Article
Rheumatology
Aurelie Najm, Felicie Costantino, Stefano Alivernini, Alessia Alunno, Elettra Bianchi, Jacqueline Bignall, Brendan Boyce, Juan D. Canete, Francesco Carubbi, Patrick Durez, Joao Eurico Fonseca, Soren Andreas Just, Raquel Largo, Antonio Manzo, Mark Maybury, Esperanza Naredo, Carl Orr, Costantino Pitzalis, Felice Rivellese, Vasco C. Romao, Jef van Rompay, Sander W. Tas, Douglas J. Veale, Maria-Antonietta D'agostino, Andrew Filer
Summary: There are discrepancies in reporting synovial tissue research, impeding progress in the field. Under the support of the European Alliance of Associations for Rheumatology, minimal reporting requirements for synovial tissue research have been proposed to guide transparent and robust research development.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Hilde Berner Hammer, Roberto Caporali
Summary: Clinical joint examination is important for evaluating patients with RA, but there are discrepancies among rheumatologists. US has high accordance with other imaging modalities and contributes to assessments of difficult joints. However, the optimal use and standardized use of US in rheumatology are still debated.
Review
Rheumatology
Aurelie Najm, Felicie Costantino, Catherine Weill, Andrew Filer, Maria Antonieta D'Agostino
Summary: This study aims to summarize the impact of biopsy procedures, tissue handling, tissue quality, and disease-specific factors on synovial tissue outcome. The study found that study design, population, sample handling, randomization, and analysis can affect the final results of synovial tissue research.
Article
Medicine, General & Internal
Paul Nona, Cori Russell
Summary: Inflammation plays a crucial role in the development of atherosclerosis, yet there is a lack of awareness on the association between inflammation and cardiovascular disease, leading to undertreatment in preventive cardiac care for patients.
MEDICAL CLINICS OF NORTH AMERICA
(2022)
Editorial Material
Rheumatology
Marc Feldmann, Ravinder N. Maini, Enrique R. Soriano, Vibeke Strand, Tsutomu Takeuchi
Summary: In this Viewpoint article, five rheumatology researchers discuss how biologic therapy has transformed clinical practice and reflect on their own experiences, past and current challenges, and the future prospects of biologic drugs.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Mrinalini Dey, Sizheng Steven Zhao, Robert J. Moots
Summary: TNF inhibitors have revolutionized the treatment of rheumatic diseases, but their high acquisition cost has limited their use. The development of biosimilar TNFis has provided more cost-effective access to effective therapies. Additionally, the introduction of targeted synthetic disease-modifying drugs has offered cheaper and equally effective treatments for rheumatic diseases, changing the treatment landscape.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2021)
Article
Rheumatology
Pauline Richebe, Guillaume Coiffier, Pascal Guggenbuhl, Denis Mulleman, Marion Couderc, Emanuelle Dernis, Valentine Deprez, Carine Salliot, Saik Urien, Rachel Brault, Adeline Ruyssen-Witrand, Emmanuel Hoppe, Emmanuel Chatelus, Christian Hubert Roux, Sebastien Ottaviani, Marie Baufrere, Alexia Michaut, Loic Pauvele, Christelle Darrieutort-Laffite, Daniel Wendling, Pascal Coquerelle, Geraldine Bart, Elisabeth Gervais, Vincent Goeb, Marc Ardizzone, Edouard Pertuiset, Sophie Derolez, Jean Marc Ziza, Rene-Marc Flipo, Sophie Godot, Raphaele Seror
Summary: This study described the current management and outcome of native joint septic arthritis in French rheumatology departments, revealing a severe prognosis with high morbidity and mortality rates. The study found that management of NJSA was heterogeneous and highlighted the importance of the new French recommendations for facilitating NJSA management.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Rheumatology
Robert B. M. Landewe, Desiree van der Heijde
Summary: This article discusses the multidimensionality of rheumatic and musculoskeletal diseases (RMDs) and the importance of composite outcome measures in disease assessment. It highlights the potential issues with multidimensional composites and proposes simple solutions to overcome these challenges.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: This study aimed to externally validate a revised Boolean remission criteria using a higher patient global assessment (PtGA) threshold and validate the provisionally endorsed index-based criteria. The results showed that using the higher PtGA threshold increased the proportion of patients classified as achieving remission under the "Boolean2.0" criteria, improved agreement with index-based criteria, and did not compromise predictive value for radiographic or functional outcomes. The study findings were endorsed by ACR and EULAR.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Dermatology
Lucy M. Carter, Dennis McGonagle, Edward M. Vital, Miriam Wittmann
