Journal
STEM CELL RESEARCH
Volume 17, Issue 1, Pages 32-35Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scr.2016.05.003
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Funding
- JSPS KAKENHI [24890250, 15K09789]
- Lydia O'Leary Memorial Foundation
- Takeda Science Foundation
- ReproCELL's Innovative Research Grant Program
- Grants-in-Aid for Scientific Research [24890250, 15K09789] Funding Source: KAKEN
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Expanded human T cells from a Japanese female with recessive dystrophic epidermolysis bullosa (RDBE) were used to generate integration-free induced pluripotent stem cells (iPSCs) by exogenous expression of four reprogramming factors, OCT3/4, SOX2, cMYC, KLF4, using Sendai virus vector (SeVdp). The authenticity of established iPSC line, RDEB-iPSC26, was confirmed by the expressions of stem cell markers and the differentiation capability into three germ layer. RDEB-iPSC26 may be a useful cell resource for the establishment of in vitro RDEB modeling and the study for developing gene and cell therapy. (C) 2016 The Authors. Published by Elsevier B.V.
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