Article
Oncology
Junyi Fu, Jiamin Zeng, Minyi Huang, Shunyao Liang, Yong He, Longchang Xie, Yinhui Deng, Jinxiu Yu
Summary: This study compared the long-term outcomes of primary versus postoperative Gamma Knife radiosurgery (GKRS) for benign meningiomas. The results showed that primary GKRS provided similar radiological and clinical outcomes, as well as similar complication rates compared with postoperative GKRS. For selected patients with benign meningiomas, GKRS could be considered as an alternative primary treatment.
Article
Oncology
Serena Ammendola, Paola Chiara Rizzo, Michele Longhi, Emanuele Zivelonghi, Serena Pedron, Giampietro Pinna, Francesco Sala, Antonio Nicolato, Aldo Scarpa, Valeria Barresi
Summary: The loss of H3K27me3 in meningiomas is significantly associated with tumor progression and shorter PFS after stereotactic radiosurgery (SRS), suggesting a weaker response to SRS in these cases.
Article
Clinical Neurology
Yavuz Samanci, M. Orbay Askeroglu, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Andrew Legarreta, David Fernandes Cabral, Sharath Anand, Ajay Niranjan, L. Dade Lunsford, Manjul Tripathi, Narendra Kumar, Roman Liscak, Jaromir May, Cheng-chia Lee, Huai-che Yang, Nuria Martinez Moreno, Roberto Martinez Alvarez, Keiss Douri, David Mathieu, Stylianos Pikis, Georgios Mantziaris, Jason P. Sheehan, Kenneth Bernstein, Douglas Kondziolka, Selcuk Peker
Summary: This study evaluated the safety and efficacy of SRS in managing pediatric meningiomas. The results suggest that SRS may be a safe and effective treatment option for surgically inaccessible, recurrent, or residual pediatric meningiomas.
Article
Oncology
Haomiao Zhang, Hanfeng Wu, Jianjie Lu, Wencheng Shao, Lili Yu
Summary: This study reported a case of recurrent orbital meningioma treated with a hybrid treatment model, including postoperative radiation therapy and gamma knife multifractionated stereotactic radiosurgery (MF-SRS). Through this treatment model, the patient's lesion disappeared completely, and some symptoms after surgery were significantly relieved.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Matthew Gallitto, Michelle Savacool, Albert Lee, Tony J. C. Wang, Michael B. Sisti
Summary: This study reports on the feasibility of using GammaKnife ICON for five-fraction SRS in the management of newly diagnosed GBM. Progression free survival was comparable to historical data without significant radiation-induced toxicities.
Article
Ophthalmology
O. Gishti, R. O. B. de Keizer, S. E. Detiger, C. van Rij, C. Slagter, D. Paridaens
Summary: A retrospective follow-up study on 25 patients who received fractionated stereotactic radiotherapy (fSRT) revealed that most patients had improved visual acuity and retinal nerve fiber layer thickness after treatment. Additionally, there was a significant reduction in radiation retinopathy and improvement in globe and eyelid position. In conclusion, fSRT is an effective and safe treatment option for this type of orbital tumor, providing long-term visual and cosmetic benefits.
Article
Oncology
Niema B. Razavian, Corbin A. Helis, Adrian Laxton, Stephen Tatter, J. Daniel Bourland, Ryan Mott, Glenn J. Lesser, Roy Strowd, Jaclyn J. White, Michael D. Chan, Christina K. Cramer
Summary: The purpose of this study was to evaluate the efficacy and safety of stereotactic radiosurgery (SRS) for radiation-induced meningiomas (RIMs). The results showed that SRS is a safe and effective treatment option, especially for WHO grade I RIMs or lesions treated in the upfront setting. However, WHO grade II lesions and recurrent lesions are at increased risk for disease progression.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Stylianos Pikis, Adomas Bunevicius, Jason Sheehan
Summary: This study evaluated the safety and efficacy of Gamma Knife radiosurgery for the management of asymptomatic skull base meningiomas. Results showed that GKRS affords long-standing tumor control and neurologic preservation in the majority of patients treated. Further studies are needed to identify the optimal management of asymptomatic skull base meningiomas.
