Journal
STEM CELL RESEARCH
Volume 16, Issue 1, Pages 75-78Publisher
ELSEVIER
DOI: 10.1016/j.scr.2015.12.006
Keywords
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Funding
- Danish National Advanced Technology Foundation [047-2011-1]
- European Union [PIAP-GA-2012-324451-STEMMAD]
- Novo Nordisk Fonden [NNF11OC1014514] Funding Source: researchfish
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Skin fibroblasts were obtained from a 59-year-old woman diagnosed with frontotemporal dementia. The disease is caused by a R406W mutation in microtubule-associated protein tau (MAPT). Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained the expected c.1216C > T substitution in exon 13 of the MAPT gene, expressed the expected pluripotency markers, displayed in vitro differentiation potential to the three germ layers and had normal karyotype. The iPSC line may be useful for studying hereditary frontotemporal dementia and TAU pathology in vitro. (C) 2015 The Authors. Published by Elsevier B.V.
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