Article
Engineering, Civil
Yiling Deng, Pengjun Zhao
Summary: This study investigates the determinants of participation in and usage of free-floating bike share (FBS) using a nationally representative dataset in China. The study finds that ICT use significantly affects both participation and usage of FBS, while social context only has a significant effect on participation. Nonlinear effects of age and annual individual income on FBS usage are also identified. The findings provide policy suggestions for promoting FBS use.
Article
Biology
Tonghui Yu, Liming Xiang, Huixia Judy Wang
Summary: In this paper, a quantile regression for survival data with covariates subject to detection limits is proposed, offering a more flexible tool for modeling the distribution of survival outcomes. The new method utilizes a novel multiple imputation approach to avoid stringent parametric restrictions on censored covariates, demonstrating satisfactory performance in simulation results and application to real data.
Article
Engineering, Multidisciplinary
Laila A. Al-Essa, Ahmed A. Soliman, Gamal A. Abd-Elmougod, Huda M. Alshanbari
Summary: In this study, the class of lifetime distributions with bathtub-shaped failure rate functions is examined. Statistical inference methods are used to estimate the parameters of the model, and the Bayesian approach is compared with classical methods. The study also discusses the evaluation of product relative merits based on lifetime duration under a hybrid censoring scheme.
ALEXANDRIA ENGINEERING JOURNAL
(2024)
Article
Health Care Sciences & Services
T. Baghfalaki, M. Ganjali
Summary: The study utilized the INLA approach for joint modeling of zero-inflated count and time-to-event data, introducing zero-inflated hurdle and Weibull models as sub-models, as well as a joint partially linear model. The method's performance was assessed through simulation studies and compared with MCMC approach, and applied to analyze two real datasets on pregnancy and HIV research.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2021)
Article
Agronomy
Ednah Kangogo, David Jakinda Otieno, Julius Okello, Obed Mwenye, Eliya Kapalasa
Summary: Enhancing the productivity of crops through the adoption and uptake of technologies improves farmers' socioeconomic status through increased market participation. However, smallholder farmers in Sub-Saharan Africa (SSA) face a myriad of challenges that make it difficult for them to access and participate in the output markets. This study examines the relationship between the uptake of improved potato seed and donor-funded training on market participation.
Article
Public, Environmental & Occupational Health
Michael E. Griswold, Rajesh Talluri, Xiaoqian Zhu, Dan Su, Jonathan Tingle, Rebecca F. Gottesman, Jennifer Deal, Andreea M. Rawlings, Thomas H. Mosley, B. Gwen Windham, Karen Bandeen-Roche
Summary: This article discusses the common issue of missing data in longitudinal studies and recommends the shared-parameter model (SPM) as a more widely used approach. The article provides reproducible research code and data to facilitate the use of SPMs in practice and teaching in epidemiology, biostatistics, and data science, aiming to increase understanding and usage of these methods.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Mathematical & Computational Biology
Peng Ye, Shuo Bai, Wan Tang, Han Feng, Xinhua Qiao, Hua He, Shengjia Tu
Summary: This article aims to address the censoring issue in measuring substance concentration in biological matrices and untangle the different relationships between exposed and non-exposed subjects and the outcome using a novel joint modeling approach.
STATISTICS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Di Wu, Chenxi Li
Summary: A joint modeling method is developed for multivariate and univariate interval-censored survival data and time-dependent covariates. Simulation studies show that the method performs well under realistic sample sizes.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2021)
Article
Engineering, Multidisciplinary
Hui Wang, Ronggang Yang, Jiawei Xiang
Summary: This study uses a lumped parameter model in the numerical simulation of gears to generate enough training samples, aiming to achieve fault diagnosis. By constructing and updating the lumped parameter model, and generating a sample matrix using simulated and measured signals, artificial intelligence models are used to classify unknown fault samples. The results show that using lumped parameter models to generate sample data is a feasible approach for fault classification.
Article
Multidisciplinary Sciences
Mohamed G. M. Ghazal, Mustafa M. Hasaballah, Rashad M. EL-Sagheer, Oluwafemi Samson Balogun, Mahmoud E. Bakr
Summary: This article explores the application of joint censoring technique in assessing the comparative advantages of products in terms of their service times. The study utilizes the three-parameter Burr-XII distribution and a joint progressive Type II censoring approach for two separate samples. Both maximum likelihood and Bayesian methods are employed for estimating the model parameters. The article also presents approximate confidence intervals based on the observed information matrix and utilizes four bootstrap methods to obtain confidence intervals. Extensive simulation experiments are conducted to evaluate the performance of the estimators, and a real dataset is analyzed for practical illustration.
