Review
Medicine, General & Internal
Shu-Yu Wu, Jia-Fong Jhang, Hsin-Ho Liu, Jian-Ting Chen, Jian-Ri Li, Bin Chiu, Sung-Lang Chen, Hann-Chorng Kuo
Summary: Bladder dysfunction is a common complication after chronic spinal cord injury, which can lead to renal function loss, urinary tract infection, and other serious issues. Effective patient care and bladder management options are crucial for preserving renal function and improving clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Anesthesiology
Sam Eldabe, Sue Copley, Ashish Gulve, Ganesan Baranidharan, Beatrice Bretherton, Anu Kansal, Grace Madzinga, Morag Brookes, Simon Thomson, Rui Duarte
Summary: This study aimed to report on the long-term follow-up of DRG stimulation for intractable chronic pain. The findings showed that DRG stimulation can effectively relieve pain and improve quality of life in patients suffering from neuropathic pain. However, there was a high revision rate within the first 24 months and some patients experienced shorter than expected battery life.
Article
Medicine, General & Internal
Doori Kim, Joon-Shik Shin, Young-Joo Moon, Gwanghyun Ryu, Wonbin Shin, Jiyun Lee, Suyeon Lim, Hyun A. Jeon, Ji-Yeon Seo, Wu Hao Wang, Jin-Ho Lee, Kyoung Sun Park, Yoon Jae Lee, In-Hyuk Ha
Summary: Patients with lumbar spinal stenosis who received inpatient integrative Korean medicine treatment showed significant improvements in back pain NRS score, leg pain NRS score, and ODI score at long-term follow-up. This suggests that this treatment approach has a positive impact on reducing pain and functional disability in LSS patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Arjun Muralidharan, Susana G. Sotocinal, Noosha Yousefpour, Nur Akkurt, Lucas Lima, Shannon Tansley, Marc Parisien, Chengyang Wang, Jean-Sebastien Austin, Boram Ham, Gabrielle M. G. S. Dutra, Philippe Rousseau, Sioui Maldonado-Bouchard, Teleri Clark, Sarah F. Rosen, Mariam R. Majeed, Olivia Silva, Rachel Nejade, Xinyu Li, Stephania Donayre Pimentel, Christopher S. Nielsen, G. Gregory Neely, Chantal Autexier, Luda Diatchenko, Alfredo Ribeiro-da-Silva, Jeffrey S. Mogil
Summary: Mice with experimental nerve damage display long-lasting neuropathic pain behavior. Senescence in the spinal cord for 4 months results in the maintenance of pain and a decreased lifespan. Nerve injury increases the number of p53-positive cells in the spinal cord neurons, astrocytes, and microglia, with a male-specific increase observed only in microglia. Repeated administration of a p53-specific substance reverses pain hypersensitivity.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Shiva Hashemizadeh, Zeinab Gharaylou, Saereh Hosseindoost, Maryam Sardari, Ameneh Omidi, Hassan Hosseini Ravandi, Mahmoudreza Hadjighassem
Summary: This study found that early administration of bumetanide after spinal cord injury can promote recovery of locomotor function. The results showed that bumetanide can reduce the expression of NKCC1 gene and increase GAP protein levels, thereby having neuroprotective and regenerative effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Fengwu Tang, Jiaguang Tang, Yannan Zhao, Jiaojiao Zhang, Zhifeng Xiao, Bing Chen, Guang Han, Na Yin, Xianfeng Jiang, Changyu Zhao, Shixiang Cheng, Ziqiang Wang, Yumei Chen, Qiaoling Chen, Keran Song, Zhiwei Zhang, Junjie Niu, Lingjun Wang, Qin Shi, Liang Chen, Huilin Yang, Shuxun Hou, Sai Zhang, Jianwu Dai
Summary: Studies have shown that transplantation of scaffolds combined with stem cells into spinal cord injury patients can promote neural regeneration and functional recovery, especially with promising results observed in patients with acute SCI. Long-term follow-up results indicate the feasibility of this treatment method for complete SCI patients.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Clinical Neurology
Tomas Hoikkanen, Mette Nissen, Tiina-Mari Ikaheimo, Henna-Kaisa Jyrkkanen, Jukka Huttunen, Mikael von Und Zu Fraunberg
Summary: A retrospective study on 35 consecutive CRPS patients undergoing SCS treatment found that 70% continued using the SCS device over an 8-year follow-up period, but some patients experienced device explantation or complications, with no significant change in medication use.
