Article
Optics
Tzu-Sen Yang, Le-Thanh-Hang Nguyen, Yu-Cheng Hsiao, Li-Chern Pan, Cheng-Jen Chang
Summary: The objective of this study was to assess the effect of low-level laser therapy using a diode laser on the growth processes of human fibroblast cells involved in wound healing. The results showed that LLLT at a wavelength of 633 nm had a positive effect on wound healing by promoting collagen synthesis and increasing the levels of growth factors.
Article
Dentistry, Oral Surgery & Medicine
Shu Takemura, Koji Mizutani, Risako Mikami, Keita Nakagawa, Masahiro Hakariya, Eri Sakaniwa, Natsumi Saito, Hiromi Kominato, Daisuke Kido, Kohei Takeda, Akira Aoki, Takanori Iwata
Summary: This study suggests that low-level erbium-doped: yttrium, aluminum, and garnet (Er:YAG) laser irradiation may promote periodontal tissue healing by enhancing angiogenetic effect of endothelial cells via TRPV1.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Micaela Berni, Alice Maria Brancato, Camilla Torriani, Valentina Bina, Salvatore Annunziata, Elena Cornella, Michelangelo Trucchi, Eugenio Jannelli, Mario Mosconi, Giulia Gastaldi, Laura Caliogna, Federico Alberto Grassi, Gianluigi Pasta
Summary: Low-level laser therapy (LLLT) is increasingly used in orthopedics practices to promote angiogenesis, fracture healing, and osteogenic differentiation of stem cells. However, the cellular mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation, and frequency of LLLT influence the cellular mechanisms, and the effects of LLLT vary according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process to improve its clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Evdoxia Mathioudaki, Michail Rallis, Konstantinos Politopoulos, Eleni Alexandratou
Summary: This study investigates the effectiveness of low power red light in accelerating wound healing in an in vitro keratinocyte scratch assay model and sheds light on the role of light irradiation parameters and wound closure mechanisms. The results show that low level laser light can enhance cell proliferation and migration, potentially stimulating wound healing.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Dermatology
Chengchen Gong, Yongzhou Lu, Chuanlong Jia, Nan Xu
Summary: The study found that low-level 532 nm green laser treatment has significant efficacy in wound healing after CO2 fractional laser. Laser treatment can promote collagen remodeling, increase epidermal thickness, and enhance angiogenesis. Furthermore, laser treatment can improve cell migration ability and collagen secretion function.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shirley Genah, Francesca Cialdai, Valerio Ciccone, Elettra Sereni, Lucia Morbidelli, Monica Monici
Summary: The study demonstrates the effectiveness of PBMT in controlling fibroblast activation induced by inflammatory cytokines IL-1 beta and TNF-alpha, thereby suggesting a potential therapeutic approach for managing persistent inflammation.
Article
Medicine, General & Internal
Esraa Sabry Mahmoud, Amal Mohamed Abd El-Baky, Osama Mohamed Sayed, Hussein Gamal Hussein Mogahed
Summary: The study findings support the significant effectiveness of low-level diode laser therapy on wound healing after gingivectomy, showing a highly significant difference compared to the control group. This concludes that low-level diode laser therapy is an effective method for improving wound healing after gingivectomy.
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sirajunnisa Abdul Razack, Yeachan Lee, Hwarang Shin, Surendhiran Duraiarasan, Byung-Soo Chun, Hyun Wook Kang
Summary: A study investigated the efficacy of a nanoemulgel fabricated with oregano essential oil nanoemulsion and low-level laser therapy in diabetic wound healing. The nanoemulgel, made from chitosan, gelatin, and polyvinyl pyrollidone, demonstrated excellent physio-mechanical properties and healing efficiency. The combination of nanoemulgel and low-level laser therapy showed rapid healing effects in diabetic rat models with foot ulcers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Engineering, Biomedical
Yinglin Xu, Haolin Chen, Yifen Fang, Jun Wu
Summary: Combining hydrogels with phototherapy shows great potential for wound healing, overcoming the shortcomings of traditional treatment methods. Phototherapy can effectively treat bacterial infections, while hydrogels provide a moist environment for wound healing.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Emergency Medicine
Jonathan J. Hew, Roxanne J. Parungao, Craig P. Mooney, Julian K. Smyth, Sarah Kim, Kevin H-Y Tsai, Huaikai Shi, Cassandra Chong, Renee C. F. Chan, Beba Attia, Caroline Nicholls, Zhe Li, Samantha M. Solon-Biet, David G. Le Couteur, Stephen J. Simpson, Marc G. Jeschke, Peter K. Maitz, Yiwei Wang
Summary: This study investigated the optimal macronutrient balance for cutaneous wound healing using a mouse model and the Geometric Framework. The results suggest that a low-protein intake, coupled with a balanced intake of carbohydrate and fat, may have a greater potential to accelerate wound healing than current high-protein diets, leading to quicker wound healing and enhanced collagen production.
