Article
Cell & Tissue Engineering
Tomoyuki Kamenaga, Yuichi Kuroda, Kanto Nagai, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Toshihisa Maeda, Naoki Nakano, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto
Summary: The study found that SVF cells can enhance bone healing, with cryopreserved cells showing almost equal potential as fresh cells. SVF cells can be used to improve nonunion bone fracture healing as an alternative to other mesenchymal stem cells, and their effect can be maintained under cryopreservation.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kishor K. Sivaraj, Paul-Georg Majev, Hyun-Woo Jeong, Backialakshmi Dharmalingam, Dagmar Zeuschner, Silke Schroder, M. Gabriele Bixel, Melanie Timmen, Richard Stange, Ralf H. Adams
Summary: The study demonstrates the crucial role of mesenchymal stromal cell-derived septoclasts in development and fracture healing, showing their disappearance after development completion and re-emergence during fracture healing. These septoclasts disappear in adult and ageing bones but reappear in association with growing vessels during fracture healing.
NATURE COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Julien Guerrero, Boris Dasen, Agne Frismantiene, Sebastien Pigeot, Tarek Ismail, Dirk J. Schaefer, Maria Philippova, Therese J. Resink, Ivan Martin, Arnaud Scherberich
Summary: The presence of T-cadherin-positive cells derived from the stromal vascular fraction (SVF) is essential for the osteogenic and vasculogenic properties of SVF cells. The crosstalk between stromal cells and T-cadherin-expressing endothelial cells within adipose tissue critically regulates osteogenesis.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Emerito Carlos Rodriguez-Merchan
Summary: This article reviews recent findings on the molecular mechanisms of bone healing and presents various biological alternatives for treating recalcitrant nonunions, such as using morin, BMP9, and leptin. It also discusses factors that impact bone regeneration, including inhibition of estrogen receptor signaling, smoking-induced inflammatory responses, and delayed fracture healing in diabetic animals due to BMP6 deficiency. The combination of bioceramics and expanded autologous human mesenchymal stem cells from bone marrow is highlighted as a promising alternative for treating nonunions that do not respond well to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Jeremy Lynn, Kavitha Ranganathan, Alexandra O. Luby, Kevin M. Urlaub, Alexis Donneys, Noah S. Nelson, Steven R. Buchman
Summary: This study compares the effects of adipose-derived stem cells (ASCs) and bone marrow stromal cells (BMSCs) on irradiated mandibular fracture repair in mice. The results show that ASCs have superior therapeutic efficacy in terms of union rate, vascular morphology, and trend in biomechanical strength compared to BMSCs. The robust vascular response induced by ASCs better recapitulates the sequence and synchronicity of physiological bone healing, improving the reliability of irradiated fracture repair.
ANNALS OF PLASTIC SURGERY
(2022)
Article
Medicine, Research & Experimental
Kai Chen, Shijie Liao, Yicheng Li, Haibo Jiang, Yun Liu, Chao Wang, Vincent Kuek, Jacob Kenny, Boxiang Li, Qian Huang, Jianxin Hong, Yan Huang, Shek Man Chim, Jennifer Tickner, Nathan J. Pavlos, Jinmin Zhao, Qian Liu, An Qin, Jiake Xu
Summary: EGFL6 serves as a crucial regulator in coupling osteogenesis to angiogenesis during bone repair. Overexpression of EGFL6 enhances osteogenic capacity, while deficiency leads to compromised bone repair.