Article
Clinical Neurology
Chengyue Ji, Yuluo Rong, Hongyu Jia, Ning Yan, Tiesheng Hou, Yao Li, Weihua Cai, Shunzhi Yu
Summary: Surgical decompression should be considered in patients with cervical SCI in the chronic stage and persistent spinal cord compression and/or gross cervical instability. Lower initial AMS, longer duration, injury above C4 level, higher age, and female gender are the five major relevant factors for functional recovery.
EUROPEAN SPINE JOURNAL
(2021)
Article
Gastroenterology & Hepatology
N. Surci, C. Bassi, R. Salvia, G. Marchegiani, L. Casetti, G. Deiro, C. Bergmann, K. Walenta, D. Tamandl, M. Schindl, K. Sahora, J. Muehlbacher
Summary: This study evaluated the impact of surgery on patients with chronic pancreatitis. The results showed that surgery can relieve pain, but it has a negative effect on pancreatic function and does not significantly influence nutritional status.
Article
Neurosciences
Olaia Baylo-Marin, Africa Flores, Guillermo Garcia-Alias
Summary: Voluntary sensorimotor rehabilitation can decrease task error variability and drive the recovery of movement gestures, but the achieved plasticity is insufficient for full functional recovery. Additional interventional therapies are necessary to promote repair.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Gastroenterology & Hepatology
Awais Ahmed, Ishani Shah, Rachel Bocchino, Steven D. Freedman, Darshan J. Kothari, Sunil G. Sheth
Summary: This study compared the clinical characteristics, outcomes, and healthcare utilization between chronic pancreatitis (CP) patients with and without pain. The results showed that among 368 CP patients, 49 (13.3%) were pain-free at diagnosis and remained so for >9 years. Compared to patients with pain, pain-free patients were older, had better disease progression, less exocrine pancreatic insufficiency (EPI) and recurrent acute pancreatitis (RAP), and had overall favorable outcomes with minimal resource utilization.
GASTROENTEROLOGY REPORT
(2023)
Article
Engineering, Biomedical
Wonok Kang, Jinseung Lee, Wonsuk Choi, Jinseok Kim, Junesun Kim, Sung-Min Park
Summary: This study proposes a fully wireless neurostimulation system for long-term animal studies on neuropathic pain relief. The system allows for remote control of stimulation parameters and wireless charging, and has been proven to be effective and durable in animal experiments.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Silvia Castany, Anna Bago-Mas, Jose Miguel Vela, Enrique Verdu, Karolina Bretova, Viktorie Svobodova, Petr Dubovy, Pere Boadas-Vaello
Summary: This study aimed to determine whether neuroinflammatory factor over-expression in the spinal cord and supraspinal structures may be associated with reflexive and nonreflexive pain response development from acute spinal cord injury (SCI) phase to 12 weeks post-injury in female mice. The results show that transient reflexive responses were observed during the SCI acute phase associated with transient cytokine overexpression in the spinal cord. In contrast, increased nonreflexive pain responses were observed in the chronic phase associated with cytokine overexpression in supraspinal structures, especially in mPFC. In addition, results revealed the contribution of neuron-glia crosstalk in the development of nonreflexive pain responses in the chronic spinal cord injury phase, as indicated by increased glial activation and CX3CL1/CX3CR1 upregulation in the neurons in the mPFC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Toxicology
Fernando Bessone, Antonella Ferrari, Nelia Hernandez, Manuel Mendizabal, Ezequiel Ridruejo, Alina Zerega, Federico Tanno, Maria Virginia Reggiardo, Julio Vorobioff, Hugo Tanno, Marco Arrese, Vinicius Nunes, Martin Tagle, Inmaculada Medina-Caliz, Mercedes Robles-Diaz, Hao Niu, Ismael Alvarez-Alvarez, Camilla Stephens, M. Isabel Lucena, Raul J. Andrade
