Article
Oncology
Sophie J. M. Reijers, Olga Husson, Vicky L. M. N. Soomers, Lukas B. Been, Johannes J. Bonenkamp, Michiel A. J. van de Sande, Cornelis Verhoef, Winette T. A. van der Graaf, Winan J. van Houdt
Summary: The study found that there was no significant difference in long-term patient reported outcomes (PROs) between patients with locally advanced extremity soft tissue sarcoma (eSTS) who underwent isolated limb perfusion followed by resection (IR) and those who underwent extended resection (ER). However, both IR and ER outperformed primary amputation or secondary amputation after IR in terms of functioning and functionality.
Article
Oncology
Weifeng Liu, Yongkun Yang, Tao Jin, Yang Sun, Yuan Li, Lin Hao, Qing Zhang, Xiaohui Niu
Summary: This study explored the oncological and functional outcomes of limb salvage surgery for primary malignant bone tumors in the forearm, finding that the incidence of radial malignant tumors is higher than that of ulnar lesions. Unplanned excisions, ulnar tumors, proximal forearm tumors, and inadequate surgical margins are risk factors for local recurrence, while distant metastasis is an independent poor prognostic factor.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Juri Teras, Michael J. Carr, Jonathan S. Zager, Hidde M. Kroon
Summary: Isolated limb infusion (ILI) and hyperthermic isolated limb perfusion (HILP) have been effective in treating melanoma and sarcoma with high response rates and no systemic side-effects. ILI, simpler than HILP, takes advantage of the limb's environment to potentiate anti-tumour activity and can be used to test new cytotoxic regimens.
Review
Medicine, General & Internal
Danielle K. DePalo, Jonathan S. Zager
Summary: Treatment of soft tissue sarcomas (STSs) is complicated and has not seen significant benefits from recent advances in other soft tissue malignancies. Surgical resection is the standard for resectable disease, but alternative approaches are needed for unresectable, locally advanced STS. Isolated limb infusion (ILI) is a potential option for extremity STS, but limited literature exists. This review provides an overview of patient eligibility, the procedure, significant publications, and opportunities for further progress in ILI for STS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Kaixu Yu, Ying Chen, Kehan Song, Fanxiu Xiong, Yahao Tian, Hanfeng Guan, Feng Li
Summary: Limb salvage surgery has positive impact on prognosis of patients with EBST sarcomas, but the extent of impact varies depending on the pathological subtype and stage.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Anne Huibers, Danielle K. Depalo, Matthew C. Perez, Jonathan S. Zager, Roger Olofsson Bagge
Summary: For patients with cutaneous melanoma, surgical removal can lead to in-transit metastases, while for patients with uveal melanoma, the majority develop isolated liver metastases. In the era of modern immunotherapy, locoregional treatment modalities have become effective treatment options.
CLINICAL & EXPERIMENTAL METASTASIS
(2023)
Article
Oncology
Matthew T. Houdek, Michael B. Stuart, Elizabeth P. Wellings, Eric R. Wagner, Dennis Asante, Lindsey R. Sangaralingham, Peter S. Rose, Steven L. Moran
Summary: Socioeconomic and hospital factors in adult bone sarcoma patients with medical insurance at the time of diagnosis were associated with the decision to undergo amputation or limb salvage. Poorer patients and those treated at smaller, public hospitals were more likely to undergo amputation.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Surgery
Zane B. Perkins, Alexander J. Kersey, Joseph M. White, Alexis L. Lauria, Brandon W. Propper, Nigel R. M. Tai, Todd E. Rasmussen
Summary: The study found that successful limb salvage is closely related to the duration of ischemia, with a 10% reduction in the probability of successful limb salvage for every hour delay to revascularization. Military trauma systems should prioritize rapid hemorrhage control and early limb revascularization.
Article
Oncology
Sophie J. M. Reijers, Emma Davies, Dirk J. Gruenhagen, Marco Fiore, Charles Honore, Marco Rastrelli, Nikolaos Vassos, Lars E. Podleska, Maya Niethard, Jens Jakob, Andraz Perhavec, Carlos Duarte, Felipe Gonzalez, Jan P. Deroose, Marguerite Stas, Veerle Boecxstaens, Yvonne Schrage, Hayden Snow, Salvador Martin Algarra, Hector Martinez Said, Dorian Yarih Garcia-Ortega, Karla Martin, Jan Mattsson, Reza Djafarrian, Giorgia Di Lorenzo, Chiara Colombo, Alessandro Gronchi, Maurice Matter, Cornelis Verhoef, Roger Olofsson Bagge, Peter Hohenberger, Andrew J. Hayes, Winan J. van Houdt
Summary: The aim of this study was to investigate the response rates of different extremity soft-tissue sarcoma subtypes (eSTS) after isolated limb perfusion (ILP). The study found that ILP with recombinant human tumor necrosis factor (rhTNFα) resulted in significantly better overall response rates and complete responses compared to ILP without rhTNFα. Additionally, the response rates were significantly higher for Kaposi sarcoma (KS), angiosarcoma (AS), and clear cell sarcoma (CCS). Overall, ILP showed high response rates, but with significant differences between subtypes. Rating: 8/10.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Maya Niethard, Heilwig Fischer, Bernhard Gassmann, Lyubomir Haralambiev, Alexander Tipp, Per-Ulf Tunn
Summary: This study compares the total blood loss (BLt) in patients with soft tissue sarcomas (STS) during drug circulation with and without perioperative regional anesthesia (RA). The results show that the use of perioperative RA, especially during perfusion of the upper extremities, can help stabilize hemodynamic anesthetic management and reduce BLt.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Maya Kirilova, Alexander Klein, Lars H. Lindner, Silke Nachbichler, Thomas Knosel, Christof Birkenmaier, Andrea Baur-Melnyk, Hans Roland Durr
Summary: This study reveals that sarcoma patients who require amputation have worse oncological outcomes in terms of overall survival compared to limb salvage surgery. Whether undergoing primary or secondary amputations after failed LSS for various reasons, patients showed the same oncological results.