Summary: Insights into early interventions in autoimmune diseases can improve long-term outcomes, and the optimal window of opportunity may extend into asymptomatic preclinical phases.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Rheumatology
Kevin L. Winthrop, John D. Isaacs, Philip J. Mease, Dimitrios T. Boumpas, Xenofon Baraliakos, Jacques-Eric Gottenberg, Stefan Siebert, Marta Mosca, Neil Basu, Dana Orange, R. Lories, Daniel Aletaha, Iain B. McInnes, Tom W. J. Huizinga, Reinhard E. Voll, Ellen M. Gravallese, Ferry C. Breedveld, Josef S. Smolen
Summary: This article summarizes the unmet clinical and scientific needs in the field of rheumatology. It highlights the importance of clinical trial design innovation and the need to better understand the natural history of rheumatic diseases. The article also identifies the specific unmet needs in different rheumatological disease-specific groups and emphasizes the importance of developing therapies and therapeutic strategies for treatment-refractory disease.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Yusuf Karabulut, Nuran Oz, Halise Hande Gezer, Irfan Esen, Mehmet Tuncay Duruoz
Summary: This study retrospectively investigated the clinical characteristics and treatment methods of patients diagnosed with sarcoidosis. The results showed that sarcoidosis can present with various rheumatological symptoms and may overlap with other rheumatic diseases.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Rheumatology
Eve M. D. Smith, Naomi Egbivwie, Katherine Cowan, Athimalaipet Ramanan, Clare E. Pain
Summary: The study aims to identify research priorities in the field of paediatric rheumatic diseases. Ideas for research priorities were collected through surveys and face-to-face meetings with various stakeholders. A modified Delphi process was used to rank and evaluate these ideas, resulting in a list of important disease-specific and general research priorities, providing guidance for clinicians, academics, and funding bodies.
LANCET RHEUMATOLOGY
(2022)
Article
Rheumatology
Jinming Wen, Pang Lyu, Iris Stolzer, Jin Xu, Andreas Giessl, Zhen Lin, Darja Andreev, Katerina Kachler, Rui Song, Xianyi Meng, Shan Cao, Giuliana Guggino, Francesco Ciccia, Claudia Guenther, Georg Schett, Aline Bozec
Summary: This study investigates the role of the mucosal barrier in the intestine in the development of arthritis. The expression of intestinal hypoxia-inducible factor (HIF)-2 alpha is found to be associated with the onset of experimental arthritis and rheumatoid arthritis (RA). Deletion of HIF-2 alpha in intestinal epithelial cells inhibits arthritis, improves intestinal barrier function, and reduces activation of immune cells. Mechanistically, HIF-2 alpha induces the transcription of claudin-15, which affects intestinal barrier integrity.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Neurosciences
Stephanie Guder, Fatemeh Sadeghi, Simone Zittel, Fanny Quandt, Chi-Un Choe, Marlene Boenstrup, Bastian Cheng, Goetz Thomalla, Christian Gerloff, Robert Schulz
Summary: Brain imaging studies have revealed that the cerebellum plays a significant role in recovery after non-cerebellar stroke. When stroke occurs, the function and structure of the contralesional cerebellum can be altered, leading to crossed cerebellar diaschisis (CCD). However, the spatial distribution of structural CCD and its impact on persistent deficits after stroke are still not well understood. In this study, structural MRI and clinical data were analyzed from chronic stroke patients, and it was found that lobule VI of the cerebellum is particularly prone to CCD and is associated with higher levels of disability and motor deficits. These findings provide new insights into stroke-related cerebellar plasticity and highlight the potential role of lobule VI in recovery and residual motor functioning.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Yunju Yang, Maria J. Knol, Ruiqi Wang, Aniket Mishra, Dan Liu, Michelle Luciano, Alexander Teumer, Nicola Armstrong, Joshua C. Bis, Min A. Jhun, Shuo Li, Hieab H. H. Adams, Nasir Ahmad Aziz, Mark E. Bastin, Mathieu Bourgey, Jennifer A. Smith, Stefan Frenzel, Rebecca F. Gottesman, Norbert Hosten, Lifang Hou, Sharon L. R. Kardia, Valerie Lohner, Pascale Marquis, Susana Munoz Maniega, Claudia L. Satizabal, Farzaneh A. Sorond, Maria C. Valdes Hernandez, Cornelia M. van Duijn, Meike W. Vernooij, Katharina Wittfeld, Qiong Yang, Wei Zhao, Eric Boerwinkle, Daniel Levy, Ian J. Deary, Jiyang Jiang, Karen A. Mather, Thomas H. Mosley, Bruce M. Psaty, Perminder S. Sachdev, Jennifer A. Smith, Nona Sotoodehnia, Charles S. DeCarli, Monique M. B. Breteler, M. Arfan Ikram, Hans J. Grabe, Joanna Wardlaw, W. T. Longstreth, Lenore J. Launer, Sudha Seshadri, Stephanie Debette, Myriam Fornage
Summary: This study investigates the association between epigenetic changes and white matter hyperintensities in adults. The findings suggest that blood-brain barrier dysfunction and the immune response are related to white matter hyperintensity burden, and antihyperlipidemic agents might be a potential treatment.
