Review
Biochemistry & Molecular Biology
Maria Carmela Cerra, Mariacristina Filice, Alessia Caferro, Rosa Mazza, Alfonsina Gattuso, Sandra Imbrogno
Summary: Aquatic animals are facing increasing challenges due to fluctuations in oxygen levels caused by global warming and eutrophication. Teleost fish, such as species from the Cyprinidae family, demonstrate species-specific adaptability to low oxygen environments. These fish have developed unique mechanisms to preserve cardiac function, allowing them to survive in low oxygen conditions. By studying these adaptations, researchers can gain insights into functional changes and molecular events in the fish heart, with potential applications in environmental management and decision making.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Sander Verheule, Ulrich Schotten
Summary: Fibrosis is recognized as a key determinant of conduction disturbances in both atria and ventricles, with different forms such as replacement, endomysial, perimysial, perivascular, endocardial, and epicardial fibrosis. The impact on conduction depends on how the patterns of electrical connections between myocytes are altered. Evaluating cardiac fibrosis should exclude fibrous tissue that does not affect conduction and differentiate between different types.
Article
Cardiac & Cardiovascular Systems
Pieter Martens, Matthias Dupont, Jeroen Dauw, Petra Nijst, Lieven Herbots, Paul Dendale, Pieter Vandervoort, Liesbeth Bruckers, Wai Hong Wilson Tang, Wilfried Mullens
Summary: The study demonstrated that treatment with ferric carboxymaltose (FCM) in patients with heart failure with reduced ejection fraction (HFrEF) and iron deficiency led to significant improvements in cardiac function, including LVEF, LVESV, and cardiac force-frequency relationship.
EUROPEAN HEART JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Deborah M. Eaton, Thomas G. Martin, Michael Kasa, Natasa Djalinac, Senka Ljubojevic-Holzer, Dirk Von Lewinski, Maria Poettler, Theerachat Kampaengsri, Andreas Krumphuber, Katharina Scharer, Heinrich Maechler, Andreas Zirlik, Timothy A. McKinsey, Jonathan A. Kirk, Steven R. Houser, Peter P. Rainer, Markus Wallner
Summary: This study evaluated the effects of the pan-HDAC inhibitor SAHA on cardiac function in a heart failure model and found that SAHA can improve cardiomyocyte and contractile protein function by increasing myofilament calcium sensitivity and reducing diastolic tension.
Review
Medicine, General & Internal
Procolo Marchese, Francesca Gennaro, Giovanni Mazzotta, Claudia Acciarri, Stenio Amabili, Carlo Bonanni, Antonella D'Antonio, Domenico Delfino, Luca Di Vito, Manrico Partemi, Riccardo Pascucci, Andrea Romandini, Giancarla Scalone, Simona Silenzi, Pierfrancesco Grossi
Summary: Cardiac amyloidosis can lead to severe heart failure. Cardiac contractility modulation has been shown to be effective in treating symptomatic heart failure, but its application in patients with cardiac amyloidosis has not been studied. We present a case where cardiac contractility modulation therapy was effective in improving clinical status and reducing hospital admissions in a patient with TTR amyloidosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Niels Grote Beverborg, Daniela Spater, Ralph Knoll, Alejandro Hidalgo, Steve T. Yeh, Zaher Elbeck, Herman H. W. Sillje, Tim R. Eijgenraam, Humam Siga, Magdalena Zurek, Malin Palmer, Susanne Pehrsson, Tamsin Albery, Nils Bomer, Martijn F. Hoes, Cornelis J. Boogerd, Michael Frisk, Eva van Rooij, Sagar Damle, William E. Louch, Qing-Dong Wang, Regina Fritsche-Danielson, Kenneth R. Chien, Kenny M. Hansson, Adam E. Mullick, Rudolf A. de Boer, Peter van der Meer
Summary: The study shows that antisense inhibition of PLN is an effective therapeutic strategy in preclinical models of genetic cardiomyopathy and ischemia-driven heart failure, significantly improving cardiac function and survival rates.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Xiaopu Lin, Chuna Chen, Yingshan Liu, Yu Peng, Zhenguo Chen, Haishan Huang, Lingling Xu
Summary: This study demonstrated that nerve conduction studies (NCS) and sympathetic skin response (SSR) are reliable methods to detect diabetic cardiac autonomic neuropathy (DCAN). Abnormality in the peroneal nerve (motor nerve) is crucial in predicting the disease. SSR may also help predict DCAN.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Lukas Menges, Jan Giesen, Kerem Yilmaz, Evanthia Mergia, Annette Fuechtbauer, Ernst-Martin Fuechtbauer, Doris Koesling, Michael Russwurm
Summary: The presence of NO/cGMP signaling in cardiac cells is still disputed. Recent experiments have shown that NO can induce cGMP signals in cardiac fibroblasts, but not in cardiomyocytes. However, in a co-culture model, cGMP produced in fibroblasts in response to NO can enter cardiomyocytes through gap junctions. In intact tissue, we demonstrate that cGMP produced in cardiac fibroblasts can be transferred to cardiomyocytes via gap junctions.
