Journal
CLINICA CHIMICA ACTA
Volume 450, Issue -, Pages 83-89Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2015.08.002
Keywords
Coenzyme Q10; Heart failure; Hypertension; Endothelial dysfunction
Categories
Funding
- China Postdoctoral Science Foundation [2012T50865]
- Beijing Science and Technology Program [Z131100002613006]
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Advancing age is a major risk factor for the development of cardiovascular diseases. The aetiology of several cardiovascular disorders is thought to involve impaired mitochondrial function and oxidative stress. Coenzyme Q10 (CoQ10) acts as both an antioxidant and as an electron acceptor at the level of the mitochondria. Furthermore, in cardiac patients, plasma CoQ10 has been found to be an independent predictor of mortality. Based on the fundamental role of CoQ10 in mitochondrial bioenergetics and its well-acknowledged antioxidant properties, several clinical trials evaluating CoQ10 have been undertaken in cardiovascular disorders of ageing including chronic heart failure, hypertension, and endothelial dysfunction. CoQ10 as a therapy appears to be safe and well tolerated. (C) 2015 Elsevier B.V. All rights reserved.
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