Article
Endocrinology & Metabolism
Stewart J. Wiseman, Jun-Fang Zhang, Calum Gray, Charlene Hamid, Maria Del C. Valdes Hernandez, Lucia Ballerini, Michael J. Thrippleton, Cameron Manning, Michael Stringer, Emilie Sleight, Susana Munoz Maniega, Alasdair Morgan, Yajun Cheng, Carmen Arteaga, Dany Jaime Garcia, Una Clancy, Fergus N. Doubal, Baljean Dhillon, Tom MacGillivray, Yun-Cheng Wu, Joanna M. Wardlaw
Summary: Cerebral small vessel disease (SVD) can cause stroke and dementia. Optical coherence tomography angiography (OCTA) of retinal capillary microvessels is related to brain microvessels. This study found that lower retinal vessel density and sparser branching were associated with white matter damage and impaired cerebrovascular reactivity in patients with minor stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Philip M. Bath, Iris Mhlanga, Lisa J. Woodhouse, Fergus Doubal, Katherine Oatey, Alan A. Montgomery, Joanna M. Wardlaw
Summary: The study is a feasibility study to evaluate the effectiveness of silostazol and isosorbide mononitrate in preventing the progression of cerebral small vessel disease (SVD). This study is of great importance for the prevention and treatment of SVD.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Clinical Neurology
Kailash Krishnan, Zhe Kang Law, Lisa J. Woodhouse, Rob A. Dineen, Nikola Sprigg, Joanna M. Wardlaw, Philip M. Bath
Summary: In this study, measures of intracranial compartments in acute intracerebral haemorrhage (ICH) were assessed using computerised tomography scans. The study found that ICH volume adjusted for intracranial and cerebral parenchymal volume could be useful in predicting functional outcomes in acute stroke. Additionally, midline shift and cistern effacement may predict outcome but further validation is needed.
STROKE AND VASCULAR NEUROLOGY
(2023)
Letter
Clinical Neurology
Grant Mair, Phil White, Philip Bath, Keith W. Muir, Francesca M. Chappell, Joanna M. Wardlaw, RITeS Collaborative
ANNALS OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Una Clancy, Ratko Radakovic, Fergus Doubal, Maria del C. Valdes Hernandez, Susana Munoz Maniega, Adele M. Taylor, Janie Corley, Francesca M. Chappell, Tom C. Russ, Simon R. Cox, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw
Summary: This study aimed to identify the association between apathy, depression, anxiety, and subjective memory complaints with longitudinal white matter hyperintensity (WMH) progression. The study found that apathy symptoms were associated with an increase in WMH, while depression, anxiety, and subjective memory complaints were not.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Awad Alzahrani, Xinyu Zhang, Adel Albukhari, Joanna M. Wardlaw, Grant Mair
Summary: This study aims to determine the threshold for brain attenuation on nonenhanced computed tomography (NECT) to differentiate CTP-defined penumbra vs core, and to correlate NECT features with CTP. The results showed that isolated swelling is highly specific to penumbra and can be differentiated by measuring lesion attenuation.
Article
Cardiac & Cardiovascular Systems
Mateusz Siedlinski, Lorenzo Carnevale, Xiaoguang Xu, Daniela Carnevale, Evangelos Evangelou, Mark J. Caulfield, Pasquale Maffia, Joanna Wardlaw, Nilesh J. Samani, Maciej Tomaszewski, Giuseppe Lembo, Michael Holmes, Tomasz J. Guzik
Summary: Observational and genetic data were used to study the relationship between blood pressure and cognitive function. The study identified brain structures associated with blood pressure and found that higher systolic blood pressure may have an adverse effect on cognitive function. These findings contribute to our understanding of the negative impact of hypertension on cognitive performance.
