Review
Endocrinology & Metabolism
Ling Huang, Hanfeng Wang, Minglu Shi, Weizheng Kong, Mei Jiang
Summary: This meta-analysis aimed to evaluate the differences in lipid profile levels between patients with primary ovarian insufficiency (POI) and healthy controls. The results showed that women with POI had significantly elevated levels of total cholesterol, triglycerides, and low density lipoprotein, while the level of high density lipoprotein did not change significantly. Subgroup analysis suggested that the heterogeneity in the correlation between lipid profile and POI might be influenced by region, sample size, number of cases, mean body mass index, and mean age.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Geriatrics & Gerontology
Eleni K. Karamitrou, Panagiotis Anagnostis, Konstantina Vaitsi, Loukas Athanasiadis, Dimitrios G. Goulis
Summary: This study reviewed and analyzed the association between early menopause or premature ovarian insufficiency and the risk of dementia. The findings suggest that women with early menopause or premature ovarian insufficiency may have a higher risk of dementia compared to women with normal menopause age. However, further research is needed to confirm this hypothesis.
Article
Obstetrics & Gynecology
Lauren Verrilli, Erica Johnstone, Corrine Welt, Kristina Allen-Brady
Summary: The study investigates the familial clustering of primary ovarian insufficiency (POI) at the population level by examining multi-generational genealogical information linked to electronic medical records. The results demonstrate an increased risk of POI among the extended relatives of cases, supporting a genetic contribution to POI.
FERTILITY AND STERILITY
(2023)
Review
Geriatrics & Gerontology
Efstathios Divaris, Panagiotis Anagnostis, Nifon K. Gkekas, Evangelia Kouidi, Dimitrios G. Goulis
Summary: The purpose of this systematic review and meta-analysis was to evaluate the association between age at menopause and the risk of sarcopenia. The analysis of 6 studies found that early menopause and premature ovarian insufficiency are associated with decreased muscle mass, strength, and performance.
Article
Endocrinology & Metabolism
Axel Netterlid, Helena Morse, Aleksander Giwercman, Emir Henic, Kristina E. Akesson, Eva-Marie Erfurth, Maria Elfving
Summary: The study found that female childhood cancer survivors with premature ovarian insufficiency are more likely to develop metabolic syndrome. Compared with controls, survivors of childhood cancer have a higher prevalence of metabolic syndrome.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Cynthia A. Stuenkel, Anne Gompel
Summary: A 23-year-old woman with a 6-month history of amenorrhea, mood swings, irritability, and disrupted sleep presents for evaluation. She questions if these symptoms are due to stress related to a new job. Physical examination is normal and hormone test results indicate postmenopausal range levels of follicle-stimulating hormone (FSH). Further evaluation and treatment are needed for this patient.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Geriatrics & Gerontology
Irene Lambrinoudaki, Stavroula A. Paschou, Mary Ann Lumsden, Stephanie Faubion, Evangelos Makrakis, Sophia Kalantaridou, Nick Panay
Summary: POI is the loss of ovarian activity before the age of 40, which can have significant physical and emotional consequences for patients and their families. Diagnosing and treating POI in a timely manner is crucial, but often delayed, highlighting the need for increased awareness and education within the medical community.
Article
Rheumatology
Arporn Jutiviboonsuk, Lingling Salang, Nuntasiri Eamudomkarn, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Chingching Foocharoen
Summary: The study found that POI in Thai female SSc patients was uncommon, while early menopause and low ovarian reserve were frequently revealed. A high cumulative dose of CYC was associated with both POI and early menopause. Physicians should be aware of reproductive outcomes and advise patients at risk.