ACTA NEUROCHIRURGICA
(2021)
Article
Oncology
Stylianos Pikis, Georgios Mantziaris, Abdurrahman I. Islim, Selcuk Peker, Yavuz Samanci, Ahmed M. Nabeel, Wael A. Reda, Khaled Abdelkarim, Amr M. N. El-Shehaby, Sameh R. Tawadros, Reem M. Emad, Violaine Delabar, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Roman Licsak, Jaromir Hanuska, Roberto Martinez Alvarez, Dev N. Patel, Douglas Kondziolka, Kenneth Bernstein, Nuria Martinez Moreno, Manjul Tripathi, Herwin Speckter, Camilo Albert, Greg N. Bowden, Ronald J. Benveniste, Dade L. Lunsford, Michael D. Jenkinson, Jason Sheehan
Summary: This study suggests that stereotactic radiosurgery (SRS) is a low-risk and effective treatment strategy for asymptomatic convexity meningiomas. More patients achieved tumor control after SRS compared to active surveillance. Increasing age was predictive of tumor growth.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Review
Oncology
Antonio Santacroce, Constantin Tuleasca, Roman Liscak, Enrico Motti, Christer Lindquist, Matthias Radatz, Brigitte Gatterbauer, Bodo E. Lippitz, Roberto Martinez Alvarez, Nuria Martinez Moreno, Marcel A. Kamp, Bente Sandvei Skeie, Stephanie Schipmann, Michele Longhi, Frank Unger, Ian Sabin, Thomas Mindermann, Otto Bundschuh, Gerhard A. Horstmann, A. T. C. J. van Eck, Maja Walier, Manfred Berres, Makoto Nakamura, Hans Jakob Steiger, Daniel Haenggi, Thomas Fortmann, Samer Zawy Alsofy, Jean Regis, Christian Ewelt
Summary: Meningiomas are common tumors of the central nervous system, and cavernous sinus meningiomas (CSMs) require special treatment due to their location. Stereotactic radiosurgery (SRS) has been found to be a safe and effective alternative for the treatment of CSMs. This multicenter study analyzed the outcomes of over 1000 patients with CSMs treated with SRS, and found that SRS achieved a high tumor control rate with few complications.
Article
Oncology
Sten Myrehaug, John Hudson, Hany Soliman, Mark Ruschin, Chia-Lin Tseng, Jay Detsky, Zain Husain, Julia Keith, Eshetu G. Atenafu, Pejman Maralani, Chris Heyn, Sunit Das, Nir Lipsman, Arjun Sahgal
Summary: This study aimed to report mature image-based outcomes for MLC-Linac HSRT, focusing on clinical and dosimetric factors associated with local failure (LF). The results showed that daily 5-fraction 30Gy HSRT treatment can achieve optimal local control, irrespective of tumor volume and histology, with an acceptable risk of radiation necrosis.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Clinical Neurology
Leila Maria Da Roz, Geovanne Pedro Mauro, Vinicius de Carvalho Gico, Eduardo Weltman, Evandro Cesar de Souza, Eberval Gadelha Figueiredo, Manoel Jacobsen Teixeira
Summary: This study retrospectively reviewed AVM patients treated with radiation or a combination of radiation and embolization. The results showed that stereotactic radiosurgery plays an important role in AVM treatment and should be preferred whenever possible.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Adomas Bunevicius, Rithika Kormath Anand, Mohanad Suleiman, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Marco Perez Caceres, David Mathieu, Cheng-chia Lee, Huai-che Yang, Piero Picozzi, Andrea Franzini, Luca Attuati, Herwin Speckter, Jeremy Olivo, Samir Patel, Christopher P. Cifarelli, Daniel T. Cifarelli, Joshua D. Hack, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Kareem R. Fakhoury, Chad G. Rusthoven, Ronald E. Warnick, Jason Sheehan
Summary: SRS provides durable tumor control and acceptable rates of vision preservation in perioptic meningiomas. A prescription dose of >= 12 Gy is associated with improved tumor control, while a dose to the optic apparatus of >= 10 Gy and tumor progression are associated with post-SRS visual decline.
Article
Biology
Cheng-Siu Chang, Cheng-Wei Huang, Hsi-Hsien Chou, Hsien-Tang Tu, Ming-Tsung Lee, Chuan-Fu Huang
Summary: This retrospective study compared the outcomes of two treatment approaches for large incidental meningiomas. The results suggest that a pathophysiological approach with gamma knife radiosurgery achieves similar rates of tumor control and reduces the risk of peritumoral edema.