COMMUNICATIONS BIOLOGY
(2023)
Article
Clinical Neurology
Lara Rosler, Glenn van der Lande, Jeanne Leerssen, Austin G. Vandegriffe, Oti Lakbila-Kamal, Jessica C. Foster-Dingley, Anne C. W. Albers, Eus J. W. van Someren
Summary: This study evaluates the objective quantification of insomnia by assessing state-related changes in cardiac measures. The researchers found that incorporating these changes in cardiac features in the ambulatory monitoring of sleep could provide a more sensitive biomarker for diagnosing and assessing the severity of insomnia.
Article
Cardiac & Cardiovascular Systems
Sebastian Wolfrum, Kevin Roedl, Alexia Hanebutte, Rudiger Pfeifer, Volkhard Kurowski, Reimer Riessen, Anne Daubmann, Stephan Braune, Gerold Soffker, Eric Bibiza-Freiwald, Karl Wegscheider, Heribert Schunkert, Holger Thiele, Stefan Kluge
Summary: This study found that hypothermic temperature control after IHCA did not improve survival nor functional outcome. The study may have been underpowered to detect clinically important differences between hypothermic temperature control and normothermia.
Article
Medicine, General & Internal
Sang Hoon Oh, Ho-Shik Kim, Kyu Nam Park, Sanghee Ji, Ji-Young Park, Seung Pill Choi, Jee Yong Lim, Han Joon Kim
Summary: Early circulating microRNAs (miRNAs) levels in cardiac arrest patients undergoing targeted temperature management (TTM) are associated with 6-month neurological outcomes. The predictive value of miRNAs is superior to protein biomarkers, especially when combined.
Article
Cardiac & Cardiovascular Systems
Qingtong Wang, Ying Wang, Toni M. West, Yongming Liu, Gopireddy R. Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K. Xiang
Summary: By studying the molecular signaling and positive cardiac contractility induced by beta-blockers in the heart, it was found that carvedilol can promote cardiac inotropy and have a protective effect in diabetic mice. The observations suggest a novel beta(1)AR-NOS3 signaling pathway that may be targeted in therapy for heart diseases with reduced ejection fraction.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Zihan Li, Qiming Liu, Shenghua Zhou, Yichao Xiao
Summary: CCM is a novel therapeutic approach for heart failure patients who are unresponsive to cardiac resynchronization therapy. Despite some limitations, such as insufficient data and specialized device implantation skills, further research and wider usage can improve therapeutic outcomes and benefit more patients.
Article
Cardiac & Cardiovascular Systems
Qingtong Wang, Ying Wang, Toni M. West, Yongming Liu, Gopireddy R. Reddy, Federica Barbagallo, Bing Xu, Qian Shi, Bingqing Deng, Wei Wei, Yang K. Xiang
Summary: The study investigated the molecular signaling and effects of beta-blockers on cardiac inotropy in animal hearts. The results showed that carvedilol, a beta-blocker, can promote cardiac contractility through a specific signaling pathway, restoring heart function in diabetic mice and reducing cell apoptosis and hypertrophy in diabetic hearts.
CARDIOVASCULAR RESEARCH
(2021)
Article
Peripheral Vascular Disease
Lindsea C. Booth, R. Anethra U. de Silva, Roberto B. Pontes, Song T. Yao, Sally G. Hood, Yugeesh R. Lankadeva, Junko Kosaka, Nina Eikelis, Gavin W. Lambert, Markus P. Schlaich, Clive N. May
Summary: Clinical studies suggest that renal denervation (RDN) has beneficial effects on the autonomic control of the heart in heart failure, with experimental evidence showing improvements in sodium handling and clearance. In sheep with established heart failure, catheter-based RDN led to decreased heart rate, increased parasympathetic control, and improved kidney function, indicating potential benefits for both the heart and kidneys in heart failure.