the algorithm was compared to radiologists and clinical models, and it was found that the AI model outperformed the other models in predicting lymph node metastasis. The AI model-predicted positive LN metastasis was also associated with worse survival.
Article
Obstetrics & Gynecology
Tanja Ignatov, Johannes Gassner, Mihaela Bozukova, Stylianos Ivros, Jozsef Meszaros, Olaf Ortmann, Holm Eggemann, Atanas Ignatov
Summary: The risk of contralateral non-SLN metastases in patients with unilateral SLN metastases in vulvar cancer is low, suggesting a need for further investigation into the impact of contralateral lymphadenectomy on patient survival.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Surgery
Anouk Overwater, Bas L. A. M. Weusten, Jelle P. Ruurda, Richard van Hillegersberg, Roel J. Bennink, Bart de Keizer, Sybren L. Meijer, Lodewijk A. A. Brosens, Roos E. Pouw, Jacques J. G. H. M. Bergman, Mark I. van Berge Henegouwen, Suzanne S. Gisbertz
Summary: This study evaluated the feasibility and safety of SNNS using a hybrid tracer in patients with high-risk T1b EAC, showing that all patients could identify and resect SNs, with high concordance between preoperative and intraoperative detection. Indocyanine green fluorescence appears to be valuable for detecting peritumoral SNs.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Esther A. Nieuwenhuis, Sanne N. van Munster, Wouter L. Curvers, Bas L. A. M. Weusten, Lorenza Alvarez Herrero, Auke Bogte, Alaa Alkhalaf, B. Ed Schenk, Arjun D. Koch, Manon C. W. Spaander, Thjon J. Tang, Wouter B. Nagengast, Jessie Westerhof, Martin H. M. G. Houben, Jacques J. G. H. M. Bergman, Erik J. Schoon, Roos E. Pouw
Summary: One quarter of patients with confirmed low grade dysplasia (LGD) in Barrett's esophagus (BE) diagnosed in a community hospital had high grade dysplasia (HGD) or cancer after re-staging at an expert center. Referral of patients with confirmed LGD, even without visible lesions, for re-staging endoscopy at an expert center is necessary.
Article
Gastroenterology & Hepatology
Sanne N. van Munster, Eva P. D. Verheij, Esther A. Nieuwenhuis, Johan G. J. A. Offerhaus, Sybren L. Meijer, Lodewijk A. A. Brosens, Bas L. A. M. Weusten, Alaa Alkhalaf, Ed B. E. Schenk, Erik J. Schoon, Wouter L. Curvers, Laurelle van Tilburg, Steffi E. M. van de Ven, Thjon J. Tang, Wouter B. Nagengast, Martin H. M. G. Houben, Kees C. A. Seldenrijk, Jacques J. G. H. M. Bergman, Arjun D. Koch, Roos E. Pouw
Summary: ESD allows safe removal of BE neoplasia, with a 97% en bloc resection rate. 87% of HGD or T1a EAC lesions achieved both en bloc and R0 resections, while the corresponding value for T1b EAC lesions was 49%. 29% of R1 resections showed residual cancer, but only one third of them had persisting neoplasia at follow-up.
Article
Oncology
Sofie P. G. Henckens, Eliza R. C. Hagens, Mark I. van Berge Henegouwen, Sybren L. Meijer, Wietse J. Eshuis, Suzanne S. Gisbertz
Summary: This study investigates the impact of lymph node yield after transthoracic esophagectomy on lymph node metastasis, complications, and survival in patients with esophageal adenocarcinoma. The results demonstrate that a lymph node yield of 31 or higher is associated with an increased number of positive lymph nodes, improved disease-free survival, and overall survival, without increasing morbidity.
Article
Gastroenterology & Hepatology
Anouk Overwater, Sjoerd G. Elias, Erik J. Schoon, Jacques J. G. H. M. Bergman, Roos E. Pouw, Bas L. A. M. Weusten
Summary: This study aimed to describe the course of pain and dysphagia after radiofrequency ablation (RFA) treatment for Barrett's esophagus (BE) neoplasia and identify associated risk factors. The results showed that 95% of patients reported post-RFA pain, with 64% experiencing major pain. Dysphagia was present in 83% of patients.
Article
Nutrition & Dietetics
Maurits R. Visser, Jennifer Straatman, Daan M. Voeten, Suzanne S. Gisbertz, Jelle P. Ruurda, Misha D. P. Luyer, Pieter C. van der Sluis, Donald L. van der Peet, Mark I. van Berge Henegouwen, Richard van Hillegersberg
Summary: The study investigated the variation in the placement, surgical techniques, and safety of feeding jejunostomies (FJ) during minimally invasive esophagectomy (MIE) in the Netherlands. Data from the Dutch Upper Gastrointestinal Cancer Audit (DUCA) were analyzed, and hospital variation in FJ placement rates and short-term outcomes were examined. The study found a wide range of FJ placement rates among hospitals and identified higher complication rates in hospitals that did not routinely perform FJ placement. The study concludes that FJs can be safely placed, with lower complication rates, in centers that perform routine placement.