Article
Orthopedics
Tianyou Kan, Zihao He, Jingke Du, Mingming Xu, Junqi Cui, Xuequan Han, Dake Tong, Hanjun Li, Mengning Yan, Zhifeng Yu
Summary: Through animal experiments and in vitro cell experiments, it was found that irisin can promote bone fracture healing by enhancing osteogenesis and angiogenesis, which is of great significance in understanding the interaction between muscle and bone during fracture healing.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Materials Science, Multidisciplinary
Seong Chae Park, Woo Sub Yang, Ji Yeon Ahn, Jong Bo Park, Jong-Hwan Lee, Youngjin Jung, Hwa Rang Kim, Ji Yoon Kim, Jeong Mook Lim, Byung Hee Hong
Summary: This study investigated the potential of hydroxyapatite-mineralized graphene film to support osteogenic differentiation of human adipose-derived stromal cells in vitro. Results indicated that the optimized treatment promoted cell proliferation and osteogenic differentiation of hASCs through the BMP/Smad signaling pathway.
Article
Cell Biology
Chih-Yi Yang, Rita Jui-Hsien Lu, Ming-Kang Lee, Felix Shih-Hsian Hsiao, Ya-Ping Yen, Chun-Chun Cheng, Pu-Sheng Hsu, Yi-Tzang Tsai, Shih-Kuo Chen, I-Hsuan Liu, Pao-Yang Chen, Shau-Ping Lin
Summary: MSCs lacking DNMT3L exhibit reduced colony forming ability and impaired osteogenesis in vitro, with differentially regulated genes associated with bone morphology-related phenotypes. The observed defects are hypothesized to result from pre-deposited epigenetic signatures from DNMT3L-expressing progenitors, rather than a direct effect of missing DNMT3L in MSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Mingming Wang, Hongyan Zhan, Jianhua Wang, Hua Song, Jianhua Sun, Gang Zhao
Summary: This study demonstrates that CS can enhance the proliferation of ADSCs and improve their migration ability through inhibiting apoptosis and oxidative stress. CS also promotes the expression of CXCR4 in ADSCs and enhances their migration and angiogenic capacity. Importantly, CS improves the efficacy of ADSCs in wound healing both in vivo and in vitro, providing potential materials for the treatment of wound healing.
Review
Cell Biology
Yang An, Shuyan Lin, Xiaojie Tan, Shiou Zhu, Fangfei Nie, Yonghuan Zhen, Luosha Gu, Chunlei Zhang, Baicheng Wang, Wei Wei, Dong Li, Junhao Wu
Summary: ADSCs-EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling to inhibit scar hyperplasia in wounds. Compared with ADSCs therapeutics, ADSCs-EXOs have high stability, easy storage, immune system non-rejection, homing effect, and easily controlled dosage. In patients with diabetes mellitus, ADSCs-EXOs can improve fat grafting and promote wound healing.
CELL PROLIFERATION
(2021)
Review
Biochemistry & Molecular Biology
Qing Zhao, Xinran Liu, Chuanying Yu, Yu Xiao
Summary: This review provides a deep insight into the synergistic performance of BMSCs and macrophages in fracture healing, discussing their respective functions, relevant impact factors, and mechanisms. It aims to offer valuable cues and technical support for research on macrophage- and BMSC-related treatments, such as combined cell therapy for bone fractures.
DNA AND CELL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lingli Ding, Song Gu, Bingyu Zhou, Min Wang, Yage Zhang, Siluo Wu, Hong Zou, Guoping Zhao, Zhao Gao, Liangliang Xu
Summary: Fractures have a negative impact on an individual's quality of life, but Ginsenoside Compound K (CK) found in Ginseng has shown potential for promoting bone regeneration and angiogenesis. This study found that CK can promote osteogenic differentiation of rat bone marrow mesenchymal stem cells and increase tube formation capacity in human umbilical vein endothelial cells. In a rat open femoral fracture model, CK was found to improve fracture repair and increase the formation of H type vessel in the fracture callus.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
R. Tevlin, H. desJardins-Park, J. Huber, S. E. DiIorio, M. T. Longaker, D. C. Wan
Summary: Osteoarthritis is a global burden that affects joints and bones. Tissue engineering, specifically adipose-derived stromal cells, shows promise as a treatment option. Advancements in material science allow for improved engraftment of these cells and activation of biophysical signals through designed microstructures.
