Metabolic Reprogramming and Dependencies Associated with Epithelial Cancer Stem Cells Independent of the Epithelial-Mesenchymal Transition Program

Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer

(2015) Tiejun Pan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

Different Levels of Twist1 Regulate Skin Tumor Initiation, Stemness, and Progression

(2015) Benjamin Beck et al.   Cell Stem Cell

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

(2015) Qian Wang et al.   JOURNAL OF PATHOLOGY

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

(2015) Arianna De Luca et al.   Oncotarget

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(2015) Elisabet Cuyàs et al.   Oncotarget

Metabolic Asymmetry in Cancer: A “Balancing Act” that Promotes Tumor Growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   CANCER CELL

Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis

(2014) Tania Valencia et al.   CANCER CELL

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation

(2014) Prashant Mishra et al.   Cell Metabolism

Oral epithelial stem cells—Implications in normal development and cancer metastasis

(2014) Silvana Papagerakis et al.   EXPERIMENTAL CELL RESEARCH

Cancer Stem Cell Theory and the Warburg Effect, Two Sides of the Same Coin?

(2014) Nicola Pacini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Pyruvate Dehydrogenase Complexes: Structure-based Function and Regulation

(2014) Mulchand S. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPARC mediates metastatic cooperation between CSC and non-CSC prostate cancer cell subpopulations

(2014) Francesca Mateo et al.   Molecular Cancer

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

(2014) I. R. Schlaepfer et al.   MOLECULAR CANCER THERAPEUTICS

Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance

(2014) Hariharan Easwaran et al.   MOLECULAR CELL

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers

(2014) Allison S. Cleary et al.   NATURE

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Mitochondrial Morphological Features Are Associated with Fission and Fusion Events

(2014) Laura M. Westrate et al.   PLoS One

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

Targeting Unique Metabolic Properties of Breast Tumor Initiating Cells

(2014) Weiguo Feng et al.   STEM CELLS

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment

(2014) D Ciavardelli et al.   Cell Death & Disease

Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion

(2014) Anna Chapman et al.   Cell Reports

Characterization of the Usage of the Serine Metabolic Network in Human Cancer

(2014) Mahya Mehrmohamadi et al.   Cell Reports

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

A proposed role for glutamine in cancer cell growth through acid resistance

(2013) Weijiao Huang et al.   CELL RESEARCH

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

(2013) P M Tedeschi et al.   Cell Death & Disease

Wnt/Snail Signaling Regulates Cytochrome c Oxidase and Glucose Metabolism

(2012) S. Y. Lee et al.   CANCER RESEARCH

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

(2012) Toni Celià-Terrassa et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting glucose metabolism for cancer therapy: Figure 1.

(2012) Robert B. Hamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy

(2012) Chin-Chih Lin et al.   Scientific Reports

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells

(2011) Yunfei Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine Biosynthesis with One Carbon Catabolism and the Glycine Cleavage System Represents a Novel Pathway for ATP Generation

(2011) Alexei Vazquez et al.   PLoS One

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling

(2010) Anatoly A. Starkov   Annals of the New York Academy of Sciences

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs

(2010) Jonghwan Kim et al.   CELL

Empowering self-renewal and differentiation: the role of mitochondria in stem cells

(2010) Jalees Rehman   JOURNAL OF MOLECULAR MEDICINE-JMM

Metabolic flexibility and cell hierarchy in metastatic cancer

(2010) Michael V. Berridge et al.   MITOCHONDRION

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Energetic requirements and bioenergetic modulation of mitochondrial morphology and dynamics

(2009) Cécile Sauvanet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Epithelial-Mesenchymal Transition Induced by Growth Suppressor p12CDK2-AP1 Promotes Tumor Cell Local Invasion but Suppresses Distant Colony Growth

(2008) T. Tsuji et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells

(2008) David J. Wong et al.   Cell Stem Cell