Article
Ophthalmology
Lan-Ting Wu, Jia-Lin Wang, Yan-Ling Wang
Summary: This study used 3D model reconstruction and hemodynamic simulation to analyze the morphological and hemodynamic changes of the ophthalmic artery (OA) in patients with acute coronary syndrome (ACS). The results showed a slower OA blood velocity in ACS patients, which was associated with clinical parameters. There were no significant differences in morphological aspects and hemodynamics compared to the healthy control group.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Neuroimaging
Ivan Lylyk, Carlos Bleise, Pedro N. Lylyk, Nicolas Perez, Javier Lundquist, Esteban Scrivano, Anibal A. Francone, Martin Charles, Tamara Zompa, Pedro Lylyk
Summary: The study aims to investigate the correlation between AMD and compromised blood flow in the eye, as well as to demonstrate the potential of OA angioplasty as a treatment for late-stage AMD. Results showed the feasibility and safety of OA angioplasty, with perceived benefits in patients with profound vision loss. Further clinical trials are needed to confirm these findings.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Letter
Acoustics
M. Gonser, L. Vonzun, N. Ochsenbein-Kolble
Summary: This Correspondence comments on the studies by Sapantzoglou et al. and Sarno et al.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Clinical Neurology
Hilal Akdemir Aktas, Kadriye Mine Ergun, Ilkan Tatar, Anil Arat, Kadir Mutlu Hayran
Summary: This study determined the morphometry of the ophthalmic artery and its branches in a large series of pediatric patients using superselective angiography. The origin, diameter, and angiographic visibility percentages of the ophthalmic artery and its branches were examined. The findings provide valuable information for surgeons and radiologists in avoiding complications during various procedures.
INTERVENTIONAL NEURORADIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Panagiotis Parissis, Alexandros Romeos, Athanasios Giannadakis, Alexandros Kalarakis, Michail Peroulis
Summary: This research studied the hemodynamic field of an occluded artery with anastomosis by computational simulation. The main objective was to investigate the 3D flow field phenomena in the bypass region and the effect of the bypass graft to stenosis volume flow ratio. Different turbulence models were used and compared with experimental visualizations. The results showed that the SST k-omega turbulence model had better visual representation of flow patterns and demonstrated distinct flow patterns depending on the flow ratio.
BIOENGINEERING-BASEL
(2023)
Review
Clinical Neurology
Kun Hou, Wei Wu, Ying Liu, Lai Qu, Baofeng Xu, Jinlu Yu
Summary: The ophthalmic artery is a crucial artery that can be involved in various neurovascular diseases. During endovascular treatment, it is important to be cautious of unexpected embolization and potential injuries to the central retinal artery. The artery can also provide collateral flow in certain situations and should be preserved in cases of aneurysm treatment.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Environmental Sciences
Olivier Berne, Lydiane Agier, Antoine Hardy, Emmanuel Lellouch, Olivier Aumont, Jerome Mariette, Tamara Ben-Ari
Summary: In the context of global warming, academics have started to examine the environmental and carbon footprint of their professional activities. Existing studies have shown that air travel frequency is related to the number of citations, but not to publication rate or h-index. However, a comprehensive survey of over 6000 scientists in France reveals that higher air travel is associated with higher publication rate and h-index, suggesting that flying is a means for scientists to gain and maintain visibility in their field.
ENVIRONMENTAL RESEARCH LETTERS
(2022)
Article
Multidisciplinary Sciences
Mary Hammes, Andres Moya-Rodriguez, Cameron Bernstein, Sandeep Nathan, Rakesh Navuluri, Anindita Basu
Summary: This study utilized computational modeling to analyze the hemodynamics of the cephalic arch in patients with arteriovenous fistula, revealing that increased velocity and pressure in the cephalic arch can lead to stenosis. The establishment of a 3D model can help identify pathologic stenosis earlier.
