Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Zhang, Haijing Zhao, Yayi Liu, Manqin Zeng, Jun Zhang, Dapeng Hao
Summary: This study assessed the diagnostic performance of DCE-MRI and 18F-FDG PET/CT parameters in evaluating the biological behavior of soft tissue tumors. The results showed that these parameters can effectively differentiate between benign and malignant tumors as well as high and low-proliferation malignant tumors.
ACADEMIC RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Amandine Crombe, George R. Matcuk, David Fadli, Andrea Sambri, Dakshesh B. Patel, Anna Paioli, Michele Kind, Paolo Spinnato
Summary: Imaging is not fully utilized in the initial staging of patients with soft tissue sarcomas (STS), and few radiological features are currently used for prognosis and treatment guidance. However, qualitative and quantitative prognostic characteristics from MRI and PET have been identified. This review aims to summarize complex and innovative MRI, PET, and radiomics features and highlight their role in predicting patient outcomes indirectly (through histologic grade) or directly.
ACADEMIC RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Julie K. Shade, Adityo Prakosa, Dan M. Popescu, Rebecca Yu, David R. Okada, Jonathan Chrispin, Natalia A. Trayanova
Summary: The study introduces a two-step precision risk prediction technology for patients with CS, accurately assessing arrhythmogenic propensity and potentially transforming CS risk stratification.
Article
Oncology
Steven P. Rowe, Martin G. Pomper
Summary: Molecular imaging, defined as visualizing, characterizing, and measuring biological processes at the molecular and cellular levels, has rapidly developed in recent years, with a particular focus on oncology for early detection and optimal disease management. The expansion of molecular imaging is driven by new animal models, sensitive imaging devices, high-throughput methods, genetic manipulation techniques, and cloud computing. Researchers and clinicians are utilizing molecular imaging for a variety of physiological processes, with a focus on oncology for its potential in detecting diseases at an early stage.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Review
Endocrinology & Metabolism
Jie Jiang, Xiaoxia Tang, Yongzhu Pu, Yong Yang, Conghui Yang, Fake Yang, Yadong Tian, Jindan Li, Hua Sun, Sheng Zhao, Long Chen
Summary: This article reviews the progress of PET/CT research in biochemical recurrence of prostate cancer, aiming to introduce new technologies and provide more direction for future research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Wenxia Dong, Ning Wang, Zhe Qi
Summary: The prevalence of brain cancer is increasing and brings significant healthcare challenges. Immunotherapies present diagnostic imaging challenges for brain tumors. Effective neuroimaging techniques are necessary for diagnosing and monitoring brain tumors, but differentiating between tumors and necrotic lesions or inflamed tissues remains a challenge. This review summarizes recent advances in neuroimaging methods for enhancing brain tumor diagnosis and evaluating inflamed lesions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Health Care Sciences & Services
Igino Simonetti, Piero Trovato, Vincenza Granata, Carmine Picone, Roberta Fusco, Sergio Venanzio Setola, Mauro Mattace Raso, Corrado Caraco, Paolo A. Ascierto, Fabio Sandomenico, Antonella Petrillo
Summary: Interval metastasis is a specific type of lymph node metastasis in patients with melanoma. Imaging techniques such as ultrasound, CT, MRI, lymphoscintigraphy, and PET are used for evaluation. Understanding these methods and collaborating with clinicians are essential for treatment and survival.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Valeria Romeo, Thomas H. Helbich, Katja Pinker
Summary: The recent introduction of hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) as a promising imaging modality for breast cancer assessment has sparked extensive research on its clinical applications. This state-of-the-art review provides an overview of advanced MRI techniques, PET tracers, and the use of radiomics and artificial intelligence techniques in hybrid breast PET/MRI. The strengths and limitations of hybrid PET/MRI in the real world are also discussed.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Ponsiglione, Arnaldo Stanzione, Gaia Spadarella, Agah Baran, Luca Alessandro Cappellini, Kevin Groot Lipman, Peter Van Ooijen, Renato Cuocolo
Summary: The overall methodological rigor of radiomics studies in the ovarian field is not ideal, with a lack of prospective design and formal validation of results. This limits the reproducibility of results and potential translation to clinical setting.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, Research & Experimental
Marius E. Mayerhoefer, Markus Raderer, Wolfgang Lamm, Verena Pichler, Sarah Pfaff, Michael Weber, Barbara Kiesewetter, Markus Hacker, Lukas Kazianka, Philipp B. Staber, Hans-Juergen Wester, Johannes Rohrbeck, Ingrid Simonitsch-Klupp, Alexander Haug
Summary: In this prospective study, [Ga-68]Pentixafor-PET showed higher sensitivity and detection rates compared to [F-18]FDG-PET in patients with mantle cell lymphoma (MCL), indicating that it may be a potential alternative for imaging in these patients. The study also found that SUVs and TBRs were significantly higher for [Ga-68]Pentixafor-PET, with the most notable difference observed in mean TBRblood values.