Article
Engineering, Mechanical
Sun SongSong, Wu Chang, Wan MaoSong, Zhao Fengkui
Summary: Fatigue strength is a crucial parameter for critical engine components like crankshafts during the design and manufacturing process. The accuracy of predicting fatigue limit loads for crankshafts with different features is influenced by the definition of critical distance theories. Experimental verification and model parameter error analysis showed that the direct-defined TCD approach is more suitable for engineering applications due to its better accuracy and lower sensitivity to parameter errors.
ENGINEERING FAILURE ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Ole Koenig, Joern Wilms, Riccardo Arcodia, Thomas Dauser, Konrad Dennerl, Victor Doroshenko, Frank Haberl, Steven Haemmerich, Christian Kirsch, Ingo Kreykenbohm, Maximilian Lorenz, Adam Malyali, Andrea Merloni, Arne Rau, Thomas Rauch, Gloria Sala, Axel Schwope, Valery Suleimanov, Philipp Weber, Klaus Werner
Summary: Novae are caused by runaway thermonuclear burning in the hydrogen-rich envelopes of accreting white dwarfs. This study reports observations of a bright and soft X-ray flash associated with the classical Galactic nova YZ Reticuli, which appeared 11 hours before its optical brightening. The flash lasted less than 8 hours and its spectral shape is consistent with a black-body or a white dwarf atmosphere radiating at the Eddington luminosity.
Article
Engineering, Electrical & Electronic
Sheng Lei, Kuanmin Mao, Wei Tian, Li Li
Summary: In this study, a three-dimensional transition interface model with geometric and physical parameters is proposed to simulate bolt connections. A parameter database is constructed for machine tool bolt joints. The physical parameters and thickness of the model are identified using a model updating method. The practicality of the model and the usage of the parameter database are validated using an engineering example.
Article
Mathematics
Yahia Abdel-Aty, Mohamed Kayid, Ghadah Alomani
Summary: This paper considers generalized Bayesian estimation based on a learning rate parameter to study the impact of the parameter on the estimation results using a joint censored sample of type-II exponential populations. Squared error, Linex, and general entropy loss functions are used in the Bayesian approach. Monte Carlo simulations are conducted to compare the performance of different approaches for various values of the learning rate parameter and different losses.
Article
Mathematical & Computational Biology
Juned Siddique, Michael J. Daniels, Gul Inan, Samuel Battalio, Bonnie Spring, Donald Hedeker
Summary: This study proposes a novel joint modeling framework for modeling the number and duration of physical activity bouts. The model allows estimation of how the number and duration of physical activity bouts vary together over the course of an intervention and by treatment condition, specifically capturing the unique features of physical activity measured by accelerometers.
STATISTICS IN MEDICINE
(2023)
Review
Medicine, Research & Experimental
Juan Jose Garcia Sanchez, Juliette Thompson, David A. Scott, Rachel Evans, Naveen Rao, Elisabeth Sorstadius, Glen James, Stephen Nolan, Eric T. Wittbrodt, Alyshah Abdul Sultan, Bergur V. Stefansson, Dan Jackson, Keith R. Abrams
Summary: Contemporary data suggest that augmenting RAAS inhibitors with new drug classes has the potential to improve clinical outcomes in a broad range of patients with CKD.
ADVANCES IN THERAPY
(2022)
Review
Health Care Sciences & Services
Valerie Aponte Ribero, Monica Daigl, Yasmina Marti, Ksenija Gorni, Rachel Evans, David Alexander Scott, Anadi Mahajan, Keith R. Abrams, Neil Hawkins
Summary: Indirect comparisons indicate that risdiplam is superior to nusinersen in terms of improved survival and motor function in Type 1 SMA. However, concrete conclusions couldn't be drawn due to substantial differences in study populations for comparisons with onasemnogene abeparvovec in Type 1 SMA and nusinersen in Types 2/3 SMA.
