Concise Review: Signaling Control of Early Fate Decisions Around the Human Pluripotent Stem Cell State

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types

(2016) Kyle M. Loh et al.   CELL

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs

(2016) Jyoti Rao et al.   Cell Stem Cell

Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory

(2016) William A. Pastor et al.   Cell Stem Cell

Human-Mouse Chimerism Validates Human Stem Cell Pluripotency

(2016) Victoria L. Mascetti et al.   Cell Stem Cell

Molecular Criteria for Defining the Naive Human Pluripotent State

(2016) Thorold W. Theunissen et al.   Cell Stem Cell

Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes

(2016) Thomas Touboul et al.   JOURNAL OF HEPATOLOGY

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4

(2015) Nina S. Funa et al.   Cell Stem Cell

Generation of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem Cells

(2015) Yongchang Chen et al.   Cell Stem Cell

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq

(2015) Paul Blakeley et al.   DEVELOPMENT

Endogenous WNT Signals Mediate BMP-Induced and Spontaneous Differentiation of Epiblast Stem Cells and Human Embryonic Stem Cells

(2015) Dorota Kurek et al.   Stem Cell Reports

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

NANOG and CDX2 Pattern Distinct Subtypes of Human Mesoderm during Exit from Pluripotency

(2014) Sasha Mendjan et al.   Cell Stem Cell

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

(2014) Thorold W. Theunissen et al.   Cell Stem Cell

Efficient Endoderm Induction from Human Pluripotent Stem Cells by Logically Directing Signals Controlling Lineage Bifurcations

(2014) Kyle M. Loh et al.   Cell Stem Cell

Derivation of naive human embryonic stem cells

(2014) C. B. Ware et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of a Human Pluripotent State with Distinct Regulatory Circuitry that Resembles Preimplantation Epiblast

(2013) Yun-Shen Chan et al.   Cell Stem Cell

Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells

(2013) Asif M. Maroof et al.   Cell Stem Cell

The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak

(2013) Yoji Kojima et al.   Cell Stem Cell

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

Modeling Neural Crest Induction, Melanocyte Specification, and Disease-Related Pigmentation Defects in hESCs and Patient-Specific iPSCs

(2013) Yvonne Mica et al.   Cell Reports

Distinct Lineage Specification Roles for NANOG, OCT4, and SOX2 in Human Embryonic Stem Cells

(2012) Zheng Wang et al.   Cell Stem Cell

Small Molecule-Assisted, Line-Independent Maintenance of Human Pluripotent Stem Cells in Defined Conditions

(2012) Stefan Frank et al.   PLoS One

FGF Inhibition Directs BMP4-Mediated Differentiation of Human Embryonic Stem Cells to Syncytiotrophoblast

(2012) Smita Sudheer et al.   STEM CELLS AND DEVELOPMENT

Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors

(2012) Timothy A. Blauwkamp et al.   Nature Communications

In Vivo Differentiation Potential of Epiblast Stem Cells Revealed by Chimeric Embryo Formation

(2012) Yali Huang et al.   Cell Reports

Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions

(2012) Qi Gu et al.   Protein & Cell

Pluripotency Factors in Embryonic Stem Cells Regulate Differentiation into Germ Layers

(2011) Matt Thomson et al.   CELL

FGF2 Sustains NANOG and Switches the Outcome of BMP4-Induced Human Embryonic Stem Cell Differentiation

(2011) Pengzhi Yu et al.   Cell Stem Cell

FGF signalling inhibits neural induction in human embryonic stem cells

(2011) Boris Greber et al.   EMBO JOURNAL

Pluripotency factors regulate definitive endoderm specification through eomesodermin

(2011) A. K. K. Teo et al.   GENES & DEVELOPMENT

Distinct Developmental Ground States of Epiblast Stem Cell Lines Determine Different Pluripotency Features

(2011) Christof Bernemann et al.   STEM CELLS

Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

(2010) Christopher J. Lengner et al.   CELL

Epiblast Stem Cell Subpopulations Represent Mouse Embryos of Distinct Pregastrulation Stages

(2010) Dong Wook Han et al.   CELL

Conserved and Divergent Roles of FGF Signaling in Mouse Epiblast Stem Cells and Human Embryonic Stem Cells

(2010) Boris Greber et al.   Cell Stem Cell

The Multiple Phases and Faces of Wnt Signaling During Cardiac Differentiation and Development

(2010) Susanne Gessert et al.   CIRCULATION RESEARCH

Vitamin C Promotes Widespread Yet Specific DNA Demethylation of the Epigenome in Human Embryonic Stem Cells

(2010) Tung-Liang Chung et al.   STEM CELLS

Naive and Primed Pluripotent States

(2009) Jennifer Nichols et al.   Cell Stem Cell

Activin/Nodal signalling maintains pluripotency by controlling Nanog expression

(2009) L. Vallier et al.   DEVELOPMENT

Signaling Pathways Controlling Pluripotency and Early Cell Fate Decisions of Human Induced Pluripotent Stem Cells

(2009) Ludovic Vallier et al.   STEM CELLS

NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCs

(2008) Ren-He Xu et al.   Cell Stem Cell

Control of Early Fate Decisions in Human ES Cells by Distinct States of TGFβ Pathway Activity

(2008) Boris Greber et al.   STEM CELLS AND DEVELOPMENT