Article
Ophthalmology
Kenneth K. H. Lai, Emmy Y. M. Li, Regine Y. C. Chan, Winnie C. W. Chu, Andy C. O. Cheng, Karen K. W. Chan, Joyce K. Y. Chin, Jeremy S. W. Kwok, Ida Y. F. Io, Nelson K. F. Yip, Kenneth K. W. Li, Wai Ho Chan, Nai Man Lam, Wilson W. K. Yip, Alvin L. Young, Edwin Chan, Callie K. L. Ko, Simon T. C. Ko, Hunter K. L. Yuen, Clement C. Y. Tham, Chi-Pui Pang, Kelvin K. L. Chong
Summary: This study found that approximately 60% of patients required long-term maintenance oral corticosteroid therapy, and steroid dependence was associated with elevated baseline serum IgG4 level and Mikulicz syndrome. Debulking surgery is an alternative treatment for a subgroup of patients with discrete orbital lesions, normal baseline IgG4 level, and no Mikulicz syndrome.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Clinical Neurology
Mitsushige Ando, Yoshinori Maki, Masato Hojo, Taketo Hatano
Summary: Herein, we report two rare cases of anastomosis between the bilateral ICAs formed by recurrent arteries branching from the first segment of the ophthalmic artery (OphA).
Review
Obstetrics & Gynecology
Kypros H. Nicolaides, Manoel Sarno, Alan Wright
Summary: The ophthalmic artery Doppler provides a useful biomarker for the prediction of preeclampsia, as it can provide information on the intracranial circulation. Studies have shown that there is a decrease in impedance to flow and an increase in velocities in the flow velocity waveforms from the ophthalmic arteries in women with preeclampsia. The peak systolic velocity ratio in ophthalmic artery Doppler has been found to be superior to other biomarkers in predicting preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Ching-Min Lin, Shih-Lung Lin, Yu-Ju Hung, Chih-Jan Ko, Chia-En Hsieh, Yao-Li Chen, Chien-Hsiang Chang
Summary: This study compared the conventional microscope with a novel 3D digital microscope for hepatic artery anastomosis, showing comparable results with no statistical differences. The exoscope provided better ergonomics in the operation room, reducing musculoskeletal strain for surgeons.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sadullah Simsek, Akif Islek
Summary: This study investigates the diagnostic and predictive value of resistive and pulsatility index (RI and PI) of the ophthalmic artery (OA) and common carotid artery (CCA) for diabetic retinopathy (DRP) development. The results suggest that the OA RI accurately reflects DRP-induced orbital blood flow changes and serves as a predictive index for DRP prognosis.
Article
Multidisciplinary Sciences
E. Greenan, Q. Pilson, J. Ni Gabhann-Dromgoole, C. C. Murphy
Summary: This study aimed to measure the impact of the COVID-19 pandemic on symptoms, health, and quality of life in patients with Primary Sjogren's Syndrome (pSS). The results showed that despite a significant number of participants having their outpatient appointments affected, the patients' quality of life remained stable. These findings highlight the importance of using validated health and quality of life questionnaires as an adjunct to telemedicine consultations for assessing pSS patients in the post-pandemic era.
SCIENTIFIC REPORTS
(2022)
Article
Acoustics
E. Gibbone, I. Sapantzoglou, M. E. Nunez-Cerrato, A. Wright, K. H. Nicolaides, M. Charakida
Summary: This study aimed to investigate the association between the PSV ratio and maternal cardiovascular function in an unselected population at 19-23 weeks' gestation. It found weak associations between the PSV ratio and most cardiovascular indices in the total population, except for mean arterial pressure. However, in the subgroup that developed PE, a moderately strong association between the PSV ratio and left ventricular mass indexed for body surface area was noted.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Editorial Material
Ophthalmology
Sonia De Francesco, Paolo Galluzzi, Sandra Bracco, Alessandro Di Maggio, Arianna Sgheri, Theodora Hadijstilianou