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Stefan Sennfalt, Michael J. Thrippleton, Michael Stringer, Carmen Arteaga Reyes, Francesca Chappell, Fergus Doubal, Daniela J. Garcia, Junfang Zhang, Yajun Cheng, Joanna Wardlaw
Summary: This study investigates brain fluid outflow pathways using MRI techniques and finds that these pathways can be visualized using conventional MRI. The results suggest that interstitial fluid drains via cortical perivenous spaces and are associated with small vessel disease.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Nivedita Agarwal, Laura D. Lewis, Lydiane Hirschler, Leonardo Rivera Rivera, Shinji Naganawa, Swati Rane Levendovszky, Geir Ringstad, Marijan Klarica, Joanna Wardlaw, Costantino Iadecola, Cheryl Hawkes, Roxana Octavia Carare, Jack Wells, Erik N. T. P. Bakker, Vartan Kurtcuoglu, Lynne Bilston, Maiken Nedergaard, Yuki Mori, Marcus Stoodley, Noam Alperin, Mony de Leon, Matthias J. P. van Osch
Summary: Neurofluids refer to all fluids in the brain and spine, including blood, cerebrospinal fluid, and interstitial fluid. Neuroscientists have identified various fluid environments that interact harmoniously to support optimal brain function. Animal studies have been crucial in understanding the dynamics of neurofluids, while human studies are limited due to the lack of noninvasive imaging techniques. The future development of noninvasive MRI techniques holds promise in imaging neurofluid dynamics and identifying pathological processes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Rheumatology
Maria del C. Valdes Hernandez, Karen J. Ferguson, Pearlyn Loon, Grant Kirkwood, Jun-Fang Zhang, Nicole Amft, Stuart H. Ralston, Yun-Cheng Wu, Joanna M. Wardlaw, Stewart J. Wiseman
Summary: Objectives Nasal, paranasal sinus and mucosal disorders are common symptoms in autoimmune rheumatic diseases. Soft tissue changes and fluid accumulation in the osteomeatal complexes and paranasal sinuses manifest as opaqueness on radiological images. This study investigates the association of paranasal sinus opaqueness on MRI with disease activity and small vessel disease in SLE patients.
Editorial Material
Clinical Neurology
David S. Liebeskind, Joanna M. Wardlaw
Review
Cell Biology
Stefanie Schreiber, Jose Bernal, Philipp Arndt, Frank Schreiber, Patrick Mueller, Lorena Morton, Ruediger Christian Braun-Dullaeus, Maria Del Carmen Valdes-Hernandez, Roberto Duarte, Joanna Marguerite Wardlaw, Sven Guenther Meuth, Grazia Mietzner, Stefan Vielhaber, Ildiko Rita Dunay, Alexander Dityatev, Solveig Jandke, Hendrik Mattern
Summary: Brain vascular health is crucial in preventing and slowing down the progression of amyotrophic lateral sclerosis (ALS). Impaired brain vascular health in ALS leads to decreased levels of vascular endothelial growth factor, compromised endothelial cell formation, and blood-brain barrier integrity. This review discusses the pathogenesis of impaired brain vascular health in ALS and the potential of novel magnetic resonance imaging techniques in its detection. It also highlights the importance of blood supply patterns to the motor cortex as a marker of resistance and resilience against vascular risk and events in ALS, providing insights for ALS management and understanding of the disease.
Review
Biochemistry & Molecular Biology
Daniela Jaime Garcia, Audrey Chagnot, Joanna M. Wardlaw, Axel Montagne
Summary: Small vessel disease (SVD) is a prevalent disorder of the brain's microvessels and is a common cause of dementia and strokes. Recent evidence suggests that endothelial dysfunction and a compromised blood-brain barrier play a key role in the development and progression of SVD. Understanding the molecular mechanisms underlying endothelial dysfunction in SVD could lead to better diagnostic tools and potential therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Luigi Lorenzini, Silvia Ingala, Lyduine E. Collij, Viktor Wottschel, Sven Haller, Kaj Blennow, Giovanni Frisoni, Gael Chetelat, Pierre Payoux, Pablo Lage-Martinez, Michael Ewers, Adam Waldman, Joanna Wardlaw, Craig Ritchie, Juan Domingo Gispert, Henk J. M. M. Mutsaerts, Pieter Jelle Visser, Philip Scheltens, Betty Tijms, Frederik Barkhof, Alle Meije Wink
Summary: Amyloid-beta accumulation in highly connected brain regions is associated with functional connectivity alterations in the early stages of Alzheimer's disease. Dynamic functional connectivity variations indicate increased regional flexibility and promote functional integration. This study investigates the associations between abnormal cerebrospinal fluid amyloid and static and dynamic properties of functional hubs, and their relationship with cognitive performance in non-demented participants. The results suggest that dynamic eigenvector centrality is an early biomarker of Alzheimer's disease pathology and cognitive decline.
BRAIN COMMUNICATIONS
(2023)