Article
Endocrinology & Metabolism
Geetha Mohan, Evan Yu-An Lay, Haley Berka, Lorna Ringwood, Alexander Kot, Haiyan Chen, Wei Yao, Nancy E. Lane
CALCIFIED TISSUE INTERNATIONAL
(2017)
Article
Endocrinology & Metabolism
Zhendong A. Zhong, Alexander Kot, Yu-An E. Lay, Hongliang Zhang, Junjing Jia, Nancy E. Lane, Wei Yao
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Cell & Tissue Engineering
Baarkullah Awan, David Turkov, Cameron Schumacher, Antonio Jacobo, Amber McEnerney, Ashley Ramsey, Gege Xu, Dayoung Park, Stefanos Kalomoiris, Wei Yao, Li-En Jao, Miguel L. Allende, Carlito B. Lebrilla, Fernando A. Fierro
Article
Orthopedics
Kie Shidara, Geetha Mohan, Yan-An Evan Lay, Karl J. Jepsen, Wei Yao, Nancy E. Lane
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2019)
Article
Cell & Tissue Engineering
Elizabeth Cortez-Toledo, Melanie Rose, Emmanuel Agu, Heather Dahlenburg, Wei Yao, Jan A. Nolta, Ping Zhou
STEM CELLS AND DEVELOPMENT
(2019)
Article
Toxicology
Hongliang Zhang, Bing Xiao, Li Jiang, Wei Yao, Huahao Shen, Xudong Xiang
TOXICOLOGY LETTERS
(2019)
Article
Endocrinology & Metabolism
Chenlin Dai, Junjing Jia, Alexander Kot, Xueping Liu, Lixian Liu, Min Jiang, Nancy E. Lane, Barton L. Wise, Wei Yao
Article
Biochemistry & Molecular Biology
Vivian Alonso-Garcia, Cutter Chaboya, Qiongyu Li, Bryan Le, Timothy J. Congleton, Jose Florez, Victoria Tran, Gang-Yu Liu, Wei Yao, Carlito B. Lebrilla, Fernando A. Fierro
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Min Jiang, Ruiwu Liu, Lixian Liu, Alexander Kot, Xueping Liu, Wenwu Xiao, Junjing Jia, Yuanpei Li, Kit S. Lam, Wei Yao
NATURE COMMUNICATIONS
(2020)
Article
Medicine, Research & Experimental
Jennifer Zieba, Lisette Nevarez, Davis Wachtell, Jorge H. Martin, Alexander Kot, Sereen Wong, Daniel H. Cohn, Deborah Krakow
Summary: Osteogenesis imperfecta (OI) is a disorder characterized by bone fragility and increased fracture incidence, as well as short stature. The study shows that OI affects the growth plate and endochondral ossification, leading to negative effects on linear growth beyond its known impacts on bone.
Meeting Abstract
Endocrinology & Metabolism
Wei Yao, Abhijit Chaudhari, Yuan Lay, Mie Jin Lim, Alexander Kot, Donald Kimmel, Nancy Lane
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Meeting Abstract
Endocrinology & Metabolism
Wei Yao, Geetha Mohan, Yu-An Lay, Alexander Kot, MieJin Lim, Donald Kimmel, Nancy Lane
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Meeting Abstract
Rheumatology
Alanna Dubrovsky, Wei Yao, Geetha Mohan, Mie Jin Lim, Yu-An Evan Lay, Donald Kimmel, Nancy E. Lane
ARTHRITIS & RHEUMATOLOGY
(2017)
Article
Materials Science, Biomaterials
Xiaobao Xu, Gaomai Yang, Xiangdong Xue, Hongwei Lu, Hao Wu, Yee Huang, Di Jing, Wenwu Xiao, Jingkui Tian, Wei Yao, Chong-xian Pan, Tzu-yin Lin, Yuanpei Li
JOURNAL OF MATERIALS CHEMISTRY B
(2018)