Summary: High resolution MRI play a crucial role in decision-making in RB, providing us with a last chance to save the globe.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Letter
Clinical Neurology
Sara Leonini, Eugenio Bertelli, Sandra Bracco, Andrea Guasti
Article
Neuroimaging
Francesco Diana, Sergio Lucio Vinci, Maria Ruggiero, Vittorio Semeraro, Sandra Bracco, Giulia Frauenfelder, Aldo Paolucci, Luigi Cirillo, Alessandro Pesce, Agostino Tessitore, Christian Commodaro, Maria Porzia Ganimede, Matteo Zanoni, Renato Saponiero, Andrea Zini, Mariano Velo, Beatrice Modello, Nicola Burdi, Samuele Cioni, Luigi Simonetti, Daniele Giuseppe Romano
Summary: There is no consensus on the most effective endovascular technique for patients with acute ischemic stroke due to terminal internal carotid artery occlusion. This study compared the safety and efficacy of aspiration technique (AT) and combined technique (CT) as first-line approach, revealing that CT yielded better technical and functional outcomes.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Clinical Neurology
Manuel Cappellari, Valentina Saia, Giovanni Procucci, Fainardi Enrico, Arturo Consoli, Sergio Nappini, Lucio Castellon, Sandra Bracco, Mauro Bergui, Mirco Cosottini, Alessandra Briatico Vangosa, Sergio Vinci, Maria Ruggiero, Edoardo Puglielli, Luigi Chiumarulo, Giacomo Cester, Chiara Comelli, Umberto Silvagni, Daniele Morosetti, Valentina Caldiera, Nicola Cavasin, Valeria Ledda, Giuseppina Sanfilippo, Andrea Saletti, Pietro Filauri, Ivan Gallesio, Nunzio Paolo Nuzzi, Pitero Amista, Cecilia Zivelonghi, Mauro Plebani, Marco Pavia, Daniele Romano, Francesco Biraschi, Roberto Menozzi, Roberto M. Gasparotti, Andrea Giorgianni, Andrea Zini, Domenico Inzitari, Danilo Toni, Salvatore Mangiafico
Summary: The Careggi Collateral Score (CCS) is a helpful tool for predicting outcomes in stroke patients undergoing thrombectomy for middle cerebral artery occlusion. A higher CCS score is associated with better prognosis, with CCS >= 3 being the optimal threshold for predicting excellent outcomes and CCS >= 1 for predicting survival.
JOURNAL OF NEUROLOGY
(2022)
Correction
Clinical Neurology
Manuel Cappellari, Valentina Saia, Giovanni Pracucci, Enrico Fainardi, Arturo Consoli, Sergio Nappini, Lucio Castellan, Sandra Bracco, Mauro Bergui, Mirco Cosottini, Alessandra Briatico Vangosa, Sergio Vinci, Maria Ruggiero, Edoardo Puglielli, Luigi Chiumarulo, Giacomo Cester, Chiara Comelli, Umberto Silvagni, Daniele Morosetti, Valentina Caldiera, Nicola Cavasin, Valeria Ledda, Giuseppina Sanfilippo, Andrea Saletti, Pietro Filauri, Ivan Gallesio, Nunzio Paolo Nuzzi, Pitero Amista, Cecilia Zivelonghi, Mauro Plebani, Marco Pavia, Daniele Romano, Francesco Biraschi, Roberto Menozzi, Roberto Gasparotti, Andrea Giorgianni, Andrea Zini, Domenico Inzitari, Danilo Toni, Salvatore Mangiafico
JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, Research & Experimental
Elisabetta Weber, Margherita Agliano, Eugenio Bertelli, Guido Gabriele, Paolo Gennaro, Virginia Barone
Summary: Secondary lymphedema is a common side effect of oncological treatments, affecting the daily lives of patients and the healthcare system. Treatment involves surgical techniques to connect lymphatic vessels and veins, but successful results depend on the functional structure of the vessel. This article reviews the structure of lymphatic collecting vessels in health and in lymphedema, focusing on histopathological changes that affect the success of lymphatic-venular anastomosis.
LYMPHATIC RESEARCH AND BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Maurizio Acampa, Francesca Guideri, Sandra Bracco, Rossana Tassi, Carlo Domenichelli, Pietro Enea Lazzerini, Samuele Cioni, Giuseppe Martini
Summary: The case report presents a patient with cortical blindness due to embolic occlusion of both posterior cerebral arteries, who was successfully treated with combined thrombolysis. The good outcome of this case encourages the use of combined stroke treatments in posterior circulation stroke.