Article
Chemistry, Multidisciplinary
Johanna J. Joosten, Paul R. Bloemen, Richard M. van den Elzen, Jeffrey Dalli, Ronan A. Cahill, Mark I. van Berge Henegouwen, Roel Hompes, Daniel M. de Bruin
Summary: The aim of this study is to investigate light distribution and the center-periphery effect among five different NIR imaging devices. The results showed considerable variability in regard to light distribution among the five camera systems, especially toward the periphery of the field of view. NIR signal distribution varies between different systems and within the same displayed image, and the fluorescence intensity diminishes peripherally away from the center of the field of view.
APPLIED SCIENCES-BASEL
(2023)
Article
Oncology
N. Schuring, W. T. Stam, V. D. Plat, M. C. Kalff, M. C. C. M. Hulshof, H. W. M. van Laarhoven, S. Derks, D. L. van der Peet, M. I. van Berge Henegouwen, F. Daams, S. S. Gisbertz
Summary: This study investigated the recurrence patterns and survival after multimodal therapy for recurrent esophageal adenocarcinoma. It found that recurrent disease was most frequently located distantly with poor prognosis, but a subgroup of patients with loco-regional recurrence had prolonged survival when treated with curative intent. These findings suggest the need for intensive surveillance protocols and further research to identify high-risk patients.
Article
Oncology
Sergio Gaspar-Figueiredo, Pierre Allemann, Alexander B. J. Borgstein, Gaetan-Romain Joliat, Valentine Luzuy-Guarnero, Christophe Brunel, Christine Sempoux, Suzanne Sarah Gisbertz, Nicolas Demartines, Mark Ivo van Berge Henegouwen, Markus Schafer, Styliani Mantziari
Summary: This study aimed to assess the prognostic value of microscopically positive margins (R1) after gastrectomy on survival and tumor recurrence in diffuse-type gastric cancer (DTGC) patients. It showed that patients with R1 had poorer overall survival and disease-free survival, as well as higher early tumor recurrence rates. Therefore, achieving R0 resection should be pursued whenever possible.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Nannet Schuring, Noel E. Donlon, Eliza R. C. Hagens, Didier Gootjes, Claire L. Donohoe, Mark I. van Berge Henegouwen, John V. Reynolds, Suzanne S. Gisbertz
Summary: This study externally validated the nomogram model for predicting 5-year overall survival in a cohort of esophageal cancer patients from another high-volume center. The model demonstrated moderate discrimination and accuracy in predicting conditional survival.
Article
Gastroenterology & Hepatology
Kammy Keywani, Alexander B. J. Borgstein, Djamila Boerma, Stijn van Esser, Wietse J. Eshuis, Mark van Berge I. Henegouwen, Johanna van Sandick, Suzanne S. Gisbertz
Summary: Curative therapy for gastric cancer usually includes perioperative chemotherapy and radical gastrectomy. The role of omentectomy in improving survival remains uncertain. This study presents the follow-up data of the OMEGA study.
Article
Surgery
Sander Ubels, Moniek H. P. Verstegen, Bastiaan R. Klarenbeek, Stefan Bouwense, Mark I. van Berge Henegouwen, Freek Daams, Marc J. van Det, Ewen A. Griffiths, Jan Willem Haveman, Joos Heisterkamp, Grard Nieuwenhuijzen, Fatih Polat, Jeroen Schouten, Peter D. Siersema, Pritam Singh, Bas Wijnhoven, Gerjon Hannink, Frans van Workum, Camiel Rosman
Summary: This retrospective cohort study aimed to assess the effectiveness of different treatment strategies for anastomotic leak after oesophagectomy. The study found that less invasive primary treatment resulted in fewer complications. Therefore, less invasive primary treatment may lead to better clinical outcomes, but further studies are needed to confirm these findings.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
B. Feike Kingma, Eliza R. C. Hagens, Mark. I. Van Berge I. Henegouwen, Alicia. S. S. Borggreve, Jelle. P. P. Ruurda, Suzanne. S. S. Gisbertz, R. Richard van Hillegersberg
Summary: This study investigated the impact of paratracheal lymphadenectomy on lymph node yield and short-term outcomes in patients undergoing esophagectomy for cancer in the Netherlands. The results showed that paratracheal lymphadenectomy increased lymph node yield, but also led to longer hospital stay and more re-interventions.
Article
Surgery
Aiysha Puri, Nikhil M. Patel, Viknesh Sounderajah, Lorenzo Ferri, Ewen A. Griffiths, Donald Low, Nick Maynard, Carmen Mueller, Manuel Pera, Mark I. van Berge Henegouwen, David Watson, Giovanni Zaninotto, George B. Hanna, Sheraz R. Markar
Summary: This study developed a symptom severity instrument (POST tool) specific to para-oesophageal hernia (POH). Through a systematic review and Delphi consensus process, the POST tool was created, which includes five symptoms that reached consensus among international experts.
BRITISH JOURNAL OF SURGERY
(2022)