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2022)
Article
Medicine, General & Internal
William D. Toff, David Hildick-Smith, Jan Kovac, Michael J. Mullen, Olaf Wendler, Anita Mansouri, Ines Rombach, Keith R. Abrams, Simon P. Conroy, Marcus D. Flather, Alastair M. Gray, Philip MacCarthy, Mark J. Monaghan, Bernard Prendergast, Simon Ray, Christopher P. Young, David C. Crossman, John G. F. Cleland, Mark A. de Belder, Peter F. Ludman, Stephen Jones, Cameron G. Densem, Steven Tsui, Manoj Kuduvalli, Joseph D. Mills, Adrian P. Banning, Rana Sayeed, Ragheb Hasan, Douglas G. W. Fraser, Uday Trivedi, Simon W. Davies, Alison Duncan, Nick Curzen, Sunil K. Ohri, Christopher J. Malkin, Pankaj Kaul, Douglas F. Muir, W. Andrew Owens, Neal G. Uren, Renzo Pessotto, Simon Kennon, Wael Awad, Saib S. Khogali, Maciej Matuszewski, Richard J. Edwards, Bandigowdanapalya C. Ramesh, Miles Dalby, Shahzad G. Raja, Giovanni Mariscalco, Clinton Lloyd, Ian D. Cox, Simon R. Redwood, Mark G. Gunning, Paul D. Ridley
Summary: This study aimed to determine whether TAVI was noninferior to surgery in patients at moderately increased operative risk. The results showed that among patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk, TAVI was noninferior to surgery with respect to all-cause mortality at 1 year.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Christopher Martin, Daniel F. Pan, Carl Melbourne, Lucy Teece, Avinash Aujayeb, Rebecca Baggaley, Luke L. Bryant, Sue Carr, Bindu Gregary, Amit Gupta, Anna B. Guyatt, Catherine John, I. Chris McManus, Joshua D. Nazareth, Laura Nellums, Rubina Reza, Sandra Simpson, Martin R. Tobin, Katherine J. Woolf, Stephen Zingwe, Kamlesh Khunti, Keith Abrams, Laura Gray, Manish Pareek
Summary: This study identified key sociodemographic and occupational risk factors associated with SARS-CoV-2 infection among UK HCWs, highlighting the importance of social and occupational factors in driving ethnic disparities in COVID-19 outcomes.
Article
Health Care Sciences & Services
Christopher A. Martin, Daniel Pan, Joshua Nazareth, Avinash Aujayeb, Luke Bryant, Sue Carr, Laura J. Gray, Bindu Gregary, Amit Gupta, Anna L. Guyatt, Alan Gopal, Thomas Hine, Catherine John, I. Chris McManus, Carl Melbourne, Laura B. Nellums, Rubina Reza, Sandra Simpson, Martin D. Tobin, Katherine Woolf, Stephen Zingwe, Kamlesh Khunti, Manish Pareek
Summary: During the COVID-19 pandemic in the UK, a significant number of healthcare workers did not have consistent access to appropriate personal protective equipment (PPE). Older healthcare workers and those working in intensive care units were more likely to have consistent access to PPE, while Asian healthcare workers, those in allied health professional and dental roles, and those who saw a higher number of COVID-19 patients were less likely to have consistent access to PPE.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Health Care Sciences & Services
Janharpreet Singh, Sandro Gsteiger, Lorna Wheaton, Richard D. Riley, Keith R. Abrams, Clare L. Gillies, Sylwia Bujkiewicz
Summary: This study develops a method for synthesizing data from single-arm trials and randomized controlled trials in network meta-analysis to estimate relative treatment effects. The study finds that incorporating single-arm trials in network meta-analysis may be useful in some situations where a treatment is not directly compared to other treatments.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Mathematical & Computational Biology
Tasos Papanikos, John R. Thompson, Keith R. Abrams, Sylwia Bujkiewicz
Summary: Bivariate meta-analysis is a useful method for combining information from related studies and evaluating treatment efficacy. However, the standard approach may lead to biased results when modeling surrogate endpoints. This article proposes new modeling methods to improve the assessment of surrogate endpoints.