Article
Oncology
Hirotaka Hasegawa, Kunal Vakharia, Michael J. Link, Scott L. Stafford, Paul D. Brown, Ian F. Parney, Terry C. Burns, Elizabeth S. Yan, Anita Mahajan, Nadia N. Laack, Bruce E. Pollock
Summary: This retrospective analysis of 68 patients with atypical meningiomas (AM) receiving stereotactic radiosurgery (SRS) showed poor progression-free survival (PFS) despite treatment. Prior external beam radiation therapy (EBRT) was associated with worse tumor control, higher tumor-related mortality, and an increased risk of adverse radiation events (AREs). Further research is needed to determine if upfront adjuvant SRS improves tumor control compared to salvage SRS.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Review
Oncology
Olga Golubnitschaja, Peter Kubatka, Alena Mazurakova, Marek Samec, Abdullah Alajati, Frank A. Giordano, Vincenzo Costigliola, Joerg Ellinger, Manuel Ritter
Summary: Prostate cancer is a multifactorial disease with increasing global incidence and rapidly rising treatment costs. Specific blood profiles play a crucial role in risk assessment, disease prevention, and personalized treatment, presenting a new paradigm in PCa management.
Review
Oncology
Tijana Vlatkovic, Marlon R. Veldwijk, Frank A. Giordano, Carsten Herskind
Summary: This review summarizes the knowledge in brain tumor treatment through radiosensitization and cell cycle checkpoint inhibition via targeting ATM, ATR, CHK1, CHK2, and WEE1 kinases. Radiation therapy is an important part of standard treatment for brain tumors, but tumor cells' resistance limits its efficacy. Inhibiting cell cycle checkpoint control to increase tumor sensitivity to radiation therapy is a promising approach.
Article
Otorhinolaryngology
Muemtaz Koeksal, Leonard Saur, Davide Scafa, Gustavo Sarria, Christina Leitzen, Christopher Schmeel, Frederick Far, Sebastian Strieth, Frank A. Giordano
Summary: This study identified factors associated with decision regret among head and neck cancer patients who underwent surgery and adjuvant radiotherapy. Higher decision regret scores were linked to lower single fraction dose, more restriction in everyday life, and various post-treatment symptoms such as trouble speaking and swallowing. Recommendations include psychosocial support for patients undergoing adjuvant radiation and considering hypofractionation for lower decision regret.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Chun-Shan Liu, Inmaculada Rioja, Ali Bakr, Marlon R. Veldwijk, Elena Sperk, Carsten Herskind, Dieter Weichenhan, Rab K. Prinjha, Christoph Plass, Peter Schmezer, Odilia Popanda
Summary: This study investigated the effects and toxicity of different inhibitors targeting BET proteins on radiation-induced fibroblast activation. The results showed that BD2-selective targeting inhibitors efficiently suppressed the expression of DGKA and profibrotic markers without showing cytotoxicity.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Christian Moehring, Aliki Timotheou, Adrianna Manczak, Farsaneh Sadeghlar, Taotao Zhou, Robert Mahn, Alexandra Bartels, Malte Monin, Marieta Toma, Georg Feldmann, Peter Brossart, Muemtaz Koeksal, Gustavo R. Sarria, Frank A. Giordano, Philipp Lingohr, Azin Jafari, Joerg C. Kalff, Christian P. Strassburg, Maria A. Gonzalez-Carmona
Summary: This study analyzed the real-life experience of elderly patients with advanced or metastatic GC or AEG treated with FLOT as first-line palliative chemotherapy. The ECOG performance status showed a stronger prognostic value than patient age in this cohort.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Muemtaz Koeksal, Maike van der Hoek, Davide Scafa, David Koch, Christina Leitzen, Leonard C. Schmeel, Georg Feldmann, Andreas Strauss, Sebastian Koob, Frank A. Giordano
Summary: In this study, the researchers investigated the effects of adjuvant radiotherapy on patients with extremity soft-tissue sarcomas and analyzed the side effects of radiotherapy as well as predictive factors for patient prognosis. The results showed that radiotherapy was beneficial for improving local control, especially for high-grade sarcomas. Although radiotherapy caused some side effects, the occurrence rate of severe long-term function-limiting adverse events was low.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Siyao Deng, Tijana Vlatkovic, Moying Li, Tianzuo Zhan, Marlon R. Veldwijk, Carsten Herskind
Summary: This review focuses on the role of DNA damage response and repair pathways in radiotherapy, and the potential for enhancing the sensitivity of colorectal cancer to radiotherapy by targeting cell-cycle checkpoint proteins.