Article
Cardiac & Cardiovascular Systems
Aylina Glasenapp, Katja Derlin, Marcel Gutberlet, Annika Hess, Tobias L. Ross, Hans-Juergen Wester, Frank M. Bengel, James T. Thackeray
Summary: The study focused on investigating the interplay between ventricle loading conditions, tissue inflammation, and progressive fibrosis in pressure overload heart failure using noninvasive multimodality molecular imaging. Inflammation and fibrosis play crucial roles in the early response to pressure overload and can be sensitively monitored by multimodality imaging, which may guide novel treatment strategies in nonischemic heart failure.
CIRCULATION RESEARCH
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Masaya Kawaguchi, Hiroki Kato, Yoshifumi Noda, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Fuminori Hyodo, Masayuki Matsuo
Summary: Accurate preoperative diagnosis is crucial for malignant skin tumors (MSTs) due to the different clinical management required for each histological subtype. Radiological imaging plays a significant role in evaluating the extent of local invasion, nodal involvement, and distant metastasis in MSTs. Recent studies have identified characteristic radiological features that aid in the differential diagnosis of MSTs, such as configuration, intratumoral homogeneity, signal intensity, cyst formation, and hemorrhage. Clinical data, including age, gender, and site of occurrence, are also important for determining the histological subtype of MSTs.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Jiang, Honghong Wu, Yufei Zhao, Ying Cui, Jingyue Dai, Shanshan Huang, Cheng Li, Hui Mao, Shenghong Ju, Xin-Gui Peng
Summary: This study aims to investigate and develop imaging biomarkers for the diagnosis of cancer-associated cachexia based on the organ and tissue-specific abnormal metabolisms measured by fluorine-18-fluorodeoxyglucose (F-18-FDG) PET/CT. The study analyzed FDG PET/CT data from 390 cancer patients and divided them into a development cohort and a validation cohort. Logistic regression analysis was performed to identify independent variables associated with cachexia and a regression model was generated. The model showed promising results in both the development and validation cohorts, indicating that organ and tissue-specific abnormal glucose metabolism could be used as a biomarker for cancer-associated cachexia.
EUROPEAN RADIOLOGY
(2023)
Review
Cell Biology
John J. McCabe, Nicholas R. Evans, Sarah Gorey, Shiv Bhakta, James H. F. Rudd, Peter J. Kelly
Summary: In this review, the development of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) as an imaging modality for quantifying plaque vulnerability is discussed, along with the challenges in standardization of image acquisition and analysis, its potential application to routine clinical care after stroke, and its possible role in future drug discovery.
Editorial Material
Oncology
Hannah M. Linden, David A. Mankoff
Summary: [F-18]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker that predicts clinical benefit of endocrine therapy and measures target activity in drug development. A recent study showed that tumor heterogeneity of expression predicts clinical benefit, and serial FES monitoring can assess estrogen receptor blockade and posttreatment release.
CLINICAL CANCER RESEARCH
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Youngjune Kim, Choong Guen Chee, Junghoon Kim, Jungheum Cho, Min A. Yoon, Hye Won Chung
Summary: The study aimed to assess the diagnostic performance of plain radiography for sacroiliitis in patients suspected of having axial spondyloarthritis. The results showed that plain radiography had low sensitivity but reasonable specificity for diagnosing sacroiliitis in these patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jae Sung Yun, Min Hee Lee, Seung Min Lee, Jong Seok Lee, Hwa Jung Kim, Sun Joo Lee, Hye Won Chung, Sang Hoon Lee, Myung Jin Shin
Summary: Benign and malignant PNSTs exhibit distinct features on both MRI and DWI. A combination of mean ADC value and absence of split fat is highly effective in discriminating malignant from benign PNSTs.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyun Kyung Lim, Hong Il Ha, Sun-Young Park, Junhee Han
Summary: This study evaluated the prediction performance of femoral osteoporosis using machine-learning analysis with radiomics features and APCT, showing high validity with more than 93% accuracy, specificity, and negative predictive value.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Young Suh, Sun-Young Park, Sung Hye Koh, In Jae Lee, Kwanseop Lee
Summary: Ultrasonography is a useful tool for detecting soft tissue changes in rheumatoid arthritis, beyond just synovitis. However, radiologists often overlook other manifestations of rheumatoid arthritis in daily practice, focusing primarily on synovitis. This pictorial essay provides a wide range of ultrasonographic findings in various soft tissues to aid in accurate diagnosis of rheumatoid arthritis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Min A. Yoon, Choong Guen Chee, Hye Won Chung, Dong Hyun Lee, Kyung Won Kim
Summary: The study suggests that low-dose whole-body CT as a first-line imaging modality for diagnosing plasma cell disorders demonstrates relatively high sensitivity and specificity, while DWI may not be an acceptable first-line imaging modality due to low specificity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Choong Guen Chee, Min A. Yoon, Kyung Won Kim, Yusun Ko, Su Jung Ham, Young Chul Cho, Bumwoo Park, Hye Won Chung
Summary: The combined radiomics-clinical model showed good calibration and discrimination in predicting malignancy of vertebral compression fractures on CT. It outperformed both the radiomics score and clinical predictor model in terms of discrimination performance and accurately stratified patients into low and high risk groups.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Choong Guen Chee, Hye Won Chung, Wanlim Kim, Min A. Yoon, So Myoung Shin, Guk Bae Kim
Summary: This study evaluated the osseous anatomy of the proximal femur using 3D-MRI with Dixon or water excitation (WE) fat suppression methods. The results showed that the maximum difference between WE and Dixon methods was higher in the WE method. However, the mean differences were equivalent, indicating that WE and Dixon fat suppression methods are comparable. The femoral shaft area had the highest mean difference among different anatomical areas.
