Article
Multidisciplinary Sciences
Veronica Moncho-Amor, Probir Chakravarty, Christophe Galichet, Ander Matheu, Robin Lovell-Badge, Karine Rizzoti
Summary: The study reveals the role of SOX2 in endocrine tumorigenesis in p27(-/-) pituitaries, showing that increased levels of SOX2 in both endocrine and stem cells are associated with pituitary hyperplasia. SOX2 is required cell autonomously in endocrine cells for tumor formation and in stem cells for promotion of tumorigenesis. Single cell transcriptomic analysis further highlights the importance of the SOX2-dependent MAPK pathway in stem cells for tumorigenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Endocrinology & Metabolism
Paul R. Le Tissier, Joanne F. Murray, Patrice Mollard
Summary: Plasticity of function is crucial for the anterior pituitary endocrine axes to adapt to changes in hormone demand and environmental challenges. The size and organization of pituitary cell populations play a role in this plasticity. SOX2+ve cells act as sentinels and actuators of cell number, regulating secretion and other aspects of endocrine cell functional mass.
Article
Biochemistry & Molecular Biology
Brianna Chen, Dylan McCuaig-Walton, Sean Tan, Andrew P. Montgomery, Bryan W. Day, Michael Kassiou, Lenka Munoz, Ariadna Recasens
Summary: The study demonstrates the important role of DYRK1A kinase in regulating the differentiation commitment of glioblastoma stem cells. Inhibiting DYRK1A insulates GSCs from differentiation-inducing signals, promoting differentiation and limiting stemness acquisition through deactivation of CDK5. This novel DYRK1A-CDK5-SOX2 pathway sheds further light on the mechanisms underlying the maintenance of glioblastoma stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jose Mario Gonzalez-Meljem, Juan Pedro Martinez-Barbera
Summary: Cellular senescence can prevent tumour development autonomously but also promote tumour growth non-autonomously by creating a permissive tumour microenvironment. In a specific pituitary tumour ACP, senescent cell clusters with SASP play a critical role in tumour initiation. Evidence suggests that paracrine signalling from senescent cells may underlie tumourigenesis in various tumour and cancer models.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell & Tissue Engineering
Hongwei Gao, Hui Dong, Jiachun Zheng, Xufeng Jiang, Mingzhi Gong, Le Hu, Jinshan He, Yongxiang Wang
Summary: The study identified LINC01119 as a negative regulator of osteogenic differentiation in MSCs, with its knockdown promoting calcification and osteogenic differentiation. It was revealed that LINC01119 negatively regulates osteogenesis through the Wnt pathway by targeting FZD4, with transcription factor EBF3 directly binding to LINC01119's promoter region.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Larischa de Wet, Anthony Williams, Marc Gillard, Steven Kregel, Sophia Lamperis, Lisa C. Gutgesell, Jordan E. Vellky, Ryan Brown, Kelly Conger, Gladell P. Paner, Heng Wang, Elizabeth E. Platz, Angelo M. De Marzo, Ping Mu, Jonathan L. Coloff, Russell Z. Szmulewitz, Donald J. Vander Griend
Summary: This study investigated the impact of SOX2 expression on patient outcomes and its function within prostate cancer cells. The results revealed that SOX2 expression promotes metastatic progression and therapy resistance in prostate cancer, and affects the metabolic pathways and metabolites of cancer cells. These findings contribute to a better understanding of the role of SOX2 in prostate cancer and suggest its potential as a biomarker and pharmacologic target in clinical settings.
Article
Medicine, Research & Experimental
Zhengguang Li, Zhirong Yang, Wei Liu, Wanglong Zhu, Lan Yin, Zhenyu Han, Yu Xian, Jie Wen, Hualong Tang, Xinyue Lin, Yuhan Yang, Jingyi Wang, Kun Zhang
Summary: The study revealed that DVL3 is overexpressed in colorectal cancer (CRC) and is associated with malignant behaviors, metastasis, and prognosis. Furthermore, DVL3 promotes epithelial-to-mesenchymal transition (EMT) and cancer stem-like cell (CSLC) properties in CRC through the activation of the Wnt/beta-catenin/c-Myc/SOX2 axis. This research provides a new strategy for successful treatment of CRC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Yan Qu, Yifan He, Bowen Meng, Xiao Zhang, Junjun Ding, Xiaoxing Kou, Wei Teng, Songtao Shi
Summary: This study revealed that pluripotent stem cell-derived apoptotic vesicles (PSC-apoVs) can inherit pluripotent molecules and promote the activation of adult stem cells and skin wound healing. These findings provide a potential cell-free strategy for clinical applications using PSC-apoVs.
