Journal
STEM CELL RESEARCH
Volume 17, Issue 3, Pages 564-567Publisher
ELSEVIER
DOI: 10.1016/j.scr.2016.10.006
Keywords
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Funding
- Danish Agency for Science, Technology and Innovation [6114-00003B-768138]
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework programme FP7 under REA grant agreement (STEMMAD) [PIAPP-GA-2012-324451]
- Innovation Fund Denmark (BrainStem - Stem cell Centre of Excellence in Neurology) [4108-00008B]
- Novo Nordisk Fonden [NNF11OC1014514] Funding Source: researchfish
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Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the gene coding the microtubule-associated protein tau (MAPT) can cause FTDP-17 but the underlying mechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required neuronal cell type. Here, we report the generation of iPSCs from a 44-year-old symptomatic woman carrying a S305I mutation in the MAPT-gene. (C) 2016 The Authors. Published by Elsevier B.V.
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