Article
Dentistry, Oral Surgery & Medicine
Oznur Ozalp, Alper Sindel, Mehmet Ali Altay, Irem Hicran Ozbudak, Busehan Bilgin, Burak Kocabalkan, Dincer Kader
Summary: The present study evaluated and compared the effectiveness of ozone therapy and low-level laser therapy (LLLT) on healing of oral mucosal wounds in rats through histological assessment. The results showed that both ozone and laser groups demonstrated improved acute inflammation and tissue repair compared to the control group, with no significant differences between the ozone and laser groups.
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Oncology
Rita E. Roberts, Jacqueline Cavalcante-Silva, Mercedes Del Rio-Moreno, Onur Bilgen, Rhonda D. Kineman, Timothy J. Koh
Summary: Chronic wounds in diabetic patients are difficult to heal, but low-intensity vibration (LIV) has shown potential in improving angiogenesis and wound healing. This study found that LIV-enhanced wound healing in diabetic mice was associated with increased levels of insulin-like growth factor 1 (IGF1) protein in the liver, blood, and wounds. Knockdown of IGF1 in the liver reduced the beneficial effects of LIV on wound healing, indicating a possible crosstalk between the liver and wound in promoting skin wound healing.
JOURNAL OF PATHOLOGY
(2023)
Article
Engineering, Biomedical
Yihua Chen, Liqiang Liu, Jincai Fan, Tiran Zhang, Yan Zeng, Zhiguo Su
Summary: The study aimed to explore the effects and mechanisms of low-level laser therapy on hair follicle stem cells in full-thickness skin wound healing in mice. The results showed that low-level laser treatment significantly promoted the proliferation, differentiation, and migration of CK15+ hair follicle stem cells, accelerating skin wound healing. RNA sequencing and protein analysis validated the effects of laser therapy on the expression of genes related to hair follicle stem cells and cytokines.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Zhaosong Meng, Zhe Li, Shuling Guo, Danfeng Wu, Ran Wei, Jiacheng Liu, Lizhi Hu, Lei Sui
Summary: The study found that MED1 deficiency accelerates oral mucosal wound healing, possibly through regulating the expression of Activin A/Follistatin to activate the JNK/c-Jun pathway. In vitro studies showed that knockdown of MED1 enhanced the proliferation and migration of keratinocytes, promoting epithelial regeneration and accelerating the healing of oral mucosal wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Leonie Wittner, Lukas Wagener, Jakob J. Wiese, Iris Stolzer, Susanne M. Krug, Elisabeth Naschberger, Rene Jackstadt, Rudi Beyaert, Raja Atreya, Anja A. Kuehl, Gregor Sturm, Miguel Gonzalez-Acera, Jay V. Patankar, Christoph Becker, Britta Siegmund, Zlatko Trajanoski, Beate Winner, Markus F. Neurath, Michael Schumann, Claudia Guenther
Summary: The paracaspase MALT1 plays a crucial role in mucosal inflammation. It is highly expressed in colonic epithelial cells of UC patients and experimental colitis. Mechanistically, MALT1 protease function inhibits ferroptosis and contributes to NF-kappa B signaling and STAT3 signaling, which are involved in inflammation and tissue healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Otorhinolaryngology
Catherine F. Sinclair, Erin Buczek, Elizabeth Cottril, Peter Angelos, Marcin Barczynski, Allen Ho, Viktor Makarin, Thomas Musholt, Joseph Scharpf, Rick Schneider, Brendan C. Stack, Maria J. Tellez, Neil Tolley, Gayle Woodson, Che Wei Wu, Greg Randolph
Summary: This paper aims to define categories of benefit for I-IONM/C-IONM and to clarify and standardize their reporting outcomes. I-IONM can assist in diagnosis, classification, and prevention of nerve injury, while C-IONM provides real-time information on nerve functional integrity.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Biochemical Research Methods
Allen S. Ho, Aaron Robinson, Wonwoo Shon, Anna Laury, Koen Raedschelders, Vidya Venkatraman, Ronald Holewinski, Yi Zhang, Stephen L. Shiao, Michelle M. Chen, Jon Mallen-St. Clair, De-Chen Lin, Zachary S. Zumsteg, Jennifer E. Van Eyk
Summary: This study investigated protein differential expression in HPV(+) OPSCC samples and found that functional pathways involved in cell death, apoptosis, WNT signaling, and Rho GTPase signaling play important roles in disease recurrence. Downregulation of certain molecular targets is associated with recurrence and may serve as markers for high-risk disease. Immunohistochemistry staining validated some of the mass spectrometry findings.
JOURNAL OF PROTEOME RESEARCH
(2022)
Letter
Otorhinolaryngology
Michelle M. Chen, Allen S. Ho
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Oncology
Nicole M. Mott, Michelle L. Mierzwa, Keith A. Casper, Jennifer L. Shah, Jon Mallen-St Clair, Allen S. Ho, Zachary S. Zumsteg, Mark E. P. Prince, Lesly A. Dossett, Michelle M. Chen
Summary: This study aimed to compare the financial hardship of patients with head and neck cancer (HNC) to patients with other cancers, focusing on the domains of coping behaviors and psychologic response. The results showed that patients with HNC had higher levels of hardship in coping behaviors but similar levels in psychologic response compared to patients with other cancers.