Article
Oncology
Mumtaz Koeksal, Romy Streppel, Stefan Hauser, Alina Abramian, Christina Kaiser, Maria Gonzalez-Carmona, Georg Feldmann, Niklas Schaefer, Sebastian Koob, Mohammed Banat, Motaz Hamed, Frank A. Giordano, Leonard C. Schmeel
Summary: This study investigated whether the severity of early side effects after radiotherapy are associated with patient nationality and other sociodemographic and clinical characteristics. The results showed that non-German patients were more likely to have severe side effects, and side effect severity was also associated with tumor entity, concomitant therapy, body mass index, and age. These findings suggest a need to develop targeted preventive measures for foreign cancer patients and further research on predicting factors for radiotherapy side effects, including other sociodemographic characteristics, to better personalize therapy regimens.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
J. Weller, N. Schaefer, C. Schaub, T. Tzaridis, T. Zeyen, M. Schneider, A. L. Potthoff, F. A. Giordano, J. P. Steinbach, P. S. Zeiner, T. Kowalski, M. Sabel, P. Hau, D. Krex, O. Grauer, R. Goldbrunner, O. Schnell, G. Tabatabai, F. Ringel, F. Schmidt-Graf, S. Brehmer, J. C. Tonn, L. Bullinger, P. Vajkoczy, M. Glas, H. Vatter, U. Herrlinger, C. Seidel
Summary: In the CeTeG/NOA-09 randomized phase III trial, TMZ/CCNU combination therapy was found to be superior to TMZ in newly diagnosed MGMT methylated glioblastoma, with higher incidence of hematotoxicity. This study analyzed high-grade hematotoxicity and its prognostic relevance in the trial population.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Cas S. Dejonckheere, Alexander M. C. Boehner, Eva Schmitz, Tobias A. W. Holderried, Leonard C. Schmeel, Peter Brossart, Frank A. Giordano, Mumtaz A. Koeksal
Summary: A retrospective analysis of 48 adult patients showed that a longer interval of >= 3 days between TBI completion and allo-HSCT was associated with improved overall survival and better peripheral blood kinetics after successful engraftment, suggesting the importance of timing in improving patient outcomes.
Article
Oncology
Douglas Guedes de Castro, Paulo Issamu Sanematsu Junior, Antonio Cassio Assis Pellizzon, Sergio Hideki Suzuki, Ricardo Cesar Fogaroli, Jose Eduardo Souza Dias Junior, Guilherme Rocha Melo Gondim, Daniel Alvarez Estrada, Maria Leticia Gobo Silva, Marcio Saquy Rassi, Michael Jenwei Chen, Richard Giacomelli, Henderson Ramos, Elson Santos Neto, Carolina Humeres Abrahao, Tharcisio Machado Coelho, Liao Shin Yu, Cassio de Queiroz Tannous, Vinicius Fernando Calsavara, Frank Anton Giordano, Jean Goncalves de Oliveira
Summary: Objective: To evaluate the effect of intraoperative radiotherapy (IORT) on local control (LC) and brain disease control (BDC) after resection of brain metastases (BM). Conclusion: IORT for completely resected BM is associated with a potential high local control and low risk of radiation necrosis (RN), warranting further studies.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Lea Hoppen, Gustavo R. Sarria, Chung S. Kwok, Judit Boda-Heggemann, Daniel Buergy, Michael Ehmann, Frank A. Giordano, Jens Fleckenstein
Summary: This study evaluated the impact of daily online adaptive radiation therapy (ART) strategies on dose-volume metrics in patients with lung cancer. The results showed that ART can reduce lung doses while maintaining good target coverage or escalate target doses without increasing ipsilateral lung exposure. The clinical benefits of these strategies should be further evaluated in prospective clinical trials.
RADIATION ONCOLOGY
(2023)
Review
Oncology
Stefan Janssen, Rami A. El Shafie, Arne M. Ruder, Daniel Buergy, Davide Scafa, Frank A. Giordano, Nils H. Nicolay, Marco M. E. Vogel, Stephanie E. Combs, Fabian B. Fahlbusch, Dirk Rades, Lukas Kaesmann
Summary: This article reviews the existing scientific literature on mobile applications in the field of radiation oncology and evaluates the characteristics of commercially available apps across different platforms. A systematic review of the literature and searches in major app marketplaces were conducted. The findings show that there is a limited availability of radiation oncology apps for patients and healthcare professionals in common marketplaces, with most apps focusing on supporting healthcare professionals.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Oncology
Julian P. Layer, Katharina Layer, Gustavo R. Sarria, Fred Roehner, Cas S. Dejonckheere, Lea L. Friker, Thomas Zeyen, David Koch, Davide Scafa, Christina Leitzen, Muemtaz Koeksal, Frederic Carsten Schmeel, Niklas Schaefer, Jennifer Landsberg, Michael Hoelzel, Ulrich Herrlinger, Matthias Schneider, Frank A. Giordano, Leonard Christopher Schmeel
Summary: This study evaluates the safety and outcome profile of five-fraction stereotactic radiotherapy (FSRT) for brain metastases (BM). It shows that FSRT is a feasible and efficient approach for both adjuvant and definitive treatment, with acceptable local control rates and comparable radiation necrosis rates.