Summary: In this study, the demographics, clinical characteristics, biochemical features, and outcome of nitrofurantoin-induced liver injury were described. The majority of the cases were women with a mean age of 61 years. Hepatocellular damage was the most common pattern of liver injury, and about half of the patients were asymptomatic. Most patients recovered within six months, but a small number developed nitrofurantoin-induced autoimmune-like hepatitis.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Surgery
Jenna N. Whitrock, Ryan C. Chae, Alexandra B. Kinzer, Aaron M. Delman, Adam D. Price, Stephanie Sisak, Michela M. Carter, Madison C. Cuffy, Kristina H. Lemon, Alex L. Chang, Latifa S. Silski, Ralph C. Quillin, Shimul A. Shah
Summary: Temporary abdominal closure after liver transplantation is commonly used when primary fascial closure is challenging. This study found that patients requiring temporary abdominal closure had higher MELD scores, higher rates of preoperative dialysis, and were more likely to be hospitalized within 90 days after transplantation. However, there was no significant difference in long-term survival between temporary abdominal closure and primary fascial closure.
Review
Anesthesiology
Joshua Lim, Dili Chen, Ewan McNicol, Lokesh Sharma, Grihith Varaday, Anshuman Sharma, Elizabeth Wilson, Tiffany Wright-Yatsko, Lauren Yaeger, Ian Gilron, Nanna B. Finnerup, Simon Haroutounian
Summary: This study systematically reviewed the literature on risk factors of Persistent postsurgical pain (PPSP) after breast and thoracic surgeries and identified consistent factors. Understanding these factors can help optimize perioperative care in high-risk patients and develop targeted, risk-stratified interventions for PPSP prevention.
Article
Endocrinology & Metabolism
Christopher Rohde, Nanna Brix Finnerup, Norbert Schmitz, Troels Staehelin Jensen, Reimar Wernich Thomsen, Soren Dinesen Ostergaard
Summary: This study found that individuals with diabetic neuropathy have a significantly higher risk of developing mental disorders compared to diabetes-duration-matched individuals without diabetic neuropathy.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Anesthesiology
Nanna B. Finnerup, Lone Nikolajsen, Andrew S. C. Rice
Article
Clinical Neurology
Kristine Bennedsgaard, Kasper Grosen, Nadine Attal, Didier Bouhassira, Geert Crombez, Troels S. Jensen, David L. Bennett, Lise Ventzel, Inge S. Andersen, Nanna B. Finnerup
Summary: This study investigated the symptoms, intensity, and interference of chemotherapy-induced peripheral neuropathy (CIPN) in breast cancer survivors. It found that although less common, foot pain in patients who received chemotherapy was more intense and had a higher interference with daily life compared to pain in the surgical area.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Review
Biochemistry & Molecular Biology
Johannes van Niel, Petra Bloms-Funke, Ombretta Caspani, Jose Maria Cendros, Luis Garcia-Larrea, Andrea Truini, Irene Tracey, Sonya C. Chapman, Nicolas Marco-Arino, Inaki F. Troconiz, Keith Phillips, Nanna Brix Finnerup, Andre Mouraux, Rolf-Detlef Treede
Summary: There is a need for improved analgesics, especially for neuropathic and chronic pain conditions. Many candidate drugs have failed in clinical trials despite promising preclinical results. A consortium of researchers from academia and the pharmaceutical industry was established to identify and validate functional biomarkers for assessing drug effects on pain processing. A systematic literature search was conducted to find pharmacological probes for validating these biomarkers. Once validated, these biomarkers combined with pharmacometric modelling are expected to accelerate analgesic drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Anesthesiology
Morten Hoegh, Annina B. Schmid, Per Hansson, Nanna Brix Finnerup
Article
Clinical Neurology
Nina Lykkegaard Gehr, Kristine Bennedsgaard, Lise Ventzel, Nanna Brix Finnerup
Summary: This article briefly discusses the importance of pain assessment after cancer treatment, including identifying the presence, underlying causes, impact, and mechanisms of pain.