Article
Orthopedics
Ozgur Baysal, Fevzi Saglam, Omer Sofulu, Okan Yigit, Evrim Sirin, Bulent Erol
Summary: The most common causes of amputation after limb-salvage surgery were found to be local recurrence and prosthetic infection. Patients who underwent amputation after limb-salvage surgery had a high rate of distant organ metastasis during follow-up and experienced reduced survival rates.
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
(2021)
Article
Surgery
Jorge A. Miranda, Zachary Pallister, Sherene Sharath, Lucas Ferrer, Jayer Chung, Brian Lepow, Joseph L. Mills, Miguel Montero-Baker
Summary: This study reviewed the outcomes of venous arterialization (VA) in chronic limb-threatening ischemia (CLTI). The findings suggest that superficial and deep VA are feasible options for limb salvage in patients who cannot undergo conventional revascularization methods.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Maarten C. Verwer, Joep G. J. Wijnand, Martin Teraa, Marianne C. Verhaar, Gert J. de Borst
Summary: The study found that five years after inclusion, 43% of patients with non-revascularisable CLTI survived without amputation. However, this outcome was mainly driven by all cause mortality and amputation rate, especially in the first year.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Article
Multidisciplinary Sciences
Zihui Li, Jie Deng, Fei Yan, Li Liu, Yanling Ma, Jianhai Sun
Summary: The study compared the efficacy of hyperthermic intrathoracic chemotherapy and pleural catheter drainage in patients with initially diagnosed lung cancer and symptomatic pleural effusion. The results showed that hyperthermic intrathoracic chemotherapy had better outcomes, prolonging intrathoracic pleural effusion progression-free survival and overall survival. Furthermore, patients who received targeted therapy or chemotherapy also had better control of pleural effusion.
SCIENTIFIC REPORTS
(2023)
Article
Surgery
Angela Hill, Franklin Olumba, William Chapman
Summary: Transplantation for HCC is a complex topic, requiring considerations of multiple factors. Balancing tumor size with post-transplant outcome is still an ongoing challenge. Tumor downstaging and the use of new technologies have increased the number of HCC transplants, and these advances can also be applied to other liver tumors.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Olanrewaju A. Eletta, Guergana G. Panayotova, Keri E. Lunsford
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Brianna Ruch, Kayla Kumm, Sandra Arias, Nitin N. Katariya, Amit K. Mathur
Summary: DCD liver transplantation is an underutilized method that can increase access to liver transplantation. With proper donor and recipient selection, matching, surgical technique, and perioperative management, these transplants can achieve similar patient and graft survival rates as DBD liver transplantation. The main limitations in the further growth of DCD liver transplantation are driven by risk aversion, and the current experience is mainly concentrated in large centers. With the advancement of regional and machine perfusion techniques, the definition of a viable DCD liver allograft may be redefined, encouraging wider usage and acceptance.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Lauren Matevish, Madhukar S. Patel, Parsia A. Vagefi
Summary: Downstaging has been shown to be feasible within UNOS-DS criteria, with successful long-term outcomes. Interventional liver-directed therapies have been the standard, but systemic therapies are becoming more effective. Immunotherapy holds promise in downstaging, but further trials are needed to assess feasibility and safety. Individual expertise will continue to guide treatment until more data is available.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Hassan Aziz, Paramita Nayak, David C. Mulligan
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Catherine G. Pratt, Jenna N. Whitrock, Shimul A. Shah, Zhi Ven Fong
Summary: hCCA is a biologically aggressive disease and surgical resection is the only curative treatment. Factors such as patient's physical condition, tumor involvement, residual liver volume, and assessment of metastatic disease heavily influence the feasibility of surgical resection. A multidisciplinary, holistic, and individualized approach is critical for accurately determining resectability and optimizing clinical outcomes for patients with hCCA.
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Sara-Catherine Whitney Zingg, Kristina Lemon
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Christopher J. Sonnenday
SURGICAL CLINICS OF NORTH AMERICA
(2024)
Article
Surgery
Alban Longchamp, Tsukasa Nakamura, Korkut Uygun, James F. Markmann
SURGICAL CLINICS OF NORTH AMERICA
(2024)