JCO ONCOLOGY PRACTICE
(2022)
Article
Oncology
Anthony T. Nguyen, Michael Luu, Vina P. Nguyen, Diana J. Lu, Stephen L. Shiao, Mitchell Kamrava, Katelyn M. Atkins, Alain C. Mita, Kevin S. Scher, Daniel E. Spratt, Mark B. Faries, Timothy J. Daskivich, De-Chen Lin, Michelle M. Chen, Jon Mallen-St Clair, Howard M. Sandler, Allen S. Ho, Zachary S. Zumsteg
Summary: Metastatic lymph node number is a universal and dominant predictor of outcome across solid tumors, and should serve as a foundation for pathologic nodal staging.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Endocrinology & Metabolism
Gregory W. Randolph, Julie Ann Sosa, Yangyang Hao, Trevor E. Angell, David C. Shonka, Virginia A. LiVolsi, Paul W. Ladenson, Thomas C. Blevins, Quan-Yang Duh, Ronald Ghossein, Mack Harrell, Kepal Narendra Patel, Michael H. Shanik, S. Thomas Traweek, P. Sean Walsh, Michael W. Yeh, Amr H. Abdelhamid Ahmed, Allen S. Ho, Richard J. Wong, Joshua P. Klopper, Jing Huang, Giulia C. Kennedy, Richard T. Kloos, Peter M. Sadow
Summary: In this study, a RNA-sequencing MTC classifier was developed that accurately identified MTC from preoperative thyroid nodule FNAB specimens. This identification may facilitate an MTC-specific preoperative evaluation and resulting treatment.
Article
Medicine, Research & Experimental
Eric M. Anderson, Michael Luu, Diana J. Lu, Eric M. Chung, Christopher Gay, Kevin S. Scher, Alain C. Mita, Jon Mallen-St Clair, Allen S. Ho, Zachary S. Zumsteg
Summary: The study confirms that lymphovascular invasion and histologic grade are the strongest predictors of neck lymph node metastasis in cN0 patients with pharynx and larynx cancer. Neck dissection is still necessary for cN0 patients to identify the risk of lymph node metastasis even in the modern era.
Letter
Medicine, Research & Experimental
Eric Anderson, Michael Luu, Allen S. Ho, Zachary S. Zumsteg
Article
Otorhinolaryngology
Allen S. Ho, Michael Luu, Bonnie L. Balzer, Katri Aro, Julie K. Jang, Alain C. Mita, Kevin S. Scher, Jon Mallen-St. Clair, Missael Vasquez, Amanda J. Bastien, Joel B. Epstein, De-Chen Lin, Michelle M. Chen, Zachary S. Zumsteg
Summary: This study investigated the impact of histologic variants and grade on the prognosis of salivary cancer. The results showed that histologic variants had different mortality risks, but these differences were diminished in multivariable analysis. In contrast, worsening grade was strongly associated with deteriorating survival. Integrating grade into stage can improve the predictive ability of the current staging system.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Letter
Oncology
Allen S. S. Ho, Wendy L. Sacks, Zachary S. Zumsteg
Letter
Otorhinolaryngology
Allen S. Ho, Michael Luu, Bonnie L. Balzer, Zachary S. Zumsteg
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Eric M. Anderson, Michael Luu, Eric M. Chung, Christopher Gay, Jon Mallen-St Clair, Allen S. Ho, Zachary S. Zumsteg
Summary: Elective lymph node dissection (ELND) is commonly performed for early-stage oral cavity squamous cell carcinomas (OCSCC) with clinically negative necks. However, the validity of depth of invasion (DOI) as a predictor of lymph node positivity (pN+) varies in different OC sites. This study found that lymphovascular invasion and histologic grade were strong independent predictors of pN+ in cN0 OCSCC, while DOI was not associated with pN+ in the overall OCSCC population, but showed some predictive value in the oral tongue subset.
Article
Otorhinolaryngology
Amanda J. Bastien, Allen S. Ho
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
(2024)
Article
Biotechnology & Applied Microbiology
Yueyuan Zheng, Benjamin Ziman, Allen S. Ho, Uttam K. Sinha, Li-Yan Xu, En-Min Li, H. Phillip Koeffler, Benjamin P. Berman, De-Chen Lin
Summary: Researchers analyzed whole-genome bisulfite sequencing data on 45 esophageal tumor and nonmalignant samples from both subtypes, revealing distinct DNA methylation features and partially methylated domains (PMDs) associated with transcription repression, chromatin compartments, and somatic mutation rate. They also found that these features co-occur in other cancers originating from the same cell types.
Letter
Oncology
Allen S. Ho, Wendy L. Sacks, Zachary S. Zumsteg