ACTA BIOMATERIALIA
(2022)
Article
Agriculture, Dairy & Animal Science
Kotaro Horiguchi, Ken Fujiwara, Takehiro Tsukada, Takashi Nakakura, Saishu Yoshida, Rumi Hasegawa, Shu Takigami
Summary: This study found that CD9/SOX2-positive cells on the IL side may act as adult stem cells in the AL parenchyma, producing PRL cells under the influence of estrogen.
JOURNAL OF REPRODUCTION AND DEVELOPMENT
(2022)
Article
Cell Biology
Qian Lan, Jiadong Cao, Xueting Bi, Xin Xiao, Dongsheng Li, Yilong Ai
Summary: This study suggests that using Cur-PDLSC-EV as a curcumin carrier can promote osteogenic differentiation of periodontal ligament stem cells, providing potential therapeutic value for periodontal diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Charlotte Nys, Yu-Lun Lee, Heleen Roose, Freya Mertens, Ellen De Pauw, Hiroto Kobayashi, Raf Sciot, Marie Bex, Georges Versyck, Steven De Vleeschouwer, Johannes Van Loon, Emma Laporte, Hugo Vankelecom
Summary: This study explored the biology of stem cells in mouse and human pituitary tumors using various experimental approaches. The researchers discovered that in both mouse and human tumors, pituitary stem cells exhibited an activated state characterized by increased proliferation and specific cytokine/chemokine phenotypes. Additionally, they found that upregulated cytokines, particularly interleukin-6, promoted the development and growth of stem cell-derived organoids. Overall, this study revealed the activation phenotype of pituitary-resident stem cells in tumorigenic glands and tumors, providing insights into the functional role of these cells in pituitary tumor pathogenesis.
ENDOCRINE-RELATED CANCER
(2022)
Article
Cell Biology
Prakash P. Praharaj, Srimanta Patra, Soumya R. Mishra, Subhadip Mukhopadhyay, Daniel J. Klionsky, Shankargouda Patil, Sujit K. Bhutia
Summary: This study found that cisplatin treatment activated higher mitophagy in oral cancer stem cells by regulating CLU levels. CLU regulated mitochondrial fission by activating AKT kinase, leading to mitochondrial fission. Furthermore, CLU-mediated mitophagy positively regulated oral cancer stem cells by degrading MSX2 and preventing its nuclear translocation, which suppressed SOX2 activity and inhibited cancer stemness and self-renewal ability.
Article
Health Care Sciences & Services
Chih-Huang Tseng, Pei-Hsuan Lu, Yi-Ping Wang, Julia Yu Fong Chang
Summary: Ameloblastoma is a common benign odontogenic neoplasm with aggressive behavior and high recurrence rate. This study found the presence of SOX2-positive cells in ameloblastomas, possibly correlated with BRAF(V600E) mutation. These findings may guide the development of personalized treatments.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biology
Yao Xiao, Froylan Sosa, Pablo J. Ross, Kenneth E. Diffenderfer, Peter J. Hansen
Summary: Activin A stimulates NANOG expression while reducing SOX2 expression, and CHIR99021 suppresses both NANOG and SOX2 expression. Furthermore, activin A promotes blastocyst development, while CHIR99021 treatment impairs blastocyst formation and reduces the number of blastomeres.
Review
Biochemistry & Molecular Biology
Jiajia Wang, Xichen Wan, Qihua Le
Summary: SOX9, a member of the SRY-related HMG-box transcription factors, plays a critical role in fetal development and stem cell homeostasis. The interactions between SOX9 and the canonical Wnt signalling pathway are involved in various physiological and pathological processes of stem cells, including organ development, stem cell proliferation, differentiation, and tumorigenesis. This review summarizes the molecular mechanism of cross-interactions between SOX9 and the canonical Wnt signalling pathway, outlines its regulatory effects on homeostasis in different types of stem cells, and explores its potential in translational stem cell therapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Editorial Material
Cell Biology
Abigail S. Tucker, Cynthia L. Andoniadou
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Eduardo Zabala Aldunate, Valentina Di Foggia, Fabiana Di Marco, Laura Abelleira Hervas, Joana Claudio Ribeiro, Daniel L. Holder, Aara Patel, Tommaso B. Jannini, Dorothy A. Thompson, Juan Pedro Martinez-Barbera, Rachael A. Pearson, Robin R. Ali, Jane C. Sowden
SCIENTIFIC REPORTS
(2019)
Editorial Material
Endocrinology & Metabolism
Stefan R. Bornstein, Tobias D. Bornstein, Cynthia L. Andoniadou
NATURE REVIEWS ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Juan Pedro Martinez-Barbera, Cynthia Lilian Andoniadou
NEUROENDOCRINOLOGY
(2020)
Letter
Clinical Neurology