CLINICAL RHEUMATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Bin Zhang, Zhi-Fei Li, Zhuo-Yu An, Li Zhang, Jing-Yi Wang, Meng-Di Hao, Yi-Jing Jin, Dong Li, An-Jian Song, Qiang Ren, Wen-Biao Chen
Summary: The study found that asthma patients have an increased risk of cardiovascular disease morbidity and mortality, as well as all-cause mortality. Female asthma patients have a higher risk of cardiovascular disease morbidity and all-cause mortality, and late-onset asthma patients have a higher risk of cardiovascular disease morbidity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Obstetrics & Gynecology
S. R. Mishra, H-F Chung, M. Waller, G. D. Mishra
Summary: This study evaluated estrogen exposure measurement and the mutual effect of age at menarche and age at menopause on the risk of cardiovascular disease events. Reproductive lifespan was the most commonly used method for estrogen exposure measurement. The findings suggest that a shorter reproductive lifespan is associated with a higher risk of cardiovascular disease events, particularly stroke.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Endocrinology & Metabolism
Elinor Chelsom Vogt, Francisco Gomez Real, Eystein Sverre Husebye, Sigridur Bjornsdottir, Bryndis Benediktsdottir, Randi Jacobsen Bertelsen, Pascal Demoly, Karl Anders Franklin, Leire Sainz de Aja Gallastegui, Francisco Javier Callejas Gonzalez, Joachim Heinrich, Mathias Holm, Nils Oscar Jogi, Benedicte Leynaert, Eva Lindberg, Andrei Malinovschi, Jesus Martinez-Moratalla, Raul Godoy Mayoral, Anna Oudin, Antonio Pereira-Vega, Chantal Raherison Semjen, Vivi Schlunssen, Kai Triebner, Marianne Oksnes
Summary: This study investigated markers of premature menopause and the prevalence of autoimmune primary ovarian insufficiency (POI) in European women. The results showed that premature menopause was associated with nulliparity, obesity, osteoporosis, hormone replacement therapy, and never smokers. It was found that 1.1% of women had idiopathic POI and 4.5% of POI cases were likely of autoimmune origin based on positive steroidogenic autoantibodies.
ENDOCRINE CONNECTIONS
(2022)
Article
Obstetrics & Gynecology
Leigh A. M. Demain, Eline Boetje, Jonathan J. Edgerley, Emma Miles, Cheryl T. Fitzgerald, Gail Busby, Glenda M. Beaman, James O'Sullivan, Raymond T. O'Keefe, William G. Newman
Summary: A 21-year-old woman with primary amenorrhoea was found to have a nonsense variant and whole gene deletion in STAG3, which are associated with primary ovarian failure type 8 and are a rare cause of POI.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Review
Obstetrics & Gynecology
Hajra Khattak, Rosamund Malhas, Laurentiu Craciunas, Yousri Afifi, Christiani A. Amorim, Simon Fishel, Sherman Silber, Debra Gook, Isabelle Demeestere, Olga Bystrova, Alla Lisyanskaya, Georgy Manikhas, Laura Lotz, Ralf Dittrich, Lotte Berdiin Colmorn, Kirsten Tryde Macklon, Ina Marie Dueholm Hjorth, Stine Gry Kristensen, Ioannis Gallos, Arri Coomarasamy
Summary: Ovarian tissue cryopreservation and transplantation techniques have evolved over the past two decades with the aim of restoring fertility and hormonal function in women. Although evidence of success is largely based on case reports, studies demonstrate that this technology can restore reproductive and hormonal functions in women.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Obstetrics & Gynecology
Leigh A. M. Demain, Kay Metcalfe, Eline Boetje, Peter Clayton, Elizabeth A. Martindale, Gail Busby, Raymond T. O'Keefe, William G. Newman
Summary: This study found that a 13-year-old patient's primary ovarian insufficiency (POI) may be associated with a homozygous missense variant in the BMP15 gene.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Cell Biology
Seung Joo Chon, Zobia Umair, Mee-Sup Yoon
Summary: Premature ovarian insufficiency (POI) is a condition characterized by the loss of normal ovarian function before the age of 40, affecting a small percentage of women under 40. The condition is biochemically defined by amenorrhea, low estrogen levels, and high gonadotropin levels, potentially leading to infertility. POI has a heterogeneous etiology, including both genetic and non-genetic factors, and current research focuses on genetic basis, non-coding RNA, and animal models to uncover pathogenesis and potential treatment targets. Despite recent advances, understanding gene regulatory networks and exploring therapies remain critical for future research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)