STATISTICS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Neyme Veli, Christopher A. Martin, Katherine Woolf, Joshua Nazareth, Daniel Pan, Amani Al-Oraibi, Rebecca F. Baggaley, Luke Bryant, Laura B. Nellums, Laura J. Gray, Kamlesh Khunti, Manish Pareek
Summary: This study found that nearly a quarter of UK HCWs were hesitant about receiving a regular SARS-CoV-2 vaccination. Black HCWs, those with previous COVID-19 episodes, and those who have not received influenza vaccination were more likely to be hesitant. On the other hand, HCWs who received influenza vaccination and trusted official vaccine information were less likely to hesitate.
Article
Public, Environmental & Occupational Health
Humaira Hussein, Clareece R. Nevill, Anna Meffen, Keith R. Abrams, Sylwia Bujkiewicz, Alex J. Sutton, Laura J. Gray
Summary: This study investigates the issue of double-counting of individuals in evidence synthesis using real-world and observational data in public health. It highlights the challenges and proposes potential solutions, emphasizing the need for methodological development and guidelines to address this issue.
Article
Public, Environmental & Occupational Health
Luke Bryant, Robert C. Free, Katherine Woolf, Carl Melbourne, Anna L. Guyatt, Catherine John, Amit Gupta, Laura J. Gray, Laura Nellums, Christopher A. Martin, I. Chris McManus, Claire Garwood, Vishant Modhawdia, Sue Carr, Louise Wain, Martin D. Tobin, Kamlesh Khunti, Ibrahim Akubakar, Manish Pareek
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Health Care Sciences & Services
Sylwia Bujkiewicz, Janharpreet Singh, Lorna Wheaton, David Jenkins, Reynaldo Martina, Kimme L. Hyrich, Keith R. Abrams
Summary: This study aims to optimize the evidence base for biologic therapies in rheumatoid arthritis using real-world data, allowing evidence on first-line therapies to inform estimates of effectiveness in second-line treatment. By emulating treatment sequences and conducting a bivariate network meta-analysis, the study provides effectiveness estimates for both first-line and second-line treatments.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Review
Oncology
Chinyereugo M. M. Umemneku-Chikere, Olubukola Ayodele, Marta Soares, Sam Khan, Keith Abrams, Rhiannon Owen, Sylwia Bujkiewicz
Summary: This review examines the reporting of evidence for the treatment effects in HER2-positive advanced breast cancer (ABC) patients based on hormone receptor status. The study highlights a lack of reporting on the effectiveness of therapies based on hormone receptor subgroups in the identified randomized controlled trials (RCTs), with only a minority reporting progression-free survival. The analysis suggests that future trials in ABC should include reporting on the effects of cancer therapies in hormone receptor subgroups for all outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Economics
Francis Shupo, Keith R. Abrams, Zanfina Ademi, Grace Wayi-Wayi, Natasa Zibelnik, Matt Kirchmann, Carolyn Rutherford, Kelly Makarounas-Kirchmann
Summary: This paper presents an Australian model for the assessment of the cost-effectiveness of siltuximab for idiopathic Multicentric Castleman Disease (iMCD) in Australia. The model was informed by literature reviews, clinical trial data, and stakeholder input, and estimated an incremental cost-effectiveness ratio of A$84,935 per quality-adjusted life-year (QALY) gained. The results suggest that siltuximab has a 72.1% probability of being cost-effective compared with placebo and best supportive care at a willingness-to-pay threshold of A$100,000 per QALY.
PHARMACOECONOMICS-OPEN
(2023)
Correction
Geriatrics & Gerontology
Laia Maynou, Rhiannon Owen, Rob Konstant-Hambling, Towhid Imam, Suzanne Arkill, Deborah Bertfield, Andrew Street, Keith R. Abrams, Simon Conroy
EUROPEAN GERIATRIC MEDICINE
(2022)
Article
Geriatrics & Gerontology
Laia Maynou, Rhiannon Owen, Rob Konstant-Hambling, Towhid Imam, Suzanne Arkill, Deborah Bertfield, Andrew Street, Keith R. Abrams, Simon Conroy
Summary: This study investigated the impact of COVID-19 and frailty risk on mortality in older people, and found that intermediate and high frailty risk were associated with increased mortality risk compared to low frailty risk. Any level of elevated frailty risk should be considered an important prognostic marker for older people hospitalized with COVID-19.
EUROPEAN GERIATRIC MEDICINE
(2022)