Article
Oncology
Heejung Chae, Jeong Eun Kim, Wanlim Kim, Jong-Seok Lee, Si Yeol Song, Min Hee Lee, Hye Won Chung, Kyung-Ja Cho, Joon Seon Song, Jin-Hee Ahn
Summary: This study aimed to describe the clinical course of liposarcoma (LPS) and evaluate the clinical impact of programmed death-ligand 1 (PD-L1). The results showed that the clinical course of LPS varied according to histology and anatomic location. Clear resection margin and postoperative radiotherapy were important for reducing recurrence. PD-L1 was positive in a portion of LPS cases, but its prognostic role was unclear.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Yeon Kim, Min A. Yoon, Su Jung Ham, Young Chul Cho, Yousun Ko, Bumwoo Park, Seonok Kim, Eugene Lee, Ro Woon Lee, Choong Guen Chee, Min Hee Lee, Sang Hoon Lee, Hye Won Chung
Summary: This study developed and validated prediction models for differentiating acute and chronic vertebral compression fractures based on radiologic and radiomic features on CT. The results showed that the integrated model combining radiomics with radiologic findings had better performance in determining the acuity of vertebral compression fractures.
ACADEMIC RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sun-Young Park, Hong Il Ha, Injae Lee, Hyun Kyung Lim
Summary: HU histogram analysis (HUHA) showed better performance than bone mineral density (BMD) in assessing proximal femoral fragility fractures. HUHA(fat) had a higher odds ratio and AUC compared to BMD, indicating its feasibility as a potential tool for clinical assessment of fragility fractures.
EUROPEAN RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sun-Young Park, Hong Il Ha, Sang Min Lee, In Jae Lee, Hyun Kyung Lim
Summary: By comparing the computed tomography (CT) indexes in abdominal-pelvic CT using two- and three-dimensional analyses, the study found that the CT indexes on 3D-VOI showed similar diagnostic accuracy in predicting femoral osteoporosis with better measurement reproducibility compared to 2D-ROI.
Article
Oncology
Hyehyun Jeong, Hyeon-Su Im, Wanlim Kim, Jong-Seok Lee, Si Yeol Song, Joon Seon Song, Kyung-Ja Cho, Hye Won Chung, Min Hee Lee, Jeong Eun Kim, Jin-Hee Ahn
Summary: The study analyzed 28 years of sarcoma patient data and found changes in treatment patterns for soft tissue and bone sarcomas. Older age and early diagnosis were associated with poorer survival outcomes.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Duck Min Seo, Sang Min Lee, Ji Won Park, Min-Jeong Kim, Hong Il Ha, Sun-Young Park, Kwanseop Lee
Summary: This retrospective study aimed to determine the number of times the ultrasound-guided attenuation parameter (UGAP) should be measured during the evaluation of hepatic steatosis. The study found that there were no significant differences between UGAP measurements repeated six times and those repeated 12 times, and the reliability was maintained. Therefore, six UGAP measurements seem sufficient for evaluating hepatic steatosis using UGAP.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kyung Ho Kim, Min Hee Lee, Sun-Young Park, Hwa Jung Kim, Choong Guen Chee, Min A. Yoon, Hye Won Chung, Sang Hoon Lee
Summary: This study aimed to evaluate the association between DTI parameters of the ulnar nerve at the elbow and clinical outcomes in patients undergoing cubital tunnel decompression surgery for ulnar neuropathy. The results showed that the AUCs of FA, AD, and MD were higher at level 1 than at levels 2 and 3, with FA showing the highest AUC.
EUROPEAN RADIOLOGY
(2023)