J. R. Apps, C. Stache, J. M. Gonzalez-Meljem, A. Gutteridge, J. Chalker, T. S. Jacques, T. Forshew, A. Hoelsken, J. P. Martinez-Barbera
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2020)
Review
Endocrinology & Metabolism
Laura D. Scriba, Stefan R. Bornstein, Alice Santambrogio, Gregor Mueller, Angela Huebner, Julia Hauer, Andreas Schedl, Ben Wielockx, Graeme Eisenhofer, Cynthia L. Andoniadou, Charlotte Steenblock
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Cell Biology
Ana Guerrero, Romain Guiho, Nicolas Herranz, Anthony Uren, Dominic J. Withers, Juan Pedro Martinez-Barbera, Lutz F. Tietze, Jesus Gil
Review
Clinical Neurology
Gabriela Carreno, Romain Guiho, Juan Pedro Martinez-Barbera
Summary: The study of cell senescence is rapidly growing, with senescent cells secreting biologically active products that can affect the cellular microenvironment, known as SASP, with both beneficial and detrimental effects on tissue homeostasis. The use of senolytic drugs to eliminate senescent cells has shown promise in improving age-related diseases, and clearance of senescent cells may also improve neurodegenerative diseases and cancer.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Review
Medicine, General & Internal
Hermann L. Mueller, Maithe Tauber, Elizabeth A. Lawson, Jale Oezyurt, Brigitte Bison, Juan-Pedro Martinez-Barbera, Stephanie Puget, Thomas E. Merchant, Hanneke M. van Santen
Summary: Hypothalamic syndrome is a rare disorder caused by injury to the hypothalamus from various diseases or their treatment. This Primer provides an overview of the epidemiology, pathophysiology, diagnosis and management of the syndrome, as well as the challenges in preventing hypothalamic injury and treating its sequelae.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Oncology
Florian Selt, Romain Sigaud, Gintvile Valinciute, Philipp Sievers, Julia Zaman, Clara Alco, Simone Schmid, Heike Peterziel, Jessica W. Tsai, Romain Guiho, Juan Pedro Martinez-Barbera, Stefan Pusch, Jing Deng, Yifan Zhai, Cornelis M. van Tilburg, Martin U. Schuhman, Ahmed E. L. Damaty, Pratiti Bandopadhayay, Christel Herold-Mende, Andreas von Deimling, Stefan M. Pfister, Joan Montero, David Capper, Ina Oehme, Felix Sahm, David T. W. Jones, Olaf Witt, Till Milde
Summary: Our study demonstrates that BCL-XL is critical for the survival of senescent PA tumor cells and provides evidence for the use of clinically available BCL-XL-dependent senolytic agents.
Review
Endocrinology & Metabolism
John Richard Apps, Hermann Lothar Muller, Todd Cameron Hankinson, Torunn Ingrid Yock, Juan Pedro Martinez-Barbera
Summary: Craniopharyngiomas are aggressive tumors that tend to recur after therapy. They are divided into two types based on histology and molecular features. Patients often experience symptoms related to the tumor location, such as increased intracranial pressure, endocrine deficiencies, and visual defects. Treatment options are diverse but mostly noncurative, including surgery and radiotherapy. Targeted therapies have been used in recent years, and clinical trials are ongoing. For patients at risk of hypothalamic syndrome, treatment strategies that spare the hypothalamus are recommended.
Editorial Material
Oncology
John Richard Apps, Juan Pedro Martinez-Barbera
Article
Multidisciplinary Sciences
Jose Mario Gonzalez-Meljem, Sarah Ivins, Cynthia Lilian Andoniadou, Paul Le Tissier, Peter Scambler, Juan Pedro Martinez-Barbera
Summary: The role of the chemokine SDF-1 and its receptor CXCR4 in pituitary gland development was investigated. The expression patterns of CXCR4, SDF-1, and CXCR7 were characterized, and it was found that SDF-1 is expressed in progenitor-rich regions of the pituitary gland. Conditional deletion of CXCR4 in embryonic pituitary progenitors did not lead to observable defects, suggesting that CXCR4 expression in HESX1+ cells and their descendants is not essential for normal pituitary development in mice.
Review
Biochemistry & Molecular Biology
Jose Mario Gonzalez-Meljem, Juan Pedro Martinez-Barbera
Summary: Cellular senescence can prevent tumour development autonomously but also promote tumour growth non-autonomously by creating a permissive tumour microenvironment. In a specific pituitary tumour ACP, senescent cell clusters with SASP play a critical role in tumour initiation. Evidence suggests that paracrine signalling from senescent cells may underlie tumourigenesis in various tumour and cancer models.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Meeting Abstract
Genetics & Heredity
Saba Manshaei, Scott Haston, Jesus Gil, Juan Pedro Martinez-Barbera