CURRENT DRUG SAFETY
(2022)
Article
Clinical Neurology
Ilaria Casetta, Enrico Fainardi, Giovanni Pracucci, Valentina Saia, Fabrizio Sallustio, Valerio da Ros, Sergio Nappini, Patrizia Nencini, Guido Bigliardi, Sergio Vinci, Francesco Grillo, Sandra Bracco, Rossana Tassi, Mauro Bergui, Paolo Cerrato, Andrea Saletti, Alessandro De Vito, Roberto Gasparotti, Mauro Magoni, Luigi Simonetti, Andrea Zini, Maria Ruggiero, Marco Longoni, Lucio Castellan, Laura Malfatto, Paola Castellini, Mirco Cosottini, Alessio Comai, Enrica Franchini, Emilio Lozupone, Giacomo Della Marca, Edoardo Puglielli, Alfonsina Casalena, Claudio Baracchini, Daniele Savio, Enrica Duc, Giuseppe Ricciardi, Manuel Cappellari, Luigi Chiumarulo, Marco Petruzzellis, Anna Cavallini, Nicola Cavasin, Adriana Critelli, Nicola Burdi, Giovanni Boero, Andrea Giorgianni, Maurizio Versino, Francesco Biraschi, Ettore Nicolini, Simone Comelli, Maurizio Melis, Riccardo Padolecchia, Tiziana Tassinari, Nunzio Paolo Nuzzi, Simona Marcheselli, Simona Sacco, Paolo Invernizzi, Ivan Gallesio, Delfina Ferrandi, Maria Fancello, Maria Valeria Saddi, Monia Russo, Aldo Pischedda, Antonio Baule, Marina Mannino, Francesco Florio, Vincenzo Inchingolo, Maria Elena Flacco, Daniele Romano, Umberto Silvagni, Domenico Inzitari, Salvatore Mangiafico, Danilo Toni
Summary: In patients with stroke due to large vessel occlusion treated with mechanical thrombectomy, women have a higher chance of achieving complete recanalization and 3-month functional independence compared to men.
EUROPEAN STROKE JOURNAL
(2022)
Review
Cell Biology
Laura Bianchi, Annalisa Altera, Virginia Barone, Denise Bonente, Tommaso Bacci, Elena De Benedetto, Luca Bini, Gian Marco Tosi, Federico Galvagni, Eugenio Bertelli
Summary: Idiopathic epiretinal membranes (iERMs) are fibrocellular sheets of tissue that develop at the vitreoretinal interface. The extracellular matrix (ECM) composed of various proteins plays a crucial role in matrix biology in iERMs. This study used a bioinformatics approach to analyze the interactome of key proteins in iERM, revealing interactions among ECM molecules, cell receptors, and intra- or extracellular proteins. The modulation of matrix deposition by biomarkers found in the vitreous humor of iERM patients is also discussed, along with the proposed techniques for pharmacologic vitreolysis in iERM treatment.
Article
Clinical Neurology
Fabrizio Sallustio, Giovanni Pracucci, Manuel Cappellari, Valentina Saia, Alfredo Paolo Mascolo, Federico Marrama, Roberto Gandini, Giacomo Koch, Marina Diomedi, Federica D'Agostino, Alessandro Rocco, Valerio Da Ros, Andrea Wlderk, Marco Nezzo, Renato Argiro, Daniele Morosetti, Leonardo Renieri, Patrizia Nencini, Stefano Vallone, Andrea Zini, Guido Bigliardi, Antonio Pitrone, Francesco Grillo, Sandra Bracco, Rossana Tassi, Mauro Bergui, Andrea Naldi, Giuseppe Carita, Ilaria Casetta, Roberto Gasparotti, Mauro Magoni, Luigi Simonetti, Nicolo Haznedari, Matteo Paolucci, Nicola Mavilio, Laura Malfatto, Roberto Menozzi, Antonio Genovese, Mirco Cosottini, Giovanni Orlandi, Alessio Comai, Enrica Franchini, Alessandro Pedicelli, Giovanni Frisullo, Edoardo Puglielli, Alfonsina Casalena, Giacomo Cester, Claudio Baracchini, Davide Castellano, Alessandra Di Liberto, Giuseppe Kenneth Ricciardi, Luigi Chiumarulo, Marco Petruzzellis, Elvis Lafe, Alessandra Persico, Nicola Cavasin, Adriana Critelli, Vittorio Semeraro, Angelica Tinelli, Andrea Giorgianni, Federico Carimati, William Auteri, Stefano Rizzuto, Francesco Biraschi, Ettore Nicolini, Antonio Ferrari, Maurizio Melis, Stefano Calia, Tiziana Tassinari, Nunzio Paolo Nuzzi, Manuel Corato, Simona Sacco, Guido Squassina, Paolo Invernizzi, Ivan Gallesio, Luigi Ruiz, Giovanni Dui, Nicola Carboni, Pietro Amista, Monia Russo, Mario Maiore, Bastianina Zanda, Giuseppe Craparo, Marina Mannino, Domenico Inzitari, Danilo Toni, Salvatore Mangiafico
Summary: This study investigated the outcomes of AIS patients with tandem occlusion (TO) treated with carotid artery stenting (CAS) during endovascular thrombectomy (EVT). The results showed that CAS was associated with lower 3 months' mortality and higher rates of successful recanalization among TO-AIS patients.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Biochemistry & Molecular Biology