SCANDINAVIAN JOURNAL OF PAIN
(2022)
Editorial Material
Clinical Neurology
Nanna Brix Finnerup
Article
Anesthesiology
Kanita Zubcevic, Merete Petersen, Flemming Winther Bach, Aksel Heinesen, Thomas Peter Enggaard, Thomas Peter Almdal, Jakob Vormstrup Holbech, Lene Vase, Troels Stahelin Jensen, Christian Stevns Hansen, Nanna Brix Finnerup, Soren H. Sindrup
Summary: This study aimed to examine the effect of two cannabinoids and their combination on peripheral neuropathic pain. The results showed that CBD, THC, and their combination did not relieve neuropathic pain.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Medicine, General & Internal
Giovanni E. Ferreira, Christina Abdel-Shaheed, Martin Underwood, Nanna B. Finnerup, Richard Day, Andrew McLachlan, Sam Eldabe, Joshua R. Zadro, Christopher G. Maher
Summary: This study provides a comprehensive overview of the efficacy, safety, and tolerability of antidepressants for different pain conditions. The results show that antidepressants are effective in some pain conditions, particularly proton pump inhibitors, postoperative pain, neuropathic pain, and fibromyalgia. However, there is insufficient evidence to support the efficacy of antidepressants in other pain conditions. A more nuanced approach is needed when prescribing antidepressants for pain conditions.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Review
Anesthesiology
Annina B. B. Schmid, Brigitte Tampin, Ralf Baron, Nanna B. B. Finnerup, Per Hansson, Aki Hietaharju, Kika Konstantinou, Chung-Wei Christine Lin, John Markman, Christine Price, Blair H. H. Smith, Helen Slater
Summary: This article presents the outcomes of a working group commissioned by the Neuropathic Pain Special Interest Group (NeuPSIG) of the International Association for the Study of Pain (IASP), which aimed to revise the use of terminology for classifying spine-related leg pain and propose a way forward on the identification of neuropathic pain in this context.
Article
Clinical Neurology
Eva Widerstrom-Noga, Fin Biering-Sorensen, Thomas N. Bryce, Diana D. Cardenas, Nanna B. Finnerup, Mark P. Jensen, J. Scott Richards, Jan Rosner, Julian Taylor
Summary: To update the International Spinal Cord Injury Pain Basic Data Set (ISCIPBDS version 2.0) and incorporate suggestions from the SCI pain clinical and research community, the study group revised the ISCIPBDS (Version 3.0) through expert opinion, feedback, revisions, and final consensus, making the dataset more flexible and useful.
Correction
Anesthesiology
Nanna B. Finnerup, Lone Nikolajsen, Andrew S. C. Rice
Article
Clinical Neurology
Mustapha Itani, Sif Gylfadottir, Thomas Kroigard, Laura Gaist, Jakob Vormstrup Holbech, Alexander Gramm Kristensen, Pall Karlsson, Soren Moller, Hatice Tankisi, David Gaist, Troels S. Jensen, Nanna Brix Finnerup, Soren Hein Sindrup
Summary: This study compared the demographics, cardiovascular risk factors, and clinical characteristics of diabetic polyneuropathy (DPN) and idiopathic polyneuropathy (IPN). The results showed that patients with DPN were older, had higher body mass index and waist circumference, and were more likely to be diagnosed with hypertension. In addition, DPN patients had slightly higher neuropathy symptom scores, lower frequency of hyperalgesia and decreased vibration on quantitative sensory testing, lower intraepidermal nerve fibre density count, and higher prevalence of small-fiber neuropathy.
BMJ NEUROLOGY OPEN
(2022)
Meeting Abstract
Clinical Neurology
Sandra Gylfadottir, Mustafa Itani, Jens Nyengaard, Soren Sindrup, Troels Jensen, Nanna Finnerup, Pall Karlsson
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2022)