Denise Bonente, Laura Bianchi, Rossana De Salvo, Claudio Nicoletti, Elena De Benedetto, Tommaso Bacci, Luca Bini, Giovanni Inzalaco, Lorenzo Franci, Mario Chiariello, Gian Marco Tosi, Eugenio Bertelli, Virginia Barone
Summary: Epiretinal membranes (ERMs) are pathological tissues that form in the vitreoretinal interface, leading to vision loss. Understanding the molecular dysfunctions that contribute to ERM development is crucial. Our bioinformatics study identified CD44 as a central regulator of ERM dynamics, and its interaction with PDPN could promote migration in epithelial cells. PDPN, overexpressed in various cancers, plays a relevant role in fibrotic and inflammatory pathologies, modulating signaling pathways involved in ERM formation. Understanding the role of PDPN may open new therapeutic options for fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neuroimaging
Andrea Naldi, Giovanni Pracucci, Roberto Cavallo, Valentina Saia, Andrea Boghi, Piergiorgio Lochner, Ilaria Casetta, Fabrizio Sallustio, Andrea Zini, Enrico Fainardi, Manuel Cappellari, Rossana Tassi, Sandra Bracco, Guido Bigliardi, Stefano Vallone, Patrizia Nencini, Mauro Bergui, Salvatore Mangiafico, Danilo Toni
Summary: This study aimed to evaluate the outcomes, safety, and time intervals of mechanical thrombectomy (MT) in patients with in-hospital stroke (IHS) compared with out-of-hospital stroke (OHS) patients. The results showed that IHS patients had worse functional outcomes and higher mortality at 3 months. However, the recanalization rates and risk of symptomatic intracranial hemorrhage were similar. Improvements in the management and shorter time intervals are needed for IHS patients.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Multidisciplinary Sciences
Lisa Gherardini, Veronica Vetri Buratti, Mirko Maturi, Giovanni Inzalaco, Erica Locatelli, Letizia Sambri, Sara Gargiulo, Virginia Barone, Denise Bonente, Eugenio Bertelli, Silvia Tortorella, Lorenzo Franci, Antonio Fioravanti, Mauro Comes Franchini, Mario Chiariello
Summary: The study aimed to design new negative temperature-responsive gel formulations to locally release TMZ for the treatment of GBM. The biocompatibility of the gel formulations containing nanoparticles or microparticles was confirmed in vitro and in vivo, and the therapeutic potential of these formulations was tested in a glioblastoma resection and recurrence mouse model. The gel formulations showed promising results in inducing cell death in vitro and significantly reducing tumor recurrence in vivo.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Analytical
Chiara Vagaggini, Annalaura Brai, Denise Bonente, Jessica Lombardi, Federica Poggialini, Claudia Pasqualini, Virginia Barone, Claudio Nicoletti, Eugenio Bertelli, Elena Dreassi
Summary: In this study, a sensitive and reproducible LC-MS/MS method was developed and validated for the quantification of short-chain fatty acids (SCFAs) in human, rat, and mouse plasma. The method showed good performance in terms of recovery (> 80%), precision (RSD <14%), accuracy (RE < ± 10%), and sensitivity (LOQ of 0.01 μM for acetic, butyric, propionic, and isobutyric acid). The results highlighted the correlation between plasma concentrations of SCFAs and age, emphasizing the importance of developing a reliable method for their quantification to study their biological role.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Anatomy & Morphology
Denise Bonente, Virginia Barone, Vitaliano Francesco Muzii, Sara Ottolenghi, Miriam Durante, Sandra Bracco, Claudio Nicoletti, Eugenio Bertelli
Summary: This study characterizes the morphology and topography of the spina musculi recti lateralis (SMRL) and compares it to known bony landmarks. The results show that the SMRL is a process of the sphenoidal orbital plate and serves as a reliable landmark for the insertion of the tendinous ring and lateral rectus. This is an important variation for orbital surgeons to be aware of.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2024)
